NPAS2 (neuronal PAS domain protein 2)

2007-07-01  

Identity

HGNC
NPAS2
LOCATION
2q11.2
LOCUSID
4862
ALIAS
MOP4,PASD4,bHLHe9
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4862
MIM: 603347
HGNC: 7895
Ensembl: ENSG00000170485

Variants:

dbSNP: 4862
ClinVar: 4862
TCGA: ENSG00000170485
COSMIC: NPAS2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170485ENST00000335681Q99743
ENSG00000170485ENST00000335681A2I2P5
ENSG00000170485ENST00000427413H7C0Z2
ENSG00000170485ENST00000433408H7C080
ENSG00000170485ENST00000448812H7BZA3
ENSG00000170485ENST00000450763H7BZY5
ENSG00000170485ENST00000451740H7C0J4

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Circadian rhythmKEGGko04710
Circadian rhythmKEGGhsa04710
Circadian ClockREACTOMER-HSA-400253
BMAL1:CLOCK,NPAS2 activates circadian gene expressionREACTOMER-HSA-1368108
RORA activates gene expressionREACTOMER-HSA-1368082
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)REACTOMER-HSA-400206
PPARA activates gene expressionREACTOMER-HSA-1989781

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
200721162010Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CLOCK and VIP with bipolar disorder.91
165287482006Suggestive evidence for association of the circadian genes PERIOD3 and ARNTL with bipolar disorder.88
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
174577202007Three circadian clock genes Per2, Arntl, and Npas2 contribute to winter depression.80
126553192003Circadian clock-related polymorphisms in seasonal affective disorder and their relevance to diurnal preference.74
199343272009Testing the circadian gene hypothesis in prostate cancer: a population-based case-control study.51
172648412007Association of Per1 and Npas2 with autistic disorder: support for the clock genes/social timing hypothesis.50
172648412007Association of Per1 and Npas2 with autistic disorder: support for the clock genes/social timing hypothesis.50
208177222010Characterization of the core mammalian clock component, NPAS2, as a REV-ERBalpha/RORalpha target gene.50
198399952009Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia.49

Citation

Dessen P

NPAS2 (neuronal PAS domain protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-07-01

Online version: http://atlasgeneticsoncology.org/gene/47635/npas2