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NRAS (neuroblastoma RAS viral oncogene homolog)

Written1999-02Franz Watzinger, Thomas Lion
Children's Cancer Research Institute (CCRI), Kinderspitalgasse 6, A-1090 Vienna, Austria

(Note : for Links provided by Atlas : click)

Identity

Other namesN-RAS (neuroblastoma RAS viral oncogene homolog)
HGNC (Hugo) NRAS
LocusID (NCBI) 4893
Atlas_Id 92
Location 1p13.2
Location_base_pair Starts at 115247085 and ends at 115259515 bp from pter ( according to hg19-Feb_2009)  [Mapping NRAS.png]
Fusion genes
(updated 2016)
SS18 (18q11.2) / NRAS (1p13.2)
Note more on the RAS family is available as a deep insight

DNA/RNA

 
  evolution of two N-ras mRNA transcripts
the slightly differing consensus sequence of the poly A addition site (AATATA instead of AATAAA) leads to inefficient processing and to two different RNA transcripts; exons that encode protein are shown as black boxes, untranslated exons as white boxes; the upstream untranslated exon is indicated as Exon -1
Description consists of seven exons, spread over 8kb of genomic DNA
Transcription inefficient processing of pre-mRNA reveals two different transcripts of 4.3kb and 2kb (see Fig), differing in the extension of the 3 end of the smaller message; the longer transcript is probably a result of an RNA-extension through the termination site

Protein

Description p21N-ras; regular RAS protein - characterized in the page
Expression ubiquitously expressed
Localisation anchored to the inner surface of the plasma membrane
Function analogously to other GTP-binding proteins (such as Translation Elongation Factor EFTu or signal transducing G-Proteins) RAS proteins are involved in signal transduction pathways
Homology ras gene family is part of the ras superfamily including the mammalian RAS, RAL, RAC, RHO, RAP, and RAB gene families and the yeast homologs like SEC4 and YPT1 genes; genes encode small monomeric proteins of low molecular mass (20-30 kDa) which share at least 30% homology to RAS proteins

Implicated in

Note
Entity tumor (frequency of N-RAS mutations); references in Full Bibliography
  
Entity acute non lymphocytic leukemia and myelodysplasia (20-40%)
  
Entity chronic myelogenous leukemia, acute lymphocytic leukemia (0-10%)
  
Entity brain (0-15%)
  
Entity skin (0-20%)
  
Entity thyroid (0-60%)
  
Entity testis (0-40%)
  
Entity stomach (gastric tumors) (5%)
  
Entity testis liver (0-15%)
  

Bibliography

Transforming ras genes from human melanoma: a manifestation of tumour heterogeneity?
Albino AP, Le Strange R, Oliff AI, Furth ME, Old LJ
Nature. 1984 ; 308 (5954) : 69-72.
PMID 6700714
 
A new oncogene in human thyroid papillary carcinomas and their lymph-nodal metastases.
Fusco A, Grieco M, Santoro M, Berlingieri MT, Pilotti S, Pierotti MA, Della Porta G, Vecchio G
Nature. 1987 ; 328 (6126) : 170-172.
PMID 3600795
 
Human cancer and cellular oncogenes.
Nishimura S, Sekiya T
The Biochemical journal. 1987 ; 243 (2) : 313-327.
PMID 3307760
 
Incidence of ras gene mutations in neuroblastoma.
Ballas K, Lyons J, Janssen JW, Bartram CR
European journal of pediatrics. 1988 ; 147 (3) : 313-314.
PMID 3292251
 
The ras gene family and human carcinogenesis.
Bos JL
Mutation research. 1988 ; 195 (3) : 255-271.
PMID 3283542
 
Activated ras oncogenes in human thyroid cancers.
Lemoine NR, Mayall ES, Wyllie FS, Farr CJ, Hughes D, Padua RA, Thurston V, Williams ED, Wynford-Thomas D
Cancer research. 1988 ; 48 (16) : 4459-4463.
PMID 3293774
 
Detection of activated ras oncogenes in human thyroid carcinomas.
Su´rez HG, Du Villard JA, Caillou B, Schlumberger M, Tubiana M, Parmentier C, Monier R
Oncogene. 1988 ; 2 (4) : 403-406.
PMID 3283656
 
ras oncogenes in human cancer: a review.
Bos JL
Cancer research. 1989 ; 49 (17) : 4682-4689.
PMID 2547513
 
High frequency of ras oncogene activation in all stages of human thyroid tumorigenesis.
Lemoine NR, Mayall ES, Wyllie FS, Williams ED, Goyns M, Stringer B, Wynford-Thomas D
Oncogene. 1989 ; 4 (2) : 159-164.
PMID 2648253
 
Activated ras genes in human seminoma: evidence for tumor heterogeneity.
Mulder MP, Keijzer W, Verkerk A, Boot AJ, Prins ME, Splinter TA, Bos JL
Oncogene. 1989 ; 4 (11) : 1345-1351.
PMID 2682461
 
N-ras mutations in human cutaneous melanoma from sun-exposed body sites.
van 't Veer LJ, Burgering BM, Versteeg R, Boot AJ, Ruiter DJ, Osanto S, Schrier PI, Bos JL
Molecular and cellular biology. 1989 ; 9 (7) : 3114-3116.
PMID 2674680
 
ras oncogenes: their role in neoplasia.
Barbacid M
European journal of clinical investigation. 1990 ; 20 (3) : 225-235.
PMID 2114981
 
Analysis of ras gene mutations in human hepatic malignant tumors by polymerase chain reaction and direct sequencing.
Tada M, Omata M, Ohto M
Cancer research. 1990 ; 50 (4) : 1121-1124.
PMID 2153451
 
No N-ras mutations in human uveal melanoma: the role of ultraviolet light revisited.
Mooy CM, Van der Helm MJ, Van der Kwast TH, De Jong PT, Ruiter DJ, Zwarthoff EC
British journal of cancer. 1991 ; 64 (2) : 411-413.
PMID 1892776
 
Infrequent point mutations in codons 12 and 61 of ras oncogenes in human hepatocellular carcinomas.
Challen C, Guo K, Collier JD, Cavanagh D, Bassendine MF
Journal of hepatology. 1992 ; 14 (2-3) : 342-346.
PMID 1323601
 
ras activation in experimental carcinogenesis.
Mangues R, Pellicer A
Seminars in cancer biology. 1992 ; 3 (4) : 229-239.
PMID 1421167
 
Detection of RAS mutations in archival testicular germ cell tumors by polymerase chain reaction and oligonucleotide hybridization.
Moul JW, Theune SM, Chang EH
Genes, chromosomes & cancer. 1992 ; 5 (2) : 109-118.
PMID 1381946
 
Multiple point mutation of N-ras and K-ras oncogenes in myelodysplastic syndrome and acute myelogenous leukemia.
Nakagawa T, Saitoh S, Imoto S, Itoh M, Tsutsumi M, Hikiji K, Nakamura H, Matozaki S, Ogawa R, Nakao Y
Oncology. 1992 ; 49 (2) : 114-122.
PMID 1574246
 
High incidence of ras gene mutation in intrahepatic cholangiocarcinoma.
Tada M, Omata M, Ohto M
Cancer. 1992 ; 69 (5) : 1115-1118.
PMID 1739910
 
N-ras gene mutations in acute myeloid leukemia: accurate detection by solid-phase minisequencing.
Syvänen AC, Söderlund H, Laaksonen E, Bengtström M, Turunen M, Palotie A
International journal of cancer. Journal international du cancer. 1992 ; 50 (5) : 713-718.
PMID 1544704
 
K-ras oncogene codon 12 point mutations in testicular cancer.
Ridanpää M, Lothe RA, Onfelt A, Fosså S, B&oring;rresen AL, Husgafvel-Pursiainen K
Environmental health perspectives. 1993 ; 101 Suppl 3 : 185-187.
PMID 8143614
 
Investigation of the role of the ras protooncogene point mutation in human uveal melanomas.
Soparker CN, O'Brien JM, Albert DM
Investigative ophthalmology & visual science. 1993 ; 34 (7) : 2203-2209.
PMID 8505202
 
Prognostic importance of mutations in the ras proto-oncogenes in de novo acute myeloid leukemia.
Neubauer A, Dodge RK, George SL, Davey FR, Silver RT, Schiffer CA, Mayer RJ, Ball ED, Wurster-Hill D, Bloomfield CD
Blood. 1994 ; 83 (6) : 1603-1611.
PMID 8123851
 
Absence of N-ras mutations in myeloid and lymphoid blast crisis of chronic myeloid leukemia.
Watzinger F, Gaiger A, Karlic H, Becher R, Pillwein K, Lion T
Cancer research. 1994 ; 54 (14) : 3934-3938.
PMID 8033117
 
Ras oncogene mutations in thyroid tumors: polymerase chain reaction-restriction-fragment-length polymorphism analysis from paraffin-embedded tissues.
Capella G, Matias-Guiu X, Ampudia X, de Leiva A, Perucho M, Prat J
Diagnostic molecular pathology : the American journal of surgical pathology, part B. 1996 ; 5 (1) : 45-52.
PMID 8919545
 
N-ras gene point mutations in Brazilian acute myelogenous leukemia patients correlate with a poor prognosis.
De Melo MB, Lorand-Metze I, Lima CS, Saad ST, Costa FF
Leukemia & lymphoma. 1997 ; 24 (3-4) : 309-317.
PMID 9156660
 
Mutation of ras oncogene in gastric adenocarcinoma: association with histological phenotype.
Kim TY, Bang YJ, Kim WS, Kang SH, Lee KU, Choe KJ, Kim NK
Anticancer research. 1997 ; 17 (2B) : 1335-1339.
PMID 9137494
 
Ras oncogene mutations in childhood brain tumors.
Maltzman TH, Mueller BA, Schroeder J, Rutledge JC, Patterson K, Preston-Martin S, Faustman EM
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 1997 ; 6 (4) : 239-243.
PMID 9107428
 
RAS, FMS and p53 mutations and poor clinical outcome in myelodysplasias: a 10-year follow-up.
Padua RA, Guinn BA, Al-Sabah AI, Smith M, Taylor C, Pettersson T, Ridge S, Carter G, White D, Oscier D, Chevret S, West R
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 1998 ; 12 (6) : 887-892.
PMID 9639416
 
Correlation of N-ras point mutations with specific chromosomal abnormalities in primary myelodysplastic syndrome.
de Souza Fernandez T, Menezes de Souza J, Macedo Silva ML, Tabak D, Abdelhay E
Leukemia research. 1998 ; 22 (2) : 125-134.
PMID 9593469
 

Citation

This paper should be referenced as such :
Watzinger, F ; Lion, T
N-RAS (neuroblastoma RAS viral oncogene homolog)
Atlas Genet Cytogenet Oncol Haematol. 1999;3(2):68-70.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/NRASID92.html


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 8 ]
  Classification of myelodysplastic syndromes 2015
Chronic Myelomonocytic Leukemia (CMML)
i(17q) solely in myeloid malignancies
inv(3)(q21q26) RPN1/MECOM;t(3;3)(q21;q26) RPN1/MECOM;ins(3;3)(q26;q21q26) RPN1/MECOM
Juvenile Chronic Myelogenous Leukemia (JCML)
Plasma cell leukemia (PCL)
Primary cutaneous CD30+ anaplastic large cell lymphoma
t(3;21)(q26;q22) RUNX1/MECOM

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 8 ]
  Thyroid: Anaplastic (undifferentiated) carcinoma
Nervous system: Astrocytic tumors
Breast tumors : an overview
Colon: Colorectal adenocarcinoma
Bone: Dedifferentiated chondrosarcoma
Breast: Ductal carcinoma
Thyroid: Medullary carcinoma
Head and Neck: Primary oral mucosal melanoma
Skin: Melanoma

Other Cancer prone implicated (Data extracted from papers in the Atlas) [ 1 ]
  Noonan syndrome

External links

Nomenclature
HGNC (Hugo)NRAS   7989
Cards
AtlasNRASID92
Entrez_Gene (NCBI)NRAS  4893  neuroblastoma RAS viral oncogene homolog
AliasesALPS4; CMNS; N-ras; NCMS; 
NRAS1; NS6
GeneCards (Weizmann)NRAS
Ensembl hg19 (Hinxton)ENSG00000213281 [Gene_View]  chr1:115247085-115259515 [Contig_View]  NRAS [Vega]
Ensembl hg38 (Hinxton)ENSG00000213281 [Gene_View]  chr1:115247085-115259515 [Contig_View]  NRAS [Vega]
ICGC DataPortalENSG00000213281
TCGA cBioPortalNRAS
AceView (NCBI)NRAS
Genatlas (Paris)NRAS
WikiGenes4893
SOURCE (Princeton)NRAS
Genomic and cartography
GoldenPath hg19 (UCSC)NRAS  -     chr1:115247085-115259515 -  1p13.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)NRAS  -     1p13.2   [Description]    (hg38-Dec_2013)
EnsemblNRAS - 1p13.2 [CytoView hg19]  NRAS - 1p13.2 [CytoView hg38]
Mapping of homologs : NCBINRAS [Mapview hg19]  NRAS [Mapview hg38]
OMIM114500   137550   162900   163200   164790   188470   249400   613224   614470   
Gene and transcription
Genbank (Entrez)AF493919 AW021410 AY941100 AY941101 BC005219
RefSeq transcript (Entrez)NM_002524
RefSeq genomic (Entrez)NC_000001 NC_018912 NG_007572 NT_032977 NW_004929290
Consensus coding sequences : CCDS (NCBI)NRAS
Cluster EST : UnigeneHs.486502 [ NCBI ]
CGAP (NCI)Hs.486502
Alternative Splicing GalleryENSG00000213281
Gene ExpressionNRAS [ NCBI-GEO ]   NRAS [ EBI - ARRAY_EXPRESS ]   NRAS [ SEEK ]   NRAS [ MEM ]
Gene Expression Viewer (FireBrowse)NRAS [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4893
GTEX Portal (Tissue expression)NRAS
Protein : pattern, domain, 3D structure
UniProt/SwissProtP01111 (Uniprot)
NextProtP01111  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP01111
Splice isoforms : SwissVarP01111 (Swissvar)
PhosPhoSitePlusP01111
Domaine pattern : Prosite (Expaxy)RAS (PS51421)   
Domains : Interpro (EBI)P-loop_NTPase    Small_GTP-bd_dom    Small_GTPase    Small_GTPase_Ras   
Domain families : Pfam (Sanger)Ras (PF00071)   
Domain families : Pfam (NCBI)pfam00071   
Domain families : Smart (EMBL)RAS (SM00173)  
DMDM Disease mutations4893
Blocks (Seattle)NRAS
PDB (SRS)3CON   
PDB (PDBSum)3CON   
PDB (IMB)3CON   
PDB (RSDB)3CON   
Structural Biology KnowledgeBase3CON   
SCOP (Structural Classification of Proteins)3CON   
CATH (Classification of proteins structures)3CON   
SuperfamilyP01111
Human Protein AtlasENSG00000213281
Peptide AtlasP01111
HPRD01273
IPIIPI00000005   
Protein Interaction databases
DIP (DOE-UCLA)P01111
IntAct (EBI)P01111
FunCoupENSG00000213281
BioGRIDNRAS
STRING (EMBL)NRAS
ZODIACNRAS
Ontologies - Pathways
QuickGOP01111
Ontology : AmiGOGolgi membrane  MAPK cascade  stimulatory C-type lectin receptor signaling pathway  GTP binding  Golgi apparatus  plasma membrane  epidermal growth factor receptor signaling pathway  Ras protein signal transduction  axon guidance  protein transport  membrane  protein complex binding  Fc-epsilon receptor signaling pathway  ERBB2 signaling pathway  leukocyte migration  extracellular exosome  establishment of protein localization to Golgi  
Ontology : EGO-EBIGolgi membrane  MAPK cascade  stimulatory C-type lectin receptor signaling pathway  GTP binding  Golgi apparatus  plasma membrane  epidermal growth factor receptor signaling pathway  Ras protein signal transduction  axon guidance  protein transport  membrane  protein complex binding  Fc-epsilon receptor signaling pathway  ERBB2 signaling pathway  leukocyte migration  extracellular exosome  establishment of protein localization to Golgi  
Pathways : KEGGMAPK signaling pathway    ErbB signaling pathway    Ras signaling pathway    Rap1 signaling pathway    Chemokine signaling pathway    FoxO signaling pathway    PI3K-Akt signaling pathway    Axon guidance    VEGF signaling pathway    Tight junction    Gap junction    Natural killer cell mediated cytotoxicity    T cell receptor signaling pathway    B cell receptor signaling pathway    Fc epsilon RI signaling pathway    Long-term potentiation    Neurotrophin signaling pathway    Cholinergic synapse    Serotonergic synapse    Long-term depression    Regulation of actin cytoskeleton    Insulin signaling pathway    GnRH signaling pathway    Estrogen signaling pathway    Melanogenesis    Prolactin signaling pathway    Thyroid hormone signaling pathway    Alcoholism    Hepatitis C    Hepatitis B    HTLV-I infection    Pathways in cancer    Viral carcinogenesis    Proteoglycans in cancer    MicroRNAs in cancer    Renal cell carcinoma    Endometrial cancer    Glioma    Prostate cancer    Thyroid cancer    Melanoma    Bladder cancer    Chronic myeloid leukemia    Acute myeloid leukemia    Non-small cell lung cancer   
REACTOMEP01111 [protein]
REACTOME PathwaysR-HSA-5654693 FRS-mediated FGFR1 signaling [pathway]
REACTOME PathwaysR-HSA-5655253 Signaling by FGFR2 in disease [pathway]
REACTOME PathwaysR-HSA-5654699 SHC-mediated cascade:FGFR2 [pathway]
REACTOME PathwaysR-HSA-2871796 FCERI mediated MAPK activation [pathway]
REACTOME PathwaysR-HSA-5675221 Negative regulation of MAPK pathway [pathway]
REACTOME PathwaysR-HSA-1250196 SHC1 events in ERBB2 signaling [pathway]
REACTOME PathwaysR-HSA-1433557 Signaling by SCF-KIT [pathway]
REACTOME PathwaysR-HSA-2424491 DAP12 signaling [pathway]
REACTOME PathwaysR-HSA-5654706 FRS-mediated FGFR3 signaling [pathway]
REACTOME PathwaysR-HSA-2179392 EGFR Transactivation by Gastrin [pathway]
REACTOME PathwaysR-HSA-1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants [pathway]
REACTOME PathwaysR-HSA-1963640 GRB2 events in ERBB2 signaling [pathway]
REACTOME PathwaysR-HSA-5218921 VEGFR2 mediated cell proliferation [pathway]
REACTOME PathwaysR-HSA-5673000 RAF activation [pathway]
REACTOME PathwaysR-HSA-171007 p38MAPK events [pathway]
REACTOME PathwaysR-HSA-5654700 FRS-mediated FGFR2 signaling [pathway]
REACTOME PathwaysR-HSA-375165 NCAM signaling for neurite out-growth [pathway]
REACTOME PathwaysR-HSA-112412 SOS-mediated signalling [pathway]
REACTOME PathwaysR-HSA-5658442 Regulation of RAS by GAPs [pathway]
REACTOME PathwaysR-HSA-5654704 SHC-mediated cascade:FGFR3 [pathway]
REACTOME PathwaysR-HSA-5655332 Signaling by FGFR3 in disease [pathway]
REACTOME PathwaysR-HSA-74751 Insulin receptor signalling cascade [pathway]
REACTOME PathwaysR-HSA-5674135 MAP2K and MAPK activation [pathway]
REACTOME PathwaysR-HSA-112412 SOS-mediated signalling [pathway]
REACTOME PathwaysR-HSA-5673001 RAF/MAP kinase cascade [pathway]
REACTOME PathwaysR-HSA-2428933 SHC-related events triggered by IGF1R [pathway]
REACTOME PathwaysR-HSA-179812 GRB2 events in EGFR signaling [pathway]
REACTOME PathwaysR-HSA-5655291 Signaling by FGFR4 in disease [pathway]
REACTOME PathwaysR-HSA-5654688 SHC-mediated cascade:FGFR1 [pathway]
REACTOME PathwaysR-HSA-210993 Tie2 Signaling [pathway]
REACTOME PathwaysR-HSA-5655302 Signaling by FGFR1 in disease [pathway]
REACTOME PathwaysR-HSA-180336 SHC1 events in EGFR signaling [pathway]
REACTOME PathwaysR-HSA-1250347 SHC1 events in ERBB4 signaling [pathway]
REACTOME PathwaysR-HSA-1169092 Activation of RAS in B cells [pathway]
REACTOME PathwaysR-HSA-167044 Signalling to RAS [pathway]
REACTOME PathwaysR-HSA-186763 Downstream signal transduction [pathway]
REACTOME PathwaysR-HSA-5654719 SHC-mediated cascade:FGFR4 [pathway]
REACTOME PathwaysR-HSA-5637810 Constitutive Signaling by EGFRvIII [pathway]
REACTOME PathwaysR-HSA-5654712 FRS-mediated FGFR4 signaling [pathway]
REACTOME PathwaysR-HSA-5621575 CD209 (DC-SIGN) signaling [pathway]
NDEx Network
Atlas of Cancer Signalling NetworkNRAS
Wikipedia pathwaysNRAS
Orthology - Evolution
OrthoDB4893
GeneTree (enSembl)ENSG00000213281
Phylogenetic Trees/Animal Genes : TreeFamNRAS
Homologs : HomoloGeneNRAS
Homology/Alignments : Family Browser (UCSC)NRAS
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerNRAS [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NRAS
dbVarNRAS
ClinVarNRAS
1000_GenomesNRAS 
Exome Variant ServerNRAS
ExAC (Exome Aggregation Consortium)NRAS (select the gene name)
Genetic variants : HAPMAP4893
Genomic Variants (DGV)NRAS [DGVbeta]
Mutations
ICGC Data PortalNRAS 
TCGA Data PortalNRAS 
Broad Tumor PortalNRAS
OASIS PortalNRAS [ Somatic mutations - Copy number]
Cancer Gene: CensusNRAS 
Somatic Mutations in Cancer : COSMICNRAS 
intOGen PortalNRAS
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Mendelian genes
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch NRAS
DgiDB (Drug Gene Interaction Database)NRAS
DoCM (Curated mutations)NRAS (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NRAS (select a term)
intoGenNRAS
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)1:115247085-115259515  ENSG00000213281
CONAN: Copy Number AnalysisNRAS 
Mutations and Diseases : HGMDNRAS
OMIM114500    137550    162900    163200    164790    188470    249400    613224    614470   
MedgenNRAS
Genetic Testing Registry NRAS
NextProtP01111 [Medical]
TSGene4893
GENETestsNRAS
Huge Navigator NRAS [HugePedia]
snp3D : Map Gene to Disease4893
BioCentury BCIQNRAS
ClinGenNRAS
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4893
Chemical/Pharm GKB GenePA31768
Drug Sensitivity NRAS
Clinical trialNRAS
Miscellaneous
canSAR (ICR)NRAS (select the gene name)
Other databasehttp://cancergenome.broadinstitute.org/index.php?tgene=NRAS
Probes
Litterature
PubMed352 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNRAS
EVEXNRAS
GoPubMedNRAS
iHOPNRAS
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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