NPFFR2 (neuropeptide FF receptor 2)

2014-11-01 Affiliation

Identity

HGNC

NPFFR2

LOCATION

4q13.3

LOCUSID

10886

ALIAS

GPR74,HLWAR77,NPFF2,NPGPR

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 10886
MIM: 607449
HGNC: 4525
Ensembl: ENSG00000056291

Variants:

dbSNP: 10886
ClinVar: 10886
TCGA: ENSG00000056291
COSMIC: NPFFR2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000056291	ENST00000308744	Q9Y5X5
ENSG00000056291	ENST00000344413	Q9Y5X5
ENSG00000056291	ENST00000358749	Q9Y5X5
ENSG00000056291	ENST00000358749	A0PJM9
ENSG00000056291	ENST00000395999	Q9Y5X5

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Neuroactive ligand-receptor interaction	KEGG	ko04080
Neuroactive ligand-receptor interaction	KEGG	hsa04080
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class A/1 (Rhodopsin-like receptors)	REACTOME	R-HSA-373076
Peptide ligand-binding receptors	REACTOME	R-HSA-375276
Orexin and neuropeptides FF and QRFP bind to their respective receptors	REACTOME	R-HSA-389397
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (q) signalling events	REACTOME	R-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPK	REACTOME	R-HSA-881907

References

Pubmed ID	Year	Title	Citations
20600636	2010	Human kisspeptins activate neuropeptide FF2 receptor.	16
15608144	2005	Neuropeptide FF (NPFF) analogs functionally antagonize opioid activities in NPFF2 receptor-transfected SH-SY5Y neuroblastoma cells.	13
21818152	2011	Polymorphisms in the NPY2R gene show significant associations with BMI that are additive to FTO, MC4R, and NPFFR2 gene effects.	13
22375000	2012	GRK2 protein-mediated transphosphorylation contributes to loss of function of μ-opioid receptors induced by neuropeptide FF (NPFF2) receptors.	13
19944730	2010	Pharmacological characterization of the mouse NPFF2 receptor.	6
25326382	2014	Identification and functional characterization of the phosphorylation sites of the neuropeptide FF2 receptor.	5
17503329	2007	A common haplotype in the G-protein-coupled receptor gene GPR74 is associated with leanness and increased lipolysis.	4
17503329	2007	A common haplotype in the G-protein-coupled receptor gene GPR74 is associated with leanness and increased lipolysis.	4
18565622	2008	Neuropeptide FF2 receptor distribution in the human brain. An immunohistochemical study.	4
15127947	2003	Functional properties of Pfr(Tic)amide and BIBP3226 at human neuropeptide FF2 receptors.	2

Citation

Dessen P

NPFFR2 (neuropeptide FF receptor 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/70922/npffr2