NRDC (nardilysin convertase)

2015-11-01  

Identity

HGNC
LOCATION
1p32.3
LOCUSID
ALIAS
NRD1,hNRD1,hNRD2
FUSION GENES

Other Information

Locus ID:

NCBI: 4898
MIM: 602651
HGNC: 7995
Ensembl: ENSG00000078618

Variants:

dbSNP: 4898
ClinVar: 4898
TCGA: ENSG00000078618
COSMIC: NRDC

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000078618ENST00000352171O43847
ENSG00000078618ENST00000354831O43847
ENSG00000078618ENST00000440943H0Y5G9
ENSG00000078618ENST00000539524G3V1R5
ENSG00000078618ENST00000544028F5H7V1

Expression (GTEx)

0
50
100
150

References

Pubmed IDYearTitleCitations
211511012011Antigen processing by nardilysin and thimet oligopeptidase generates cytotoxic T cell epitopes.43
114328222001N-arginine dibasic convertase is a specific receptor for heparin-binding EGF-like growth factor that mediates cell migration.38
217036342011A meta-analysis of two genome-wide association studies identifies 3 new loci for alcohol dependence.35
226534432012Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion.28
169238192006Nardilysin enhances ectodomain shedding of heparin-binding epidermal growth factor-like growth factor through activation of tumor necrosis factor-alpha-converting enzyme.23
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
183554452008Ectodomain shedding of TNF-alpha is enhanced by nardilysin via activation of ADAM proteases.16
222946992012Identification and characterization of nardilysin as a novel dimethyl H3K4-binding protein involved in transcriptional regulation.16
223516062012Nardilysin and ADAM proteases promote gastric cancer cell growth by activating intrinsic cytokine signalling via enhanced ectodomain shedding of TNF-α.13
241681652014NRD1, which encodes nardilysin protein, promotes esophageal cancer cell invasion through induction of MMP2 and MMP3 expression.10

Citation

Dessen P

NRDC (nardilysin convertase)

Atlas Genet Cytogenet Oncol Haematol. 2015-11-01

Online version: http://atlasgeneticsoncology.org/gene/41579/nrdc