Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 10062
MIM: 602423
HGNC: 7966
Ensembl: ENSG00000025434
Variants:
dbSNP: 10062
ClinVar: 10062
TCGA: ENSG00000025434
COSMIC: NR1H3
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA346 | SULT2A1 | Gene | MultilinkAnnotation | associated | 26555224 | ||
| PA443796 | Coronary Artery Disease | Disease | ClinicalAnnotation | associated | PD | 21562465 | |
| PA444552 | Hypertension | Disease | ClinicalAnnotation | associated | PD | 21562465 | |
| PA448499 | atenolol | Chemical | ClinicalAnnotation | associated | PD | 21562465 | |
| PA451868 | verapamil | Chemical | ClinicalAnnotation | associated | PD | 21562465 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38740636 | 2024 | Decreased mRNA expression of NR1H3 and ABCA1 in pulmonary tuberculosis patients from population of Punjab, India. | 0 |
| 38740636 | 2024 | Decreased mRNA expression of NR1H3 and ABCA1 in pulmonary tuberculosis patients from population of Punjab, India. | 0 |
| 36251137 | 2023 | Insulin Downregulates the Expression of ATP-binding Cassette Transporter A-I in Human Hepatoma Cell Line HepG2 in a FOXO1 and LXR Dependent Manner. | 1 |
| 36592658 | 2023 | Sterol-regulated transmembrane protein TMEM86a couples LXR signaling to regulation of lysoplasmalogens in macrophages. | 2 |
| 36854764 | 2023 | Contributions of NR1H3 genetic polymorphisms to susceptibility and effects of narrowband UVB phototherapy to nonsegmental vitiligo. | 0 |
| 36930354 | 2023 | Inhibition of LXR controls the polarization of human inflammatory macrophages through upregulation of MAFB. | 4 |
| 38016947 | 2023 | Liver X receptor alpha ensures blood-brain barrier function by suppressing SNAI2. | 0 |
| 36251137 | 2023 | Insulin Downregulates the Expression of ATP-binding Cassette Transporter A-I in Human Hepatoma Cell Line HepG2 in a FOXO1 and LXR Dependent Manner. | 1 |
| 36592658 | 2023 | Sterol-regulated transmembrane protein TMEM86a couples LXR signaling to regulation of lysoplasmalogens in macrophages. | 2 |
| 36854764 | 2023 | Contributions of NR1H3 genetic polymorphisms to susceptibility and effects of narrowband UVB phototherapy to nonsegmental vitiligo. | 0 |
| 36930354 | 2023 | Inhibition of LXR controls the polarization of human inflammatory macrophages through upregulation of MAFB. | 4 |
| 38016947 | 2023 | Liver X receptor alpha ensures blood-brain barrier function by suppressing SNAI2. | 0 |
| 34697082 | 2022 | Transcriptional Regulation of Carboxylesterase 1 in Human Liver: Role of the Nuclear Receptor Subfamily 1 Group H Member 3 and Its Splice Isoforms. | 1 |
| 35810773 | 2022 | CYP27A1 inhibits proliferation and migration of clear cell renal cell carcinoma via activation of LXRs/ABCA1. | 6 |
| 35907563 | 2022 | Association between the rs2279238 of the Liver X receptor alpha gene polymorphism and advanced carotid atherosclerosis in the Slovenian cohort. | 2 |
Citation
Dessen P
NR1H3 (nuclear receptor subfamily 1 group H member 3)
Atlas Genet Cytogenet Oncol Haematol. 2007-04-01
Online version: http://atlasgeneticsoncology.org/gene/47418/nr1h3
