NPR2 (natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B))

Identity

Other names	AMDM
	ANPRB
	GUC2B
	GUCY2B
	NPRB
	NPRBi
HGNC	NPR2
Location	9p21-p12
Location_base_pair	Starts at 35782406 and ends at 35799728 bp from pter ( according to hg18-March_2006).
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	NPR2   7944
Entrez_Gene	NPR2  4882  natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)
	Cards
GeneCards	NPR2
Ensembl	ENSG00000159899 [Gene_View]  NPR2 [Vega]
Genatlas	NPR2
	Genomic and cartography
GoldenPath	NPR2  -     chr9:35782406-35799728 +  9p13.3   [Description]    (hg18-March_2006)
Ensembl	NPR2 - 9p13.3 [CytoView]
NCBI	Mapview
OMIM	108961 Disease map [OMIM]
OMIM	602875 Disease map [OMIM]
HomoloGene	NPR2
	Gene and transcription
Genbank	AJ005282 [ ENTREZ ]
Genbank	BC023017 [ ENTREZ ]
Genbank	BC166642 [ ENTREZ ]
Genbank	BQ446138 [ ENTREZ ]
Genbank	L13436 [ ENTREZ ]
RefSeq	NM_003995 [ SRS ]    NM_003995 [ ENTREZ ]
RefSeq	AC_000052 [ SRS ]    AC_000052 [ ENTREZ ]
RefSeq	AC_000141 [ SRS ]    AC_000141 [ ENTREZ ]
RefSeq	NC_000009 [ SRS ]    NC_000009 [ ENTREZ ]
RefSeq	NT_008413 [ SRS ]    NT_008413 [ ENTREZ ]
RefSeq	NW_001839149 [ SRS ]    NW_001839149 [ ENTREZ ]
RefSeq	NW_924062 [ SRS ]    NW_924062 [ ENTREZ ]
CCDS	NPR2 CCDS - NCBI
AceView	NPR2 AceView - NCBI
Unigene	Hs.78518 [ SRS ]    Hs.78518 [ NCBI ]
Fast-db	6817 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P20594 [ SRS]    P20594 [ EXPASY ]     P20594 [ INTERPRO ]     P20594 [ UNIPROT ] P20594 [ VarSplice FASTA ]
Prosite	PS00458 ANF_RECEPTORS [ SRS ]    PS00458 ANF_RECEPTORS [ Expasy ]
Prosite	PS00452 GUANYLATE_CYCLASE_1 [ SRS ]    PS00452 GUANYLATE_CYCLASE_1 [ Expasy ]
Prosite	PS50125 GUANYLATE_CYCLASE_2 [ SRS ]    PS50125 GUANYLATE_CYCLASE_2 [ Expasy ]
Prosite	PS50011 PROTEIN_KINASE_DOM [ SRS ]    PS50011 PROTEIN_KINASE_DOM [ Expasy ]
Interpro	IPR001054 A/G_cyclase [ SRS ]    IPR001054 A/G_cyclase [ EBI ]
Interpro	IPR001828 ANF_lig_bd_rcpt [ SRS ]    IPR001828 ANF_lig_bd_rcpt [ EBI ]
Interpro	IPR001170 Ntpep_rcpt_N [ SRS ]    IPR001170 Ntpep_rcpt_N [ EBI ]
Interpro	IPR000719 Prot_kinase_core [ SRS ]    IPR000719 Prot_kinase_core [ EBI ]
Interpro	IPR017442 Se/Thr_pkinase-rel [ SRS ]    IPR017442 Se/Thr_pkinase-rel [ EBI ]
CluSTr	P20594
Pfam	PF01094 ANF_receptor [ SRS ]    PF01094 ANF_receptor [ Sanger ]    pfam01094 [ NCBI-CDD ]
Pfam	PF00211 Guanylate_cyc [ SRS ]    PF00211 Guanylate_cyc [ Sanger ]    pfam00211 [ NCBI-CDD ]
Pfam	PF00069 Pkinase [ SRS ]    PF00069 Pkinase [ Sanger ]    pfam00069 [ NCBI-CDD ]
Smart	SM00044 CYCc [EMBL]
Prodom	PD000001 Prot_kinase[INRA-Toulouse]
Prodom	P20594 ANPRB_HUMAN [ Domain structure ]   P20594 ANPRB_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	P20594
HPRD	00166
	Protein Interaction databases
DIP	P20594
IntAct	P20594
	Polymorphism : SNP, mutations, diseases
OMIM	108961    [ map ]
OMIM	602875    [ map ]
GENETests	108961
GENETests	602875
SNP	NPR2 [dbSNP-NCBI]
SNP	NM_003995 [SNP-NCI]
SNP	NPR2 [GeneSNPs - Utah]  NPR2] [HGBASE - SRS]
HAPMAP	NPR2 [HAPMAP]
COSMIC	NPR2 [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	NPR2
Genetic Association	NPR2
CDC HuGE	NPR2
	General knowledge
Family Browser	NPR2 [UCSC Family Browser]
SOURCE	NM_003995
SMD	Hs.78518
SAGE	Hs.78518
Enzyme	4.6.1.2 [ Enzyme-Expasy ]   4.6.1.2 [ Enzyme-SRS ]   4.6.1.2 [ IntEnz-EBI ]   4.6.1.2 [ BRENDA ]   4.6.1.2 [ KEGG ]
GO	guanylate cyclase activity [Amigo]  guanylate cyclase activity
GO	protein kinase activity [Amigo]  protein kinase activity
GO	transmembrane receptor activity [Amigo]  transmembrane receptor activity
GO	ATP binding [Amigo]  ATP binding
GO	plasma membrane [Amigo]  plasma membrane
GO	cGMP biosynthetic process [Amigo]  cGMP biosynthetic process
GO	protein amino acid phosphorylation [Amigo]  protein amino acid phosphorylation
GO	cell surface receptor linked signal transduction [Amigo]  cell surface receptor linked signal transduction
GO	intracellular signaling cascade [Amigo]  intracellular signaling cascade
GO	regulation of blood pressure [Amigo]  regulation of blood pressure
GO	peptide receptor activity, G-protein coupled [Amigo]  peptide receptor activity, G-protein coupled
GO	integral to membrane [Amigo]  integral to membrane
KEGG	Purine metabolism
KEGG	Gap junction
KEGG	Long-term depression
PubGene	NPR2
TreeFam	NPR2
CTD	4882 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	NPR2 Related clones (RZPD - Berlin)
	PubMed
PubMed	28 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

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Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Thu Nov 27 14:00:46 2008