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NR0B2 (nuclear receptor subfamily 0 group B member 2)

Identity

Alias_namesnuclear receptor subfamily 0
Alias_symbol (synonym)SHP
Other aliasSHP1
HGNC (Hugo) NR0B2
LocusID (NCBI) 8431
Atlas_Id 45993
Location 1p36.11  [Link to chromosome band 1p36]
Location_base_pair Starts at 27237975 and ends at 27240567 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NR0B2   7961
Cards
Entrez_Gene (NCBI)NR0B2  8431  nuclear receptor subfamily 0 group B member 2
AliasesSHP; SHP1
GeneCards (Weizmann)NR0B2
Ensembl hg19 (Hinxton)ENSG00000131910 [Gene_View]  chr1:27237975-27240567 [Contig_View]  NR0B2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000131910 [Gene_View]  chr1:27237975-27240567 [Contig_View]  NR0B2 [Vega]
ICGC DataPortalENSG00000131910
TCGA cBioPortalNR0B2
AceView (NCBI)NR0B2
Genatlas (Paris)NR0B2
WikiGenes8431
SOURCE (Princeton)NR0B2
Genetics Home Reference (NIH)NR0B2
Genomic and cartography
GoldenPath hg19 (UCSC)NR0B2  -     chr1:27237975-27240567 -  1p36.11   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)NR0B2  -     1p36.11   [Description]    (hg38-Dec_2013)
EnsemblNR0B2 - 1p36.11 [CytoView hg19]  NR0B2 - 1p36.11 [CytoView hg38]
Mapping of homologs : NCBINR0B2 [Mapview hg19]  NR0B2 [Mapview hg38]
OMIM601665   604630   
Gene and transcription
Genbank (Entrez)AA872285 AI457167 AK310048 BC030207 DA930064
RefSeq transcript (Entrez)NM_021969
RefSeq genomic (Entrez)NC_000001 NC_018912 NG_012143 NT_032977 NW_004929289
Consensus coding sequences : CCDS (NCBI)NR0B2
Cluster EST : UnigeneHs.427055 [ NCBI ]
CGAP (NCI)Hs.427055
Alternative Splicing GalleryENSG00000131910
Gene ExpressionNR0B2 [ NCBI-GEO ]   NR0B2 [ EBI - ARRAY_EXPRESS ]   NR0B2 [ SEEK ]   NR0B2 [ MEM ]
Gene Expression Viewer (FireBrowse)NR0B2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8431
GTEX Portal (Tissue expression)NR0B2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15466   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15466  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15466
Splice isoforms : SwissVarQ15466
PhosPhoSitePlusQ15466
Domains : Interpro (EBI)Nucl_hrmn_rcpt_lig-bd    Nuclear_hrmn_rcpt   
Domain families : Pfam (Sanger)Hormone_recep (PF00104)   
Domain families : Pfam (NCBI)pfam00104   
Domain families : Smart (EMBL)HOLI (SM00430)  
Conserved Domain (NCBI)NR0B2
DMDM Disease mutations8431
Blocks (Seattle)NR0B2
PDB (SRS)1YUC    2Q3Y    2Z4J    4DOR    4ONI   
PDB (PDBSum)1YUC    2Q3Y    2Z4J    4DOR    4ONI   
PDB (IMB)1YUC    2Q3Y    2Z4J    4DOR    4ONI   
PDB (RSDB)1YUC    2Q3Y    2Z4J    4DOR    4ONI   
Structural Biology KnowledgeBase1YUC    2Q3Y    2Z4J    4DOR    4ONI   
SCOP (Structural Classification of Proteins)1YUC    2Q3Y    2Z4J    4DOR    4ONI   
CATH (Classification of proteins structures)1YUC    2Q3Y    2Z4J    4DOR    4ONI   
SuperfamilyQ15466
Human Protein AtlasENSG00000131910
Peptide AtlasQ15466
HPRD05219
IPIIPI00017483   
Protein Interaction databases
DIP (DOE-UCLA)Q15466
IntAct (EBI)Q15466
FunCoupENSG00000131910
BioGRIDNR0B2
STRING (EMBL)NR0B2
ZODIACNR0B2
Ontologies - Pathways
QuickGOQ15466
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  DNA binding  steroid hormone receptor activity  transcription corepressor activity  protein binding  nucleus  nucleoplasm  cytoplasm  transcription initiation from RNA polymerase II promoter  Notch signaling pathway  transcription factor binding  cholesterol metabolic process  response to glucose  positive regulation of gene expression  negative regulation of gene expression  protein domain specific binding  organ regeneration  positive regulation of insulin secretion  protein complex binding  protein homodimerization activity  peroxisome proliferator activated receptor binding  protein complex  steroid hormone mediated signaling pathway  negative regulation of sequence-specific DNA binding transcription factor activity  retinoid X receptor binding  thyroid hormone receptor binding  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  DNA binding  steroid hormone receptor activity  transcription corepressor activity  protein binding  nucleus  nucleoplasm  cytoplasm  transcription initiation from RNA polymerase II promoter  Notch signaling pathway  transcription factor binding  cholesterol metabolic process  response to glucose  positive regulation of gene expression  negative regulation of gene expression  protein domain specific binding  organ regeneration  positive regulation of insulin secretion  protein complex binding  protein homodimerization activity  peroxisome proliferator activated receptor binding  protein complex  steroid hormone mediated signaling pathway  negative regulation of sequence-specific DNA binding transcription factor activity  retinoid X receptor binding  thyroid hormone receptor binding  
Pathways : BIOCARTAMechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha) [Genes]    FXR and LXR Regulation of Cholesterol Metabolism [Genes]    Nuclear Receptors in Lipid Metabolism and Toxicity [Genes]   
Pathways : KEGGBile secretion   
NDEx NetworkNR0B2
Atlas of Cancer Signalling NetworkNR0B2
Wikipedia pathwaysNR0B2
Orthology - Evolution
OrthoDB8431
GeneTree (enSembl)ENSG00000131910
Phylogenetic Trees/Animal Genes : TreeFamNR0B2
HOVERGENQ15466
HOGENOMQ15466
Homologs : HomoloGeneNR0B2
Homology/Alignments : Family Browser (UCSC)NR0B2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNR0B2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NR0B2
dbVarNR0B2
ClinVarNR0B2
1000_GenomesNR0B2 
Exome Variant ServerNR0B2
ExAC (Exome Aggregation Consortium)NR0B2 (select the gene name)
Genetic variants : HAPMAP8431
Genomic Variants (DGV)NR0B2 [DGVbeta]
DECIPHER (Syndromes)1:27237975-27240567  ENSG00000131910
CONAN: Copy Number AnalysisNR0B2 
Mutations
ICGC Data PortalNR0B2 
TCGA Data PortalNR0B2 
Broad Tumor PortalNR0B2
OASIS PortalNR0B2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNR0B2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNR0B2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NR0B2
DgiDB (Drug Gene Interaction Database)NR0B2
DoCM (Curated mutations)NR0B2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NR0B2 (select a term)
intoGenNR0B2
Cancer3DNR0B2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601665    604630   
Orphanet
MedgenNR0B2
Genetic Testing Registry NR0B2
NextProtQ15466 [Medical]
TSGene8431
GENETestsNR0B2
Huge Navigator NR0B2 [HugePedia]
snp3D : Map Gene to Disease8431
BioCentury BCIQNR0B2
ClinGenNR0B2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8431
Chemical/Pharm GKB GenePA31747
Clinical trialNR0B2
Miscellaneous
canSAR (ICR)NR0B2 (select the gene name)
Probes
Litterature
PubMed124 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNR0B2
EVEXNR0B2
GoPubMedNR0B2
iHOPNR0B2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:19:18 CET 2017

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