NR1H3 (nuclear receptor subfamily 1 group H member 3)

2007-04-01  

Identity

HGNC
LOCATION
11p11.2
LOCUSID
ALIAS
LXR-a,LXRA,RLD-1

Other Information

Locus ID:

NCBI: 10062
MIM: 602423
HGNC: 7966
Ensembl: ENSG00000025434

Variants:

dbSNP: 10062
ClinVar: 10062
TCGA: ENSG00000025434
COSMIC: NR1H3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000025434ENST00000395397Q13133
ENSG00000025434ENST00000405576B5MBY7
ENSG00000025434ENST00000405853Q13133
ENSG00000025434ENST00000407404Q13133
ENSG00000025434ENST00000412937C9J2C8
ENSG00000025434ENST00000419652F8WEY6
ENSG00000025434ENST00000420369F8WC63
ENSG00000025434ENST00000436029C9JBS2
ENSG00000025434ENST00000436778C9JJ16
ENSG00000025434ENST00000437276C9JEC2
ENSG00000025434ENST00000441012Q13133
ENSG00000025434ENST00000441012F1D8N1
ENSG00000025434ENST00000444396C9J4R0
ENSG00000025434ENST00000449369C9JCS0
ENSG00000025434ENST00000457932C9JTS4
ENSG00000025434ENST00000467728Q13133
ENSG00000025434ENST00000467728F1D8N1
ENSG00000025434ENST00000481889E9PLL4
ENSG00000025434ENST00000527949E9PID2
ENSG00000025434ENST00000531660E9PPA1
ENSG00000025434ENST00000616973B4DXU5

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
PPAR signaling pathwayKEGGko03320
PPAR signaling pathwayKEGGhsa03320
Hepatitis CKEGGko05160
Hepatitis CKEGGhsa05160
Non-alcoholic fatty liver disease (NAFLD)KEGGhsa04932
Non-alcoholic fatty liver disease (NAFLD)KEGGko04932
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Nuclear Receptor transcription pathwayREACTOMER-HSA-383280
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Lipid digestion, mobilization, and transportREACTOMER-HSA-73923
Lipoprotein metabolismREACTOMER-HSA-174824
Insulin resistanceKEGGhsa04931
VLDL interactionsREACTOMER-HSA-8855121
VLDLR internalisation and degradationREACTOMER-HSA-8866427

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA346SULT2A1GeneMultilinkAnnotationassociated26555224
PA443796Coronary Artery DiseaseDiseaseClinicalAnnotationassociatedPD21562465
PA444552HypertensionDiseaseClinicalAnnotationassociatedPD21562465
PA448499atenololChemicalClinicalAnnotationassociatedPD21562465
PA451868verapamilChemicalClinicalAnnotationassociatedPD21562465

References

Pubmed IDYearTitleCitations
387406362024Decreased mRNA expression of NR1H3 and ABCA1 in pulmonary tuberculosis patients from population of Punjab, India.0
387406362024Decreased mRNA expression of NR1H3 and ABCA1 in pulmonary tuberculosis patients from population of Punjab, India.0
362511372023Insulin Downregulates the Expression of ATP-binding Cassette Transporter A-I in Human Hepatoma Cell Line HepG2 in a FOXO1 and LXR Dependent Manner.1
365926582023Sterol-regulated transmembrane protein TMEM86a couples LXR signaling to regulation of lysoplasmalogens in macrophages.2
368547642023Contributions of NR1H3 genetic polymorphisms to susceptibility and effects of narrowband UVB phototherapy to nonsegmental vitiligo.0
369303542023Inhibition of LXR controls the polarization of human inflammatory macrophages through upregulation of MAFB.4
380169472023Liver X receptor alpha ensures blood-brain barrier function by suppressing SNAI2.0
362511372023Insulin Downregulates the Expression of ATP-binding Cassette Transporter A-I in Human Hepatoma Cell Line HepG2 in a FOXO1 and LXR Dependent Manner.1
365926582023Sterol-regulated transmembrane protein TMEM86a couples LXR signaling to regulation of lysoplasmalogens in macrophages.2
368547642023Contributions of NR1H3 genetic polymorphisms to susceptibility and effects of narrowband UVB phototherapy to nonsegmental vitiligo.0
369303542023Inhibition of LXR controls the polarization of human inflammatory macrophages through upregulation of MAFB.4
380169472023Liver X receptor alpha ensures blood-brain barrier function by suppressing SNAI2.0
346970822022Transcriptional Regulation of Carboxylesterase 1 in Human Liver: Role of the Nuclear Receptor Subfamily 1 Group H Member 3 and Its Splice Isoforms.1
358107732022CYP27A1 inhibits proliferation and migration of clear cell renal cell carcinoma via activation of LXRs/ABCA1.6
359075632022Association between the rs2279238 of the Liver X receptor alpha gene polymorphism and advanced carotid atherosclerosis in the Slovenian cohort.2

Citation

Dessen P

NR1H3 (nuclear receptor subfamily 1 group H member 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47418/nr1h3