Atlas of Genetics and Cytogenetics in Oncology and Haematology

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NPPA (natriuretic peptide A)

Identity

Alias (NCBI)ANF
ANP
ATFB6
ATRST2
CDD
CDD-ANF
CDP
PND
HGNC (Hugo) NPPA
HGNC Previous nameANP
 PND
HGNC Previous namenatriuretic peptide precursor A
LocusID (NCBI) 4878
Atlas_Id 41567
Location 1p36.22  [Link to chromosome band 1p36]
Location_base_pair Starts at 11845710 and ends at 11847783 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  del(6p) (loss of JARID2 and DTNBP1) in myeloid malignances

External links

Nomenclature
HGNC (Hugo)NPPA   7939
LRG (Locus Reference Genomic)LRG_751
Cards
Entrez_Gene (NCBI)NPPA    natriuretic peptide A
AliasesANF; ANP; ATFB6; ATRST2; 
CDD; CDD-ANF; CDP; PND
GeneCards (Weizmann)NPPA
Ensembl hg19 (Hinxton)ENSG00000175206 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000175206 [Gene_View]  ENSG00000175206 [Sequence]  chr1:11845710-11847783 [Contig_View]  NPPA [Vega]
ICGC DataPortalENSG00000175206
TCGA cBioPortalNPPA
AceView (NCBI)NPPA
Genatlas (Paris)NPPA
SOURCE (Princeton)NPPA
Genetics Home Reference (NIH)NPPA
Genomic and cartography
GoldenPath hg38 (UCSC)NPPA  -     chr1:11845710-11847783 -  1p36.22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NPPA  -     1p36.22   [Description]    (hg19-Feb_2009)
GoldenPathNPPA - 1p36.22 [CytoView hg19]  NPPA - 1p36.22 [CytoView hg38]
ImmunoBaseENSG00000175206
genome Data Viewer NCBINPPA [Mapview hg19]  
OMIM108780   612201   615745   
Gene and transcription
Genbank (Entrez)AA779538 BC005893 K02044 M30262
RefSeq transcript (Entrez)NM_006172
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NPPA
Alternative Splicing GalleryENSG00000175206
Gene ExpressionNPPA [ NCBI-GEO ]   NPPA [ EBI - ARRAY_EXPRESS ]   NPPA [ SEEK ]   NPPA [ MEM ]
Gene Expression Viewer (FireBrowse)NPPA [ Firebrowse - Broad ]
GenevisibleExpression of NPPA in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4878
GTEX Portal (Tissue expression)NPPA
Human Protein AtlasENSG00000175206-NPPA [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP01160   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP01160  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP01160
Splice isoforms : SwissVarP01160
PhosPhoSitePlusP01160
Domaine pattern : Prosite (Expaxy)NATRIURETIC_PEPTIDE (PS00263)   
Domains : Interpro (EBI)Natr_peptide    Natr_peptide_CS    Natriuretic_peptide_atrial   
Domain families : Pfam (Sanger)ANP (PF00212)   
Domain families : Pfam (NCBI)pfam00212   
Domain families : Smart (EMBL)NAT_PEP (SM00183)  
Conserved Domain (NCBI)NPPA
Blocks (Seattle)NPPA
PDB (RSDB)1ANP    1YK0    3N57   
PDB Europe1ANP    1YK0    3N57   
PDB (PDBSum)1ANP    1YK0    3N57   
PDB (IMB)1ANP    1YK0    3N57   
Structural Biology KnowledgeBase1ANP    1YK0    3N57   
SCOP (Structural Classification of Proteins)1ANP    1YK0    3N57   
CATH (Classification of proteins structures)1ANP    1YK0    3N57   
SuperfamilyP01160
Human Protein Atlas [tissue]ENSG00000175206-NPPA [tissue]
Peptide AtlasP01160
HPRD00164
IPIIPI00221279   IPI00644997   
Protein Interaction databases
DIP (DOE-UCLA)P01160
IntAct (EBI)P01160
BioGRIDNPPA
STRING (EMBL)NPPA
ZODIACNPPA
Ontologies - Pathways
QuickGOP01160
Ontology : AmiGOresponse to hypoxia  negative regulation of systemic arterial blood pressure  signaling receptor binding  signaling receptor binding  hormone activity  neuropeptide hormone activity  protein binding  extracellular region  extracellular region  extracellular space  nucleus  cytoplasm  brush border  cGMP biosynthetic process  cGMP biosynthetic process  transcription initiation from RNA polymerase II promoter  protein folding  receptor guanylyl cyclase signaling pathway  receptor guanylyl cyclase signaling pathway  neuropeptide signaling pathway  neuropeptide signaling pathway  female pregnancy  regulation of blood pressure  positive regulation of heart rate  positive regulation of cGMP-mediated signaling  cardiac muscle hypertrophy in response to stress  cGMP-mediated signaling  negative regulation of cell growth  response to insulin  protein-containing complex  response to muscle stretch  vasodilation  mast cell granule  cell projection  perikaryon  negative regulation of JUN kinase activity  cellular protein metabolic process  perinuclear region of cytoplasm  hormone receptor binding  hormone receptor binding  regulation of atrial cardiac muscle cell membrane repolarization  positive regulation of cardiac muscle contraction  cell growth involved in cardiac muscle cell development  collagen-containing extracellular matrix  cellular response to mechanical stimulus  neuropeptide receptor binding  regulation of high voltage-gated calcium channel activity  positive regulation of delayed rectifier potassium channel activity  regulation of calcium ion transmembrane transport via high voltage-gated calcium channel  positive regulation of histamine secretion by mast cell  positive regulation of potassium ion export across plasma membrane  regulation of cardiac conduction  negative regulation of collecting lymphatic vessel constriction  
Ontology : EGO-EBIresponse to hypoxia  negative regulation of systemic arterial blood pressure  signaling receptor binding  signaling receptor binding  hormone activity  neuropeptide hormone activity  protein binding  extracellular region  extracellular region  extracellular space  nucleus  cytoplasm  brush border  cGMP biosynthetic process  cGMP biosynthetic process  transcription initiation from RNA polymerase II promoter  protein folding  receptor guanylyl cyclase signaling pathway  receptor guanylyl cyclase signaling pathway  neuropeptide signaling pathway  neuropeptide signaling pathway  female pregnancy  regulation of blood pressure  positive regulation of heart rate  positive regulation of cGMP-mediated signaling  cardiac muscle hypertrophy in response to stress  cGMP-mediated signaling  negative regulation of cell growth  response to insulin  protein-containing complex  response to muscle stretch  vasodilation  mast cell granule  cell projection  perikaryon  negative regulation of JUN kinase activity  cellular protein metabolic process  perinuclear region of cytoplasm  hormone receptor binding  hormone receptor binding  regulation of atrial cardiac muscle cell membrane repolarization  positive regulation of cardiac muscle contraction  cell growth involved in cardiac muscle cell development  collagen-containing extracellular matrix  cellular response to mechanical stimulus  neuropeptide receptor binding  regulation of high voltage-gated calcium channel activity  positive regulation of delayed rectifier potassium channel activity  regulation of calcium ion transmembrane transport via high voltage-gated calcium channel  positive regulation of histamine secretion by mast cell  positive regulation of potassium ion export across plasma membrane  regulation of cardiac conduction  negative regulation of collecting lymphatic vessel constriction  
Pathways : KEGGHIF-1 signaling pathway   
NDEx NetworkNPPA
Atlas of Cancer Signalling NetworkNPPA
Wikipedia pathwaysNPPA
Orthology - Evolution
OrthoDB4878
GeneTree (enSembl)ENSG00000175206
Phylogenetic Trees/Animal Genes : TreeFamNPPA
HOGENOMP01160
Homologs : HomoloGeneNPPA
Homology/Alignments : Family Browser (UCSC)NPPA
Gene fusions - Rearrangements
Fusion : QuiverNPPA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNPPA [hg38]
dbVarNPPA
ClinVarNPPA
MonarchNPPA
1000_GenomesNPPA 
Exome Variant ServerNPPA
GNOMAD BrowserENSG00000175206
Varsome BrowserNPPA
Genomic Variants (DGV)NPPA [DGVbeta]
DECIPHERNPPA [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNPPA 
Mutations
ICGC Data PortalNPPA 
TCGA Data PortalNPPA 
Broad Tumor PortalNPPA
OASIS PortalNPPA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNPPA  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNPPA
Mutations and Diseases : HGMDNPPA
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NPPA
DgiDB (Drug Gene Interaction Database)NPPA
DoCM (Curated mutations)NPPA (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NPPA (select a term)
intoGenNPPA
Cancer3DNPPA(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM108780    612201    615745   
Orphanet982    8592   
DisGeNETNPPA
MedgenNPPA
Genetic Testing Registry NPPA
NextProtP01160 [Medical]
GENETestsNPPA
Target ValidationNPPA
Huge Navigator NPPA [HugePedia]
ClinGenNPPA
Clinical trials, drugs, therapy
MyCancerGenomeNPPA
Protein Interactions : CTD
Pharm GKB GenePA256
PharosP01160
Clinical trialNPPA
Miscellaneous
canSAR (ICR)NPPA (select the gene name)
HarmonizomeNPPA
DataMed IndexNPPA
Probes
Litterature
PubMed269 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXNPPA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jan 1 18:29:19 CET 2021
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