Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

NR1D2 (nuclear receptor subfamily 1 group D member 2)

Identity

Alias (NCBI)BD73
EAR-1R
REVERBB
REVERBbeta
RVR
HGNC (Hugo) NR1D2
HGNC Alias symbBD73
RVR
EAR-1r
HZF2
Hs.37288
REVERBB
REVERBbeta
HGNC Previous namenuclear receptor subfamily 1, group D, member 2
LocusID (NCBI) 9975
Atlas_Id 46810
Location 3p24.2  [Link to chromosome band 3p24]
Location_base_pair Starts at 23945286 and ends at 23980617 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CMTM8 (3p22.3) / NR1D2 (3p24.2)NR1D2 (3p24.2) / AC106722.1 ()NR1D2 (3p24.2) / MDC1 (6p21.33)
CMTM8 3p22.3 / NR1D2 3p24.2NR1D2 3p24.2 AC106722.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(3;3)(p22;p24) CMTM8/NR1D2


External links

Nomenclature
HGNC (Hugo)NR1D2   7963
Cards
Entrez_Gene (NCBI)NR1D2  9975  nuclear receptor subfamily 1 group D member 2
AliasesBD73; EAR-1R; REVERBB; REVERBbeta; 
RVR
GeneCards (Weizmann)NR1D2
Ensembl hg19 (Hinxton)ENSG00000174738 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000174738 [Gene_View]  ENSG00000174738 [Sequence]  chr3:23945286-23980617 [Contig_View]  NR1D2 [Vega]
ICGC DataPortalENSG00000174738
TCGA cBioPortalNR1D2
AceView (NCBI)NR1D2
Genatlas (Paris)NR1D2
WikiGenes9975
SOURCE (Princeton)NR1D2
Genetics Home Reference (NIH)NR1D2
Genomic and cartography
GoldenPath hg38 (UCSC)NR1D2  -     chr3:23945286-23980617 +  3p24.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NR1D2  -     3p24.2   [Description]    (hg19-Feb_2009)
GoldenPathNR1D2 - 3p24.2 [CytoView hg19]  NR1D2 - 3p24.2 [CytoView hg38]
ImmunoBaseENSG00000174738
genome Data Viewer NCBINR1D2 [Mapview hg19]  
OMIM602304   
Gene and transcription
Genbank (Entrez)AB209091 AB307693 AK293273 AK301925 AK313464
RefSeq transcript (Entrez)NM_001145425 NM_005126
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NR1D2
Alternative Splicing GalleryENSG00000174738
Gene ExpressionNR1D2 [ NCBI-GEO ]   NR1D2 [ EBI - ARRAY_EXPRESS ]   NR1D2 [ SEEK ]   NR1D2 [ MEM ]
Gene Expression Viewer (FireBrowse)NR1D2 [ Firebrowse - Broad ]
GenevisibleExpression of NR1D2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9975
GTEX Portal (Tissue expression)NR1D2
Human Protein AtlasENSG00000174738-NR1D2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14995   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14995  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14995
Splice isoforms : SwissVarQ14995
PhosPhoSitePlusQ14995
Domaine pattern : Prosite (Expaxy)NR_LBD (PS51843)    NUCLEAR_REC_DBD_1 (PS00031)    NUCLEAR_REC_DBD_2 (PS51030)   
Domains : Interpro (EBI)NHR-like_dom_sf    Nucl_hrmn_rcpt_lig-bd    Nuclear_hrmn_rcpt    Znf_hrmn_rcpt    Znf_NHR/GATA   
Domain families : Pfam (Sanger)Hormone_recep (PF00104)    zf-C4 (PF00105)   
Domain families : Pfam (NCBI)pfam00104    pfam00105   
Domain families : Smart (EMBL)HOLI (SM00430)  ZnF_C4 (SM00399)  
Conserved Domain (NCBI)NR1D2
DMDM Disease mutations9975
Blocks (Seattle)NR1D2
PDB (RSDB)2V0V    2V7C    3CQV    4N73   
PDB Europe2V0V    2V7C    3CQV    4N73   
PDB (PDBSum)2V0V    2V7C    3CQV    4N73   
PDB (IMB)2V0V    2V7C    3CQV    4N73   
Structural Biology KnowledgeBase2V0V    2V7C    3CQV    4N73   
SCOP (Structural Classification of Proteins)2V0V    2V7C    3CQV    4N73   
CATH (Classification of proteins structures)2V0V    2V7C    3CQV    4N73   
SuperfamilyQ14995
Human Protein Atlas [tissue]ENSG00000174738-NR1D2 [tissue]
Peptide AtlasQ14995
HPRD03809
IPIIPI00788022   IPI00816040   IPI00923391   IPI00431747   
Protein Interaction databases
DIP (DOE-UCLA)Q14995
IntAct (EBI)Q14995
FunCoupENSG00000174738
BioGRIDNR1D2
STRING (EMBL)NR1D2
ZODIACNR1D2
Ontologies - Pathways
QuickGOQ14995
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  nuclear chromatin  RNA polymerase II regulatory region sequence-specific DNA binding  RNA polymerase II proximal promoter sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription repressor activity, RNA polymerase II-specific  steroid hormone receptor activity  nuclear receptor activity  nuclear receptor activity  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  cytoplasm  regulation of transcription, DNA-templated  transcription initiation from RNA polymerase II promoter  transcription factor binding  zinc ion binding  hormone-mediated signaling pathway  regulation of lipid metabolic process  cell differentiation  intracellular receptor signaling pathway  signaling receptor activity  host cell nucleus  regulation of circadian rhythm  steroid hormone mediated signaling pathway  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  circadian behavior  regulation of inflammatory response  negative regulation of inflammatory response  lipid homeostasis  RNA polymerase II transcription factor complex  energy homeostasis  regulation of skeletal muscle cell differentiation  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  nuclear chromatin  RNA polymerase II regulatory region sequence-specific DNA binding  RNA polymerase II proximal promoter sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription repressor activity, RNA polymerase II-specific  steroid hormone receptor activity  nuclear receptor activity  nuclear receptor activity  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  cytoplasm  regulation of transcription, DNA-templated  transcription initiation from RNA polymerase II promoter  transcription factor binding  zinc ion binding  hormone-mediated signaling pathway  regulation of lipid metabolic process  cell differentiation  intracellular receptor signaling pathway  signaling receptor activity  host cell nucleus  regulation of circadian rhythm  steroid hormone mediated signaling pathway  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  circadian behavior  regulation of inflammatory response  negative regulation of inflammatory response  lipid homeostasis  RNA polymerase II transcription factor complex  energy homeostasis  regulation of skeletal muscle cell differentiation  
NDEx NetworkNR1D2
Atlas of Cancer Signalling NetworkNR1D2
Wikipedia pathwaysNR1D2
Orthology - Evolution
OrthoDB9975
GeneTree (enSembl)ENSG00000174738
Phylogenetic Trees/Animal Genes : TreeFamNR1D2
HOGENOMQ14995
Homologs : HomoloGeneNR1D2
Homology/Alignments : Family Browser (UCSC)NR1D2
Gene fusions - Rearrangements
Fusion : MitelmanCMTM8/NR1D2 [3p22.3/3p24.2]  
Fusion PortalCMTM8 3p22.3 NR1D2 3p24.2 BRCA
Fusion PortalNR1D2 3p24.2 AC106722.1 LUAD
Fusion : QuiverNR1D2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNR1D2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NR1D2
dbVarNR1D2
ClinVarNR1D2
MonarchNR1D2
1000_GenomesNR1D2 
Exome Variant ServerNR1D2
GNOMAD BrowserENSG00000174738
Varsome BrowserNR1D2
Genetic variants : HAPMAP9975
Genomic Variants (DGV)NR1D2 [DGVbeta]
DECIPHERNR1D2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNR1D2 
Mutations
ICGC Data PortalNR1D2 
TCGA Data PortalNR1D2 
Broad Tumor PortalNR1D2
OASIS PortalNR1D2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNR1D2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNR1D2
Mutations and Diseases : HGMDNR1D2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NR1D2
DgiDB (Drug Gene Interaction Database)NR1D2
DoCM (Curated mutations)NR1D2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NR1D2 (select a term)
intoGenNR1D2
Cancer3DNR1D2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602304   
Orphanet
DisGeNETNR1D2
MedgenNR1D2
Genetic Testing Registry NR1D2
NextProtQ14995 [Medical]
TSGene9975
GENETestsNR1D2
Target ValidationNR1D2
Huge Navigator NR1D2 [HugePedia]
snp3D : Map Gene to Disease9975
BioCentury BCIQNR1D2
ClinGenNR1D2
Clinical trials, drugs, therapy
Protein Interactions : CTD9975
Pharm GKB GenePA31749
Clinical trialNR1D2
Miscellaneous
canSAR (ICR)NR1D2 (select the gene name)
HarmonizomeNR1D2
DataMed IndexNR1D2
Probes
Litterature
PubMed42 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNR1D2
EVEXNR1D2
GoPubMedNR1D2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 14 14:24:44 CEST 2020

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.