Atlas of Genetics and Cytogenetics in Oncology and Haematology


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NPFFR2 (neuropeptide FF receptor 2)

Identity

Alias_namesGPR74
G protein-coupled receptor 74
Alias_symbol (synonym)NPFF2
NPGPR
Other aliasHLWAR77
HGNC (Hugo) NPFFR2
LocusID (NCBI) 10886
Atlas_Id 70922
Location 4q13.3  [Link to chromosome band 4q13]
Location_base_pair Starts at 72039132 and ends at 72148201 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CDH1 (16q22.1) / NPFFR2 (4q13.3)HS6ST2 (Xq26.2) / NPFFR2 (4q13.3)HS6ST2 NPFFR2
CDH1 NPFFR2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(4;16)(q13;q22) CDH1/NPFFR2
t(X;4)(q26;q13) HS6ST2/NPFFR2


External links

Nomenclature
HGNC (Hugo)NPFFR2   4525
Cards
Entrez_Gene (NCBI)NPFFR2  10886  neuropeptide FF receptor 2
AliasesGPR74; HLWAR77; NPFF2; NPGPR
GeneCards (Weizmann)NPFFR2
Ensembl hg19 (Hinxton)ENSG00000056291 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000056291 [Gene_View]  chr4:72039132-72148201 [Contig_View]  NPFFR2 [Vega]
ICGC DataPortalENSG00000056291
TCGA cBioPortalNPFFR2
AceView (NCBI)NPFFR2
Genatlas (Paris)NPFFR2
WikiGenes10886
SOURCE (Princeton)NPFFR2
Genetics Home Reference (NIH)NPFFR2
Genomic and cartography
GoldenPath hg38 (UCSC)NPFFR2  -     chr4:72039132-72148201 +  4q13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NPFFR2  -     4q13.3   [Description]    (hg19-Feb_2009)
EnsemblNPFFR2 - 4q13.3 [CytoView hg19]  NPFFR2 - 4q13.3 [CytoView hg38]
Mapping of homologs : NCBINPFFR2 [Mapview hg19]  NPFFR2 [Mapview hg38]
OMIM607449   
Gene and transcription
Genbank (Entrez)AF119815 AF236083 AF257210 AF268899 AF330053
RefSeq transcript (Entrez)NM_001144756 NM_004885 NM_053036
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NPFFR2
Cluster EST : UnigeneHs.99231 [ NCBI ]
CGAP (NCI)Hs.99231
Alternative Splicing GalleryENSG00000056291
Gene ExpressionNPFFR2 [ NCBI-GEO ]   NPFFR2 [ EBI - ARRAY_EXPRESS ]   NPFFR2 [ SEEK ]   NPFFR2 [ MEM ]
Gene Expression Viewer (FireBrowse)NPFFR2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10886
GTEX Portal (Tissue expression)NPFFR2
Human Protein AtlasENSG00000056291-NPFFR2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y5X5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y5X5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y5X5
Splice isoforms : SwissVarQ9Y5X5
PhosPhoSitePlusQ9Y5X5
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)GPCR_Rhodpsn    GPCR_Rhodpsn_7TM    NPFF_rcpt    NPFF_rcpt_2   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Domain families : Smart (EMBL)7TM_GPCR_Srsx (SM01381)  
Conserved Domain (NCBI)NPFFR2
DMDM Disease mutations10886
Blocks (Seattle)NPFFR2
SuperfamilyQ9Y5X5
Human Protein Atlas [tissue]ENSG00000056291-NPFFR2 [tissue]
Peptide AtlasQ9Y5X5
HPRD16244
IPIIPI00306912   IPI00221213   IPI00221214   IPI00221215   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y5X5
IntAct (EBI)Q9Y5X5
FunCoupENSG00000056291
BioGRIDNPFFR2
STRING (EMBL)NPFFR2
ZODIACNPFFR2
Ontologies - Pathways
QuickGOQ9Y5X5
Ontology : AmiGO###############################################################################################################################################################################################################################################################                                
Ontology : EGO-EBI###############################################################################################################################################################################################################################################################                                
Pathways : KEGGNeuroactive ligand-receptor interaction   
NDEx NetworkNPFFR2
Atlas of Cancer Signalling NetworkNPFFR2
Wikipedia pathwaysNPFFR2
Orthology - Evolution
OrthoDB10886
GeneTree (enSembl)ENSG00000056291
Phylogenetic Trees/Animal Genes : TreeFamNPFFR2
HOVERGENQ9Y5X5
HOGENOMQ9Y5X5
Homologs : HomoloGeneNPFFR2
Homology/Alignments : Family Browser (UCSC)NPFFR2
Gene fusions - Rearrangements
Fusion: TCGA_MDACCHS6ST2 NPFFR2
Fusion: TCGA_MDACCCDH1 NPFFR2
Fusion PortalHS6ST2 NPFFR2
Fusion PortalCDH1 NPFFR2
Fusion : QuiverNPFFR2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNPFFR2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NPFFR2
dbVarNPFFR2
ClinVarNPFFR2
1000_GenomesNPFFR2 
Exome Variant ServerNPFFR2
ExAC (Exome Aggregation Consortium)ENSG00000056291
GNOMAD BrowserENSG00000056291
Genetic variants : HAPMAP10886
Genomic Variants (DGV)NPFFR2 [DGVbeta]
DECIPHERNPFFR2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNPFFR2 
Mutations
ICGC Data PortalNPFFR2 
TCGA Data PortalNPFFR2 
Broad Tumor PortalNPFFR2
OASIS PortalNPFFR2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNPFFR2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNPFFR2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NPFFR2
DgiDB (Drug Gene Interaction Database)NPFFR2
DoCM (Curated mutations)NPFFR2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NPFFR2 (select a term)
intoGenNPFFR2
Cancer3DNPFFR2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607449   
Orphanet
DisGeNETNPFFR2
MedgenNPFFR2
Genetic Testing Registry NPFFR2
NextProtQ9Y5X5 [Medical]
TSGene10886
GENETestsNPFFR2
Target ValidationNPFFR2
Huge Navigator NPFFR2 [HugePedia]
snp3D : Map Gene to Disease10886
BioCentury BCIQNPFFR2
ClinGenNPFFR2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10886
Chemical/Pharm GKB GenePA28918
Clinical trialNPFFR2
Miscellaneous
canSAR (ICR)NPFFR2 (select the gene name)
Probes
Litterature
PubMed23 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNPFFR2
EVEXNPFFR2
GoPubMedNPFFR2
iHOPNPFFR2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Feb 23 18:44:48 CET 2018

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