Atlas of Genetics and Cytogenetics in Oncology and Haematology

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NR1H3 (nuclear receptor subfamily 1, group H, member 3)

Identity

Other namesLXR-a
LXRA
RLD-1
HGNC (Hugo) NR1H3
LocusID (NCBI) 10062
Location 11p11.2
Location_base_pair Starts at 47279468 and ends at 47290584 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)NR1H3   7966
Entrez_Gene (NCBI)NR1H3  10062  nuclear receptor subfamily 1, group H, member 3
Cards
GeneCards (Weizmann)NR1H3
Ensembl (Hinxton)ENSG00000025434 [Gene_View]  chr11:47279468-47290584 [Contig_View]  NR1H3 [Vega]
AceView (NCBI)NR1H3
Genatlas (Paris)NR1H3
SOURCE (Stanford)NM_001130101 NM_001130102 NM_001251934 NM_001251935 NM_005693
Genomic and cartography
GoldenPath (UCSC)NR1H3  -  11p11.2   chr11:47279468-47290584 +  11p11.2   [Description]    (hg19-Feb_2009)
EnsemblNR1H3 - 11p11.2 [CytoView]
Mapping of homologs : NCBINR1H3 [Mapview]
OMIM602423   
Gene and transcription
Genbank (Entrez)AA644385 AB307698 AI097478 AI648486 AK122661
RefSeq transcript (SRS)NM_001130101 NM_001130102 NM_001251934 NM_001251935 NM_005693
RefSeq transcript (Entrez)NM_001130101 NM_001130102 NM_001251934 NM_001251935 NM_005693
RefSeq genomic (SRS)AC_000143 NC_000011 NC_018922 NG_030392 NT_009237 NW_001838022 NW_004078070
RefSeq genomic (Entrez)AC_000143 NC_000011 NC_018922 NG_030392 NT_009237 NW_001838022 NW_004078070
Consensus coding sequences : CCDS (NCBI)NR1H3
Cluster EST : UnigeneHs.438863 [ SRS ] Hs.438863 [ NCBI ]
CGAP (NCI)Hs.438863
Alternative Splicing : Fast-db (Paris)GSHG0004803
Alternative Splicing GalleryENSG00000025434
Gene ExpressionNR1H3 [ NCBI-GEO ]   NR1H3 [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13133 (SRS) Q13133 (Uniprot)
NextProtQ13133
With graphics : InterProQ13133
Splice isoforms : SwissVarQ13133(Swissvar)
Domaine pattern : Prosite (SRS)NUCLEAR_REC_DBD_1 (PS00031)    NUCLEAR_REC_DBD_2 (PS51030)   
Domaine pattern : Prosite (Expaxy)NUCLEAR_REC_DBD_1 (PS00031)    NUCLEAR_REC_DBD_2 (PS51030)   
Domains : Interpro (SRS)Liver_X_rcpt    Nucl_hormone_rcpt_ligand-bd    Nucl_hrmn_rcpt_lig-bd_core    Str_hrmn_rcpt    Znf_hrmn_rcpt    Znf_NHR/GATA   
Domains : Interpro (EBI)Liver_X_rcpt    Nucl_hormone_rcpt_ligand-bd    Nucl_hrmn_rcpt_lig-bd_core    Str_hrmn_rcpt    Znf_hrmn_rcpt    Znf_NHR/GATA   
Related proteins : CluSTrQ13133
Domain families : Pfam (SRS)Hormone_recep (PF00104)    zf-C4 (PF00105)   
Domain families : Pfam (Sanger)Hormone_recep (PF00104)    zf-C4 (PF00105)   
Domain families : Pfam (NCBI)pfam00104    pfam00105   
Domain families : Smart (EMBL)HOLI (SM00430)  ZnF_C4 (SM00399)  
DMDM10062
Blocks (Seattle)Q13133
PDB (SRS)1UHL    3IPQ    3IPS    3IPU   
PDB (PDBSum)1UHL    3IPQ    3IPS    3IPU   
PDB (IMB)1UHL    3IPQ    3IPS    3IPU   
PDB (RSDB)1UHL    3IPQ    3IPS    3IPU   
Human Protein AtlasENSG00000025434
HPRD07211
IPIIPI00220134   IPI00301894   IPI00879649   IPI00790577   IPI00791645   IPI00878572   IPI00877914   IPI00878873   IPI00878393   IPI00879201   IPI00878705   IPI00879837   IPI00796145   IPI00976161   IPI01011352   IPI00984620   
Protein Interaction databases
DIP (DOE-UCLA)Q13133
IntAct (EBI)Q13133
FunCoupENSG00000025434
REACTOMENR1H3
Protein Interaction Database10062
BioGRIDNR1H3
InParanoidQ13133
Interologous Interaction database Q13133
IntegromeDBNR1H3
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)NR1H3
SNP (GeneSNP Utah)NR1H3
SNP : HGBaseNR1H3
Genetic variants : HAPMAPNR1H3
Somatic Mutations in Cancer : COSMICNR1H3 
CONAN: Copy Number AnalysisNR1H3 
Mutations and Diseases : HGMDNR1H3
OMIM602423   
GENETests602423   
Disease Genetic AssociationNR1H3
Huge Navigator NR1H3 [HugePedia]  NR1H3 [HugeCancerGEM]
Genomic VariantsNR1H3  NR1H3 [DGVbeta]
snp3D : Map Gene to Disease10062
General knowledge
Homologs : HomoloGeneNR1H3
Homology/Alignments : Family Browser (UCSC)NR1H3
Phylogenetic Trees/Animal Genes : TreeFamNR1H3
Chemical/Protein Interactions : CTD10062
Chemical/Pharm GKB GenePA31751
Clinical trialNR1H3
Cancer Resource (Charite)ENSG00000025434
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  nuclear chromatin  DNA binding  steroid hormone receptor activity  transcription coactivator activity  ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity  protein binding  nucleus  nucleoplasm  cytoplasm  transcription initiation from RNA polymerase II promoter  zinc ion binding  insulin receptor signaling pathway  gene expression  negative regulation of macrophage derived foam cell differentiation  positive regulation of triglyceride biosynthetic process  positive regulation of receptor biosynthetic process  positive regulation of cholesterol efflux  positive regulation of cholesterol efflux  negative regulation of cholesterol storage  cholesterol binding  positive regulation of cellular protein metabolic process  negative regulation of lipid transport  positive regulation of cholesterol transport  response to progesterone stimulus  sterol response element binding  positive regulation of toll-like receptor 4 signaling pathway  cholesterol homeostasis  regulation of circadian rhythm  negative regulation of macrophage activation  apoptotic cell clearance  sequence-specific DNA binding  transcription regulatory region DNA binding  transcription regulatory region DNA binding  cellular lipid metabolic process  positive regulation of fatty acid biosynthetic process  negative regulation of proteolysis  positive regulation of transcription, DNA-dependent  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  metal ion binding  retinoid X receptor binding  protein heterodimerization activity  negative regulation of pinocytosis  negative regulation of inflammatory response  positive regulation of lipoprotein lipase activity  lipid homeostasis  sterol homeostasis  negative regulation of interferon-gamma-mediated signaling pathway  triglyceride homeostasis  cellular response to lipopolysaccharide  negative regulation of pancreatic juice secretion  negative regulation of secretion of lysosomal enzymes  positive regulation of cholesterol homeostasis  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  nuclear chromatin  DNA binding  steroid hormone receptor activity  transcription coactivator activity  ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity  protein binding  nucleus  nucleoplasm  cytoplasm  transcription initiation from RNA polymerase II promoter  zinc ion binding  insulin receptor signaling pathway  gene expression  negative regulation of macrophage derived foam cell differentiation  positive regulation of triglyceride biosynthetic process  positive regulation of receptor biosynthetic process  positive regulation of cholesterol efflux  positive regulation of cholesterol efflux  negative regulation of cholesterol storage  cholesterol binding  positive regulation of cellular protein metabolic process  negative regulation of lipid transport  positive regulation of cholesterol transport  response to progesterone stimulus  sterol response element binding  positive regulation of toll-like receptor 4 signaling pathway  cholesterol homeostasis  regulation of circadian rhythm  negative regulation of macrophage activation  apoptotic cell clearance  sequence-specific DNA binding  transcription regulatory region DNA binding  transcription regulatory region DNA binding  cellular lipid metabolic process  positive regulation of fatty acid biosynthetic process  negative regulation of proteolysis  positive regulation of transcription, DNA-dependent  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  metal ion binding  retinoid X receptor binding  protein heterodimerization activity  negative regulation of pinocytosis  negative regulation of inflammatory response  positive regulation of lipoprotein lipase activity  lipid homeostasis  sterol homeostasis  negative regulation of interferon-gamma-mediated signaling pathway  triglyceride homeostasis  cellular response to lipopolysaccharide  negative regulation of pancreatic juice secretion  negative regulation of secretion of lysosomal enzymes  positive regulation of cholesterol homeostasis  
Pathways : BIOCARTAMechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha) [Genes]    Nuclear Receptors in Lipid Metabolism and Toxicity [Genes]    FXR and LXR Regulation of Cholesterol Metabolism [Genes]   
Pathways : KEGGPPAR signaling pathway
Other databases
Probes
Litterature
PubMed174 Pubmed reference(s) in Entrez
PubGeneNR1H3
iHOPNR1H3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 1 12:20:27 CEST 2013
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