Atlas of Genetics and Cytogenetics in Oncology and Haematology


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NRG3 (neuregulin 3)

Identity

Alias (NCBI)HRG3
pro-NRG3
HGNC (Hugo) NRG3
LocusID (NCBI) 10718
Atlas_Id 41580
Location 10q23.1  [Link to chromosome band 10q23]
Location_base_pair Starts at 81875194 and ends at 82987178 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FRS2 (12q15) / NRG3 (10q23.1)JUP (17q21.2) / NRG3 (10q23.1)FRS2 12q15 / NRG3 10q23.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)NRG3   7999
Cards
Entrez_Gene (NCBI)NRG3    neuregulin 3
AliasesHRG3; pro-NRG3
GeneCards (Weizmann)NRG3
Ensembl hg19 (Hinxton)ENSG00000185737 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000185737 [Gene_View]  ENSG00000185737 [Sequence]  chr10:81875194-82987178 [Contig_View]  NRG3 [Vega]
ICGC DataPortalENSG00000185737
TCGA cBioPortalNRG3
AceView (NCBI)NRG3
Genatlas (Paris)NRG3
SOURCE (Princeton)NRG3
Genetics Home Reference (NIH)NRG3
Genomic and cartography
GoldenPath hg38 (UCSC)NRG3  -     chr10:81875194-82987178 +  10q23.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NRG3  -     10q23.1   [Description]    (hg19-Feb_2009)
GoldenPathNRG3 - 10q23.1 [CytoView hg19]  NRG3 - 10q23.1 [CytoView hg38]
ImmunoBaseENSG00000185737
Genome Data Viewer NCBINRG3 [Mapview hg19]  
OMIM605533   
Gene and transcription
Genbank (Entrez)AA704915 AK098823 AK122886 AK296563 BC136811
RefSeq transcript (Entrez)NM_001010848 NM_001165972 NM_001165973 NM_001370081 NM_001370082 NM_001370083 NM_001370084
Consensus coding sequences : CCDS (NCBI)NRG3
Gene ExpressionNRG3 [ NCBI-GEO ]   NRG3 [ EBI - ARRAY_EXPRESS ]   NRG3 [ SEEK ]   NRG3 [ MEM ]
Gene Expression Viewer (FireBrowse)NRG3 [ Firebrowse - Broad ]
GenevisibleExpression of NRG3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10718
GTEX Portal (Tissue expression)NRG3
Human Protein AtlasENSG00000185737-NRG3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP56975   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP56975  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP56975
PhosPhoSitePlusP56975
Domaine pattern : Prosite (Expaxy)EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_3 (PS50026)   
Domains : Interpro (EBI)EGF-like_dom    Neuregulin   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)NRG3
SuperfamilyP56975
AlphaFold pdb e-kbP56975   
Human Protein Atlas [tissue]ENSG00000185737-NRG3 [tissue]
HPRD16115
Protein Interaction databases
DIP (DOE-UCLA)P56975
IntAct (EBI)P56975
BioGRIDNRG3
STRING (EMBL)NRG3
ZODIACNRG3
Ontologies - Pathways
QuickGOP56975
Ontology : AmiGOregulation of cell growth  signaling receptor binding  extracellular region  extracellular space  integral component of plasma membrane  activation of transmembrane receptor protein tyrosine kinase activity  pattern specification process  growth factor activity  chemorepulsion involved in interneuron migration from the subpallium to the cortex  transmembrane receptor protein tyrosine kinase activator activity  receptor tyrosine kinase binding  intracellular signal transduction  chemorepellent activity  animal organ development  modulation of chemical synaptic transmission  mammary placode formation  glutamatergic synapse  negative regulation of neuron migration  
Ontology : EGO-EBIregulation of cell growth  signaling receptor binding  extracellular region  extracellular space  integral component of plasma membrane  activation of transmembrane receptor protein tyrosine kinase activity  pattern specification process  growth factor activity  chemorepulsion involved in interneuron migration from the subpallium to the cortex  transmembrane receptor protein tyrosine kinase activator activity  receptor tyrosine kinase binding  intracellular signal transduction  chemorepellent activity  animal organ development  modulation of chemical synaptic transmission  mammary placode formation  glutamatergic synapse  negative regulation of neuron migration  
Pathways : BIOCARTAAgrin in Postsynaptic Differentiation [Genes]    g-Secretase mediated ErbB4 Signaling Pathway [Genes]   
Pathways : KEGGErbB signaling pathway   
NDEx NetworkNRG3
Atlas of Cancer Signalling NetworkNRG3
Wikipedia pathwaysNRG3
Orthology - Evolution
OrthoDB10718
GeneTree (enSembl)ENSG00000185737
Phylogenetic Trees/Animal Genes : TreeFamNRG3
Homologs : HomoloGeneNRG3
Homology/Alignments : Family Browser (UCSC)NRG3
Gene fusions - Rearrangements
Fusion : MitelmanFRS2/NRG3 [12q15/10q23.1]  
Fusion : QuiverNRG3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNRG3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NRG3
dbVarNRG3
ClinVarNRG3
MonarchNRG3
1000_GenomesNRG3 
Exome Variant ServerNRG3
GNOMAD BrowserENSG00000185737
Varsome BrowserNRG3
ACMGNRG3 variants
VarityP56975
Genomic Variants (DGV)NRG3 [DGVbeta]
DECIPHERNRG3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNRG3 
Mutations
ICGC Data PortalNRG3 
TCGA Data PortalNRG3 
Broad Tumor PortalNRG3
OASIS PortalNRG3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNRG3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNRG3
Mutations and Diseases : HGMDNRG3
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaNRG3
DgiDB (Drug Gene Interaction Database)NRG3
DoCM (Curated mutations)NRG3
CIViC (Clinical Interpretations of Variants in Cancer)NRG3
Cancer3DNRG3
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605533   
Orphanet
DisGeNETNRG3
MedgenNRG3
Genetic Testing Registry NRG3
NextProtP56975 [Medical]
GENETestsNRG3
Target ValidationNRG3
Huge Navigator NRG3 [HugePedia]
ClinGenNRG3 (curated)
Clinical trials, drugs, therapy
MyCancerGenomeNRG3
Protein Interactions : CTDNRG3
Pharm GKB GenePA31778
Pharm GKB PathwaysPA162356267   
PharosP56975
Clinical trialNRG3
Miscellaneous
canSAR (ICR)NRG3
HarmonizomeNRG3
DataMed IndexNRG3
Probes
Litterature
PubMed48 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXNRG3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:23:18 CEST 2021

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