NPY2R (neuropeptide Y receptor Y2)

2007-02-01  

Identity

HGNC
LOCATION
4q32.1
LOCUSID
ALIAS
NPY2-R

Other Information

Locus ID:

NCBI: 4887
MIM: 162642
HGNC: 7957
Ensembl: ENSG00000185149

Variants:

dbSNP: 4887
ClinVar: 4887
TCGA: ENSG00000185149
COSMIC: NPY2R

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000185149ENST00000329476P49146
ENSG00000185149ENST00000506608P49146

Expression (GTEx)

0
1
2

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA255NPYGenePathwayassociated
PA34090PYYGenePathwayassociated

References

Pubmed IDYearTitleCitations
198745742009Genetical genomic determinants of alcohol consumption in rats and humans.93
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
168916222006Neuropeptide Y induces migration, proliferation, and tube formation of endothelial cells bimodally via Y1, Y2, and Y5 receptors.40
188288112008Neuropeptide Y receptor genes are associated with alcohol dependence, alcohol withdrawal phenotypes, and cocaine dependence.34
188288112008Neuropeptide Y receptor genes are associated with alcohol dependence, alcohol withdrawal phenotypes, and cocaine dependence.34
190860532009Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.34
204680642010Association study of 182 candidate genes in anorexia nervosa.30
119069642002Neuropeptide Y, Y1, Y2 and Y4 receptors mediate Y agonist responses in isolated human colon mucosa.21
190587892009A common variant in DRD3 receptor is associated with autism spectrum disorder.19
206761382010Neuropeptide Y and its Y2 receptor: potential targets in neuroblastoma therapy.19

Citation

Dessen P

NPY2R (neuropeptide Y receptor Y2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43703/npy2r