NRBF2 (nuclear receptor binding factor 2)

2015-10-01  

Identity

HGNC
NRBF2
LOCATION
10q21.3
LOCUSID
29982
ALIAS
COPR,COPR1,COPR2,NRBF-2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 29982
MIM: 616477
HGNC: 19692
Ensembl: ENSG00000148572

Variants:

dbSNP: 29982
ClinVar: 29982
TCGA: ENSG00000148572
COSMIC: NRBF2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000148572ENST00000277746Q96F24
ENSG00000148572ENST00000435510Q96F24

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Autophagy - animalKEGGko04140
Autophagy - animalKEGGhsa04140
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Nuclear Receptor transcription pathwayREACTOMER-HSA-383280

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
247856572014NRBF2 regulates macroautophagy as a component of Vps34 Complex I.31
250860432014Nrbf2 protein suppresses autophagy by modulating Atg14L protein-containing Beclin 1-Vps34 complex architecture and reducing intracellular phosphatidylinositol-3 phosphate levels.28
273858292016Dynamics and architecture of the NRBF2-containing phosphatidylinositol 3-kinase complex I of autophagy.22
280596662017MTORC1-mediated NRBF2 phosphorylation functions as a switch for the class III PtdIns3K and autophagy.18
260737812015Polymorphisms in a Putative Enhancer at the 10q21.2 Breast Cancer Risk Locus Regulate NRBF2 Expression.17
276300192016Characterization of Atg38 and NRBF2, a fifth subunit of the autophagic Vps34/PIK3C3 complex.17
289808672017NRBF2 is involved in the autophagic degradation process of APP-CTFs in Alzheimer disease models.14
156105202004Isolation and functional analysis of a keratinocyte-derived, ligand-regulated nuclear receptor comodulator.11
317758062019Autophagy protein NRBF2 has reduced expression in Alzheimer's brains and modulates memory and amyloid-beta homeostasis in mice.0

Citation

Dessen P

NRBF2 (nuclear receptor binding factor 2)

Atlas Genet Cytogenet Oncol Haematol. 2015-10-01

Online version: http://atlasgeneticsoncology.org/gene/55441/nrbf2