Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

NRG4 (neuregulin 4)

Identity

Alias_symbol (synonym)HRG4
Other alias
HGNC (Hugo) NRG4
LocusID (NCBI) 145957
Atlas_Id 43662
Location 15q24.2  [Link to chromosome band 15q24]
Location_base_pair Starts at 75941986 and ends at 76012444 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
NRG4 (15q24.2) / SCAPER (15q24.3)UBE2Q2 (15q24.2) / NRG4 (15q24.2)UBE2Q2 15q24.2 / NRG4 15q24.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NRG4   29862
Cards
Entrez_Gene (NCBI)NRG4  145957  neuregulin 4
AliasesHRG4
GeneCards (Weizmann)NRG4
Ensembl hg19 (Hinxton)ENSG00000169752 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000169752 [Gene_View]  chr15:75941986-76012444 [Contig_View]  NRG4 [Vega]
ICGC DataPortalENSG00000169752
TCGA cBioPortalNRG4
AceView (NCBI)NRG4
Genatlas (Paris)NRG4
WikiGenes145957
SOURCE (Princeton)NRG4
Genetics Home Reference (NIH)NRG4
Genomic and cartography
GoldenPath hg38 (UCSC)NRG4  -     chr15:75941986-76012444 -  15q24.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NRG4  -     15q24.2   [Description]    (hg19-Feb_2009)
EnsemblNRG4 - 15q24.2 [CytoView hg19]  NRG4 - 15q24.2 [CytoView hg38]
Mapping of homologs : NCBINRG4 [Mapview hg19]  NRG4 [Mapview hg38]
OMIM610894   
Gene and transcription
Genbank (Entrez)AK307362 AK311204 AK311507 AM392364 AM392365
RefSeq transcript (Entrez)NM_138573
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NRG4
Cluster EST : UnigeneHs.732438 [ NCBI ]
CGAP (NCI)Hs.732438
Alternative Splicing GalleryENSG00000169752
Gene ExpressionNRG4 [ NCBI-GEO ]   NRG4 [ EBI - ARRAY_EXPRESS ]   NRG4 [ SEEK ]   NRG4 [ MEM ]
Gene Expression Viewer (FireBrowse)NRG4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)145957
GTEX Portal (Tissue expression)NRG4
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8WWG1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8WWG1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8WWG1
Splice isoforms : SwissVarQ8WWG1
PhosPhoSitePlusQ8WWG1
Domaine pattern : Prosite (Expaxy)EGF_1 (PS00022)    EGF_3 (PS50026)   
Domains : Interpro (EBI)EGF-like_CS    EGF-like_dom   
Domain families : Pfam (Sanger)EGF (PF00008)   
Domain families : Pfam (NCBI)pfam00008   
Domain families : Smart (EMBL)EGF (SM00181)  
Conserved Domain (NCBI)NRG4
DMDM Disease mutations145957
Blocks (Seattle)NRG4
SuperfamilyQ8WWG1
Human Protein AtlasENSG00000169752
Peptide AtlasQ8WWG1
HPRD14871
IPIIPI00103330   IPI00872433   IPI00978132   IPI00980164   
Protein Interaction databases
DIP (DOE-UCLA)Q8WWG1
IntAct (EBI)Q8WWG1
FunCoupENSG00000169752
BioGRIDNRG4
STRING (EMBL)NRG4
ZODIACNRG4
Ontologies - Pathways
QuickGOQ8WWG1
Ontology : AmiGOMAPK cascade  protein tyrosine kinase activity  Ras guanyl-nucleotide exchange factor activity  protein binding  extracellular region  intracellular  plasma membrane  growth factor activity  regulation of phosphatidylinositol 3-kinase signaling  integral component of membrane  peptidyl-tyrosine phosphorylation  ERBB2 signaling pathway  positive regulation of GTPase activity  phosphatidylinositol phosphorylation  phosphatidylinositol-4,5-bisphosphate 3-kinase activity  phosphatidylinositol-mediated signaling  negative regulation of ERBB signaling pathway  regulation of cell motility  
Ontology : EGO-EBIMAPK cascade  protein tyrosine kinase activity  Ras guanyl-nucleotide exchange factor activity  protein binding  extracellular region  intracellular  plasma membrane  growth factor activity  regulation of phosphatidylinositol 3-kinase signaling  integral component of membrane  peptidyl-tyrosine phosphorylation  ERBB2 signaling pathway  positive regulation of GTPase activity  phosphatidylinositol phosphorylation  phosphatidylinositol-4,5-bisphosphate 3-kinase activity  phosphatidylinositol-mediated signaling  negative regulation of ERBB signaling pathway  regulation of cell motility  
Pathways : KEGGErbB signaling pathway   
NDEx NetworkNRG4
Atlas of Cancer Signalling NetworkNRG4
Wikipedia pathwaysNRG4
Orthology - Evolution
OrthoDB145957
GeneTree (enSembl)ENSG00000169752
Phylogenetic Trees/Animal Genes : TreeFamNRG4
HOVERGENQ8WWG1
HOGENOMQ8WWG1
Homologs : HomoloGeneNRG4
Homology/Alignments : Family Browser (UCSC)NRG4
Gene fusions - Rearrangements
Fusion : MitelmanUBE2Q2/NRG4 [15q24.2/15q24.2]  [t(15;15)(q24;q24)]  
Fusion: TCGAUBE2Q2 15q24.2 NRG4 15q24.2 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNRG4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NRG4
dbVarNRG4
ClinVarNRG4
1000_GenomesNRG4 
Exome Variant ServerNRG4
ExAC (Exome Aggregation Consortium)NRG4 (select the gene name)
Genetic variants : HAPMAP145957
Genomic Variants (DGV)NRG4 [DGVbeta]
DECIPHERNRG4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNRG4 
Mutations
ICGC Data PortalNRG4 
TCGA Data PortalNRG4 
Broad Tumor PortalNRG4
OASIS PortalNRG4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNRG4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNRG4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NRG4
DgiDB (Drug Gene Interaction Database)NRG4
DoCM (Curated mutations)NRG4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NRG4 (select a term)
intoGenNRG4
Cancer3DNRG4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610894   
Orphanet
MedgenNRG4
Genetic Testing Registry NRG4
NextProtQ8WWG1 [Medical]
TSGene145957
GENETestsNRG4
Huge Navigator NRG4 [HugePedia]
snp3D : Map Gene to Disease145957
BioCentury BCIQNRG4
ClinGenNRG4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD145957
Chemical/Pharm GKB GenePA142671246
Clinical trialNRG4
Miscellaneous
canSAR (ICR)NRG4 (select the gene name)
Probes
Litterature
PubMed20 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNRG4
EVEXNRG4
GoPubMedNRG4
iHOPNRG4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 19 12:29:13 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.