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NPLOC4 (NPL4 homolog, ubiquitin recognition factor)

Identity

Alias (NCBI)NPL4
HGNC (Hugo) NPLOC4
HGNC Alias symbNPL4
FLJ20657
KIAA1499
HGNC Previous namenuclear protein localization 4 homolog (S. cerevisiae)
 NPLOC4 ubiquitin recognition factor
LocusID (NCBI) 55666
Atlas_Id 51979
Location 17q25.3  [Link to chromosome band 17q25]
Location_base_pair Starts at 81556887 and ends at 81637112 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FAAP100 (17q25.3) / NPLOC4 (17q25.3)GPATCH8 (17q21.31) / NPLOC4 (17q25.3)NPLOC4 (17q25.3) / AC087491.2 ()
NPLOC4 (17q25.3) / ANTXR2 (4q21.21)NPLOC4 (17q25.3) / NPLOC4 (17q25.3)NPLOC4 (17q25.3) / P4HB (17q25.3)
NPLOC4 (17q25.3) / PDE6G (17q25.3)NPLOC4 (17q25.3) / SIRT7 (17q25.3)NPLOC4 (17q25.3) / TBCD (17q25.3)
SPARC (5q33.1) / NPLOC4 (17q25.3)C17orf70 NPLOC4 17q25.3GPATCH8 17q21.31 / NPLOC4 17q25.3
NPLOC4 17q25.3 AC087491.2NPLOC4 17q25.3 / P4HB 17q25.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)NPLOC4   18261
Cards
Entrez_Gene (NCBI)NPLOC4    NPL4 homolog, ubiquitin recognition factor
AliasesNPL4
GeneCards (Weizmann)NPLOC4
Ensembl hg19 (Hinxton)ENSG00000182446 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000182446 [Gene_View]  ENSG00000182446 [Sequence]  chr17:81556887-81637112 [Contig_View]  NPLOC4 [Vega]
ICGC DataPortalENSG00000182446
TCGA cBioPortalNPLOC4
AceView (NCBI)NPLOC4
Genatlas (Paris)NPLOC4
SOURCE (Princeton)NPLOC4
Genetics Home Reference (NIH)NPLOC4
Genomic and cartography
GoldenPath hg38 (UCSC)NPLOC4  -     chr17:81556887-81637112 -  17q25.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NPLOC4  -     17q25.3   [Description]    (hg19-Feb_2009)
GoldenPathNPLOC4 - 17q25.3 [CytoView hg19]  NPLOC4 - 17q25.3 [CytoView hg38]
ImmunoBaseENSG00000182446
Genome Data Viewer NCBINPLOC4 [Mapview hg19]  
OMIM606590   
Gene and transcription
Genbank (Entrez)AB040932 AK000664 AK023046 AK023272 AK024398
RefSeq transcript (Entrez)NM_001369698 NM_017921
Consensus coding sequences : CCDS (NCBI)NPLOC4
Gene ExpressionNPLOC4 [ NCBI-GEO ]   NPLOC4 [ EBI - ARRAY_EXPRESS ]   NPLOC4 [ SEEK ]   NPLOC4 [ MEM ]
Gene Expression Viewer (FireBrowse)NPLOC4 [ Firebrowse - Broad ]
GenevisibleExpression of NPLOC4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55666
GTEX Portal (Tissue expression)NPLOC4
Human Protein AtlasENSG00000182446-NPLOC4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8TAT6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8TAT6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8TAT6
PhosPhoSitePlusQ8TAT6
Domaine pattern : Prosite (Expaxy)MPN (PS50249)    ZF_RANBP2_1 (PS01358)    ZF_RANBP2_2 (PS50199)   
Domains : Interpro (EBI)MPN    Npl4    NPL4_C    Npl4_Ub-like_dom    NPL4_Zn-bd_put    Ubiquitin-like_domsf    Znf_RanBP2    Znf_RanBP2_sf   
Domain families : Pfam (Sanger)NPL4 (PF05021)    UN_NPL4 (PF11543)    zf-NPL4 (PF05020)   
Domain families : Pfam (NCBI)pfam05021    pfam11543    pfam05020   
Domain families : Smart (EMBL)ZnF_RBZ (SM00547)  
Conserved Domain (NCBI)NPLOC4
SuperfamilyQ8TAT6
AlphaFold pdb e-kbQ8TAT6   
Human Protein Atlas [tissue]ENSG00000182446-NPLOC4 [tissue]
HPRD06975
Protein Interaction databases
DIP (DOE-UCLA)Q8TAT6
IntAct (EBI)Q8TAT6
BioGRIDNPLOC4
STRING (EMBL)NPLOC4
ZODIACNPLOC4
Ontologies - Pathways
QuickGOQ8TAT6
Ontology : AmiGOprotein binding  nucleus  nucleus  nucleoplasm  endoplasmic reticulum  cytosol  ubiquitin-dependent protein catabolic process  ubiquitin-dependent protein catabolic process  Golgi organization  ubiquitin-dependent ERAD pathway  retrograde protein transport, ER to cytosol  ubiquitin protein ligase binding  negative regulation of type I interferon production  VCP-NPL4-UFD1 AAA ATPase complex  VCP-NPL4-UFD1 AAA ATPase complex  UFD1-NPL4 complex  negative regulation of RIG-I signaling pathway  nuclear outer membrane-endoplasmic reticulum membrane network  ubiquitin binding  metal ion binding  error-free translesion synthesis  
Ontology : EGO-EBIprotein binding  nucleus  nucleus  nucleoplasm  endoplasmic reticulum  cytosol  ubiquitin-dependent protein catabolic process  ubiquitin-dependent protein catabolic process  Golgi organization  ubiquitin-dependent ERAD pathway  retrograde protein transport, ER to cytosol  ubiquitin protein ligase binding  negative regulation of type I interferon production  VCP-NPL4-UFD1 AAA ATPase complex  VCP-NPL4-UFD1 AAA ATPase complex  UFD1-NPL4 complex  negative regulation of RIG-I signaling pathway  nuclear outer membrane-endoplasmic reticulum membrane network  ubiquitin binding  metal ion binding  error-free translesion synthesis  
Pathways : KEGGProtein processing in endoplasmic reticulum   
NDEx NetworkNPLOC4
Atlas of Cancer Signalling NetworkNPLOC4
Wikipedia pathwaysNPLOC4
Orthology - Evolution
OrthoDB55666
GeneTree (enSembl)ENSG00000182446
Phylogenetic Trees/Animal Genes : TreeFamNPLOC4
Homologs : HomoloGeneNPLOC4
Homology/Alignments : Family Browser (UCSC)NPLOC4
Gene fusions - Rearrangements
Fusion : MitelmanFAAP100/NPLOC4 [17q25.3/17q25.3]  
Fusion : MitelmanGPATCH8/NPLOC4 [17q21.31/17q25.3]  
Fusion : MitelmanNPLOC4/P4HB [17q25.3/17q25.3]  
Fusion : MitelmanNPLOC4/PDE6G [17q25.3/17q25.3]  
Fusion : MitelmanNPLOC4/SIRT7 [17q25.3/17q25.3]  
Fusion : QuiverNPLOC4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNPLOC4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NPLOC4
dbVarNPLOC4
ClinVarNPLOC4
MonarchNPLOC4
1000_GenomesNPLOC4 
Exome Variant ServerNPLOC4
GNOMAD BrowserENSG00000182446
Varsome BrowserNPLOC4
ACMGNPLOC4 variants
VarityQ8TAT6
Genomic Variants (DGV)NPLOC4 [DGVbeta]
DECIPHERNPLOC4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNPLOC4 
Mutations
ICGC Data PortalNPLOC4 
TCGA Data PortalNPLOC4 
Broad Tumor PortalNPLOC4
OASIS PortalNPLOC4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNPLOC4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNPLOC4
Mutations and Diseases : HGMDNPLOC4
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaNPLOC4
DgiDB (Drug Gene Interaction Database)NPLOC4
DoCM (Curated mutations)NPLOC4
CIViC (Clinical Interpretations of Variants in Cancer)NPLOC4
Cancer3DNPLOC4
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606590   
Orphanet
DisGeNETNPLOC4
MedgenNPLOC4
Genetic Testing Registry NPLOC4
NextProtQ8TAT6 [Medical]
GENETestsNPLOC4
Target ValidationNPLOC4
Huge Navigator NPLOC4 [HugePedia]
ClinGenNPLOC4
Clinical trials, drugs, therapy
MyCancerGenomeNPLOC4
Protein Interactions : CTDNPLOC4
Pharm GKB GenePA143485558
PharosQ8TAT6
Clinical trialNPLOC4
Miscellaneous
canSAR (ICR)NPLOC4
HarmonizomeNPLOC4
DataMed IndexNPLOC4
Probes
Litterature
PubMed102 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXNPLOC4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:23:09 CEST 2021

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