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NR4A2 (nuclear receptor subfamily 4, group A, member 2)

Identity

Other namesHZF-3
NOT
NURR1
RNR1
TINUR
HGNC (Hugo) NR4A2
LocusID (NCBI) 4929
Location 2q24.1
Location_base_pair Starts at 157180944 and ends at 157189287 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)NR4A2   7981
Cards
Entrez_Gene (NCBI)NR4A2  4929  nuclear receptor subfamily 4, group A, member 2
GeneCards (Weizmann)NR4A2
Ensembl (Hinxton)ENSG00000153234 [Gene_View]  chr2:157180944-157189287 [Contig_View]  NR4A2 [Vega]
ICGC DataPortalENSG00000153234
cBioPortalNR4A2
AceView (NCBI)NR4A2
Genatlas (Paris)NR4A2
WikiGenes4929
SOURCE (Princeton)NM_006186 NM_173171 NM_173172 NM_173173
Genomic and cartography
GoldenPath (UCSC)NR4A2  -  2q24.1   chr2:157180944-157189287 -  2q24.1   [Description]    (hg19-Feb_2009)
EnsemblNR4A2 - 2q24.1 [CytoView]
Mapping of homologs : NCBINR4A2 [Mapview]
OMIM168600   601828   
Gene and transcription
Genbank (Entrez)AK223625 AK291456 AK299439 AK309786 BC009288
RefSeq transcript (Entrez)NM_006186 NM_173171 NM_173172 NM_173173
RefSeq genomic (Entrez)AC_000134 NC_000002 NC_018913 NG_011821 NT_005403 NW_001838860 NW_004929305
Consensus coding sequences : CCDS (NCBI)NR4A2
Cluster EST : UnigeneHs.563344 [ NCBI ]
CGAP (NCI)Hs.563344
Alternative Splicing : Fast-db (Paris)GSHG0018078
Alternative Splicing GalleryENSG00000153234
Gene ExpressionNR4A2 [ NCBI-GEO ]     NR4A2 [ SEEK ]   NR4A2 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP43354 (Uniprot)
NextProtP43354  [Medical]
With graphics : InterProP43354
Splice isoforms : SwissVarP43354 (Swissvar)
Domaine pattern : Prosite (Expaxy)NUCLEAR_REC_DBD_1 (PS00031)    NUCLEAR_REC_DBD_2 (PS51030)   
Domains : Interpro (EBI)Nuc_orph_rcpt [organisation]   Nucl_hormone_rcpt_ligand-bd [organisation]   Nucl_hrmn_rcpt_lig-bd_core [organisation]   NURR_rcpt [organisation]   Str_hrmn_rcpt [organisation]   Znf_hrmn_rcpt [organisation]   Znf_NHR/GATA [organisation]  
Related proteins : CluSTrP43354
Domain families : Pfam (Sanger)Hormone_recep (PF00104)    zf-C4 (PF00105)   
Domain families : Pfam (NCBI)pfam00104    pfam00105   
Domain families : Smart (EMBL)HOLI (SM00430)  ZnF_C4 (SM00399)  
DMDM Disease mutations4929
Blocks (Seattle)P43354
PDB (SRS)1OVL   
PDB (PDBSum)1OVL   
PDB (IMB)1OVL   
PDB (RSDB)1OVL   
Human Protein AtlasENSG00000153234 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP43354
HPRD03493
IPIIPI01013823   IPI00018033   IPI00915939   IPI00917128   IPI00927888   IPI00927645   IPI00925153   IPI00924923   IPI00927360   
Protein Interaction databases
DIP (DOE-UCLA)P43354
IntAct (EBI)P43354
FunCoupENSG00000153234
BioGRIDNR4A2
InParanoidP43354
Interologous Interaction database P43354
IntegromeDBNR4A2
STRING (EMBL)NR4A2
Ontologies - Pathways
Ontology : AmiGOresponse to hypoxia  neuron migration  response to amphetamine  steroid hormone receptor activity  ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity  protein binding  nucleus  nucleoplasm  cytoplasm  transcription, DNA-templated  transcription initiation from RNA polymerase II promoter  signal transduction  zinc ion binding  adult locomotory behavior  post-embryonic development  response to inorganic substance  gene expression  death  response to insecticide  central nervous system projection neuron axonogenesis  habenula development  intracellular receptor signaling pathway  intracellular receptor signaling pathway  cellular response to extracellular stimulus  cellular response to oxidative stress  regulation of dopamine metabolic process  dopamine biosynthetic process  neuron maturation  positive regulation of catalytic activity  steroid hormone mediated signaling pathway  negative regulation of neuron apoptotic process  sequence-specific DNA binding  regulation of respiratory gaseous exchange  positive regulation of transcription from RNA polymerase II promoter  protein heterodimerization activity  general adaptation syndrome  dopaminergic neuron differentiation  
Ontology : EGO-EBIresponse to hypoxia  neuron migration  response to amphetamine  steroid hormone receptor activity  ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity  protein binding  nucleus  nucleoplasm  cytoplasm  transcription, DNA-templated  transcription initiation from RNA polymerase II promoter  signal transduction  zinc ion binding  adult locomotory behavior  post-embryonic development  response to inorganic substance  gene expression  death  response to insecticide  central nervous system projection neuron axonogenesis  habenula development  intracellular receptor signaling pathway  intracellular receptor signaling pathway  cellular response to extracellular stimulus  cellular response to oxidative stress  regulation of dopamine metabolic process  dopamine biosynthetic process  neuron maturation  positive regulation of catalytic activity  steroid hormone mediated signaling pathway  negative regulation of neuron apoptotic process  sequence-specific DNA binding  regulation of respiratory gaseous exchange  positive regulation of transcription from RNA polymerase II promoter  protein heterodimerization activity  general adaptation syndrome  dopaminergic neuron differentiation  
Protein Interaction DatabaseNR4A2
Wikipedia pathwaysNR4A2
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)NR4A2
snp3D : Map Gene to Disease4929
SNP (GeneSNP Utah)NR4A2
SNP : HGBaseNR4A2
Genetic variants : HAPMAPNR4A2
Exome VariantNR4A2
1000_GenomesNR4A2 
ICGC programENSG00000153234 
Somatic Mutations in Cancer : COSMICNR4A2 
CONAN: Copy Number AnalysisNR4A2 
Mutations and Diseases : HGMDNR4A2
Mutations and Diseases : intOGenNR4A2
Genomic VariantsNR4A2  NR4A2 [DGVbeta]
dbVarNR4A2
ClinVarNR4A2
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM168600    601828   
MedgenNR4A2
GENETestsNR4A2
Disease Genetic AssociationNR4A2
Huge Navigator NR4A2 [HugePedia]  NR4A2 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneNR4A2
Homology/Alignments : Family Browser (UCSC)NR4A2
Phylogenetic Trees/Animal Genes : TreeFamNR4A2
Chemical/Protein Interactions : CTD4929
Chemical/Pharm GKB GenePA31762
Clinical trialNR4A2
Cancer Resource (Charite)ENSG00000153234
Other databases
Probes
Litterature
PubMed135 Pubmed reference(s) in Entrez
CoreMineNR4A2
iHOPNR4A2
OncoSearchNR4A2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 22 19:07:58 CEST 2014

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