Identity
HGNC
LOCATION
6p25.2
LOCUSID
ALIAS
DHQV,DIA6,NMOR2,QR2
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 4835
MIM: 160998
HGNC: 7856
Ensembl: ENSG00000124588
Variants:
dbSNP: 4835
ClinVar: 4835
TCGA: ENSG00000124588
COSMIC: NQO2
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Metabolism | REACTOME | R-HSA-1430728 |
| Biological oxidations | REACTOME | R-HSA-211859 |
| Phase 1 - Functionalization of compounds | REACTOME | R-HSA-211945 |
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA443560 | Breast Neoplasms | Disease | ClinicalAnnotation | associated | PD | 21946896, 29938344 | |
| PA449165 | cyclophosphamide | Chemical | ClinicalAnnotation | associated | PD | 21946896, 29938344 | |
| PA449412 | doxorubicin | Chemical | ClinicalAnnotation | associated | PD | 21946896, 29938344 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38254976 | 2024 | Polymorphisms and Pharmacogenomics of NQO2: The Past and the Future. | 1 |
| 38254976 | 2024 | Polymorphisms and Pharmacogenomics of NQO2: The Past and the Future. | 1 |
| 36142607 | 2022 | An Axis between the Long Non-Coding RNA HOXA11-AS and NQOs Enhances Metastatic Ability in Oral Squamous Cell Carcinoma. | 5 |
| 36142607 | 2022 | An Axis between the Long Non-Coding RNA HOXA11-AS and NQOs Enhances Metastatic Ability in Oral Squamous Cell Carcinoma. | 5 |
| 31431515 | 2019 | Cancer-associated variants of human NQO1: impacts on inhibitor binding and cooperativity. | 6 |
| 31431515 | 2019 | Cancer-associated variants of human NQO1: impacts on inhibitor binding and cooperativity. | 6 |
| 29526807 | 2018 | Oxidative stress and neurodegeneration: The possible contribution of quinone reductase 2. | 13 |
| 29526807 | 2018 | Oxidative stress and neurodegeneration: The possible contribution of quinone reductase 2. | 13 |
| 28346733 | 2017 | The ontogeny and population variability of human hepatic dihydronicotinamide riboside:quinone oxidoreductase (NQO2). | 3 |
| 28346733 | 2017 | The ontogeny and population variability of human hepatic dihydronicotinamide riboside:quinone oxidoreductase (NQO2). | 3 |
| 26609153 | 2015 | Expression of Quinone Reductase-2 in the Cortex Is a Muscarinic Acetylcholine Receptor-Dependent Memory Consolidation Constraint. | 13 |
| 26609153 | 2015 | Expression of Quinone Reductase-2 in the Cortex Is a Muscarinic Acetylcholine Receptor-Dependent Memory Consolidation Constraint. | 13 |
| 24631540 | 2014 | The two common polymorphic forms of human NRH-quinone oxidoreductase 2 (NQO2) have different biochemical properties. | 12 |
| 24631540 | 2014 | The two common polymorphic forms of human NRH-quinone oxidoreductase 2 (NQO2) have different biochemical properties. | 12 |
| 23471972 | 2013 | Chloroquine binding reveals flavin redox switch function of quinone reductase 2. | 12 |
Citation
Dessen P
NQO2 (N-ribosyldihydronicotinamide:quinone reductase 2)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/45617/nqo2
