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NRG4 (neuregulin 4)

Identity

Alias (NCBI)HRG4
HGNC (Hugo) NRG4
HGNC Alias symbHRG4
LocusID (NCBI) 145957
Atlas_Id 43662
Location 15q24.2  [Link to chromosome band 15q24]
Location_base_pair Starts at 75940936 and ends at 76012424 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
NRG4 (15q24.2) / SCAPER (15q24.3)UBE2Q2 (15q24.2) / NRG4 (15q24.2)UBE2Q2 15q24.2 / NRG4 15q24.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)NRG4   29862
Cards
Entrez_Gene (NCBI)NRG4    neuregulin 4
AliasesHRG4
GeneCards (Weizmann)NRG4
Ensembl hg19 (Hinxton)ENSG00000169752 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000169752 [Gene_View]  ENSG00000169752 [Sequence]  chr15:75940936-76012424 [Contig_View]  NRG4 [Vega]
ICGC DataPortalENSG00000169752
TCGA cBioPortalNRG4
AceView (NCBI)NRG4
Genatlas (Paris)NRG4
SOURCE (Princeton)NRG4
Genetics Home Reference (NIH)NRG4
Genomic and cartography
GoldenPath hg38 (UCSC)NRG4  -     chr15:75940936-76012424 -  15q24.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NRG4  -     15q24.2   [Description]    (hg19-Feb_2009)
GoldenPathNRG4 - 15q24.2 [CytoView hg19]  NRG4 - 15q24.2 [CytoView hg38]
ImmunoBaseENSG00000169752
Genome Data Viewer NCBINRG4 [Mapview hg19]  
OMIM610894   
Gene and transcription
Genbank (Entrez)AK307362 AK311204 AK311507 AM392364 AM392365
RefSeq transcript (Entrez)NM_138573
Consensus coding sequences : CCDS (NCBI)NRG4
Gene ExpressionNRG4 [ NCBI-GEO ]   NRG4 [ EBI - ARRAY_EXPRESS ]   NRG4 [ SEEK ]   NRG4 [ MEM ]
Gene Expression Viewer (FireBrowse)NRG4 [ Firebrowse - Broad ]
GenevisibleExpression of NRG4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)145957
GTEX Portal (Tissue expression)NRG4
Human Protein AtlasENSG00000169752-NRG4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8WWG1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8WWG1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8WWG1
PhosPhoSitePlusQ8WWG1
Domaine pattern : Prosite (Expaxy)EGF_1 (PS00022)    EGF_3 (PS50026)   
Domains : Interpro (EBI)EGF-like_dom    Neuregulin   
Domain families : Pfam (Sanger)EGF (PF00008)   
Domain families : Pfam (NCBI)pfam00008   
Domain families : Smart (EMBL)EGF (SM00181)  
Conserved Domain (NCBI)NRG4
SuperfamilyQ8WWG1
AlphaFold pdb e-kbQ8WWG1   
Human Protein Atlas [tissue]ENSG00000169752-NRG4 [tissue]
HPRD14871
Protein Interaction databases
DIP (DOE-UCLA)Q8WWG1
IntAct (EBI)Q8WWG1
BioGRIDNRG4
STRING (EMBL)NRG4
ZODIACNRG4
Ontologies - Pathways
QuickGOQ8WWG1
Ontology : AmiGOMAPK cascade  protein binding  extracellular region  plasma membrane  nervous system development  growth factor activity  integral component of membrane  ERBB2 signaling pathway  positive regulation of protein kinase B signaling  regulation of cell motility  
Ontology : EGO-EBIMAPK cascade  protein binding  extracellular region  plasma membrane  nervous system development  growth factor activity  integral component of membrane  ERBB2 signaling pathway  positive regulation of protein kinase B signaling  regulation of cell motility  
Pathways : KEGGErbB signaling pathway   
NDEx NetworkNRG4
Atlas of Cancer Signalling NetworkNRG4
Wikipedia pathwaysNRG4
Orthology - Evolution
OrthoDB145957
GeneTree (enSembl)ENSG00000169752
Phylogenetic Trees/Animal Genes : TreeFamNRG4
Homologs : HomoloGeneNRG4
Homology/Alignments : Family Browser (UCSC)NRG4
Gene fusions - Rearrangements
Fusion : MitelmanUBE2Q2/NRG4 [15q24.2/15q24.2]  
Fusion : QuiverNRG4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNRG4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NRG4
dbVarNRG4
ClinVarNRG4
MonarchNRG4
1000_GenomesNRG4 
Exome Variant ServerNRG4
GNOMAD BrowserENSG00000169752
Varsome BrowserNRG4
ACMGNRG4 variants
VarityQ8WWG1
Genomic Variants (DGV)NRG4 [DGVbeta]
DECIPHERNRG4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNRG4 
Mutations
ICGC Data PortalNRG4 
TCGA Data PortalNRG4 
Broad Tumor PortalNRG4
OASIS PortalNRG4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNRG4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNRG4
Mutations and Diseases : HGMDNRG4
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaNRG4
DgiDB (Drug Gene Interaction Database)NRG4
DoCM (Curated mutations)NRG4
CIViC (Clinical Interpretations of Variants in Cancer)NRG4
Cancer3DNRG4
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610894   
Orphanet
DisGeNETNRG4
MedgenNRG4
Genetic Testing Registry NRG4
NextProtQ8WWG1 [Medical]
GENETestsNRG4
Target ValidationNRG4
Huge Navigator NRG4 [HugePedia]
ClinGenNRG4
Clinical trials, drugs, therapy
MyCancerGenomeNRG4
Protein Interactions : CTDNRG4
Pharm GKB GenePA142671246
PharosQ8WWG1
Clinical trialNRG4
Miscellaneous
canSAR (ICR)NRG4
HarmonizomeNRG4
DataMed IndexNRG4
Probes
Litterature
PubMed32 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXNRG4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:23:18 CEST 2021

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