NRDE2 (NRDE-2, necessary for RNA interference, domain containing)

2014-11-01  

Identity

HGNC
NRDE2
LOCATION
14q32.11
LOCUSID
55051
ALIAS
C14orf102
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55051
MIM: 618631
HGNC: 20186
Ensembl: ENSG00000119720

Variants:

dbSNP: 55051
ClinVar: 55051
TCGA: ENSG00000119720
COSMIC: NRDE2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000119720ENST00000354366Q9H7Z3
ENSG00000119720ENST00000553409G3V338
ENSG00000119720ENST00000554464H0YJT0
ENSG00000119720ENST00000556189H0YJT6
ENSG00000119720ENST00000628832G3V338

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
308422172019NRDE2 negatively regulates exosome functions by inhibiting MTR4 recruitment and exosome interaction.4
299021172018NRDE-2, the human homolog of fission yeast Nrl1, prevents DNA damage accumulation in human cells.2
305381482019Human nuclear RNAi-defective 2 (NRDE2) is an essential RNA splicing factor.2

Citation

Dessen P

NRDE2 (NRDE-2, necessary for RNA interference, domain containing)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/70964/nrde2