NPTN (neuroplastin)

2021-06-01  

Identity

HGNC
NPTN
LOCATION
15q24.1
LOCUSID
27020
ALIAS
GP55,GP65,SDFR1,SDR1,np55,np65

Other Information

Locus ID:

NCBI: 27020
MIM: 612820
HGNC: 17867
Ensembl: ENSG00000156642

Variants:

dbSNP: 27020
ClinVar: 27020
TCGA: ENSG00000156642
COSMIC: NPTN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000156642ENST00000345330Q9Y639
ENSG00000156642ENST00000351217Q9Y639
ENSG00000156642ENST00000562924Q9Y639
ENSG00000156642ENST00000563691Q9Y639
ENSG00000156642ENST00000565282Q9UFM8
ENSG00000156642ENST00000565325H3BU51
ENSG00000156642ENST00000567198H3BQ94

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuronal SystemREACTOMER-HSA-112316
Transmission across Chemical SynapsesREACTOMER-HSA-112315
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic CellREACTOMER-HSA-112314

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
275038932016Xkr8 phospholipid scrambling complex in apoptotic phosphatidylserine exposure.23
245145662015Single nucleotide polymorphism in the neuroplastin locus associates with cortical thickness and intellectual ability in adolescents.18
250405462014The Neuroplastin adhesion molecules: key regulators of neuronal plasticity and synaptic function.14
171237232007Association study of putative promoter polymorphisms in the neuroplastin gene and schizophrenia.10
287791302017Neuroplastin deletion in glutamatergic neurons impairs selective brain functions and calcium regulation: implication for cognitive deterioration.6
171961822007The immunolocalization of the synaptic glycoprotein neuroplastin differs substantially between the human and the rodent brain.5
301904702018Structure of the human plasma membrane Ca2+-ATPase 1 in complex with its obligatory subunit neuroplastin.4
304886682019Hippocampal expression of cell-adhesion glycoprotein neuroplastin is altered in Alzheimer's disease.3
307202262019Neuroplastin-β mediates S100A8/A9-induced lung cancer disseminative progression.2

Citation

Dessen P

NPTN (neuroplastin)

Atlas Genet Cytogenet Oncol Haematol. 2021-06-01

Online version: http://atlasgeneticsoncology.org/gene/58270/nptn