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NRG2 (neuregulin 2)

Identity

Alias (NCBI)DON1
HRG2
NTAK
HGNC (Hugo) NRG2
HGNC Alias symbDon-1
NTAK
HRG2
HGNC Alias nameneural- and thymus-derived activator for ErbB kinases
 divergent of neuregulin-1
LocusID (NCBI) 9542
Atlas_Id 50050
Location 5q31.2  [Link to chromosome band 5q31]
Location_base_pair Starts at 139846781 and ends at 140043299 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
NRG2 (5q31.2)::CYSTM1 (5q31.3)NRG2 (5q31.2)::UBE2D2 (5q31.2)SIL1 (5q31.2)::NRG2 (5q31.2)
NRG2 5q31.2 C5orf32SIL1 5q31.2::NRG2 5q31.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)NRG2   7998
Cards
Entrez_Gene (NCBI)NRG2    neuregulin 2
AliasesDON1; HRG2; NTAK
GeneCards (Weizmann)NRG2
Ensembl hg19 (Hinxton)ENSG00000158458 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000158458 [Gene_View]  ENSG00000158458 [Sequence]  chr5:139846781-140043299 [Contig_View]  NRG2 [Vega]
ICGC DataPortalENSG00000158458
TCGA cBioPortalNRG2
AceView (NCBI)NRG2
Genatlas (Paris)NRG2
SOURCE (Princeton)NRG2
Genetics Home Reference (NIH)NRG2
Genomic and cartography
GoldenPath hg38 (UCSC)NRG2  -     chr5:139846781-140043299 -  5q31.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NRG2  -     5q31.2   [Description]    (hg19-Feb_2009)
GoldenPathNRG2 - 5q31.2 [CytoView hg19]  NRG2 - 5q31.2 [CytoView hg38]
ImmunoBaseENSG00000158458
Genome Data Viewer NCBINRG2 [Mapview hg19]  
OMIM603818   
Gene and transcription
Genbank (Entrez)AB005060 AI271427 AK124504 BC103983 BC103984
RefSeq transcript (Entrez)NM_001184935 NM_004883 NM_013981 NM_013982 NM_013983 NM_013984 NM_013985
Consensus coding sequences : CCDS (NCBI)NRG2
Gene ExpressionNRG2 [ NCBI-GEO ]   NRG2 [ EBI - ARRAY_EXPRESS ]   NRG2 [ SEEK ]   NRG2 [ MEM ]
Gene Expression Viewer (FireBrowse)NRG2 [ Firebrowse - Broad ]
GenevisibleExpression of NRG2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9542
GTEX Portal (Tissue expression)NRG2
Human Protein AtlasENSG00000158458-NRG2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO14511   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO14511  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO14511
PhosPhoSitePlusO14511
Domaine pattern : Prosite (Expaxy)EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_3 (PS50026)    IG_LIKE (PS50835)   
Domains : Interpro (EBI)EGF-like_dom    Ig-like_dom    Ig-like_dom_sf    Ig-like_fold    Ig_I-set    Ig_sub    Ig_sub2    Neuregulin    Neuregulin_C   
Domain families : Pfam (Sanger)I-set (PF07679)    Neuregulin (PF02158)   
Domain families : Pfam (NCBI)pfam07679    pfam02158   
Domain families : Smart (EMBL)IG (SM00409)  IGc2 (SM00408)  
Conserved Domain (NCBI)NRG2
SuperfamilyO14511
AlphaFold pdb e-kbO14511   
Human Protein Atlas [tissue]ENSG00000158458-NRG2 [tissue]
HPRD04821
Protein Interaction databases
DIP (DOE-UCLA)O14511
IntAct (EBI)O14511
BioGRIDNRG2
STRING (EMBL)NRG2
ZODIACNRG2
Ontologies - Pathways
QuickGOO14511
Ontology : AmiGOsignaling receptor binding  extracellular region  extracellular space  plasma membrane  signal transduction  nervous system development  growth factor activity  integral component of membrane  intracellular signal transduction  animal organ development  
Ontology : EGO-EBIsignaling receptor binding  extracellular region  extracellular space  plasma membrane  signal transduction  nervous system development  growth factor activity  integral component of membrane  intracellular signal transduction  animal organ development  
Pathways : BIOCARTABIOCARTA_ERBB4PATHWAY    BIOCARTA_AGRPATHWAY   
Pathways : KEGGKEGG_ERBB_SIGNALING   
NDEx NetworkNRG2
Atlas of Cancer Signalling NetworkNRG2
Wikipedia pathwaysNRG2
Orthology - Evolution
OrthoDB9542
GeneTree (enSembl)ENSG00000158458
Phylogenetic Trees/Animal Genes : TreeFamNRG2
Homologs : HomoloGeneNRG2
Homology/Alignments : Family Browser (UCSC)NRG2
Gene fusions - Rearrangements
Fusion : MitelmanNRG2::CYSTM1 [5q31.2/5q31.3]  
Fusion : MitelmanSIL1::NRG2 [5q31.2/5q31.2]  
Fusion : QuiverNRG2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNRG2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NRG2
dbVarNRG2
ClinVarNRG2
MonarchNRG2
1000_GenomesNRG2 
Exome Variant ServerNRG2
GNOMAD BrowserENSG00000158458
Varsome BrowserNRG2
ACMGNRG2 variants
VarityO14511
Genomic Variants (DGV)NRG2 [DGVbeta]
DECIPHERNRG2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNRG2 
Mutations
ICGC Data PortalNRG2 
TCGA Data PortalNRG2 
Broad Tumor PortalNRG2
OASIS PortalNRG2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNRG2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNRG2
Mutations and Diseases : HGMDNRG2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaNRG2
DgiDB (Drug Gene Interaction Database)NRG2
DoCM (Curated mutations)NRG2
CIViC (Clinical Interpretations of Variants in Cancer)NRG2
Cancer3DNRG2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603818   
Orphanet
DisGeNETNRG2
MedgenNRG2
Genetic Testing Registry NRG2
NextProtO14511 [Medical]
GENETestsNRG2
Target ValidationNRG2
Huge Navigator NRG2 [HugePedia]
ClinGenNRG2
Clinical trials, drugs, therapy
MyCancerGenomeNRG2
Protein Interactions : CTDNRG2
Pharm GKB GenePA31777
Pharm GKB PathwaysPA162356267   
PharosO14511
Clinical trialNRG2
Miscellaneous
canSAR (ICR)NRG2
HarmonizomeNRG2
ARCHS4NRG2
DataMed IndexNRG2
Probes
Litterature
PubMed23 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXNRG2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jan 20 12:50:02 CET 2022

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