NR0B2 (nuclear receptor subfamily 0 group B member 2)

2007-02-01  

Identity

HGNC
LOCATION
1p36.11
LOCUSID
ALIAS
SHP,SHP1

Other Information

Locus ID:

NCBI: 8431
MIM: 604630
HGNC: 7961
Ensembl: ENSG00000131910

Variants:

dbSNP: 8431
ClinVar: 8431
TCGA: ENSG00000131910
COSMIC: NR0B2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000131910ENST00000254227Q15466

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Bile secretionKEGGko04976
Bile secretionKEGGhsa04976
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Nuclear Receptor transcription pathwayREACTOMER-HSA-383280

References

Pubmed IDYearTitleCitations
179090972008Metformin inhibits hepatic gluconeogenesis through AMP-activated protein kinase-dependent regulation of the orphan nuclear receptor SHP.113
157230372005Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP.71
168254952006Loss of SHP1 enhances JAK3/STAT3 signaling and decreases proteosome degradation of JAK3 and NPM-ALK in ALK+ anaplastic large-cell lymphoma.71
171457662007Coordinated recruitment of histone methyltransferase G9a and other chromatin-modifying enzymes in SHP-mediated regulation of hepatic bile acid metabolism.53
159734352005Regulation of hepatic metabolic pathways by the orphan nuclear receptor SHP.49
183253922008Epigenetic inhibition of nuclear receptor small heterodimer partner is associated with and regulates hepatocellular carcinoma growth.49
121982432002The small heterodimer partner interacts with the liver X receptor alpha and represses its transcriptional activity.48
246195562014E2F1 is a novel fibrogenic gene that regulates cholestatic liver fibrosis through the Egr-1/SHP/EID1 network.48
153141772004Role of an mSin3A-Swi/Snf chromatin remodeling complex in the feedback repression of bile acid biosynthesis by SHP.47
111362332001Mutations in the small heterodimer partner gene are associated with mild obesity in Japanese subjects.40

Citation

Dessen P

NR0B2 (nuclear receptor subfamily 0 group B member 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45993/nr0b2