Atlas of Genetics and Cytogenetics in Oncology and Haematology


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NRG1 (neuregulin 1)

Identity

Other namesARIA
GGF
GGF2
HGL
HRG
HRG1
HRGA
MST131
MSTP131
NDF
NRG1-IT2
SMDF
HGNC (Hugo) NRG1
LocusID (NCBI) 3084
Location 8p12
Location_base_pair Starts at 32453344 and ends at 32622558 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)NRG1   7997
Cards
Entrez_Gene (NCBI)NRG1  3084  neuregulin 1
GeneCards (Weizmann)NRG1
Ensembl (Hinxton)ENSG00000157168 [Gene_View]  chr8:32453344-32622558 [Contig_View]  NRG1 [Vega]
ICGC DataPortalENSG00000157168
cBioPortalNRG1
AceView (NCBI)NRG1
Genatlas (Paris)NRG1
WikiGenes3084
SOURCE (Princeton)NM_001159995 NM_001159996 NM_001159999 NM_001160001 NM_001160002 NM_001160004 NM_001160005 NM_001160007 NM_001160008 NM_004495 NM_013956 NM_013957 NM_013958 NM_013959 NM_013960 NM_013962 NM_013964
Genomic and cartography
GoldenPath (UCSC)NRG1  -  8p12   chr8:32453344-32622558 +  8p12   [Description]    (hg19-Feb_2009)
EnsemblNRG1 - 8p12 [CytoView]
Mapping of homologs : NCBINRG1 [Mapview]
OMIM142445   603013   
Gene and transcription
Genbank (Entrez)AB451331 AB451475 AF026146 AF176921 AK097005
RefSeq transcript (Entrez)NM_001159995 NM_001159996 NM_001159999 NM_001160001 NM_001160002 NM_001160004 NM_001160005 NM_001160007 NM_001160008 NM_004495 NM_013956 NM_013957 NM_013958 NM_013959 NM_013960 NM_013962 NM_013964
RefSeq genomic (Entrez)AC_000140 NC_000008 NC_018919 NG_012005 NT_167187 NW_001839128 NW_004929337
Consensus coding sequences : CCDS (NCBI)NRG1
Cluster EST : UnigeneHs.668810 [ NCBI ]
CGAP (NCI)Hs.668810
Alternative Splicing : Fast-db (Paris)GSHG0028931
Alternative Splicing GalleryENSG00000157168
Gene ExpressionNRG1 [ NCBI-GEO ]     NRG1 [ SEEK ]   NRG1 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ02297 (Uniprot)
NextProtQ02297  [Medical]
With graphics : InterProQ02297
Splice isoforms : SwissVarQ02297 (Swissvar)
Domaine pattern : Prosite (Expaxy)EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_3 (PS50026)    IG_LIKE (PS50835)   
Domains : Interpro (EBI)EG-like_dom [organisation]   EGF-like_CS [organisation]   Ig-like_dom [organisation]   Ig-like_fold [organisation]   Ig_I-set [organisation]   Ig_sub2 [organisation]   Neuregulin [organisation]   Neuregulin_1_C [organisation]  
Related proteins : CluSTrQ02297
Domain families : Pfam (Sanger)hEGF (PF12661)    I-set (PF07679)    Neuregulin (PF02158)   
Domain families : Pfam (NCBI)pfam12661    pfam07679    pfam02158   
Domain families : Smart (EMBL)EGF (SM00181)  IGc2 (SM00408)  
DMDM Disease mutations3084
Blocks (Seattle)Q02297
PDB (SRS)1HAE    1HAF    1HRE    1HRF    3U7U   
PDB (PDBSum)1HAE    1HAF    1HRE    1HRF    3U7U   
PDB (IMB)1HAE    1HAF    1HRE    1HRF    3U7U   
PDB (RSDB)1HAE    1HAF    1HRE    1HRF    3U7U   
Human Protein AtlasENSG00000157168 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasQ02297
HPRD00802
IPIIPI00296902   IPI00017547   IPI00221375   IPI00004473   IPI00221376   IPI00641213   IPI00221378   IPI00394936   IPI00307737   IPI00852764   IPI01012594   IPI00747853   IPI00930052   IPI00930100   IPI00930141   IPI00930585   IPI00930625   IPI00885030   IPI00930422   IPI00930509   IPI00974240   IPI00981110   
Protein Interaction databases
DIP (DOE-UCLA)Q02297
IntAct (EBI)Q02297
FunCoupENSG00000157168
BioGRIDNRG1
InParanoidQ02297
Interologous Interaction database Q02297
IntegromeDBNRG1
STRING (EMBL)NRG1
Ontologies - Pathways
Ontology : AmiGOMAPK cascade  cell morphogenesis  cardiac conduction system development  ventricular trabecula myocardium morphogenesis  transcription cofactor activity  receptor binding  cytokine activity  ErbB-2 class receptor binding  protein binding  extracellular region  extracellular region  extracellular space  nucleus  cytoplasm  integral component of plasma membrane  cell communication  transmembrane receptor protein tyrosine kinase signaling pathway  activation of transmembrane receptor protein tyrosine kinase activity  activation of transmembrane receptor protein tyrosine kinase activity  epidermal growth factor receptor signaling pathway  nervous system development  synapse assembly  peripheral nervous system development  locomotory behavior  growth factor activity  growth factor activity  cell proliferation  fibroblast growth factor receptor signaling pathway  embryo development  negative regulation of cardiac muscle cell apoptotic process  neural crest cell development  membrane  apical plasma membrane  cell migration  glial cell fate commitment  protein tyrosine kinase activator activity  transmembrane receptor protein tyrosine kinase activator activity  transmembrane receptor protein tyrosine kinase activator activity  positive regulation of cell growth  axon  mammary gland development  receptor tyrosine kinase binding  neuromuscular junction  Fc-epsilon receptor signaling pathway  ERBB signaling pathway  wound healing  wound healing  negative regulation of protein catabolic process  ErbB-3 class receptor binding  ErbB-3 class receptor binding  regulation of protein homodimerization activity  regulation of protein heterodimerization activity  cellular protein complex disassembly  innate immune response  neurotransmitter receptor metabolic process  positive regulation of cell adhesion  negative regulation of transcription, DNA-templated  positive regulation of Ras protein signal transduction  neurotrophin TRK receptor signaling pathway  phosphatidylinositol-mediated signaling  neuron fate commitment  negative regulation of secretion  positive regulation of striated muscle cell differentiation  positive regulation of protein kinase B signaling  cardiac muscle cell differentiation  ventricular cardiac muscle cell differentiation  positive regulation of cardiac muscle cell proliferation  cardiac muscle cell myoblast differentiation  endocardial cell differentiation  positive regulation of protein tyrosine kinase activity  negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  
Ontology : EGO-EBIMAPK cascade  cell morphogenesis  cardiac conduction system development  ventricular trabecula myocardium morphogenesis  transcription cofactor activity  receptor binding  cytokine activity  ErbB-2 class receptor binding  protein binding  extracellular region  extracellular region  extracellular space  nucleus  cytoplasm  integral component of plasma membrane  cell communication  transmembrane receptor protein tyrosine kinase signaling pathway  activation of transmembrane receptor protein tyrosine kinase activity  activation of transmembrane receptor protein tyrosine kinase activity  epidermal growth factor receptor signaling pathway  nervous system development  synapse assembly  peripheral nervous system development  locomotory behavior  growth factor activity  growth factor activity  cell proliferation  fibroblast growth factor receptor signaling pathway  embryo development  negative regulation of cardiac muscle cell apoptotic process  neural crest cell development  membrane  apical plasma membrane  cell migration  glial cell fate commitment  protein tyrosine kinase activator activity  transmembrane receptor protein tyrosine kinase activator activity  transmembrane receptor protein tyrosine kinase activator activity  positive regulation of cell growth  axon  mammary gland development  receptor tyrosine kinase binding  neuromuscular junction  Fc-epsilon receptor signaling pathway  ERBB signaling pathway  wound healing  wound healing  negative regulation of protein catabolic process  ErbB-3 class receptor binding  ErbB-3 class receptor binding  regulation of protein homodimerization activity  regulation of protein heterodimerization activity  cellular protein complex disassembly  innate immune response  neurotransmitter receptor metabolic process  positive regulation of cell adhesion  negative regulation of transcription, DNA-templated  positive regulation of Ras protein signal transduction  neurotrophin TRK receptor signaling pathway  phosphatidylinositol-mediated signaling  neuron fate commitment  negative regulation of secretion  positive regulation of striated muscle cell differentiation  positive regulation of protein kinase B signaling  cardiac muscle cell differentiation  ventricular cardiac muscle cell differentiation  positive regulation of cardiac muscle cell proliferation  cardiac muscle cell myoblast differentiation  endocardial cell differentiation  positive regulation of protein tyrosine kinase activity  negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  
Pathways : BIOCARTAAgrin in Postsynaptic Differentiation [Genes]    Neuroregulin receptor degredation protein-1 Controls ErbB3 receptor recycling [Genes]   
Pathways : KEGGErbB signaling pathway   
Protein Interaction DatabaseNRG1
Wikipedia pathwaysNRG1
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)NRG1
snp3D : Map Gene to Disease3084
SNP (GeneSNP Utah)NRG1
SNP : HGBaseNRG1
Genetic variants : HAPMAPNRG1
Exome VariantNRG1
1000_GenomesNRG1 
ICGC programENSG00000157168 
Somatic Mutations in Cancer : COSMICNRG1 
CONAN: Copy Number AnalysisNRG1 
Mutations and Diseases : HGMDNRG1
Mutations and Diseases : intOGenNRG1
Genomic VariantsNRG1  NRG1 [DGVbeta]
dbVarNRG1
ClinVarNRG1
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM142445    603013   
MedgenNRG1
GENETestsNRG1
Disease Genetic AssociationNRG1
Huge Navigator NRG1 [HugePedia]  NRG1 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneNRG1
Homology/Alignments : Family Browser (UCSC)NRG1
Phylogenetic Trees/Animal Genes : TreeFamNRG1
Chemical/Protein Interactions : CTD3084
Chemical/Pharm GKB GenePA31776
Clinical trialNRG1
Cancer Resource (Charite)ENSG00000157168
Other databases
Probes
Litterature
PubMed341 Pubmed reference(s) in Entrez
CoreMineNRG1
iHOPNRG1
OncoSearchNRG1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 26 16:58:08 CEST 2014

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