Atlas of Genetics and Cytogenetics in Oncology and Haematology


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NRG1 (neuregulin 1)

Identity

Other namesARIA
GGF
GGF2
HGL
HRG
HRG1
HRGA
MST131
MSTP131
NDF
NRG1-IT2
SMDF
HGNC (Hugo) NRG1
LocusID (NCBI) 3084
Atlas_Id 45743
Location 8p12
Location_base_pair Starts at 32453344 and ends at 32622558 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
AKAP13 (15q25.3) / NRG1 (8p12)ARHGAP26 (5q31.3) / NRG1 (8p12)CD74 (5q32) / NRG1 (8p12)
NRG1 (8p12) / DAZAP2 (12q13.13)NRG1 (8p12) / KRT78 (12q13.13)NRG1 (8p12) / NRG1 (8p12)
PCM1 (8p22) / NRG1 (8p12)PDE7A (8q13.1) / NRG1 (8p12)RAB3IL1 (11q12.2) / NRG1 (8p12)
SDC4 (20q13.12) / NRG1 (8p12)SLC3A2 (11q12.3) / NRG1 (8p12)TENM4 (11q14.1) / NRG1 (8p12)
THBS1 (15q14) / NRG1 (8p12)CD74 5q32 / NRG1 8p12AKAP13 15q25.3 / NRG1 8p12
NRG1 8p12 / KRT78 12q13.13PCM1 8p22 / NRG1 8p12PDE7A 8q13.1 / NRG1 8p12
RAB3IL1 11q12.2 / NRG1 8p12SDC4 20q13.12 / NRG1 8p12THBS1 15q14 / NRG1 8p12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NRG1   7997
Cards
Entrez_Gene (NCBI)NRG1  3084  neuregulin 1
GeneCards (Weizmann)NRG1
Ensembl hg19 (Hinxton)ENSG00000157168 [Gene_View]  chr8:32453344-32622558 [Contig_View]  NRG1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000157168 [Gene_View]  chr8:32453344-32622558 [Contig_View]  NRG1 [Vega]
ICGC DataPortalENSG00000157168
TCGA cBioPortalNRG1
AceView (NCBI)NRG1
Genatlas (Paris)NRG1
WikiGenes3084
SOURCE (Princeton)NRG1
Genomic and cartography
GoldenPath hg19 (UCSC)NRG1  -     chr8:32453344-32622558 +  8p12   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)NRG1  -     8p12   [Description]    (hg38-Dec_2013)
EnsemblNRG1 - 8p12 [CytoView hg19]  NRG1 - 8p12 [CytoView hg38]
Mapping of homologs : NCBINRG1 [Mapview hg19]  NRG1 [Mapview hg38]
OMIM142445   603013   
Gene and transcription
Genbank (Entrez)AB451331 AB451475 AF026146 AF176921 AK097005
RefSeq transcript (Entrez)NM_001159995 NM_001159996 NM_001159999 NM_001160001 NM_001160002 NM_001160004 NM_001160005 NM_001160007 NM_001160008 NM_001322197 NM_001322201 NM_001322202 NM_001322203 NM_001322205 NM_001322206 NM_001322207 NM_004495 NM_013956 NM_013957 NM_013958 NM_013959 NM_013960 NM_013962 NM_013964
RefSeq genomic (Entrez)NC_000008 NC_018919 NG_012005 NT_167187 NW_004929337
Consensus coding sequences : CCDS (NCBI)NRG1
Cluster EST : UnigeneHs.668810 [ NCBI ]
CGAP (NCI)Hs.668810
Alternative Splicing GalleryENSG00000157168
Gene ExpressionNRG1 [ NCBI-GEO ]   NRG1 [ EBI - ARRAY_EXPRESS ]   NRG1 [ SEEK ]   NRG1 [ MEM ]
Gene Expression Viewer (FireBrowse)NRG1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3084
GTEX Portal (Tissue expression)NRG1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ02297 (Uniprot)
NextProtQ02297  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ02297
Splice isoforms : SwissVarQ02297 (Swissvar)
PhosPhoSitePlusQ02297
Domaine pattern : Prosite (Expaxy)EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_3 (PS50026)    IG_LIKE (PS50835)   
Domains : Interpro (EBI)EGF-like_CS    EGF-like_dom    Ig-like_dom    Ig-like_fold    Ig_I-set    Ig_sub2    Neuregulin_C    NRG1   
Domain families : Pfam (Sanger)EGF (PF00008)    I-set (PF07679)    Neuregulin (PF02158)   
Domain families : Pfam (NCBI)pfam00008    pfam07679    pfam02158   
Domain families : Smart (EMBL)EGF (SM00181)  IGc2 (SM00408)  
DMDM Disease mutations3084
Blocks (Seattle)NRG1
PDB (SRS)1HAE    1HAF    1HRE    1HRF    3U7U   
PDB (PDBSum)1HAE    1HAF    1HRE    1HRF    3U7U   
PDB (IMB)1HAE    1HAF    1HRE    1HRF    3U7U   
PDB (RSDB)1HAE    1HAF    1HRE    1HRF    3U7U   
Structural Biology KnowledgeBase1HAE    1HAF    1HRE    1HRF    3U7U   
SCOP (Structural Classification of Proteins)1HAE    1HAF    1HRE    1HRF    3U7U   
CATH (Classification of proteins structures)1HAE    1HAF    1HRE    1HRF    3U7U   
SuperfamilyQ02297
Human Protein AtlasENSG00000157168
Peptide AtlasQ02297
HPRD00802
IPIIPI00296902   IPI00017547   IPI00221375   IPI00004473   IPI00221376   IPI00641213   IPI00221378   IPI00394936   IPI00307737   IPI00852764   IPI01012594   IPI00747853   IPI00930052   IPI00930100   IPI00930141   IPI00930585   IPI00930625   IPI00885030   IPI00930422   IPI00930509   IPI00974240   IPI00981110   
Protein Interaction databases
DIP (DOE-UCLA)Q02297
IntAct (EBI)Q02297
FunCoupENSG00000157168
BioGRIDNRG1
STRING (EMBL)NRG1
ZODIACNRG1
Ontologies - Pathways
QuickGOQ02297
Ontology : AmiGOMAPK cascade  cell morphogenesis  startle response  cardiac conduction system development  ventricular trabecula myocardium morphogenesis  transcription cofactor activity  protein tyrosine kinase activity  Ras guanyl-nucleotide exchange factor activity  receptor binding  cytokine activity  ErbB-2 class receptor binding  protein binding  extracellular region  extracellular region  extracellular space  nucleus  cytoplasm  integral component of plasma membrane  cell communication  transmembrane receptor protein tyrosine kinase signaling pathway  activation of transmembrane receptor protein tyrosine kinase activity  activation of transmembrane receptor protein tyrosine kinase activity  nervous system development  synapse assembly  peripheral nervous system development  locomotory behavior  growth factor activity  growth factor activity  regulation of blood pressure  cell proliferation  embryo development  external side of plasma membrane  negative regulation of cardiac muscle cell apoptotic process  neural crest cell development  regulation of phosphatidylinositol 3-kinase signaling  positive regulation of phosphatidylinositol 3-kinase signaling  glucose transport  membrane  apical plasma membrane  peptidyl-tyrosine phosphorylation  glial cell fate commitment  chemorepulsion involved in interneuron migration from the subpallium to the cortex  protein tyrosine kinase activator activity  transmembrane receptor protein tyrosine kinase activator activity  transmembrane receptor protein tyrosine kinase activator activity  positive regulation of cell growth  dendrite  axolemma  mammary gland development  receptor tyrosine kinase binding  neuromuscular junction  positive regulation of myelination  intracellular signal transduction  ERBB signaling pathway  ERBB2 signaling pathway  wound healing  wound healing  negative regulation of protein catabolic process  myelination  ErbB-3 class receptor binding  ErbB-3 class receptor binding  ErbB-3 class receptor binding  regulation of protein homodimerization activity  regulation of protein heterodimerization activity  positive regulation of GTPase activity  cellular protein complex disassembly  cell body  neurotransmitter receptor metabolic process  chemorepellent activity  positive regulation of axon extension  positive regulation of cell adhesion  negative regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  positive regulation of Ras protein signal transduction  phosphatidylinositol phosphorylation  phosphatidylinositol-4,5-bisphosphate 3-kinase activity  phosphatidylinositol-mediated signaling  neuron fate commitment  oligodendrocyte differentiation  positive regulation of peptidyl-tyrosine phosphorylation  negative regulation of secretion  positive regulation of striated muscle cell differentiation  positive regulation of protein kinase B signaling  cardiac muscle cell differentiation  ventricular cardiac muscle cell differentiation  positive regulation of cardiac muscle cell proliferation  cardiac muscle cell myoblast differentiation  endocardial cell differentiation  positive regulation of dendritic spine development  positive regulation of protein tyrosine kinase activity  positive regulation of calcineurin-NFAT signaling cascade  positive regulation of protein targeting to mitochondrion  positive regulation of protein localization to cell surface  regulation of cell motility  positive regulation of cardiac muscle cell differentiation  negative regulation of neuron migration  negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  
Ontology : EGO-EBIMAPK cascade  cell morphogenesis  startle response  cardiac conduction system development  ventricular trabecula myocardium morphogenesis  transcription cofactor activity  protein tyrosine kinase activity  Ras guanyl-nucleotide exchange factor activity  receptor binding  cytokine activity  ErbB-2 class receptor binding  protein binding  extracellular region  extracellular region  extracellular space  nucleus  cytoplasm  integral component of plasma membrane  cell communication  transmembrane receptor protein tyrosine kinase signaling pathway  activation of transmembrane receptor protein tyrosine kinase activity  activation of transmembrane receptor protein tyrosine kinase activity  nervous system development  synapse assembly  peripheral nervous system development  locomotory behavior  growth factor activity  growth factor activity  regulation of blood pressure  cell proliferation  embryo development  external side of plasma membrane  negative regulation of cardiac muscle cell apoptotic process  neural crest cell development  regulation of phosphatidylinositol 3-kinase signaling  positive regulation of phosphatidylinositol 3-kinase signaling  glucose transport  membrane  apical plasma membrane  peptidyl-tyrosine phosphorylation  glial cell fate commitment  chemorepulsion involved in interneuron migration from the subpallium to the cortex  protein tyrosine kinase activator activity  transmembrane receptor protein tyrosine kinase activator activity  transmembrane receptor protein tyrosine kinase activator activity  positive regulation of cell growth  dendrite  axolemma  mammary gland development  receptor tyrosine kinase binding  neuromuscular junction  positive regulation of myelination  intracellular signal transduction  ERBB signaling pathway  ERBB2 signaling pathway  wound healing  wound healing  negative regulation of protein catabolic process  myelination  ErbB-3 class receptor binding  ErbB-3 class receptor binding  ErbB-3 class receptor binding  regulation of protein homodimerization activity  regulation of protein heterodimerization activity  positive regulation of GTPase activity  cellular protein complex disassembly  cell body  neurotransmitter receptor metabolic process  chemorepellent activity  positive regulation of axon extension  positive regulation of cell adhesion  negative regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  positive regulation of Ras protein signal transduction  phosphatidylinositol phosphorylation  phosphatidylinositol-4,5-bisphosphate 3-kinase activity  phosphatidylinositol-mediated signaling  neuron fate commitment  oligodendrocyte differentiation  positive regulation of peptidyl-tyrosine phosphorylation  negative regulation of secretion  positive regulation of striated muscle cell differentiation  positive regulation of protein kinase B signaling  cardiac muscle cell differentiation  ventricular cardiac muscle cell differentiation  positive regulation of cardiac muscle cell proliferation  cardiac muscle cell myoblast differentiation  endocardial cell differentiation  positive regulation of dendritic spine development  positive regulation of protein tyrosine kinase activity  positive regulation of calcineurin-NFAT signaling cascade  positive regulation of protein targeting to mitochondrion  positive regulation of protein localization to cell surface  regulation of cell motility  positive regulation of cardiac muscle cell differentiation  negative regulation of neuron migration  negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  
Pathways : BIOCARTAAgrin in Postsynaptic Differentiation [Genes]    Neuroregulin receptor degredation protein-1 Controls ErbB3 receptor recycling [Genes]   
Pathways : KEGGErbB signaling pathway   
NDEx Network
Atlas of Cancer Signalling NetworkNRG1
Wikipedia pathwaysNRG1
Orthology - Evolution
OrthoDB3084
GeneTree (enSembl)ENSG00000157168
Phylogenetic Trees/Animal Genes : TreeFamNRG1
Homologs : HomoloGeneNRG1
Homology/Alignments : Family Browser (UCSC)NRG1
Gene fusions - Rearrangements
Fusion: TCGAAKAP13 15q25.3 NRG1 8p12 BRCA
Fusion: TCGANRG1 8p12 KRT78 12q13.13 BLCA
Fusion: TCGAPCM1 8p22 NRG1 8p12 KIRC
Fusion: TCGAPDE7A 8q13.1 NRG1 8p12 HNSC
Fusion: TCGARAB3IL1 11q12.2 NRG1 8p12 OV
Fusion: TCGASDC4 20q13.12 NRG1 8p12 LUAD
Fusion: TCGATHBS1 15q14 NRG1 8p12 HNSC
Polymorphisms : SNP, variants
NCBI Variation ViewerNRG1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NRG1
dbVarNRG1
ClinVarNRG1
1000_GenomesNRG1 
Exome Variant ServerNRG1
ExAC (Exome Aggregation Consortium)NRG1 (select the gene name)
Genetic variants : HAPMAP3084
Genomic Variants (DGV)NRG1 [DGVbeta]
Mutations
ICGC Data PortalNRG1 
TCGA Data PortalNRG1 
Broad Tumor PortalNRG1
OASIS PortalNRG1 [ Somatic mutations - Copy number]
Cancer Gene: CensusNRG1 
Somatic Mutations in Cancer : COSMICNRG1 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NRG1
DgiDB (Drug Gene Interaction Database)NRG1
DoCM (Curated mutations)NRG1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NRG1 (select a term)
intoGenNRG1
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)8:32453344-32622558  ENSG00000157168
CONAN: Copy Number AnalysisNRG1 
Mutations and Diseases : HGMDNRG1
OMIM142445    603013   
MedgenNRG1
Genetic Testing Registry NRG1
NextProtQ02297 [Medical]
TSGene3084
GENETestsNRG1
Huge Navigator NRG1 [HugePedia]
snp3D : Map Gene to Disease3084
BioCentury BCIQNRG1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3084
Chemical/Pharm GKB GenePA31776
Clinical trialNRG1
Miscellaneous
canSAR (ICR)NRG1 (select the gene name)
Probes
Litterature
PubMed399 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNRG1
EVEXNRG1
GoPubMedNRG1
iHOPNRG1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sun May 8 18:58:34 CEST 2016

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