NPY2R (neuropeptide Y receptor Y2)

2007-02-01  

Identity

HGNC
NPY2R
LOCATION
4q32.1
LOCUSID
4887
ALIAS
NPY2-R

Other Information

Locus ID:

NCBI: 4887
MIM: 162642
HGNC: 7957
Ensembl: ENSG00000185149

Variants:

dbSNP: 4887
ClinVar: 4887
TCGA: ENSG00000185149
COSMIC: NPY2R

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000185149ENST00000329476P49146
ENSG00000185149ENST00000506608P49146

Expression (GTEx)

0
1
2
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA255NPYGenePathwayassociated
PA34090PYYGenePathwayassociated

References

Pubmed IDYearTitleCitations
365259772023Structural basis for Y2 receptor-mediated neuropeptide Y and peptide YY signaling.4
365259772023Structural basis for Y2 receptor-mediated neuropeptide Y and peptide YY signaling.4
318529852019Inhibition of epileptiform activity by neuropeptide Y in brain tissue from drug-resistant temporal lobe epilepsy patients.17
318529852019Inhibition of epileptiform activity by neuropeptide Y in brain tissue from drug-resistant temporal lobe epilepsy patients.17
288571232018Evaluation of a Role for NPY and NPY2R in the Pathogenesis of Obesity by Mutation and Copy Number Variation Analysis in Obese Children and Adolescents.6
305316822018The Association of CEP135 rs4865047 and NPY2R rs1902491 Single Nucleotide Polymorphisms (SNPs) with Rapid Progression of Proliferative Diabetic Retinopathy in Patients with Type 1 Diabetes Mellitus.3
288571232018Evaluation of a Role for NPY and NPY2R in the Pathogenesis of Obesity by Mutation and Copy Number Variation Analysis in Obese Children and Adolescents.6
305316822018The Association of CEP135 rs4865047 and NPY2R rs1902491 Single Nucleotide Polymorphisms (SNPs) with Rapid Progression of Proliferative Diabetic Retinopathy in Patients with Type 1 Diabetes Mellitus.3
275840372017Association between neuropeptide Y receptor Y2 promoter variant rs6857715 and major depressive disorder.6
278899202017Neuropeptide Y receptor 1 is expressed by B and T lymphocytes and mast cells in infantile haemangiomas.7
275840372017Association between neuropeptide Y receptor Y2 promoter variant rs6857715 and major depressive disorder.6
278899202017Neuropeptide Y receptor 1 is expressed by B and T lymphocytes and mast cells in infantile haemangiomas.7
258710042015Polymorphisms in neuropeptide genes and bone mineral density in Korean postmenopausal women.1
259248212015Unwinding of the C-Terminal Residues of Neuropeptide Y is critical for Y₂ Receptor Binding and Activation.33
258710042015Polymorphisms in neuropeptide genes and bone mineral density in Korean postmenopausal women.1

Citation

Dessen P

NPY2R (neuropeptide Y receptor Y2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43703/npy2r