NPLOC4 (NPL4 homolog, ubiquitin recognition factor)

2011-01-01 Affiliation

Identity

HGNC

NPLOC4

LOCATION

17q25.3

LOCUSID

55666

ALIAS

NPL4

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 55666
MIM: 606590
HGNC: 18261
Ensembl: ENSG00000182446

Variants:

dbSNP: 55666
ClinVar: 55666
TCGA: ENSG00000182446
COSMIC: NPLOC4

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000182446	ENST00000331134	Q8TAT6
ENSG00000182446	ENST00000331134	A0A024R8R4
ENSG00000182446	ENST00000374747	Q8TAT6
ENSG00000182446	ENST00000570324	I3L4S2
ENSG00000182446	ENST00000571714	I3L3I1
ENSG00000182446	ENST00000572760	K7EJN1
ENSG00000182446	ENST00000572824	I3L0W3
ENSG00000182446	ENST00000573212	I3L283
ENSG00000182446	ENST00000573519	I3L281
ENSG00000182446	ENST00000573876	K7EJN1
ENSG00000182446	ENST00000574897	I3L4U9
ENSG00000182446	ENST00000625705	A0A0D9SFI9

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Protein processing in endoplasmic reticulum	KEGG	ko04141
Protein processing in endoplasmic reticulum	KEGG	hsa04141
p97-Ufd1-Npl4 complex	KEGG	hsa_M00400
HRD1/SEL1 ERAD complex	KEGG	hsa_M00403
HRD1/SEL1 ERAD complex	KEGG	M00403
p97-Ufd1-Npl4 complex	KEGG	M00400
DNA Repair	REACTOME	R-HSA-73894
DNA Damage Bypass	REACTOME	R-HSA-73893
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	REACTOME	R-HSA-110313
Translesion Synthesis by POLH	REACTOME	R-HSA-110320

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
28512218	2017	Ubiquitin- and ATP-dependent unfoldase activity of P97/VCP•NPLOC4•UFD1L is enhanced by a mutation that causes multisystem proteinopathy.	41
21486945	2011	Cdc48/p97-Ufd1-Npl4 antagonizes Aurora B during chromosome segregation in HeLa cells.	26
23293021	2013	Complex of Fas-associated factor 1 (FAF1) with valosin-containing protein (VCP)-Npl4-Ufd1 and polyubiquitinated proteins promotes endoplasmic reticulum-associated degradation (ERAD).	20
24248593	2014	The p97-UFD1L-NPL4 protein complex mediates cytokine-induced IκBα proteolysis.	17
20702414	2010	The p97 ATPase dislocates MHC class I heavy chain in US2-expressing cells via a Ufd1-Npl4-independent mechanism.	13
26112410	2015	The Transitional Endoplasmic Reticulum ATPase p97 Regulates the Alternative Nuclear Factor NF-κB Signaling via Partial Degradation of the NF-κB Subunit p100.	11
24429874	2014	The p97-Ufd1-Npl4 ATPase complex ensures robustness of the G2/M checkpoint by facilitating CDC25A degradation.	10
17331469	2007	Ufd1-Npl4 is a negative regulator of cholera toxin retrotranslocation.	7
18586029	2008	Analysis of Npl4 deletion mutants in mammalian cells unravels new Ufd1-interacting motifs and suggests a regulatory role of Npl4 in ERAD.	6
24019527	2013	NEDD8 ultimate buster-1 long (NUB1L) protein promotes transfer of NEDD8 to proteasome for degradation through the P97UFD1/NPL4 complex.	6

Citation

Dessen P

NPLOC4 (NPL4 homolog, ubiquitin recognition factor)

Atlas Genet Cytogenet Oncol Haematol. 2011-01-01

Online version: http://atlasgeneticsoncology.org/gene/51979/nploc4