Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

NRG3 (neuregulin 3)

Identity

Other aliasHRG3
pro-NRG3
HGNC (Hugo) NRG3
LocusID (NCBI) 10718
Atlas_Id 41580
Location 10q23.1  [Link to chromosome band 10q23]
Location_base_pair Starts at 81875314 and ends at 82987179 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
FRS2 (12q15) / NRG3 (10q23.1)JUP (17q21.2) / NRG3 (10q23.1)FRS2 12q15 / NRG3 10q23.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NRG3   7999
Cards
Entrez_Gene (NCBI)NRG3  10718  neuregulin 3
AliasesHRG3; pro-NRG3
GeneCards (Weizmann)NRG3
Ensembl hg19 (Hinxton)ENSG00000185737 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000185737 [Gene_View]  chr10:81875314-82987179 [Contig_View]  NRG3 [Vega]
ICGC DataPortalENSG00000185737
TCGA cBioPortalNRG3
AceView (NCBI)NRG3
Genatlas (Paris)NRG3
WikiGenes10718
SOURCE (Princeton)NRG3
Genetics Home Reference (NIH)NRG3
Genomic and cartography
GoldenPath hg38 (UCSC)NRG3  -     chr10:81875314-82987179 +  10q23.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NRG3  -     10q23.1   [Description]    (hg19-Feb_2009)
EnsemblNRG3 - 10q23.1 [CytoView hg19]  NRG3 - 10q23.1 [CytoView hg38]
Mapping of homologs : NCBINRG3 [Mapview hg19]  NRG3 [Mapview hg38]
OMIM605533   
Gene and transcription
Genbank (Entrez)AA704915 AK098823 AK122886 AK296563 BC136811
RefSeq transcript (Entrez)NM_001010848 NM_001165972 NM_001165973
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NRG3
Cluster EST : UnigeneHs.125119 [ NCBI ]
CGAP (NCI)Hs.125119
Alternative Splicing GalleryENSG00000185737
Gene ExpressionNRG3 [ NCBI-GEO ]   NRG3 [ EBI - ARRAY_EXPRESS ]   NRG3 [ SEEK ]   NRG3 [ MEM ]
Gene Expression Viewer (FireBrowse)NRG3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10718
GTEX Portal (Tissue expression)NRG3
Protein : pattern, domain, 3D structure
UniProt/SwissProtP56975   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP56975  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP56975
Splice isoforms : SwissVarP56975
PhosPhoSitePlusP56975
Domaine pattern : Prosite (Expaxy)EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_3 (PS50026)   
Domains : Interpro (EBI)EGF-like_CS    EGF-like_dom    Neuregulin_C   
Domain families : Pfam (Sanger)Neuregulin (PF02158)   
Domain families : Pfam (NCBI)pfam02158   
Conserved Domain (NCBI)NRG3
DMDM Disease mutations10718
Blocks (Seattle)NRG3
SuperfamilyP56975
Human Protein AtlasENSG00000185737
Peptide AtlasP56975
HPRD16115
IPIIPI00012044   IPI00749451   IPI00914901   IPI00807378   IPI01026263   IPI00719172   IPI01026364   IPI00970914   IPI00970835   IPI01010413   
Protein Interaction databases
DIP (DOE-UCLA)P56975
IntAct (EBI)P56975
FunCoupENSG00000185737
BioGRIDNRG3
STRING (EMBL)NRG3
ZODIACNRG3
Ontologies - Pathways
QuickGOP56975
Ontology : AmiGOregulation of cell growth  extracellular region  intracellular  integral component of plasma membrane  activation of transmembrane receptor protein tyrosine kinase activity  pattern specification process  growth factor activity  chemorepulsion involved in interneuron migration from the subpallium to the cortex  transmembrane receptor protein tyrosine kinase activator activity  receptor tyrosine kinase binding  intracellular signal transduction  chemorepellent activity  mammary placode formation  negative regulation of neuron migration  
Ontology : EGO-EBIregulation of cell growth  extracellular region  intracellular  integral component of plasma membrane  activation of transmembrane receptor protein tyrosine kinase activity  pattern specification process  growth factor activity  chemorepulsion involved in interneuron migration from the subpallium to the cortex  transmembrane receptor protein tyrosine kinase activator activity  receptor tyrosine kinase binding  intracellular signal transduction  chemorepellent activity  mammary placode formation  negative regulation of neuron migration  
Pathways : BIOCARTAAgrin in Postsynaptic Differentiation [Genes]    g-Secretase mediated ErbB4 Signaling [Genes]   
Pathways : KEGGErbB signaling pathway   
NDEx NetworkNRG3
Atlas of Cancer Signalling NetworkNRG3
Wikipedia pathwaysNRG3
Orthology - Evolution
OrthoDB10718
GeneTree (enSembl)ENSG00000185737
Phylogenetic Trees/Animal Genes : TreeFamNRG3
HOVERGENP56975
HOGENOMP56975
Homologs : HomoloGeneNRG3
Homology/Alignments : Family Browser (UCSC)NRG3
Gene fusions - Rearrangements
Fusion : MitelmanFRS2/NRG3 [12q15/10q23.1]  [t(10;12)(q23;q15)]  
Fusion: TCGAFRS2 12q15 NRG3 10q23.1 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNRG3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NRG3
dbVarNRG3
ClinVarNRG3
1000_GenomesNRG3 
Exome Variant ServerNRG3
ExAC (Exome Aggregation Consortium)NRG3 (select the gene name)
Genetic variants : HAPMAP10718
Genomic Variants (DGV)NRG3 [DGVbeta]
DECIPHERNRG3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNRG3 
Mutations
ICGC Data PortalNRG3 
TCGA Data PortalNRG3 
Broad Tumor PortalNRG3
OASIS PortalNRG3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNRG3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNRG3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NRG3
DgiDB (Drug Gene Interaction Database)NRG3
DoCM (Curated mutations)NRG3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NRG3 (select a term)
intoGenNRG3
Cancer3DNRG3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605533   
Orphanet
MedgenNRG3
Genetic Testing Registry NRG3
NextProtP56975 [Medical]
TSGene10718
GENETestsNRG3
Target ValidationNRG3
Huge Navigator NRG3 [HugePedia]
snp3D : Map Gene to Disease10718
BioCentury BCIQNRG3
ClinGenNRG3 (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10718
Chemical/Pharm GKB GenePA31778
Clinical trialNRG3
Miscellaneous
canSAR (ICR)NRG3 (select the gene name)
Probes
Litterature
PubMed39 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNRG3
EVEXNRG3
GoPubMedNRG3
iHOPNRG3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:47:26 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.