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NR2E1 (nuclear receptor subfamily 2, group E, member 1)

Identity

Other namesTLL
TLX
XTLL
HGNC (Hugo) NR2E1
LocusID (NCBI) 7101
Location 6q21
Location_base_pair Starts at 108487215 and ends at 108510013 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

External links

Nomenclature
HGNC (Hugo)NR2E1   7973
Entrez_Gene (NCBI)NR2E1  7101  nuclear receptor subfamily 2, group E, member 1
Cards
GeneCards (Weizmann)NR2E1
Ensembl (Hinxton)ENSG00000112333 [Gene_View]  chr6:108487215-108510013 [Contig_View]  NR2E1 [Vega]
AceView (NCBI)NR2E1
Genatlas (Paris)NR2E1
SOURCE (Stanford)NM_003269
Genomic and cartography
GoldenPath (UCSC)NR2E1  -  6q21   chr6:108487215-108510013 +  6q21   [Description]    (hg19-Feb_2009)
EnsemblNR2E1 - 6q21 [CytoView]
Mapping of homologs : NCBINR2E1 [Mapview]
OMIM603849   
Gene and transcription
Genbank (Entrez)AB307709 AF220532 AF411525 AK131541 BC028031
RefSeq transcript (SRS)NM_003269
RefSeq transcript (Entrez)NM_003269
RefSeq genomic (SRS)AC_000138 NC_000006 NC_018917 NT_025741 NW_001838990 NW_004078028
RefSeq genomic (Entrez)AC_000138 NC_000006 NC_018917 NT_025741 NW_001838990 NW_004078028
Consensus coding sequences : CCDS (NCBI)NR2E1
Cluster EST : UnigeneHs.157688 [ SRS ] Hs.157688 [ NCBI ]
CGAP (NCI)Hs.157688
Alternative Splicing : Fast-db (Paris)GSHG0025941
Alternative Splicing GalleryENSG00000112333
Gene ExpressionNR2E1 [ NCBI-GEO ]   NR2E1 [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y466 (SRS) Q9Y466 (Uniprot)
NextProtQ9Y466
With graphics : InterProQ9Y466
Splice isoforms : SwissVarQ9Y466(Swissvar)
Domaine pattern : Prosite (SRS)NUCLEAR_REC_DBD_1 (PS00031)    NUCLEAR_REC_DBD_2 (PS51030)   
Domaine pattern : Prosite (Expaxy)NUCLEAR_REC_DBD_1 (PS00031)    NUCLEAR_REC_DBD_2 (PS51030)   
Domains : Interpro (SRS)Nucl_hormone_rcpt_ligand-bd    Nucl_hrmn_rcpt_lig-bd_core    Str_hrmn_rcpt    Znf_hrmn_rcpt    Znf_NHR/GATA   
Domains : Interpro (EBI)Nucl_hormone_rcpt_ligand-bd    Nucl_hrmn_rcpt_lig-bd_core    Str_hrmn_rcpt    Znf_hrmn_rcpt    Znf_NHR/GATA   
Related proteins : CluSTrQ9Y466
Domain families : Pfam (SRS)Hormone_recep (PF00104)    zf-C4 (PF00105)   
Domain families : Pfam (Sanger)Hormone_recep (PF00104)    zf-C4 (PF00105)   
Domain families : Pfam (NCBI)pfam00104    pfam00105   
Domain families : Smart (EMBL)HOLI (SM00430)  ZnF_C4 (SM00399)  
DMDM7101
Blocks (Seattle)Q9Y466
Human Protein AtlasENSG00000112333
HPRD07230
IPIIPI00843777   IPI00000354   IPI00853328   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y466
IntAct (EBI)Q9Y466
FunCoupENSG00000112333
REACTOMENR2E1
Protein Interaction Database7101
BioGRIDNR2E1
InParanoidQ9Y466
Interologous Interaction database Q9Y466
IntegromeDBNR2E1
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)NR2E1
SNP (GeneSNP Utah)NR2E1
SNP : HGBaseNR2E1
Genetic variants : HAPMAPNR2E1
Somatic Mutations in Cancer : COSMICNR2E1 
CONAN: Copy Number AnalysisNR2E1 
Mutations and Diseases : HGMDNR2E1
OMIM603849   
GENETests603849   
Disease Genetic AssociationNR2E1
Huge Navigator NR2E1 [HugePedia]  NR2E1 [HugeCancerGEM]
Genomic VariantsNR2E1  NR2E1 [DGVbeta]
snp3D : Map Gene to Disease7101
General knowledge
Homologs : HomoloGeneNR2E1
Homology/Alignments : Family Browser (UCSC)NR2E1
Phylogenetic Trees/Animal Genes : TreeFamNR2E1
Chemical/Protein Interactions : CTD7101
Chemical/Pharm GKB GenePA31756
Clinical trialNR2E1
Cancer Resource (Charite)ENSG00000112333
Ontology : AmiGORNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription  RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription  behavioral fear response  aggressive behavior  steroid hormone receptor activity  nucleoplasm  transcription initiation from RNA polymerase II promoter  nervous system development  visual perception  zinc ion binding  glial cell migration  gene expression  dentate gyrus development  amygdala development  olfactory bulb development  layer formation in cerebral cortex  forebrain generation of neurons  cerebral cortex neuron differentiation  anterior commissure morphogenesis  extracellular matrix organization  somatic stem cell maintenance  social behavior  histone deacetylase binding  negative regulation of apoptotic process  sequence-specific DNA binding  cell fate commitment  negative regulation of neuron differentiation  positive regulation of angiogenesis  positive regulation of cell cycle  metal ion binding  negative regulation of astrocyte differentiation  regulation of dendrite morphogenesis  retina development in camera-type eye  regulation of timing of neuron differentiation  long-term synaptic potentiation  regulation of cell migration involved in sprouting angiogenesis  negative regulation of neural precursor cell proliferation  positive regulation of neural precursor cell proliferation  positive regulation of stem cell proliferation  
Ontology : EGO-EBIRNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription  RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription  behavioral fear response  aggressive behavior  steroid hormone receptor activity  nucleoplasm  transcription initiation from RNA polymerase II promoter  nervous system development  visual perception  zinc ion binding  glial cell migration  gene expression  dentate gyrus development  amygdala development  olfactory bulb development  layer formation in cerebral cortex  forebrain generation of neurons  cerebral cortex neuron differentiation  anterior commissure morphogenesis  extracellular matrix organization  somatic stem cell maintenance  social behavior  histone deacetylase binding  negative regulation of apoptotic process  sequence-specific DNA binding  cell fate commitment  negative regulation of neuron differentiation  positive regulation of angiogenesis  positive regulation of cell cycle  metal ion binding  negative regulation of astrocyte differentiation  regulation of dendrite morphogenesis  retina development in camera-type eye  regulation of timing of neuron differentiation  long-term synaptic potentiation  regulation of cell migration involved in sprouting angiogenesis  negative regulation of neural precursor cell proliferation  positive regulation of neural precursor cell proliferation  positive regulation of stem cell proliferation  
Other databases
Probes
Litterature
PubMed25 Pubmed reference(s) in Entrez
PubGeneNR2E1
iHOPNR2E1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 1 12:23:44 CEST 2013
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