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NRG1 (neuregulin 1)

Identity

Alias_namesHGL
NRG1-IT2
NRG1 intronic transcript 2 (non-protein coding)
Alias_symbol (synonym)HRG
NDF
GGF
Other aliasARIA
GGF2
HRG1
HRGA
MST131
MSTP131
SMDF
HGNC (Hugo) NRG1
LocusID (NCBI) 3084
Atlas_Id 45743
Location 8p12  [Link to chromosome band 8p12]
Location_base_pair Starts at 32595826 and ends at 32767957 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
AKAP13 (15q25.3) / NRG1 (8p12)ARHGAP26 (5q31.3) / NRG1 (8p12)CD74 (5q32) / NRG1 (8p12)
NRG1 (8p12) / DAZAP2 (12q13.13)NRG1 (8p12) / KRT78 (12q13.13)NRG1 (8p12) / NRG1 (8p12)
PCM1 (8p22) / NRG1 (8p12)PDE7A (8q13.1) / NRG1 (8p12)RAB3IL1 (11q12.2) / NRG1 (8p12)
SDC4 (20q13.12) / NRG1 (8p12)SLC3A2 (11q12.3) / NRG1 (8p12)TENM4 (11q14.1) / NRG1 (8p12)
THBS1 (15q14) / NRG1 (8p12)CD74 5q33.1 / NRG1 8p12AKAP13 15q25.3 / NRG1 8p12
NRG1 8p12 / KRT78 12q13.13PCM1 8p22 / NRG1 8p12PDE7A 8q13.1 / NRG1 8p12
RAB3IL1 11q12.2 / NRG1 8p12SDC4 20q13.12 / NRG1 8p12THBS1 15q14 / NRG1 8p12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NRG1   7997
Cards
Entrez_Gene (NCBI)NRG1  3084  neuregulin 1
AliasesARIA; GGF; GGF2; HGL; 
HRG; HRG1; HRGA; MST131; MSTP131; NDF; NRG1-IT2; SMDF
GeneCards (Weizmann)NRG1
Ensembl hg19 (Hinxton)ENSG00000157168 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000157168 [Gene_View]  chr8:32595826-32767957 [Contig_View]  NRG1 [Vega]
ICGC DataPortalENSG00000157168
TCGA cBioPortalNRG1
AceView (NCBI)NRG1
Genatlas (Paris)NRG1
WikiGenes3084
SOURCE (Princeton)NRG1
Genetics Home Reference (NIH)NRG1
Genomic and cartography
GoldenPath hg38 (UCSC)NRG1  -     chr8:32595826-32767957 +  8p12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NRG1  -     8p12   [Description]    (hg19-Feb_2009)
EnsemblNRG1 - 8p12 [CytoView hg19]  NRG1 - 8p12 [CytoView hg38]
Mapping of homologs : NCBINRG1 [Mapview hg19]  NRG1 [Mapview hg38]
OMIM142445   603013   
Gene and transcription
Genbank (Entrez)###############################################################################################################################################################################################################################################################
RefSeq transcript (Entrez)
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NRG1
Cluster EST : UnigeneHs.668810 [ NCBI ]
CGAP (NCI)Hs.668810
Alternative Splicing GalleryENSG00000157168
Gene ExpressionNRG1 [ NCBI-GEO ]   NRG1 [ EBI - ARRAY_EXPRESS ]   NRG1 [ SEEK ]   NRG1 [ MEM ]
Gene Expression Viewer (FireBrowse)NRG1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3084
GTEX Portal (Tissue expression)NRG1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ02297   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ02297  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ02297
Splice isoforms : SwissVarQ02297
PhosPhoSitePlusQ02297
Domaine pattern : Prosite (Expaxy)EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_3 (PS50026)    IG_LIKE (PS50835)   
Domains : Interpro (EBI)EGF-like_CS    EGF-like_dom    Ig-like_dom    Ig-like_fold    Ig_I-set    Ig_sub    Ig_sub2    Neuregulin_C    NRG1   
Domain families : Pfam (Sanger)EGF (PF00008)    I-set (PF07679)    Neuregulin (PF02158)   
Domain families : Pfam (NCBI)pfam00008    pfam07679    pfam02158   
Domain families : Smart (EMBL)EGF (SM00181)  IG (SM00409)  IGc2 (SM00408)  
Conserved Domain (NCBI)NRG1
DMDM Disease mutations3084
Blocks (Seattle)NRG1
PDB (SRS)1HAE    1HAF    1HRE    1HRF    3U7U   
PDB (PDBSum)1HAE    1HAF    1HRE    1HRF    3U7U   
PDB (IMB)1HAE    1HAF    1HRE    1HRF    3U7U   
PDB (RSDB)1HAE    1HAF    1HRE    1HRF    3U7U   
Structural Biology KnowledgeBase1HAE    1HAF    1HRE    1HRF    3U7U   
SCOP (Structural Classification of Proteins)1HAE    1HAF    1HRE    1HRF    3U7U   
CATH (Classification of proteins structures)1HAE    1HAF    1HRE    1HRF    3U7U   
SuperfamilyQ02297
Human Protein AtlasENSG00000157168
Peptide AtlasQ02297
HPRD00802
IPI###############################################################################################################################################################################################################################################################   
Protein Interaction databases
DIP (DOE-UCLA)Q02297
IntAct (EBI)Q02297
FunCoupENSG00000157168
BioGRIDNRG1
STRING (EMBL)NRG1
ZODIACNRG1
Ontologies - Pathways
QuickGOQ02297
Ontology : AmiGOMAPK cascade  activation of MAPK activity  cell morphogenesis  startle response  cardiac conduction system development  ventricular trabecula myocardium morphogenesis  transcription cofactor activity  protein tyrosine kinase activity  Ras guanyl-nucleotide exchange factor activity  cytokine activity  ErbB-2 class receptor binding  integrin binding  extracellular region  extracellular region  nucleoplasm  cytoplasm  integral component of plasma membrane  cell communication  activation of transmembrane receptor protein tyrosine kinase activity  nervous system development  synapse assembly  peripheral nervous system development  locomotory behavior  growth factor activity  positive regulation of cell proliferation  axon ensheathment  embryo development  external side of plasma membrane  neural crest cell development  regulation of phosphatidylinositol 3-kinase signaling  positive regulation of phosphatidylinositol 3-kinase signaling  membrane  peptidyl-tyrosine phosphorylation  glial cell fate commitment  chemorepulsion involved in interneuron migration from the subpallium to the cortex  transmembrane receptor protein tyrosine kinase activator activity  dendrite  axolemma  mammary gland development  receptor tyrosine kinase binding  neuromuscular junction  positive regulation of myelination  activation of protein kinase B activity  ERBB signaling pathway  ERBB signaling pathway  ERBB2 signaling pathway  ERBB3 signaling pathway  wound healing  negative regulation of protein catabolic process  ErbB-3 class receptor binding  regulation of protein homodimerization activity  regulation of protein heterodimerization activity  positive regulation of GTPase activity  cell body  neurotransmitter receptor metabolic process  chemorepellent activity  positive regulation of axon extension  negative regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  positive regulation of Ras protein signal transduction  phosphatidylinositol phosphorylation  phosphatidylinositol-4,5-bisphosphate 3-kinase activity  phosphatidylinositol-mediated signaling  neuron fate commitment  oligodendrocyte differentiation  positive regulation of peptidyl-tyrosine phosphorylation  negative regulation of secretion  positive regulation of striated muscle cell differentiation  positive regulation of protein kinase B signaling  cardiac muscle cell differentiation  cardiac muscle cell myoblast differentiation  endocardial cell differentiation  positive regulation of dendritic spine development  positive regulation of calcineurin-NFAT signaling cascade  negative regulation of ERBB signaling pathway  positive regulation of protein targeting to mitochondrion  positive regulation of protein localization to cell surface  regulation of cell motility  positive regulation of cardiac muscle cell differentiation  negative regulation of neuron migration  
Ontology : EGO-EBIMAPK cascade  activation of MAPK activity  cell morphogenesis  startle response  cardiac conduction system development  ventricular trabecula myocardium morphogenesis  transcription cofactor activity  protein tyrosine kinase activity  Ras guanyl-nucleotide exchange factor activity  cytokine activity  ErbB-2 class receptor binding  integrin binding  extracellular region  extracellular region  nucleoplasm  cytoplasm  integral component of plasma membrane  cell communication  activation of transmembrane receptor protein tyrosine kinase activity  nervous system development  synapse assembly  peripheral nervous system development  locomotory behavior  growth factor activity  positive regulation of cell proliferation  axon ensheathment  embryo development  external side of plasma membrane  neural crest cell development  regulation of phosphatidylinositol 3-kinase signaling  positive regulation of phosphatidylinositol 3-kinase signaling  membrane  peptidyl-tyrosine phosphorylation  glial cell fate commitment  chemorepulsion involved in interneuron migration from the subpallium to the cortex  transmembrane receptor protein tyrosine kinase activator activity  dendrite  axolemma  mammary gland development  receptor tyrosine kinase binding  neuromuscular junction  positive regulation of myelination  activation of protein kinase B activity  ERBB signaling pathway  ERBB signaling pathway  ERBB2 signaling pathway  ERBB3 signaling pathway  wound healing  negative regulation of protein catabolic process  ErbB-3 class receptor binding  regulation of protein homodimerization activity  regulation of protein heterodimerization activity  positive regulation of GTPase activity  cell body  neurotransmitter receptor metabolic process  chemorepellent activity  positive regulation of axon extension  negative regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  positive regulation of Ras protein signal transduction  phosphatidylinositol phosphorylation  phosphatidylinositol-4,5-bisphosphate 3-kinase activity  phosphatidylinositol-mediated signaling  neuron fate commitment  oligodendrocyte differentiation  positive regulation of peptidyl-tyrosine phosphorylation  negative regulation of secretion  positive regulation of striated muscle cell differentiation  positive regulation of protein kinase B signaling  cardiac muscle cell differentiation  cardiac muscle cell myoblast differentiation  endocardial cell differentiation  positive regulation of dendritic spine development  positive regulation of calcineurin-NFAT signaling cascade  negative regulation of ERBB signaling pathway  positive regulation of protein targeting to mitochondrion  positive regulation of protein localization to cell surface  regulation of cell motility  positive regulation of cardiac muscle cell differentiation  negative regulation of neuron migration  
Pathways : BIOCARTAAgrin in Postsynaptic Differentiation [Genes]    Neuroregulin receptor degredation protein-1 Controls ErbB3 receptor recycling [Genes]   
Pathways : KEGGErbB signaling pathway   
NDEx NetworkNRG1
Atlas of Cancer Signalling NetworkNRG1
Wikipedia pathwaysNRG1
Orthology - Evolution
OrthoDB3084
GeneTree (enSembl)ENSG00000157168
Phylogenetic Trees/Animal Genes : TreeFamNRG1
HOVERGENQ02297
HOGENOMQ02297
Homologs : HomoloGeneNRG1
Homology/Alignments : Family Browser (UCSC)NRG1
Gene fusions - Rearrangements
Fusion : MitelmanAKAP13/NRG1 [15q25.3/8p12]  [t(8;15)(p12;q25)]  
Fusion : MitelmanNRG1/KRT78 [8p12/12q13.13]  [t(8;12)(p12;q13)]  
Fusion : MitelmanPDE7A/NRG1 [8q13.1/8p12]  [t(8;8)(p12;q13)]  
Fusion : MitelmanRAB3IL1/NRG1 [11q12.2/8p12]  [t(8;11)(p12;q12)]  
Fusion : MitelmanTENM4/NRG1 [11q14.1/8p12]  [dic(8;11)(p12;q14)]  [t(8;11)(p12;q14)]  
Fusion: TCGAAKAP13 15q25.3 NRG1 8p12 BRCA
Fusion: TCGANRG1 8p12 KRT78 12q13.13 BLCA
Fusion: TCGAPCM1 8p22 NRG1 8p12 KIRC
Fusion: TCGAPDE7A 8q13.1 NRG1 8p12 HNSC
Fusion: TCGARAB3IL1 11q12.2 NRG1 8p12 OV
Fusion: TCGASDC4 20q13.12 NRG1 8p12 LUAD
Fusion: TCGATHBS1 15q14 NRG1 8p12 HNSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNRG1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NRG1
dbVarNRG1
ClinVarNRG1
1000_GenomesNRG1 
Exome Variant ServerNRG1
ExAC (Exome Aggregation Consortium)NRG1 (select the gene name)
Genetic variants : HAPMAP3084
Genomic Variants (DGV)NRG1 [DGVbeta]
DECIPHERNRG1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNRG1 
Mutations
ICGC Data PortalNRG1 
TCGA Data PortalNRG1 
Broad Tumor PortalNRG1
OASIS PortalNRG1 [ Somatic mutations - Copy number]
Cancer Gene: CensusNRG1 
Somatic Mutations in Cancer : COSMICNRG1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNRG1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NRG1
DgiDB (Drug Gene Interaction Database)NRG1
DoCM (Curated mutations)NRG1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NRG1 (select a term)
intoGenNRG1
Cancer3DNRG1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM142445    603013   
Orphanet
MedgenNRG1
Genetic Testing Registry NRG1
NextProtQ02297 [Medical]
TSGene3084
GENETestsNRG1
Target ValidationNRG1
Huge Navigator NRG1 [HugePedia]
snp3D : Map Gene to Disease3084
BioCentury BCIQNRG1
ClinGenNRG1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3084
Chemical/Pharm GKB GenePA31776
Clinical trialNRG1
Miscellaneous
canSAR (ICR)NRG1 (select the gene name)
Probes
Litterature
PubMed425 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNRG1
EVEXNRG1
GoPubMedNRG1
iHOPNRG1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:22:42 CEST 2017

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