NPBWR2 (neuropeptides B and W receptor 2)

2014-11-01  

Identity

HGNC
LOCATION
20q13.33
LOCUSID
ALIAS
GPR8

Other Information

Locus ID:

NCBI: 2832
MIM: 600731
HGNC: 4530
Ensembl: ENSG00000125522

Variants:

dbSNP: 2832
ClinVar: 2832
TCGA: ENSG00000125522
COSMIC: NPBWR2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000125522ENST00000369768P48146

Expression (GTEx)

0
1

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

References

Pubmed IDYearTitleCitations
127195372003Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8.37
124018092003Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8.22
157979612005G protein receptors 7 and 8 are expressed in human adrenocortical cells, and their endogenous ligands neuropeptides B and w enhance cortisol secretion by activating adenylate cyclase- and phospholipase C-dependent signaling cascades.9
273998772016Characterization of Neuropeptide B (NPB), Neuropeptide W (NPW), and Their Receptors in Chickens: Evidence for NPW Being a Novel Inhibitor of Pituitary GH and Prolactin Secretion.7

Citation

Dessen P

NPBWR2 (neuropeptides B and W receptor 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/70916/npbwr2