Atlas of Genetics and Cytogenetics in Oncology and Haematology


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NR1D1 (nuclear receptor subfamily 1 group D member 1)

Identity

Alias_namesTHRAL
nuclear receptor subfamily 1
Alias_symbol (synonym)ear-1
hRev
Rev-ErbAalpha
THRA1
Other aliasEAR1
HGNC (Hugo) NR1D1
LocusID (NCBI) 9572
Atlas_Id 41569
Location 17q21.1  [Link to chromosome band 17q21]
Location_base_pair Starts at 40092784 and ends at 40100725 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
SLC6A15 (12q21.31) / NR1D1 (17q21.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NR1D1   7962
Cards
Entrez_Gene (NCBI)NR1D1  9572  nuclear receptor subfamily 1 group D member 1
AliasesEAR1; THRA1; THRAL; ear-1; 
hRev
GeneCards (Weizmann)NR1D1
Ensembl hg19 (Hinxton)ENSG00000126368 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000126368 [Gene_View]  chr17:40092784-40100725 [Contig_View]  NR1D1 [Vega]
ICGC DataPortalENSG00000126368
TCGA cBioPortalNR1D1
AceView (NCBI)NR1D1
Genatlas (Paris)NR1D1
WikiGenes9572
SOURCE (Princeton)NR1D1
Genetics Home Reference (NIH)NR1D1
Genomic and cartography
GoldenPath hg38 (UCSC)NR1D1  -     chr17:40092784-40100725 -  17q21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NR1D1  -     17q21.1   [Description]    (hg19-Feb_2009)
EnsemblNR1D1 - 17q21.1 [CytoView hg19]  NR1D1 - 17q21.1 [CytoView hg38]
Mapping of homologs : NCBINR1D1 [Mapview hg19]  NR1D1 [Mapview hg38]
OMIM602408   
Gene and transcription
Genbank (Entrez)AH001531 AH001531 AK300155 AK315270 AY429554
RefSeq transcript (Entrez)NM_021724
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NR1D1
Cluster EST : UnigeneHs.592130 [ NCBI ]
CGAP (NCI)Hs.592130
Alternative Splicing GalleryENSG00000126368
Gene ExpressionNR1D1 [ NCBI-GEO ]   NR1D1 [ EBI - ARRAY_EXPRESS ]   NR1D1 [ SEEK ]   NR1D1 [ MEM ]
Gene Expression Viewer (FireBrowse)NR1D1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9572
GTEX Portal (Tissue expression)NR1D1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP20393   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP20393  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP20393
Splice isoforms : SwissVarP20393
PhosPhoSitePlusP20393
Domaine pattern : Prosite (Expaxy)NUCLEAR_REC_DBD_1 (PS00031)    NUCLEAR_REC_DBD_2 (PS51030)   
Domains : Interpro (EBI)Nucl_hrmn_rcpt_lig-bd    Nuclear_hrmn_rcpt    Znf_hrmn_rcpt    Znf_NHR/GATA   
Domain families : Pfam (Sanger)Hormone_recep (PF00104)    zf-C4 (PF00105)   
Domain families : Pfam (NCBI)pfam00104    pfam00105   
Domain families : Smart (EMBL)HOLI (SM00430)  ZnF_C4 (SM00399)  
Conserved Domain (NCBI)NR1D1
DMDM Disease mutations9572
Blocks (Seattle)NR1D1
PDB (SRS)1A6Y    1EF6    1GA5    1HLZ    3N00   
PDB (PDBSum)1A6Y    1EF6    1GA5    1HLZ    3N00   
PDB (IMB)1A6Y    1EF6    1GA5    1HLZ    3N00   
PDB (RSDB)1A6Y    1EF6    1GA5    1HLZ    3N00   
Structural Biology KnowledgeBase1A6Y    1EF6    1GA5    1HLZ    3N00   
SCOP (Structural Classification of Proteins)1A6Y    1EF6    1GA5    1HLZ    3N00   
CATH (Classification of proteins structures)1A6Y    1EF6    1GA5    1HLZ    3N00   
SuperfamilyP20393
Human Protein AtlasENSG00000126368
Peptide AtlasP20393
HPRD03873
IPIIPI00023603   
Protein Interaction databases
DIP (DOE-UCLA)P20393
IntAct (EBI)P20393
FunCoupENSG00000126368
BioGRIDNR1D1
STRING (EMBL)NR1D1
ZODIACNR1D1
Ontologies - Pathways
QuickGOP20393
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  negative regulation of transcription from RNA polymerase II promoter  nuclear chromatin  RNA polymerase II regulatory region sequence-specific DNA binding  RNA polymerase II core promoter proximal region sequence-specific DNA binding  core promoter sequence-specific DNA binding  transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding  transcription corepressor binding  transcription corepressor binding  steroid hormone receptor activity  transcription corepressor activity  RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding  protein binding  nucleus  nucleoplasm  cytoplasm  glycogen biosynthetic process  transcription initiation from RNA polymerase II promoter  circadian rhythm  zinc ion binding  proteasomal protein catabolic process  negative regulation of receptor biosynthetic process  nuclear body  regulation of lipid metabolic process  heme binding  cell differentiation  dendrite  intracellular receptor signaling pathway  circadian regulation of gene expression  negative regulation of toll-like receptor 4 signaling pathway  regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter  regulation of circadian rhythm  dendritic spine  steroid hormone mediated signaling pathway  transcription regulatory region DNA binding  response to leptin  regulation of fat cell differentiation  negative regulation of transcription, DNA-templated  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  circadian temperature homeostasis  regulation of insulin secretion involved in cellular response to glucose stimulus  regulation of type B pancreatic cell proliferation  positive regulation of bile acid biosynthetic process  cellular response to lipopolysaccharide  regulation of cholesterol homeostasis  positive regulation of cholesterol homeostasis  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  negative regulation of transcription from RNA polymerase II promoter  nuclear chromatin  RNA polymerase II regulatory region sequence-specific DNA binding  RNA polymerase II core promoter proximal region sequence-specific DNA binding  core promoter sequence-specific DNA binding  transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding  transcription corepressor binding  transcription corepressor binding  steroid hormone receptor activity  transcription corepressor activity  RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding  protein binding  nucleus  nucleoplasm  cytoplasm  glycogen biosynthetic process  transcription initiation from RNA polymerase II promoter  circadian rhythm  zinc ion binding  proteasomal protein catabolic process  negative regulation of receptor biosynthetic process  nuclear body  regulation of lipid metabolic process  heme binding  cell differentiation  dendrite  intracellular receptor signaling pathway  circadian regulation of gene expression  negative regulation of toll-like receptor 4 signaling pathway  regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter  regulation of circadian rhythm  dendritic spine  steroid hormone mediated signaling pathway  transcription regulatory region DNA binding  response to leptin  regulation of fat cell differentiation  negative regulation of transcription, DNA-templated  negative0reguda4ion of transcription, DNA-templated  positive regulation of transcription, DNA-templated  circadian temperature homeostasis  regulation of insulin secretion involved in cellular response to glucose stimulus  regulation of type B pancreatic cell proliferation  positive regulation of bile acid biosynthetic process  cellular response to lipopolysaccharide  regulation of cholesterol homeostasis  positive regulation of cholesterol homeostasis  
Pathways : KEGGCircadian rhythm   
NDEx NetworkNR1D1
Atlas of Cancer Signalling NetworkNR1D1
Wikipedia pathwaysNR1D1
Orthology - Evolution
OrthoDB9572
GeneTree (enSembl)ENSG00000126368
Phylogenetic Trees/Animal Genes : TreeFamNR1D1
HOVERGENP20393
HOGENOMP20393
Homologs : HomoloGeneNR1D1
Homology/Alignments : Family Browser (UCSC)NR1D1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNR1D1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NR1D1
dbVarNR1D1
ClinVarNR1D1
1000_GenomesNR1D1 
Exome Variant ServerNR1D1
ExAC (Exome Aggregation Consortium)NR1D1 (select the gene name)
Genetic variants : HAPMAP9572
Genomic Variants (DGV)NR1D1 [DGVbeta]
DECIPHERNR1D1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNR1D1 
Mutations
ICGC Data PortalNR1D1 
TCGA Data PortalNR1D1 
Broad Tumor PortalNR1D1
OASIS PortalNR1D1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNR1D1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNR1D1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NR1D1
DgiDB (Drug Gene Interaction Database)NR1D1
DoCM (Curated mutations)NR1D1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NR1D1 (select a term)
intoGenNR1D1
Cancer3DNR1D1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602408   
Orphanet
MedgenNR1D1
Genetic Testing Registry NR1D1
NextProtP20393 [Medical]
TSGene9572
GENETestsNR1D1
Target ValidationNR1D1
Huge Navigator NR1D1 [HugePedia]
snp3D : Map Gene to Disease9572
BioCentury BCIQNR1D1
ClinGenNR1D1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9572
Chemical/Pharm GKB GenePA31748
Clinical trialNR1D1
Miscellaneous
canSAR (ICR)NR1D1 (select the gene name)
Probes
Litterature
PubMed74 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNR1D1
EVEXNR1D1
GoPubMedNR1D1
iHOPNR1D1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 25 19:22:37 CEST 2017

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