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NQO2 (N-ribosyldihydronicotinamide:quinone reductase 2)

Identity

Alias_namesNMOR2
NAD(P)H menadione oxidoreductase 2, dioxin-inducible
NAD(P)H dehydrogenase, quinone 2
Alias_symbol (synonym)QR2
DHQV
DIA6
Other alias
HGNC (Hugo) NQO2
LocusID (NCBI) 4835
Atlas_Id 45617
Location 6p25.2  [Link to chromosome band 6p25]
Location_base_pair Starts at 2999816 and ends at 3019876 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MINK1 (17p13.2) / NQO2 (6p25.2)NQO2 (6p25.2) / SLC3A2 (11q12.3)RABGEF1 (7q11.21) / NQO2 (6p25.2)
RIPK1 (6p25.2) / NQO2 (6p25.2)SKAP1 (17q21.32) / NQO2 (6p25.2)MINK1 17p13.2 / NQO2 6p25.2
RIPK1 6p25.2 / NQO2 6p25.2SKAP1 17q21.32 / NQO2 6p25.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Cancer prone implicated (Data extracted from papers in the Atlas) [ 1 ]
  Hereditary breast cancer


External links

Nomenclature
HGNC (Hugo)NQO2   7856
Cards
Entrez_Gene (NCBI)NQO2  4835  N-ribosyldihydronicotinamide:quinone reductase 2
AliasesDHQV; DIA6; NMOR2; QR2
GeneCards (Weizmann)NQO2
Ensembl hg19 (Hinxton)ENSG00000124588 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000124588 [Gene_View]  chr6:2999816-3019876 [Contig_View]  NQO2 [Vega]
ICGC DataPortalENSG00000124588
TCGA cBioPortalNQO2
AceView (NCBI)NQO2
Genatlas (Paris)NQO2
WikiGenes4835
SOURCE (Princeton)NQO2
Genetics Home Reference (NIH)NQO2
Genomic and cartography
GoldenPath hg38 (UCSC)NQO2  -     chr6:2999816-3019876 +  6p25.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NQO2  -     6p25.2   [Description]    (hg19-Feb_2009)
EnsemblNQO2 - 6p25.2 [CytoView hg19]  NQO2 - 6p25.2 [CytoView hg38]
Mapping of homologs : NCBINQO2 [Mapview hg19]  NQO2 [Mapview hg38]
OMIM114480   160998   
Gene and transcription
Genbank (Entrez)AK056981 AK311746 BC006096 BI333292 BI670476
RefSeq transcript (Entrez)NM_000904 NM_001290221 NM_001290222 NM_001318940
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NQO2
Cluster EST : UnigeneHs.533050 [ NCBI ]
CGAP (NCI)Hs.533050
Alternative Splicing GalleryENSG00000124588
Gene ExpressionNQO2 [ NCBI-GEO ]   NQO2 [ EBI - ARRAY_EXPRESS ]   NQO2 [ SEEK ]   NQO2 [ MEM ]
Gene Expression Viewer (FireBrowse)NQO2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4835
GTEX Portal (Tissue expression)NQO2
Human Protein AtlasENSG00000124588-NQO2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP16083   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP16083  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP16083
Splice isoforms : SwissVarP16083
PhosPhoSitePlusP16083
Domains : Interpro (EBI)Flavodoxin_fold    Flavoprotein-like_dom   
Domain families : Pfam (Sanger)Flavodoxin_2 (PF02525)   
Domain families : Pfam (NCBI)pfam02525   
Conserved Domain (NCBI)NQO2
DMDM Disease mutations4835
Blocks (Seattle)NQO2
PDB (SRS)###############################################################################################################################################################################################################################################################   
PDB (PDBSum)###############################################################################################################################################################################################################################################################   
PDB (IMB)###############################################################################################################################################################################################################################################################   
PDB (RSDB)###############################################################################################################################################################################################################################################################   
Structural Biology KnowledgeBase###############################################################################################################################################################################################################################################################   
SCOP (Structural Classification of Proteins)###############################################################################################################################################################################################################################################################   
CATH (Classification of proteins structures)###############################################################################################################################################################################################################################################################   
SuperfamilyP16083
Human Protein Atlas [tissue]ENSG00000124588-NQO2 [tissue]
Peptide AtlasP16083
HPRD01190
IPIIPI00219129   IPI00515016   IPI00640851   IPI00556304   
Protein Interaction databases
DIP (DOE-UCLA)P16083
IntAct (EBI)P16083
FunCoupENSG00000124588
BioGRIDNQO2
STRING (EMBL)NQO2
ZODIACNQO2
Ontologies - Pathways
QuickGOP16083
Ontology : AmiGOdihydronicotinamide riboside quinone reductase activity  dihydronicotinamide riboside quinone reductase activity  protein binding  nucleoplasm  cytosol  cytosol  xenobiotic metabolic process  memory  zinc ion binding  electron carrier activity  oxidoreductase activity  oxidoreductase activity, acting on other nitrogenous compounds as donors  chloride ion binding  protein homodimerization activity  positive regulation of neuron apoptotic process  oxidation-reduction process  extracellular exosome  positive regulation of ERK1 and ERK2 cascade  FAD binding  melatonin binding  positive regulation of vascular smooth muscle cell proliferation  resveratrol binding  positive regulation of reactive oxygen species metabolic process  
Ontology : EGO-EBIdihydronicotinamide riboside quinone reductase activity  dihydronicotinamide riboside quinone reductase activity  protein binding  nucleoplasm  cytosol  cytosol  xenobiotic metabolic process  memory  zinc ion binding  electron carrier activity  oxidoreductase activity  oxidoreductase activity, acting on other nitrogenous compounds as donors  chloride ion binding  protein homodimerization activity  positive regulation of neuron apoptotic process  oxidation-reduction process  extracellular exosome  positive regulation of ERK1 and ERK2 cascade  FAD binding  melatonin binding  positive regulation of vascular smooth muscle cell proliferation  resveratrol binding  positive regulation of reactive oxygen species metabolic process  
NDEx NetworkNQO2
Atlas of Cancer Signalling NetworkNQO2
Wikipedia pathwaysNQO2
Orthology - Evolution
OrthoDB4835
GeneTree (enSembl)ENSG00000124588
Phylogenetic Trees/Animal Genes : TreeFamNQO2
HOVERGENP16083
HOGENOMP16083
Homologs : HomoloGeneNQO2
Homology/Alignments : Family Browser (UCSC)NQO2
Gene fusions - Rearrangements
Fusion : MitelmanMINK1/NQO2 [17p13.2/6p25.2]  [t(6;17)(p25;p13)]  
Fusion : MitelmanRIPK1/NQO2 [6p25.2/6p25.2]  [t(6;6)(p25;p25)]  
Fusion : MitelmanSKAP1/NQO2 [17q21.32/6p25.2]  [t(6;17)(p25;q21)]  
Fusion: TCGA_MDACCMINK1 17p13.2 NQO2 6p25.2 LUAD
Fusion: TCGA_MDACCRIPK1 6p25.2 NQO2 6p25.2 BRCA
Fusion: TCGA_MDACCSKAP1 17q21.32 NQO2 6p25.2 OV
Tumor Fusion PortalNQO2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNQO2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NQO2
dbVarNQO2
ClinVarNQO2
1000_GenomesNQO2 
Exome Variant ServerNQO2
ExAC (Exome Aggregation Consortium)ENSG00000124588
GNOMAD BrowserENSG00000124588
Genetic variants : HAPMAP4835
Genomic Variants (DGV)NQO2 [DGVbeta]
DECIPHERNQO2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNQO2 
Mutations
ICGC Data PortalNQO2 
TCGA Data PortalNQO2 
Broad Tumor PortalNQO2
OASIS PortalNQO2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNQO2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNQO2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NQO2
DgiDB (Drug Gene Interaction Database)NQO2
DoCM (Curated mutations)NQO2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NQO2 (select a term)
intoGenNQO2
Cancer3DNQO2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM114480    160998   
Orphanet
DisGeNETNQO2
MedgenNQO2
Genetic Testing Registry NQO2
NextProtP16083 [Medical]
TSGene4835
GENETestsNQO2
Target ValidationNQO2
Huge Navigator NQO2 [HugePedia]
snp3D : Map Gene to Disease4835
BioCentury BCIQNQO2
ClinGenNQO2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4835
Chemical/Pharm GKB GenePA31745
Clinical trialNQO2
Miscellaneous
canSAR (ICR)NQO2 (select the gene name)
Probes
Litterature
PubMed70 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNQO2
EVEXNQO2
GoPubMedNQO2
iHOPNQO2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:26:41 CET 2017

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