Atlas of Genetics and Cytogenetics in Oncology and Haematology


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NPR1 (natriuretic peptide receptor 1)

Identity

Alias_namesANPRA
NPRA
atrionatriuretic peptide receptor A
natriuretic peptide receptor A
Alias_symbol (synonym)GUCY2A
ANPa
Other aliasGUC2A
HGNC (Hugo) NPR1
LocusID (NCBI) 4881
Atlas_Id 43382
Location 1q21.3  [Link to chromosome band 1q21]
Location_base_pair Starts at 153678688 and ends at 153693992 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NPR1   7943
Cards
Entrez_Gene (NCBI)NPR1  4881  natriuretic peptide receptor 1
AliasesANPRA; ANPa; GUC2A; GUCY2A; 
NPRA
GeneCards (Weizmann)NPR1
Ensembl hg19 (Hinxton)ENSG00000169418 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000169418 [Gene_View]  chr1:153678688-153693992 [Contig_View]  NPR1 [Vega]
ICGC DataPortalENSG00000169418
TCGA cBioPortalNPR1
AceView (NCBI)NPR1
Genatlas (Paris)NPR1
WikiGenes4881
SOURCE (Princeton)NPR1
Genetics Home Reference (NIH)NPR1
Genomic and cartography
GoldenPath hg38 (UCSC)NPR1  -     chr1:153678688-153693992 +  1q21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NPR1  -     1q21.3   [Description]    (hg19-Feb_2009)
EnsemblNPR1 - 1q21.3 [CytoView hg19]  NPR1 - 1q21.3 [CytoView hg38]
Mapping of homologs : NCBINPR1 [Mapview hg19]  NPR1 [Mapview hg38]
OMIM108960   
Gene and transcription
Genbank (Entrez)AK025024 AK298090 AK300446 BC063304 HM005333
RefSeq transcript (Entrez)NM_000906
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NPR1
Cluster EST : UnigeneHs.490330 [ NCBI ]
CGAP (NCI)Hs.490330
Alternative Splicing GalleryENSG00000169418
Gene ExpressionNPR1 [ NCBI-GEO ]   NPR1 [ EBI - ARRAY_EXPRESS ]   NPR1 [ SEEK ]   NPR1 [ MEM ]
Gene Expression Viewer (FireBrowse)NPR1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4881
GTEX Portal (Tissue expression)NPR1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP16066   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP16066  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP16066
Splice isoforms : SwissVarP16066
Catalytic activity : Enzyme4.6.1.2 [ Enzyme-Expasy ]   4.6.1.24.6.1.2 [ IntEnz-EBI ]   4.6.1.2 [ BRENDA ]   4.6.1.2 [ KEGG ]   
PhosPhoSitePlusP16066
Domaine pattern : Prosite (Expaxy)ANF_RECEPTORS (PS00458)    GUANYLATE_CYCLASE_1 (PS00452)    GUANYLATE_CYCLASE_2 (PS50125)    PROTEIN_KINASE_DOM (PS50011)   
Domains : Interpro (EBI)A/G_cyclase    A/G_cyclase_CS    ANF_lig-bd_rcpt    ANPR/GUC    Kinase-like_dom    Nucleotide_cyclase    Peripla_BP_I    Prot_kinase_dom    Ser-Thr/Tyr_kinase_cat_dom   
Domain families : Pfam (Sanger)ANF_receptor (PF01094)    Guanylate_cyc (PF00211)    Pkinase_Tyr (PF07714)   
Domain families : Pfam (NCBI)pfam01094    pfam00211    pfam07714   
Domain families : Smart (EMBL)CYCc (SM00044)  
Conserved Domain (NCBI)NPR1
DMDM Disease mutations4881
Blocks (Seattle)NPR1
SuperfamilyP16066
Human Protein AtlasENSG00000169418
Peptide AtlasP16066
HPRD00165
IPIIPI00027200   IPI01015799   IPI00514544   
Protein Interaction databases
DIP (DOE-UCLA)P16066
IntAct (EBI)P16066
FunCoupENSG00000169418
BioGRIDNPR1
STRING (EMBL)NPR1
ZODIACNPR1
Ontologies - Pathways
QuickGOP16066
Ontology : AmiGOadenylate cyclase activity  guanylate cyclase activity  protein kinase activity  ATP binding  GTP binding  plasma membrane  plasma membrane  integral component of plasma membrane  cGMP biosynthetic process  protein phosphorylation  cell surface receptor signaling pathway  receptor guanylyl cyclase signaling pathway  G-protein coupled receptor signaling pathway  body fluid secretion  guanylate cyclase complex, soluble  regulation of blood pressure  G-protein coupled peptide receptor activity  negative regulation of angiogenesis  natriuretic peptide receptor activity  peptide hormone binding  protein kinase binding  negative regulation of cell growth  positive regulation of cGMP biosynthetic process  intracellular signal transduction  positive regulation of urine volume  positive regulation of renal sodium excretion  dopamine metabolic process  hormone binding  regulation of vascular permeability  receptor complex  negative regulation of smooth muscle cell proliferation  regulation of blood vessel diameter  regulation of cardiac conduction  
Ontology : EGO-EBIadenylate cyclase activity  guanylate cyclase activity  protein kinase activity  ATP binding  GTP binding  plasma membrane  plasma membrane  integral component of plasma membrane  cGMP biosynthetic process  protein phosphorylation  cell surface receptor signaling pathway  receptor guanylyl cyclase signaling pathway  G-protein coupled receptor signaling pathway  body fluid secretion  guanylate cyclase complex, soluble  regulation of blood pressure  G-protein coupled peptide receptor activity  negative regulation of angiogenesis  natriuretic peptide receptor activity  peptide hormone binding  protein kinase binding  negative regulation of cell growth  positive regulation of cGMP biosynthetic process  intracellular signal transduction  positive regulation of urine volume  positive regulation of renal sodium excretion  dopamine metabolic process  hormone binding  regulation of vascular permeability  receptor complex  negative regulation of smooth muscle cell proliferation  regulation of blood vessel diameter  regulation of cardiac conduction  
Pathways : KEGGPurine metabolism    Vascular smooth muscle contraction   
NDEx NetworkNPR1
Atlas of Cancer Signalling NetworkNPR1
Wikipedia pathwaysNPR1
Orthology - Evolution
OrthoDB4881
GeneTree (enSembl)ENSG00000169418
Phylogenetic Trees/Animal Genes : TreeFamNPR1
HOVERGENP16066
HOGENOMP16066
Homologs : HomoloGeneNPR1
Homology/Alignments : Family Browser (UCSC)NPR1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNPR1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NPR1
dbVarNPR1
ClinVarNPR1
1000_GenomesNPR1 
Exome Variant ServerNPR1
ExAC (Exome Aggregation Consortium)NPR1 (select the gene name)
Genetic variants : HAPMAP4881
Genomic Variants (DGV)NPR1 [DGVbeta]
DECIPHERNPR1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNPR1 
Mutations
ICGC Data PortalNPR1 
TCGA Data PortalNPR1 
Broad Tumor PortalNPR1
OASIS PortalNPR1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNPR1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNPR1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NPR1
DgiDB (Drug Gene Interaction Database)NPR1
DoCM (Curated mutations)NPR1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NPR1 (select a term)
intoGenNPR1
Cancer3DNPR1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM108960   
Orphanet
MedgenNPR1
Genetic Testing Registry NPR1
NextProtP16066 [Medical]
TSGene4881
GENETestsNPR1
Target ValidationNPR1
Huge Navigator NPR1 [HugePedia]
snp3D : Map Gene to Disease4881
BioCentury BCIQNPR1
ClinGenNPR1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4881
Chemical/Pharm GKB GenePA31736
Clinical trialNPR1
Miscellaneous
canSAR (ICR)NPR1 (select the gene name)
Probes
Litterature
PubMed80 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNPR1
EVEXNPR1
GoPubMedNPR1
iHOPNPR1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:09:21 CEST 2017

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