Atlas of Genetics and Cytogenetics in Oncology and Haematology


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NR2E1 (nuclear receptor subfamily 2 group E member 1)

Identity

Alias_namesTLX
nuclear receptor subfamily 2
Alias_symbol (synonym)TLL
XTLL
Other alias
HGNC (Hugo) NR2E1
LocusID (NCBI) 7101
Atlas_Id 51422
Location 6q21  [Link to chromosome band 6q21]
Location_base_pair Starts at 108489227 and ends at 108510013 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NR2E1   7973
Cards
Entrez_Gene (NCBI)NR2E1  7101  nuclear receptor subfamily 2 group E member 1
AliasesTLL; TLX; XTLL
GeneCards (Weizmann)NR2E1
Ensembl hg19 (Hinxton)ENSG00000112333 [Gene_View]  chr6:108489227-108510013 [Contig_View]  NR2E1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000112333 [Gene_View]  chr6:108489227-108510013 [Contig_View]  NR2E1 [Vega]
ICGC DataPortalENSG00000112333
TCGA cBioPortalNR2E1
AceView (NCBI)NR2E1
Genatlas (Paris)NR2E1
WikiGenes7101
SOURCE (Princeton)NR2E1
Genetics Home Reference (NIH)NR2E1
Genomic and cartography
GoldenPath hg19 (UCSC)NR2E1  -     chr6:108489227-108510013 +  6q21   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)NR2E1  -     6q21   [Description]    (hg38-Dec_2013)
EnsemblNR2E1 - 6q21 [CytoView hg19]  NR2E1 - 6q21 [CytoView hg38]
Mapping of homologs : NCBINR2E1 [Mapview hg19]  NR2E1 [Mapview hg38]
OMIM603849   
Gene and transcription
Genbank (Entrez)AB307709 AF220532 AF411525 AK131541 BC028031
RefSeq transcript (Entrez)NM_001286102 NM_003269
RefSeq genomic (Entrez)NC_000006 NC_018917 NG_042807 NT_025741 NW_004929328
Consensus coding sequences : CCDS (NCBI)NR2E1
Cluster EST : UnigeneHs.157688 [ NCBI ]
CGAP (NCI)Hs.157688
Alternative Splicing GalleryENSG00000112333
Gene ExpressionNR2E1 [ NCBI-GEO ]   NR2E1 [ EBI - ARRAY_EXPRESS ]   NR2E1 [ SEEK ]   NR2E1 [ MEM ]
Gene Expression Viewer (FireBrowse)NR2E1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7101
GTEX Portal (Tissue expression)NR2E1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y466   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y466  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y466
Splice isoforms : SwissVarQ9Y466
PhosPhoSitePlusQ9Y466
Domaine pattern : Prosite (Expaxy)NUCLEAR_REC_DBD_1 (PS00031)    NUCLEAR_REC_DBD_2 (PS51030)   
Domains : Interpro (EBI)Nucl_hrmn_rcpt_lig-bd    Nuclear_hrmn_rcpt    Znf_hrmn_rcpt    Znf_NHR/GATA   
Domain families : Pfam (Sanger)Hormone_recep (PF00104)    zf-C4 (PF00105)   
Domain families : Pfam (NCBI)pfam00104    pfam00105   
Domain families : Smart (EMBL)HOLI (SM00430)  ZnF_C4 (SM00399)  
Conserved Domain (NCBI)NR2E1
DMDM Disease mutations7101
Blocks (Seattle)NR2E1
PDB (SRS)4XAJ   
PDB (PDBSum)4XAJ   
PDB (IMB)4XAJ   
PDB (RSDB)4XAJ   
Structural Biology KnowledgeBase4XAJ   
SCOP (Structural Classification of Proteins)4XAJ   
CATH (Classification of proteins structures)4XAJ   
SuperfamilyQ9Y466
Human Protein AtlasENSG00000112333
Peptide AtlasQ9Y466
HPRD07230
IPIIPI00843777   IPI00000354   IPI00853328   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y466
IntAct (EBI)Q9Y466
FunCoupENSG00000112333
BioGRIDNR2E1
STRING (EMBL)NR2E1
ZODIACNR2E1
Ontologies - Pathways
QuickGOQ9Y466
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding  behavioral fear response  aggressive behavior  steroid hormone receptor activity  nucleoplasm  transcription initiation from RNA polymerase II promoter  nervous system development  visual perception  zinc ion binding  dentate gyrus development  amygdala development  olfactory bulb development  layer formation in cerebral cortex  forebrain generation of neurons  cerebral cortex neuron differentiation  anterior commissure morphogenesis  extracellular matrix organization  somatic stem cell population maintenance  social behavior  histone deacetylase binding  negative regulation of apoptotic process  steroid hormone mediated signaling pathway  sequence-specific DNA binding  cell fate commitment  negative regulation of neuron differentiation  positive regulation of angiogenesis  positive regulation of cell cycle  positive regulation of transcription from RNA polymerase II promoter  negative regulation of astrocyte differentiation  regulation of dendrite morphogenesis  retina development in camera-type eye  regulation of timing of neuron differentiation  long-term synaptic potentiation  regulation of cell migration involved in sprouting angiogenesis  negative regulation of neural precursor cell proliferation  positive regulation of neural precursor cell proliferation  positive regulation of stem cell proliferation  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding  behavioral fear response  aggressive behavior  steroid hormone receptor activity  nucleoplasm  transcription initiation from RNA polymerase II promoter  nervous system development  visual perception  zinc ion binding  dentate gyrus development  amygdala development  olfactory bulb development  layer formation in cerebral cortex  forebrain generation of neurons  cerebral cortex neuron differentiation  anterior commissure morphogenesis  extracellular matrix organization  somatic stem cell population maintenance  social behavior  histone deacetylase binding  negative regulation of apoptotic process  steroid hormone mediated signaling pathway  sequence-specific DNA binding  cell fate commitment  negative regulation of neuron differentiation  positive regulation of angiogenesis  positive regulation of cell cycle  positive regulation of transcription from RNA polymerase II promoter  negative regulation of astrocyte differentiation  regulation of dendrite morphogenesis  retina development in camera-type eye  regulation of timing of neuron differentiation  long-term synaptic potentiation  regulation of cell migration involved in sprouting angiogenesis  negative regulation of neural precursor cell proliferation  positive regulation of neural precursor cell proliferation  positive regulation of stem cell proliferation  
NDEx NetworkNR2E1
Atlas of Cancer Signalling NetworkNR2E1
Wikipedia pathwaysNR2E1
Orthology - Evolution
OrthoDB7101
GeneTree (enSembl)ENSG00000112333
Phylogenetic Trees/Animal Genes : TreeFamNR2E1
HOVERGENQ9Y466
HOGENOMQ9Y466
Homologs : HomoloGeneNR2E1
Homology/Alignments : Family Browser (UCSC)NR2E1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNR2E1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NR2E1
dbVarNR2E1
ClinVarNR2E1
1000_GenomesNR2E1 
Exome Variant ServerNR2E1
ExAC (Exome Aggregation Consortium)NR2E1 (select the gene name)
Genetic variants : HAPMAP7101
Genomic Variants (DGV)NR2E1 [DGVbeta]
DECIPHER (Syndromes)6:108489227-108510013  ENSG00000112333
CONAN: Copy Number AnalysisNR2E1 
Mutations
ICGC Data PortalNR2E1 
TCGA Data PortalNR2E1 
Broad Tumor PortalNR2E1
OASIS PortalNR2E1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNR2E1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNR2E1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NR2E1
DgiDB (Drug Gene Interaction Database)NR2E1
DoCM (Curated mutations)NR2E1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NR2E1 (select a term)
intoGenNR2E1
Cancer3DNR2E1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603849   
Orphanet
MedgenNR2E1
Genetic Testing Registry NR2E1
NextProtQ9Y466 [Medical]
TSGene7101
GENETestsNR2E1
Huge Navigator NR2E1 [HugePedia]
snp3D : Map Gene to Disease7101
BioCentury BCIQNR2E1
ClinGenNR2E1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7101
Chemical/Pharm GKB GenePA31756
Clinical trialNR2E1
Miscellaneous
canSAR (ICR)NR2E1 (select the gene name)
Probes
Litterature
PubMed39 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNR2E1
EVEXNR2E1
GoPubMedNR2E1
iHOPNR2E1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 13:19:20 CET 2017

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