Atlas of Genetics and Cytogenetics in Oncology and Haematology


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NR1I2 (nuclear receptor subfamily 1 group I member 2)

Identity

Alias_namesnuclear receptor subfamily 1
Alias_symbol (synonym)ONR1
PXR
BXR
SXR
PAR2
Other aliasPAR
PAR1
PARq
PRR
SAR
HGNC (Hugo) NR1I2
LocusID (NCBI) 8856
Atlas_Id 45797
Location 3q13.33  [Link to chromosome band 3q13]
Location_base_pair Starts at 119780484 and ends at 119818485 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
NR1I2 (3q13.33) / TMEM246 (9q31.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NR1I2   7968
Cards
Entrez_Gene (NCBI)NR1I2  8856  nuclear receptor subfamily 1 group I member 2
AliasesBXR; ONR1; PAR; PAR1; 
PAR2; PARq; PRR; PXR; SAR; SXR
GeneCards (Weizmann)NR1I2
Ensembl hg19 (Hinxton)ENSG00000144852 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000144852 [Gene_View]  chr3:119780484-119818485 [Contig_View]  NR1I2 [Vega]
ICGC DataPortalENSG00000144852
TCGA cBioPortalNR1I2
AceView (NCBI)NR1I2
Genatlas (Paris)NR1I2
WikiGenes8856
SOURCE (Princeton)NR1I2
Genetics Home Reference (NIH)NR1I2
Genomic and cartography
GoldenPath hg38 (UCSC)NR1I2  -     chr3:119780484-119818485 +  3q13.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NR1I2  -     3q13.33   [Description]    (hg19-Feb_2009)
EnsemblNR1I2 - 3q13.33 [CytoView hg19]  NR1I2 - 3q13.33 [CytoView hg38]
Mapping of homologs : NCBINR1I2 [Mapview hg19]  NR1I2 [Mapview hg38]
OMIM603065   
Gene and transcription
Genbank (Entrez)AB307701 AF061056 AF084644 AF084645 AJ009936
RefSeq transcript (Entrez)NM_003889 NM_022002 NM_033013
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NR1I2
Cluster EST : UnigeneHs.7303 [ NCBI ]
CGAP (NCI)Hs.7303
Alternative Splicing GalleryENSG00000144852
Gene ExpressionNR1I2 [ NCBI-GEO ]   NR1I2 [ EBI - ARRAY_EXPRESS ]   NR1I2 [ SEEK ]   NR1I2 [ MEM ]
Gene Expression Viewer (FireBrowse)NR1I2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8856
GTEX Portal (Tissue expression)NR1I2
Human Protein AtlasENSG00000144852-NR1I2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75469   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75469  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75469
Splice isoforms : SwissVarO75469
PhosPhoSitePlusO75469
Domaine pattern : Prosite (Expaxy)NUCLEAR_REC_DBD_1 (PS00031)    NUCLEAR_REC_DBD_2 (PS51030)   
Domains : Interpro (EBI)Nucl_hrmn_rcpt_lig-bd    Nuclear_hrmn_rcpt    Znf_hrmn_rcpt    Znf_NHR/GATA   
Domain families : Pfam (Sanger)Hormone_recep (PF00104)    zf-C4 (PF00105)   
Domain families : Pfam (NCBI)pfam00104    pfam00105   
Domain families : Smart (EMBL)HOLI (SM00430)  ZnF_C4 (SM00399)  
Conserved Domain (NCBI)NR1I2
DMDM Disease mutations8856
Blocks (Seattle)NR1I2
PDB (SRS)1ILG    1ILH    1M13    1NRL    1SKX    2O9I    2QNV    3CTB    3HVL    3R8D    4J5W    4J5X    4NY9    4S0S    4S0T    4X1F    4X1G    4XAO    4XHD    5A86   
PDB (PDBSum)1ILG    1ILH    1M13    1NRL    1SKX    2O9I    2QNV    3CTB    3HVL    3R8D    4J5W    4J5X    4NY9    4S0S    4S0T    4X1F    4X1G    4XAO    4XHD    5A86   
PDB (IMB)1ILG    1ILH    1M13    1NRL    1SKX    2O9I    2QNV    3CTB    3HVL    3R8D    4J5W    4J5X    4NY9    4S0S    4S0T    4X1F    4X1G    4XAO    4XHD    5A86   
PDB (RSDB)1ILG    1ILH    1M13    1NRL    1SKX    2O9I    2QNV    3CTB    3HVL    3R8D    4J5W    4J5X    4NY9    4S0S    4S0T    4X1F    4X1G    4XAO    4XHD    5A86   
Structural Biology KnowledgeBase1ILG    1ILH    1M13    1NRL    1SKX    2O9I    2QNV    3CTB    3HVL    3R8D    4J5W    4J5X    4NY9    4S0S    4S0T    4X1F    4X1G    4XAO    4XHD    5A86   
SCOP (Structural Classification of Proteins)1ILG    1ILH    1M13    1NRL    1SKX    2O9I    2QNV    3CTB    3HVL    3R8D    4J5W    4J5X    4NY9    4S0S    4S0T    4X1F    4X1G    4XAO    4XHD    5A86   
CATH (Classification of proteins structures)1ILG    1ILH    1M13    1NRL    1SKX    2O9I    2QNV    3CTB    3HVL    3R8D    4J5W    4J5X    4NY9    4S0S    4S0T    4X1F    4X1G    4XAO    4XHD    5A86   
SuperfamilyO75469
Human Protein Atlas [tissue]ENSG00000144852-NR1I2 [tissue]
Peptide AtlasO75469
HPRD04346
IPIIPI00334983   IPI00004364   IPI00783954   IPI00220084   IPI00220085   IPI00220086   IPI00852956   IPI00815915   
Protein Interaction databases
DIP (DOE-UCLA)O75469
IntAct (EBI)O75469
FunCoupENSG00000144852
BioGRIDNR1I2
STRING (EMBL)NR1I2
ZODIACNR1I2
Ontologies - Pathways
QuickGOO75469
Ontology : AmiGORNA polymerase II regulatory region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding  steroid hormone receptor activity  transcription coactivator activity  RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding  protein binding  nucleoplasm  nucleoplasm  transcription initiation from RNA polymerase II promoter  xenobiotic metabolic process  signal transduction  drug binding  steroid metabolic process  zinc ion binding  nuclear body  intracellular receptor signaling pathway  exogenous drug catabolic process  xenobiotic transport  steroid hormone mediated signaling pathway  intermediate filament cytoskeleton  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  drug export  
Ontology : EGO-EBIRNA polymerase II regulatory region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding  steroid hormone receptor activity  transcription coactivator activity  RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding  protein binding  nucleoplasm  nucleoplasm  transcription initiation from RNA polymerase II promoter  xenobiotic metabolic process  signal transduction  drug binding  steroid metabolic process  zinc ion binding  nuclear body  intracellular receptor signaling pathway  exogenous drug catabolic process  xenobiotic transport  steroid hormone mediated signaling pathway  intermediate filament cytoskeleton  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  drug export  
Pathways : BIOCARTATh1/Th2 Differentiation [Genes]    Nuclear Receptors in Lipid Metabolism and Toxicity [Genes]   
NDEx NetworkNR1I2
Atlas of Cancer Signalling NetworkNR1I2
Wikipedia pathwaysNR1I2
Orthology - Evolution
OrthoDB8856
GeneTree (enSembl)ENSG00000144852
Phylogenetic Trees/Animal Genes : TreeFamNR1I2
HOVERGENO75469
HOGENOMO75469
Homologs : HomoloGeneNR1I2
Homology/Alignments : Family Browser (UCSC)NR1I2
Gene fusions - Rearrangements
Tumor Fusion PortalNR1I2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNR1I2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NR1I2
dbVarNR1I2
ClinVarNR1I2
1000_GenomesNR1I2 
Exome Variant ServerNR1I2
ExAC (Exome Aggregation Consortium)ENSG00000144852
GNOMAD BrowserENSG00000144852
Genetic variants : HAPMAP8856
Genomic Variants (DGV)NR1I2 [DGVbeta]
DECIPHERNR1I2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNR1I2 
Mutations
ICGC Data PortalNR1I2 
TCGA Data PortalNR1I2 
Broad Tumor PortalNR1I2
OASIS PortalNR1I2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNR1I2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNR1I2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NR1I2
DgiDB (Drug Gene Interaction Database)NR1I2
DoCM (Curated mutations)NR1I2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NR1I2 (select a term)
intoGenNR1I2
Cancer3DNR1I2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603065   
Orphanet
DisGeNETNR1I2
MedgenNR1I2
Genetic Testing Registry NR1I2
NextProtO75469 [Medical]
TSGene8856
GENETestsNR1I2
Target ValidationNR1I2
Huge Navigator NR1I2 [HugePedia]
snp3D : Map Gene to Disease8856
BioCentury BCIQNR1I2
ClinGenNR1I2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8856
Chemical/Pharm GKB GenePA378
Clinical trialNR1I2
Miscellaneous
canSAR (ICR)NR1I2 (select the gene name)
Probes
Litterature
PubMed293 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNR1I2
EVEXNR1I2
GoPubMedNR1I2
iHOPNR1I2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:26:42 CET 2017

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