NR1I3 (nuclear receptor subfamily 1 group I member 3)

2007-02-01  

Identity

HGNC
NR1I3
LOCATION
1q23.3
LOCUSID
9970
ALIAS
CAR,CAR1,MB67

Other Information

Locus ID:

NCBI: 9970
MIM: 603881
HGNC: 7969
Ensembl: ENSG00000143257

Variants:

dbSNP: 9970
ClinVar: 9970
TCGA: ENSG00000143257
COSMIC: NR1I3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000143257ENST00000367979Q14994
ENSG00000143257ENST00000367980Q14994
ENSG00000143257ENST00000367981Q14994
ENSG00000143257ENST00000367982Q14994
ENSG00000143257ENST00000367983Q14994
ENSG00000143257ENST00000367984Q14994
ENSG00000143257ENST00000367985Q14994
ENSG00000143257ENST00000412844Q14994
ENSG00000143257ENST00000428574Q14994
ENSG00000143257ENST00000437437Q14994
ENSG00000143257ENST00000442691Q14994
ENSG00000143257ENST00000502848Q6GZ69
ENSG00000143257ENST00000502985Q6GZ72
ENSG00000143257ENST00000504010Q14994
ENSG00000143257ENST00000505005Q14994
ENSG00000143257ENST00000506018C0H5Y2
ENSG00000143257ENST00000506209E9PCF2
ENSG00000143257ENST00000507215Q6GZ81
ENSG00000143257ENST00000508387Q6GZ70
ENSG00000143257ENST00000508740Q14994
ENSG00000143257ENST00000510951Q6GZ81
ENSG00000143257ENST00000511676Q14994
ENSG00000143257ENST00000511748Q6GZ70
ENSG00000143257ENST00000511944Q6GZ72
ENSG00000143257ENST00000512340Q6GZ81
ENSG00000143257ENST00000512372Q14994
ENSG00000143257ENST00000515452B7Z8R7
ENSG00000143257ENST00000515621D6REZ7
ENSG00000143257ENST00000628566Q6GZ69

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Nuclear Receptor transcription pathwayREACTOMER-HSA-383280

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA123CYP2B6GenePathwayassociated21738081
PA130CYP3A4GenePathwayassociated21738081
PA162372840sunitinibChemicalMultilinkAnnotationassociated27561454
PA443340AnemiaDiseaseClinicalAnnotationassociatedPD24193570
PA445046Nasopharyngeal NeoplasmsDiseaseClinicalAnnotationassociatedPD24193570
PA445113NeutropeniaDiseaseClinicalAnnotationassociatedPD24193570
PA447230HIVDiseaseClinicalAnnotationassociatedPK23172109, 23173844, 24080498
PA448785carbamazepineChemicalPathwayassociated21738081
PA449383docetaxelChemicalClinicalAnnotation, MultilinkAnnotationassociatedPD24193570, 27561454
PA449441efavirenzChemicalClinicalAnnotationassociatedPK23172109, 23173844, 24080498
PA451906warfarinChemicalClinicalAnnotationassociatedPD25356900, 29298995

References

Pubmed IDYearTitleCitations
123767032002Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR.94
158315212005Xenobiotic stress induces hepatomegaly and liver tumors via the nuclear receptor constitutive androstane receptor.92
126447042003Induction of bilirubin clearance by the constitutive androstane receptor (CAR).85
126447002003Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor.83
121306892002Transcriptional regulation of the human CYP3A4 gene by the constitutive androstane receptor.50
175768042007Expression of constitutive androstane receptor, hepatic nuclear factor 4 alpha, and P450 oxidoreductase genes determines interindividual variability in basal expression and activity of a broad scope of xenobiotic metabolism genes in the human liver.49
198582202009Dephosphorylation of threonine 38 is required for nuclear translocation and activation of human xenobiotic receptor CAR (NR1I3).49
183053702008The roles of nuclear receptors CAR and PXR in hepatic energy metabolism.45
127994472003Alternatively spliced isoforms of the human constitutive androstane receptor.43
152720532004Meclizine is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for human CAR.42

Citation

Dessen P

NR1I3 (nuclear receptor subfamily 1 group I member 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46293/nr1i3