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NPPB (natriuretic peptide B)

Identity

Alias_namesnatriuretic peptide precursor B
Other aliasBNP
HGNC (Hugo) NPPB
LocusID (NCBI) 4879
Atlas_Id 41568
Location 1p36.22  [Link to chromosome band 1p36]
Location_base_pair Starts at 11917521 and ends at 11918992 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NPPB   7940
Cards
Entrez_Gene (NCBI)NPPB  4879  natriuretic peptide B
AliasesBNP
GeneCards (Weizmann)NPPB
Ensembl hg19 (Hinxton)ENSG00000120937 [Gene_View]  chr1:11917521-11918992 [Contig_View]  NPPB [Vega]
Ensembl hg38 (Hinxton)ENSG00000120937 [Gene_View]  chr1:11917521-11918992 [Contig_View]  NPPB [Vega]
ICGC DataPortalENSG00000120937
TCGA cBioPortalNPPB
AceView (NCBI)NPPB
Genatlas (Paris)NPPB
WikiGenes4879
SOURCE (Princeton)NPPB
Genetics Home Reference (NIH)NPPB
Genomic and cartography
GoldenPath hg19 (UCSC)NPPB  -     chr1:11917521-11918992 -  1p36.22   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)NPPB  -     1p36.22   [Description]    (hg38-Dec_2013)
EnsemblNPPB - 1p36.22 [CytoView hg19]  NPPB - 1p36.22 [CytoView hg38]
Mapping of homologs : NCBINPPB [Mapview hg19]  NPPB [Mapview hg38]
OMIM600295   
Gene and transcription
Genbank (Entrez)AJ708502 BC025785 CR541976 CR542003 M25296
RefSeq transcript (Entrez)NM_002521
RefSeq genomic (Entrez)NC_000001 NC_018912 NT_032977 NW_004929289
Consensus coding sequences : CCDS (NCBI)NPPB
Cluster EST : UnigeneHs.219140 [ NCBI ]
CGAP (NCI)Hs.219140
Alternative Splicing GalleryENSG00000120937
Gene ExpressionNPPB [ NCBI-GEO ]   NPPB [ EBI - ARRAY_EXPRESS ]   NPPB [ SEEK ]   NPPB [ MEM ]
Gene Expression Viewer (FireBrowse)NPPB [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4879
GTEX Portal (Tissue expression)NPPB
Protein : pattern, domain, 3D structure
UniProt/SwissProtP16860   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP16860  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP16860
Splice isoforms : SwissVarP16860
PhosPhoSitePlusP16860
Domaine pattern : Prosite (Expaxy)NATRIURETIC_PEPTIDE (PS00263)   
Domains : Interpro (EBI)Natr_peptide    Natr_peptide_CS    Natriuretic_peptide_brain   
Domain families : Pfam (Sanger)ANP (PF00212)   
Domain families : Pfam (NCBI)pfam00212   
Domain families : Smart (EMBL)NAT_PEP (SM00183)  
Conserved Domain (NCBI)NPPB
DMDM Disease mutations4879
Blocks (Seattle)NPPB
PDB (SRS)1YK1    3N56   
PDB (PDBSum)1YK1    3N56   
PDB (IMB)1YK1    3N56   
PDB (RSDB)1YK1    3N56   
Structural Biology KnowledgeBase1YK1    3N56   
SCOP (Structural Classification of Proteins)1YK1    3N56   
CATH (Classification of proteins structures)1YK1    3N56   
SuperfamilyP16860
Human Protein AtlasENSG00000120937
Peptide AtlasP16860
HPRD08974
IPIIPI00031101   IPI00844052   
Protein Interaction databases
DIP (DOE-UCLA)P16860
IntAct (EBI)P16860
FunCoupENSG00000120937
BioGRIDNPPB
STRING (EMBL)NPPB
ZODIACNPPB
Ontologies - Pathways
QuickGOP16860
Ontology : AmiGOreceptor binding  receptor binding  hormone activity  protein binding  extracellular region  extracellular space  cGMP biosynthetic process  cell surface receptor signaling pathway  receptor guanylyl cyclase signaling pathway  body fluid secretion  regulation of blood pressure  diuretic hormone activity  negative regulation of angiogenesis  negative regulation of cell growth  positive regulation of urine volume  positive regulation of renal sodium excretion  regulation of vasodilation  regulation of vascular permeability  protein complex  
Ontology : EGO-EBIreceptor binding  receptor binding  hormone activity  protein binding  extracellular region  extracellular space  cGMP biosynthetic process  cell surface receptor signaling pathway  receptor guanylyl cyclase signaling pathway  body fluid secretion  regulation of blood pressure  diuretic hormone activity  negative regulation of angiogenesis  negative regulation of cell growth  positive regulation of urine volume  positive regulation of renal sodium excretion  regulation of vasodilation  regulation of vascular permeability  protein complex  
Pathways : BIOCARTAALK in cardiac myocytes [Genes]   
NDEx NetworkNPPB
Atlas of Cancer Signalling NetworkNPPB
Wikipedia pathwaysNPPB
Orthology - Evolution
OrthoDB4879
GeneTree (enSembl)ENSG00000120937
Phylogenetic Trees/Animal Genes : TreeFamNPPB
HOVERGENP16860
HOGENOMP16860
Homologs : HomoloGeneNPPB
Homology/Alignments : Family Browser (UCSC)NPPB
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNPPB [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NPPB
dbVarNPPB
ClinVarNPPB
1000_GenomesNPPB 
Exome Variant ServerNPPB
ExAC (Exome Aggregation Consortium)NPPB (select the gene name)
Genetic variants : HAPMAP4879
Genomic Variants (DGV)NPPB [DGVbeta]
DECIPHER (Syndromes)1:11917521-11918992  ENSG00000120937
CONAN: Copy Number AnalysisNPPB 
Mutations
ICGC Data PortalNPPB 
TCGA Data PortalNPPB 
Broad Tumor PortalNPPB
OASIS PortalNPPB [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNPPB  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNPPB
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NPPB
DgiDB (Drug Gene Interaction Database)NPPB
DoCM (Curated mutations)NPPB (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NPPB (select a term)
intoGenNPPB
Cancer3DNPPB(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600295   
Orphanet
MedgenNPPB
Genetic Testing Registry NPPB
NextProtP16860 [Medical]
TSGene4879
GENETestsNPPB
Huge Navigator NPPB [HugePedia]
snp3D : Map Gene to Disease4879
BioCentury BCIQNPPB
ClinGenNPPB
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4879
Chemical/Pharm GKB GenePA31734
Clinical trialNPPB
Miscellaneous
canSAR (ICR)NPPB (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNPPB
EVEXNPPB
GoPubMedNPPB
iHOPNPPB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:19:14 CET 2017

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