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NRG2 (neuregulin 2)

Identity

Alias_symbol (synonym)Don-1
NTAK
HRG2
Other aliasDON1
HGNC (Hugo) NRG2
LocusID (NCBI) 9542
Atlas_Id 50050
Location 5q31.2  [Link to chromosome band 5q31]
Location_base_pair Starts at 139226364 and ends at 139422884 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
NRG2 (5q31.2) / CYSTM1 (5q31.3)NRG2 (5q31.2) / UBE2D2 (5q31.2)SIL1 (5q31.2) / NRG2 (5q31.2)
NRG2 5q31.2 C5orf32SIL1 5q31.2 / NRG2 5q31.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NRG2   7998
Cards
Entrez_Gene (NCBI)NRG2  9542  neuregulin 2
AliasesDON1; HRG2; NTAK
GeneCards (Weizmann)NRG2
Ensembl hg19 (Hinxton)ENSG00000158458 [Gene_View]  chr5:139226364-139422884 [Contig_View]  NRG2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000158458 [Gene_View]  chr5:139226364-139422884 [Contig_View]  NRG2 [Vega]
ICGC DataPortalENSG00000158458
TCGA cBioPortalNRG2
AceView (NCBI)NRG2
Genatlas (Paris)NRG2
WikiGenes9542
SOURCE (Princeton)NRG2
Genetics Home Reference (NIH)NRG2
Genomic and cartography
GoldenPath hg19 (UCSC)NRG2  -     chr5:139226364-139422884 -  5q31.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)NRG2  -     5q31.2   [Description]    (hg38-Dec_2013)
EnsemblNRG2 - 5q31.2 [CytoView hg19]  NRG2 - 5q31.2 [CytoView hg38]
Mapping of homologs : NCBINRG2 [Mapview hg19]  NRG2 [Mapview hg38]
OMIM603818   
Gene and transcription
Genbank (Entrez)AB005060 AI271427 AK124504 BC103983 BC103984
RefSeq transcript (Entrez)NM_001184935 NM_004883 NM_013981 NM_013982 NM_013983 NM_013984 NM_013985
RefSeq genomic (Entrez)NC_000005 NC_018916 NT_029289 NW_004929324
Consensus coding sequences : CCDS (NCBI)NRG2
Cluster EST : UnigeneHs.408515 [ NCBI ]
CGAP (NCI)Hs.408515
Alternative Splicing GalleryENSG00000158458
Gene ExpressionNRG2 [ NCBI-GEO ]   NRG2 [ EBI - ARRAY_EXPRESS ]   NRG2 [ SEEK ]   NRG2 [ MEM ]
Gene Expression Viewer (FireBrowse)NRG2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9542
GTEX Portal (Tissue expression)NRG2
Protein : pattern, domain, 3D structure
UniProt/SwissProtO14511   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO14511  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO14511
Splice isoforms : SwissVarO14511
PhosPhoSitePlusO14511
Domaine pattern : Prosite (Expaxy)EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_3 (PS50026)    IG_LIKE (PS50835)   
Domains : Interpro (EBI)EGF-like_CS    EGF-like_dom    Ig-like_dom    Ig-like_fold    Ig_I-set    Ig_sub2    Neuregulin_C   
Domain families : Pfam (Sanger)I-set (PF07679)    Neuregulin (PF02158)   
Domain families : Pfam (NCBI)pfam07679    pfam02158   
Domain families : Smart (EMBL)EGF (SM00181)  IGc2 (SM00408)  
Conserved Domain (NCBI)NRG2
DMDM Disease mutations9542
Blocks (Seattle)NRG2
SuperfamilyO14511
Human Protein AtlasENSG00000158458
Peptide AtlasO14511
HPRD04821
IPIIPI00477848   IPI00217570   IPI00217571   IPI00022325   IPI00217572   IPI00003044   IPI00217573   IPI00217574   IPI01018999   IPI00953025   IPI01011595   IPI00654663   IPI00978691   
Protein Interaction databases
DIP (DOE-UCLA)O14511
IntAct (EBI)O14511
FunCoupENSG00000158458
BioGRIDNRG2
STRING (EMBL)NRG2
ZODIACNRG2
Ontologies - Pathways
QuickGOO14511
Ontology : AmiGOMAPK cascade  protein tyrosine kinase activity  Ras guanyl-nucleotide exchange factor activity  receptor binding  extracellular region  extracellular space  intracellular  intracellular  plasma membrane  signal transduction  growth factor activity  regulation of phosphatidylinositol 3-kinase signaling  integral component of membrane  peptidyl-tyrosine phosphorylation  intracellular signal transduction  ERBB2 signaling pathway  positive regulation of GTPase activity  phosphatidylinositol phosphorylation  phosphatidylinositol-4,5-bisphosphate 3-kinase activity  phosphatidylinositol-mediated signaling  animal organ development  regulation of cell motility  
Ontology : EGO-EBIMAPK cascade  protein tyrosine kinase activity  Ras guanyl-nucleotide exchange factor activity  receptor binding  extracellular region  extracellular space  intracellular  intracellular  plasma membrane  signal transduction  growth factor activity  regulation of phosphatidylinositol 3-kinase signaling  integral component of membrane  peptidyl-tyrosine phosphorylation  intracellular signal transduction  ERBB2 signaling pathway  positive regulation of GTPase activity  phosphatidylinositol phosphorylation  phosphatidylinositol-4,5-bisphosphate 3-kinase activity  phosphatidylinositol-mediated signaling  animal organ development  regulation of cell motility  
Pathways : BIOCARTAg-Secretase mediated ErbB4 Signaling [Genes]    Agrin in Postsynaptic Differentiation [Genes]   
Pathways : KEGGErbB signaling pathway   
NDEx NetworkNRG2
Atlas of Cancer Signalling NetworkNRG2
Wikipedia pathwaysNRG2
Orthology - Evolution
OrthoDB9542
GeneTree (enSembl)ENSG00000158458
Phylogenetic Trees/Animal Genes : TreeFamNRG2
HOVERGENO14511
HOGENOMO14511
Homologs : HomoloGeneNRG2
Homology/Alignments : Family Browser (UCSC)NRG2
Gene fusions - Rearrangements
Fusion : MitelmanNRG2/CYSTM1 [5q31.2/5q31.3]  
Fusion : MitelmanSIL1/NRG2 [5q31.2/5q31.2]  [t(5;5)(q31;q31)]  
Fusion: TCGANRG2 5q31.2 C5orf32 BRCA
Fusion: TCGASIL1 5q31.2 NRG2 5q31.2 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNRG2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NRG2
dbVarNRG2
ClinVarNRG2
1000_GenomesNRG2 
Exome Variant ServerNRG2
ExAC (Exome Aggregation Consortium)NRG2 (select the gene name)
Genetic variants : HAPMAP9542
Genomic Variants (DGV)NRG2 [DGVbeta]
DECIPHER (Syndromes)5:139226364-139422884  ENSG00000158458
CONAN: Copy Number AnalysisNRG2 
Mutations
ICGC Data PortalNRG2 
TCGA Data PortalNRG2 
Broad Tumor PortalNRG2
OASIS PortalNRG2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNRG2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNRG2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NRG2
DgiDB (Drug Gene Interaction Database)NRG2
DoCM (Curated mutations)NRG2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NRG2 (select a term)
intoGenNRG2
Cancer3DNRG2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603818   
Orphanet
MedgenNRG2
Genetic Testing Registry NRG2
NextProtO14511 [Medical]
TSGene9542
GENETestsNRG2
Huge Navigator NRG2 [HugePedia]
snp3D : Map Gene to Disease9542
BioCentury BCIQNRG2
ClinGenNRG2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9542
Chemical/Pharm GKB GenePA31777
Clinical trialNRG2
Miscellaneous
canSAR (ICR)NRG2 (select the gene name)
Probes
Litterature
PubMed16 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNRG2
EVEXNRG2
GoPubMedNRG2
iHOPNRG2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 30 15:12:42 CEST 2017

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