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NR2F6 (nuclear receptor subfamily 2 group F member 6)

Identity

Alias_namesERBAL2
nuclear receptor subfamily 2
Alias_symbol (synonym)EAR-2
Other aliasEAR2
HGNC (Hugo) NR2F6
LocusID (NCBI) 2063
Atlas_Id 41572
Location 19p13.11  [Link to chromosome band 19p13]
Location_base_pair Starts at 17342694 and ends at 17356151 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
NCAN (19p13.11) / NR2F6 (19p13.11)NR2F6 (19p13.11) / ANO8 (19p13.11)NR2F6 (19p13.11) / MAST3 (19p13.11)
NR2F6 (19p13.11) / NR2F6 (19p13.11)NR2F6 (19p13.11) / USHBP1 (19p13.11)NCAN 19p13.11 / NR2F6 19p13.11
NR2F6 19p13.11 / USHBP1 19p13.11

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NR2F6   7977
Cards
Entrez_Gene (NCBI)NR2F6  2063  nuclear receptor subfamily 2 group F member 6
AliasesEAR-2; EAR2; ERBAL2
GeneCards (Weizmann)NR2F6
Ensembl hg19 (Hinxton)ENSG00000160113 [Gene_View]  chr19:17342694-17356151 [Contig_View]  NR2F6 [Vega]
Ensembl hg38 (Hinxton)ENSG00000160113 [Gene_View]  chr19:17342694-17356151 [Contig_View]  NR2F6 [Vega]
ICGC DataPortalENSG00000160113
TCGA cBioPortalNR2F6
AceView (NCBI)NR2F6
Genatlas (Paris)NR2F6
WikiGenes2063
SOURCE (Princeton)NR2F6
Genetics Home Reference (NIH)NR2F6
Genomic and cartography
GoldenPath hg19 (UCSC)NR2F6  -     chr19:17342694-17356151 -  19p13.11   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)NR2F6  -     19p13.11   [Description]    (hg38-Dec_2013)
EnsemblNR2F6 - 19p13.11 [CytoView hg19]  NR2F6 - 19p13.11 [CytoView hg38]
Mapping of homologs : NCBINR2F6 [Mapview hg19]  NR2F6 [Mapview hg38]
OMIM132880   
Gene and transcription
Genbank (Entrez)AB307712 AK298764 AK314961 BC002669 BC063018
RefSeq transcript (Entrez)NM_005234
RefSeq genomic (Entrez)NC_000019 NC_018930 NT_011295 NW_004929414
Consensus coding sequences : CCDS (NCBI)NR2F6
Cluster EST : UnigeneHs.466148 [ NCBI ]
CGAP (NCI)Hs.466148
Alternative Splicing GalleryENSG00000160113
Gene ExpressionNR2F6 [ NCBI-GEO ]   NR2F6 [ EBI - ARRAY_EXPRESS ]   NR2F6 [ SEEK ]   NR2F6 [ MEM ]
Gene Expression Viewer (FireBrowse)NR2F6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2063
GTEX Portal (Tissue expression)NR2F6
Protein : pattern, domain, 3D structure
UniProt/SwissProtP10588   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP10588  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP10588
Splice isoforms : SwissVarP10588
PhosPhoSitePlusP10588
Domaine pattern : Prosite (Expaxy)NUCLEAR_REC_DBD_1 (PS00031)    NUCLEAR_REC_DBD_2 (PS51030)   
Domains : Interpro (EBI)COUP_TF    Nucl_hrmn_rcpt_lig-bd    Nuclear_hrmn_rcpt    Znf_hrmn_rcpt    Znf_NHR/GATA   
Domain families : Pfam (Sanger)Hormone_recep (PF00104)    zf-C4 (PF00105)   
Domain families : Pfam (NCBI)pfam00104    pfam00105   
Domain families : Smart (EMBL)HOLI (SM00430)  ZnF_C4 (SM00399)  
Conserved Domain (NCBI)NR2F6
DMDM Disease mutations2063
Blocks (Seattle)NR2F6
SuperfamilyP10588
Human Protein AtlasENSG00000160113
Peptide AtlasP10588
HPRD00583
IPIIPI00021429   IPI00979709   
Protein Interaction databases
DIP (DOE-UCLA)P10588
IntAct (EBI)P10588
FunCoupENSG00000160113
BioGRIDNR2F6
STRING (EMBL)NR2F6
ZODIACNR2F6
Ontologies - Pathways
QuickGOP10588
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II distal enhancer sequence-specific DNA binding  transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding  DNA binding  transcription factor activity, sequence-specific DNA binding  steroid hormone receptor activity  RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding  thyroid hormone receptor activity  protein binding  nucleus  nucleoplasm  transcription initiation from RNA polymerase II promoter  signal transduction  zinc ion binding  intracellular receptor signaling pathway  intracellular receptor signaling pathway  entrainment of circadian clock by photoperiod  steroid hormone mediated signaling pathway  sequence-specific DNA binding  neuron development  detection of temperature stimulus involved in sensory perception of pain  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II distal enhancer sequence-specific DNA binding  transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding  DNA binding  transcription factor activity, sequence-specific DNA binding  steroid hormone receptor activity  RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding  thyroid hormone receptor activity  protein binding  nucleus  nucleoplasm  transcription initiation from RNA polymerase II promoter  signal transduction  zinc ion binding  intracellular receptor signaling pathway  intracellular receptor signaling pathway  entrainment of circadian clock by photoperiod  steroid hormone mediated signaling pathway  sequence-specific DNA binding  neuron development  detection of temperature stimulus involved in sensory perception of pain  
NDEx NetworkNR2F6
Atlas of Cancer Signalling NetworkNR2F6
Wikipedia pathwaysNR2F6
Orthology - Evolution
OrthoDB2063
GeneTree (enSembl)ENSG00000160113
Phylogenetic Trees/Animal Genes : TreeFamNR2F6
HOVERGENP10588
HOGENOMP10588
Homologs : HomoloGeneNR2F6
Homology/Alignments : Family Browser (UCSC)NR2F6
Gene fusions - Rearrangements
Fusion : MitelmanNCAN/NR2F6 [19p13.11/19p13.11]  [t(19;19)(p13;p13)]  
Fusion : MitelmanNR2F6/MAST3 [19p13.11/19p13.11]  [t(19;19)(p13;p13)]  
Fusion : MitelmanNR2F6/USHBP1 [19p13.11/19p13.11]  [t(19;19)(p13;p13)]  
Fusion: TCGANCAN 19p13.11 NR2F6 19p13.11 BRCA
Fusion: TCGANR2F6 19p13.11 USHBP1 19p13.11 HNSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNR2F6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NR2F6
dbVarNR2F6
ClinVarNR2F6
1000_GenomesNR2F6 
Exome Variant ServerNR2F6
ExAC (Exome Aggregation Consortium)NR2F6 (select the gene name)
Genetic variants : HAPMAP2063
Genomic Variants (DGV)NR2F6 [DGVbeta]
DECIPHER (Syndromes)19:17342694-17356151  ENSG00000160113
CONAN: Copy Number AnalysisNR2F6 
Mutations
ICGC Data PortalNR2F6 
TCGA Data PortalNR2F6 
Broad Tumor PortalNR2F6
OASIS PortalNR2F6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNR2F6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNR2F6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NR2F6
DgiDB (Drug Gene Interaction Database)NR2F6
DoCM (Curated mutations)NR2F6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NR2F6 (select a term)
intoGenNR2F6
Cancer3DNR2F6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM132880   
Orphanet
MedgenNR2F6
Genetic Testing Registry NR2F6
NextProtP10588 [Medical]
TSGene2063
GENETestsNR2F6
Huge Navigator NR2F6 [HugePedia]
snp3D : Map Gene to Disease2063
BioCentury BCIQNR2F6
ClinGenNR2F6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2063
Chemical/Pharm GKB GenePA31760
Clinical trialNR2F6
Miscellaneous
canSAR (ICR)NR2F6 (select the gene name)
Probes
Litterature
PubMed18 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNR2F6
EVEXNR2F6
GoPubMedNR2F6
iHOPNR2F6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:19:21 CET 2017

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