Atlas of Genetics and Cytogenetics in Oncology and Haematology


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NPR3 (natriuretic peptide receptor 3)

Identity

Alias_namesNPRC
ANPRC
C5orf23
chromosome 5 open reading frame 23
atrionatriuretic peptide receptor C
natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
natriuretic peptide receptor C
Alias_symbol (synonym)GUCY2B
FLJ14054
Other aliasANP-C
ANPR-C
NPR-C
HGNC (Hugo) NPR3
LocusID (NCBI) 4883
Atlas_Id 56548
Location 5p13.3  [Link to chromosome band 5p13]
Location_base_pair Starts at 32711438 and ends at 32791830 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
C5orf42 (5p13.2) / NPR3 (5p13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NPR3   7945
Cards
Entrez_Gene (NCBI)NPR3  4883  natriuretic peptide receptor 3
AliasesANP-C; ANPR-C; ANPRC; C5orf23; 
GUCY2B; NPR-C; NPRC
GeneCards (Weizmann)NPR3
Ensembl hg19 (Hinxton)ENSG00000113389 [Gene_View]  chr5:32711438-32791830 [Contig_View]  NPR3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000113389 [Gene_View]  chr5:32711438-32791830 [Contig_View]  NPR3 [Vega]
ICGC DataPortalENSG00000113389
TCGA cBioPortalNPR3
AceView (NCBI)NPR3
Genatlas (Paris)NPR3
WikiGenes4883
SOURCE (Princeton)NPR3
Genetics Home Reference (NIH)NPR3
Genomic and cartography
GoldenPath hg19 (UCSC)NPR3  -     chr5:32711438-32791830 +  5p13.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)NPR3  -     5p13.3   [Description]    (hg38-Dec_2013)
EnsemblNPR3 - 5p13.3 [CytoView hg19]  NPR3 - 5p13.3 [CytoView hg38]
Mapping of homologs : NCBINPR3 [Mapview hg19]  NPR3 [Mapview hg38]
OMIM108962   
Gene and transcription
Genbank (Entrez)-
RefSeq transcript (Entrez)NM_000908 NM_001204375 NM_001204376 NM_024563
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NPR3
Cluster EST : UnigeneHs.619466 [ NCBI ]
CGAP (NCI)Hs.619466
Alternative Splicing GalleryENSG00000113389
Gene ExpressionNPR3 [ NCBI-GEO ]   NPR3 [ EBI - ARRAY_EXPRESS ]   NPR3 [ SEEK ]   NPR3 [ MEM ]
Gene Expression Viewer (FireBrowse)NPR3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4883
GTEX Portal (Tissue expression)NPR3
Protein : pattern, domain, 3D structure
UniProt/SwissProtP17342   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP17342  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP17342
Splice isoforms : SwissVarP17342
PhosPhoSitePlusP17342
Domaine pattern : Prosite (Expaxy)ANF_RECEPTORS (PS00458)   
Domains : Interpro (EBI)ANF_lig-bd_rcpt    ANPR/GUC    Peripla_BP_I   
Domain families : Pfam (Sanger)ANF_receptor (PF01094)   
Domain families : Pfam (NCBI)pfam01094   
Conserved Domain (NCBI)NPR3
DMDM Disease mutations4883
Blocks (Seattle)NPR3
PDB (SRS)1JDN    1JDP    1YK0    1YK1   
PDB (PDBSum)1JDN    1JDP    1YK0    1YK1   
PDB (IMB)1JDN    1JDP    1YK0    1YK1   
PDB (RSDB)1JDN    1JDP    1YK0    1YK1   
Structural Biology KnowledgeBase1JDN    1JDP    1YK0    1YK1   
SCOP (Structural Classification of Proteins)1JDN    1JDP    1YK0    1YK1   
CATH (Classification of proteins structures)1JDN    1JDP    1YK0    1YK1   
SuperfamilyP17342
Human Protein AtlasENSG00000113389
Peptide AtlasP17342
HPRD00167
IPIIPI00013826   IPI00215700   IPI00878409   IPI00967458   IPI00968259   
Protein Interaction databases
DIP (DOE-UCLA)P17342
IntAct (EBI)P17342
FunCoupENSG00000113389
BioGRIDNPR3
STRING (EMBL)NPR3
ZODIACNPR3
Ontologies - Pathways
QuickGOP17342
Ontology : AmiGOskeletal system development  osteoclast proliferation  adenylate cyclase activity  intracellular  plasma membrane  integral component of plasma membrane  cAMP biosynthetic process  adenylate cyclase-activating G-protein coupled receptor signaling pathway  adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway  phospholipase C-activating G-protein coupled receptor signaling pathway  regulation of blood pressure  G-protein coupled peptide receptor activity  G-protein coupled peptide receptor activity  cyclic nucleotide biosynthetic process  natriuretic peptide receptor activity  peptide hormone binding  cAMP-mediated signaling  pancreatic juice secretion  regulation of osteoblast proliferation  positive regulation of urine volume  hormone binding  protein homodimerization activity  phosphatidylinositol-mediated signaling  negative regulation of smooth muscle cell proliferation  positive regulation of nitric-oxide synthase activity  extracellular exosome  
Ontology : EGO-EBIskeletal system development  osteoclast proliferation  adenylate cyclase activity  intracellular  plasma membrane  integral component of plasma membrane  cAMP biosynthetic process  adenylate cyclase-activating G-protein coupled receptor signaling pathway  adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway  phospholipase C-activating G-protein coupled receptor signaling pathway  regulation of blood pressure  G-protein coupled peptide receptor activity  G-protein coupled peptide receptor activity  cyclic nucleotide biosynthetic process  natriuretic peptide receptor activity  peptide hormone binding  cAMP-mediated signaling  pancreatic juice secretion  regulation of osteoblast proliferation  positive regulation of urine volume  hormone binding  protein homodimerization activity  phosphatidylinositol-mediated signaling  negative regulation of smooth muscle cell proliferation  positive regulation of nitric-oxide synthase activity  extracellular exosome  
NDEx NetworkNPR3
Atlas of Cancer Signalling NetworkNPR3
Wikipedia pathwaysNPR3
Orthology - Evolution
OrthoDB4883
GeneTree (enSembl)ENSG00000113389
Phylogenetic Trees/Animal Genes : TreeFamNPR3
HOVERGENP17342
HOGENOMP17342
Homologs : HomoloGeneNPR3
Homology/Alignments : Family Browser (UCSC)NPR3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNPR3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NPR3
dbVarNPR3
ClinVarNPR3
1000_GenomesNPR3 
Exome Variant ServerNPR3
ExAC (Exome Aggregation Consortium)NPR3 (select the gene name)
Genetic variants : HAPMAP4883
Genomic Variants (DGV)NPR3 [DGVbeta]
DECIPHER (Syndromes)5:32711438-32791830  ENSG00000113389
CONAN: Copy Number AnalysisNPR3 
Mutations
ICGC Data PortalNPR3 
TCGA Data PortalNPR3 
Broad Tumor PortalNPR3
OASIS PortalNPR3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNPR3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNPR3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NPR3
DgiDB (Drug Gene Interaction Database)NPR3
DoCM (Curated mutations)NPR3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NPR3 (select a term)
intoGenNPR3
Cancer3DNPR3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM108962   
Orphanet
MedgenNPR3
Genetic Testing Registry NPR3
NextProtP17342 [Medical]
TSGene4883
GENETestsNPR3
Huge Navigator NPR3 [HugePedia]
snp3D : Map Gene to Disease4883
BioCentury BCIQNPR3
ClinGenNPR3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4883
Chemical/Pharm GKB GenePA31737
Clinical trialNPR3
Miscellaneous
canSAR (ICR)NPR3 (select the gene name)
Probes
Litterature
PubMed66 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNPR3
EVEXNPR3
GoPubMedNPR3
iHOPNPR3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Tue Mar 14 13:19:15 CET 2017

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