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NPPC (natriuretic peptide C)

Identity

Alias_namesnatriuretic peptide precursor C
Alias_symbol (synonym)CNP
Other aliasCNP2
HGNC (Hugo) NPPC
LocusID (NCBI) 4880
Atlas_Id 50830
Location 2q37.1  [Link to chromosome band 2q37]
Location_base_pair Starts at 231922094 and ends at 231926403 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NPPC   7941
Cards
Entrez_Gene (NCBI)NPPC  4880  natriuretic peptide C
AliasesCNP; CNP2
GeneCards (Weizmann)NPPC
Ensembl hg19 (Hinxton)ENSG00000163273 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000163273 [Gene_View]  chr2:231922094-231926403 [Contig_View]  NPPC [Vega]
ICGC DataPortalENSG00000163273
TCGA cBioPortalNPPC
AceView (NCBI)NPPC
Genatlas (Paris)NPPC
WikiGenes4880
SOURCE (Princeton)NPPC
Genetics Home Reference (NIH)NPPC
Genomic and cartography
GoldenPath hg38 (UCSC)NPPC  -     chr2:231922094-231926403 -  2q37.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NPPC  -     2q37.1   [Description]    (hg19-Feb_2009)
EnsemblNPPC - 2q37.1 [CytoView hg19]  NPPC - 2q37.1 [CytoView hg38]
Mapping of homologs : NCBINPPC [Mapview hg19]  NPPC [Mapview hg38]
OMIM600296   
Gene and transcription
Genbank (Entrez)BC069120 BC105065 BC105067 D20847 DR003533
RefSeq transcript (Entrez)NM_024409
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NPPC
Cluster EST : UnigeneHs.627236 [ NCBI ]
CGAP (NCI)Hs.627236
Alternative Splicing GalleryENSG00000163273
Gene ExpressionNPPC [ NCBI-GEO ]   NPPC [ EBI - ARRAY_EXPRESS ]   NPPC [ SEEK ]   NPPC [ MEM ]
Gene Expression Viewer (FireBrowse)NPPC [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4880
GTEX Portal (Tissue expression)NPPC
Human Protein AtlasENSG00000163273-NPPC [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP23582   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP23582  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP23582
Splice isoforms : SwissVarP23582
PhosPhoSitePlusP23582
Domaine pattern : Prosite (Expaxy)NATRIURETIC_PEPTIDE (PS00263)   
Domains : Interpro (EBI)C_natriurtcpep    Natr_peptide    Natr_peptide_CS   
Domain families : Pfam (Sanger)ANP (PF00212)   
Domain families : Pfam (NCBI)pfam00212   
Domain families : Smart (EMBL)NAT_PEP (SM00183)  
Conserved Domain (NCBI)NPPC
DMDM Disease mutations4880
Blocks (Seattle)NPPC
PDB (SRS)1JDP   
PDB (PDBSum)1JDP   
PDB (IMB)1JDP   
PDB (RSDB)1JDP   
Structural Biology KnowledgeBase1JDP   
SCOP (Structural Classification of Proteins)1JDP   
CATH (Classification of proteins structures)1JDP   
SuperfamilyP23582
Human Protein Atlas [tissue]ENSG00000163273-NPPC [tissue]
Peptide AtlasP23582
HPRD08975
IPIIPI00012075   
Protein Interaction databases
DIP (DOE-UCLA)P23582
IntAct (EBI)P23582
FunCoupENSG00000163273
BioGRIDNPPC
STRING (EMBL)NPPC
ZODIACNPPC
Ontologies - Pathways
QuickGOP23582
Ontology : AmiGOossification  response to hypoxia  growth plate cartilage chondrocyte differentiation  growth plate cartilage chondrocyte proliferation  receptor binding  hormone activity  extracellular region  extracellular space  cGMP biosynthetic process  protein folding  receptor guanylyl cyclase signaling pathway  negative regulation of cell proliferation  post-embryonic development  secretory granule  regulation of cAMP metabolic process  regulation of cGMP metabolic process  positive regulation of cGMP biosynthetic process  regulation of multicellular organism growth  response to drug  protein homodimerization activity  protein complex  single organism reproductive process  response to ethanol  positive regulation of osteoblast differentiation  regulation of smooth muscle cell proliferation  negative regulation of DNA metabolic process  peptide hormone receptor binding  negative regulation of meiotic cell cycle  positive regulation of blood vessel diameter  negative regulation of oocyte maturation  regulation of cardiac conduction  
Ontology : EGO-EBIossification  response to hypoxia  growth plate cartilage chondrocyte differentiation  growth plate cartilage chondrocyte proliferation  receptor binding  hormone activity  extracellular region  extracellular space  cGMP biosynthetic process  protein folding  receptor guanylyl cyclase signaling pathway  negative regulation of cell proliferation  post-embryonic development  secretory granule  regulation of cAMP metabolic process  regulation of cGMP metabolic process  positive regulation of cGMP biosynthetic process  regulation of multicellular organism growth  response to drug  protein homodimerization activity  protein complex  single organism reproductive process  response to ethanol  positive regulation of osteoblast differentiation  regulation of smooth muscle cell proliferation  negative regulation of DNA metabolic process  peptide hormone receptor binding  negative regulation of meiotic cell cycle  positive regulation of blood vessel diameter  negative regulation of oocyte maturation  regulation of cardiac conduction  
NDEx NetworkNPPC
Atlas of Cancer Signalling NetworkNPPC
Wikipedia pathwaysNPPC
Orthology - Evolution
OrthoDB4880
GeneTree (enSembl)ENSG00000163273
Phylogenetic Trees/Animal Genes : TreeFamNPPC
HOVERGENP23582
HOGENOMP23582
Homologs : HomoloGeneNPPC
Homology/Alignments : Family Browser (UCSC)NPPC
Gene fusions - Rearrangements
Tumor Fusion PortalNPPC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNPPC [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NPPC
dbVarNPPC
ClinVarNPPC
1000_GenomesNPPC 
Exome Variant ServerNPRC,/A>
ExAC (Exome Aggregation Consortium)ENSG00000163273
GNOMAD BrowserENSG00000163273
Genetic variants : HAPMAP4880
Genomic Variants (DGV)NPPC [DGVbeta]
DECIPHERNPPC [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNPPC 
Mutations
ICGC Data PortalNPPC 
TCGA Data PortalNPPC 
Broad Tumor PortalNPPC
OASIS PortalNPPC [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNPPC  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNPPC
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NPPC
DgiDB (Drug Gene Interaction Database)NPPC
DoCM (Curated mutations)NPPC (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NPPC (select a term)
intoGenNPPC
Cancer3DNPPC(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600296   
Orphanet
DisGeNETNPPC
MedgenNPPC
Genetic Testing Registry NPPC
NextProtP23582 [Medical]
TSGene4880
GENETestsNPPC
Target ValidationNPPC
Huge Navigator NPPC [HugePedia]
snp3D : Map Gene to Disease4880
BioCentury BCIQNPPC
ClinGenNPPC
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4880
Chemical/Pharm GKB GenePA31735
Clinical trialNPPC
Miscellaneous
canSAR (ICR)NPPC (select the gene name)
Probes
Litterature
PubMed91 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNPPC
EVEXNPPC
GoPubMedNPPC
iHOPNPPC
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:26:38 CET 2017

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