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NPLOC4 (NPL4 homolog, ubiquitin recognition factor)

Identity

Alias_namesnuclear protein localization 4 homolog (S. cerevisiae)
NPLOC4 ubiquitin recognition factor
Alias_symbol (synonym)NPL4
FLJ20657
KIAA1499
Other alias
HGNC (Hugo) NPLOC4
LocusID (NCBI) 55666
Atlas_Id 51979
Location 17q25.3  [Link to chromosome band 17q25]
Location_base_pair Starts at 81556885 and ends at 81637153 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
FAAP100 (17q25.3) / NPLOC4 (17q25.3)GPATCH8 (17q21.31) / NPLOC4 (17q25.3)NPLOC4 (17q25.3) / AC087491.2 ()
NPLOC4 (17q25.3) / ANTXR2 (4q21.21)NPLOC4 (17q25.3) / NPLOC4 (17q25.3)NPLOC4 (17q25.3) / P4HB (17q25.3)
NPLOC4 (17q25.3) / PDE6G (17q25.3)NPLOC4 (17q25.3) / SIRT7 (17q25.3)NPLOC4 (17q25.3) / TBCD (17q25.3)
SPARC (5q33.1) / NPLOC4 (17q25.3)C17orf70 NPLOC4 17q25.3GPATCH8 17q21.31 / NPLOC4 17q25.3
NPLOC4 17q25.3 AC087491.2NPLOC4 17q25.3 / P4HB 17q25.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NPLOC4   18261
Cards
Entrez_Gene (NCBI)NPLOC4  55666  NPL4 homolog, ubiquitin recognition factor
AliasesNPL4
GeneCards (Weizmann)NPLOC4
Ensembl hg19 (Hinxton)ENSG00000182446 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000182446 [Gene_View]  chr17:81556885-81637153 [Contig_View]  NPLOC4 [Vega]
ICGC DataPortalENSG00000182446
TCGA cBioPortalNPLOC4
AceView (NCBI)NPLOC4
Genatlas (Paris)NPLOC4
WikiGenes55666
SOURCE (Princeton)NPLOC4
Genetics Home Reference (NIH)NPLOC4
Genomic and cartography
GoldenPath hg38 (UCSC)NPLOC4  -     chr17:81556885-81637153 -  17q25.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NPLOC4  -     17q25.3   [Description]    (hg19-Feb_2009)
EnsemblNPLOC4 - 17q25.3 [CytoView hg19]  NPLOC4 - 17q25.3 [CytoView hg38]
Mapping of homologs : NCBINPLOC4 [Mapview hg19]  NPLOC4 [Mapview hg38]
OMIM606590   
Gene and transcription
Genbank (Entrez)AB040932 AK000664 AK023046 AK023272 AK024398
RefSeq transcript (Entrez)NM_017921
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NPLOC4
Cluster EST : UnigeneHs.464333 [ NCBI ]
CGAP (NCI)Hs.464333
Alternative Splicing GalleryENSG00000182446
Gene ExpressionNPLOC4 [ NCBI-GEO ]   NPLOC4 [ EBI - ARRAY_EXPRESS ]   NPLOC4 [ SEEK ]   NPLOC4 [ MEM ]
Gene Expression Viewer (FireBrowse)NPLOC4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55666
GTEX Portal (Tissue expression)NPLOC4
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8TAT6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8TAT6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8TAT6
Splice isoforms : SwissVarQ8TAT6
PhosPhoSitePlusQ8TAT6
Domaine pattern : Prosite (Expaxy)ZF_RANBP2_1 (PS01358)    ZF_RANBP2_2 (PS50199)   
Domains : Interpro (EBI)Npl4    NPL4_C    Npl4_Ub-like_dom    NPL4_Zn-bd_put    Ubiquitin-rel_dom    Znf_RanBP2   
Domain families : Pfam (Sanger)NPL4 (PF05021)    UN_NPL4 (PF11543)    zf-NPL4 (PF05020)   
Domain families : Pfam (NCBI)pfam05021    pfam11543    pfam05020   
Domain families : Smart (EMBL)ZnF_RBZ (SM00547)  
Conserved Domain (NCBI)NPLOC4
DMDM Disease mutations55666
Blocks (Seattle)NPLOC4
SuperfamilyQ8TAT6
Human Protein AtlasENSG00000182446
Peptide AtlasQ8TAT6
HPRD06975
IPIIPI00290543   IPI00001676   IPI01013928   
Protein Interaction databases
DIP (DOE-UCLA)Q8TAT6
IntAct (EBI)Q8TAT6
FunCoupENSG00000182446
BioGRIDNPLOC4
STRING (EMBL)NPLOC4
ZODIACNPLOC4
Ontologies - Pathways
QuickGOQ8TAT6
Ontology : AmiGOprotein binding  nucleus  nucleoplasm  endoplasmic reticulum  cytosol  ubiquitin-dependent protein catabolic process  ubiquitin-dependent protein catabolic process  Golgi organization  zinc ion binding  ubiquitin-dependent ERAD pathway  retrograde protein transport, ER to cytosol  ubiquitin protein ligase binding  negative regulation of type I interferon production  VCP-NPL4-UFD1 AAA ATPase complex  VCP-NPL4-UFD1 AAA ATPase complex  UFD1-NPL4 complex  negative regulation of RIG-I signaling pathway  nuclear outer membrane-endoplasmic reticulum membrane network  ubiquitin binding  error-free translesion synthesis  
Ontology : EGO-EBIprotein binding  nucleus  nucleoplasm  endoplasmic reticulum  cytosol  ubiquitin-dependent protein catabolic process  ubiquitin-dependent protein catabolic process  Golgi organization  zinc ion binding  ubiquitin-dependent ERAD pathway  retrograde protein transport, ER to cytosol  ubiquitin protein ligase binding  negative regulation of type I interferon production  VCP-NPL4-UFD1 AAA ATPase complex  VCP-NPL4-UFD1 AAA ATPase complex  UFD1-NPL4 complex  negative regulation of RIG-I signaling pathway  nuclear outer membrane-endoplasmic reticulum membrane network  ubiquitin binding  error-free translesion synthesis  
Pathways : KEGGProtein processing in endoplasmic reticulum   
NDEx NetworkNPLOC4
Atlas of Cancer Signalling NetworkNPLOC4
Wikipedia pathwaysNPLOC4
Orthology - Evolution
OrthoDB55666
GeneTree (enSembl)ENSG00000182446
Phylogenetic Trees/Animal Genes : TreeFamNPLOC4
HOVERGENQ8TAT6
HOGENOMQ8TAT6
Homologs : HomoloGeneNPLOC4
Homology/Alignments : Family Browser (UCSC)NPLOC4
Gene fusions - Rearrangements
Fusion : MitelmanFAAP100/NPLOC4 [17q25.3/17q25.3]  [t(17;17)(q25;q25)]  
Fusion : MitelmanGPATCH8/NPLOC4 [17q21.31/17q25.3]  [t(17;17)(q21;q25)]  
Fusion : MitelmanNPLOC4/P4HB [17q25.3/17q25.3]  [t(17;17)(q25;q25)]  
Fusion : MitelmanNPLOC4/PDE6G [17q25.3/17q25.3]  [t(17;17)(q25;q25)]  
Fusion : MitelmanNPLOC4/SIRT7 [17q25.3/17q25.3]  [dup(17)(q25q25)]  
Fusion: TCGAC17orf70 NPLOC4 17q25.3 LUSC
Fusion: TCGAGPATCH8 17q21.31 NPLOC4 17q25.3 BRCA
Fusion: TCGANPLOC4 17q25.3 AC087491.2 BRCA
Fusion: TCGANPLOC4 17q25.3 P4HB 17q25.3 LUSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNPLOC4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NPLOC4
dbVarNPLOC4
ClinVarNPLOC4
1000_GenomesNPLOC4 
Exome Variant ServerNPLOC4
ExAC (Exome Aggregation Consortium)NPLOC4 (select the gene name)
Genetic variants : HAPMAP55666
Genomic Variants (DGV)NPLOC4 [DGVbeta]
DECIPHERNPLOC4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNPLOC4 
Mutations
ICGC Data PortalNPLOC4 
TCGA Data PortalNPLOC4 
Broad Tumor PortalNPLOC4
OASIS PortalNPLOC4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNPLOC4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNPLOC4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NPLOC4
DgiDB (Drug Gene Interaction Database)NPLOC4
DoCM (Curated mutations)NPLOC4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NPLOC4 (select a term)
intoGenNPLOC4
Cancer3DNPLOC4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606590   
Orphanet
MedgenNPLOC4
Genetic Testing Registry NPLOC4
NextProtQ8TAT6 [Medical]
TSGene55666
GENETestsNPLOC4
Target ValidationNPLOC4
Huge Navigator NPLOC4 [HugePedia]
snp3D : Map Gene to Disease55666
BioCentury BCIQNPLOC4
ClinGenNPLOC4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55666
Chemical/Pharm GKB GenePA143485558
Clinical trialNPLOC4
Miscellaneous
canSAR (ICR)NPLOC4 (select the gene name)
Probes
Litterature
PubMed62 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNPLOC4
EVEXNPLOC4
GoPubMedNPLOC4
iHOPNPLOC4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:47:15 CEST 2017

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