NRGN (neurogranin)

2014-11-01  

Identity

HGNC
NRGN
LOCATION
11q24.2
LOCUSID
4900
ALIAS
RC3,hng
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4900
MIM: 602350
HGNC: 8000
Ensembl: ENSG00000154146

Variants:

dbSNP: 4900
ClinVar: 4900
TCGA: ENSG00000154146
COSMIC: NRGN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000154146ENST00000284292Q92686
ENSG00000154146ENST00000284292A0A024R3M7
ENSG00000154146ENST00000412681Q92686
ENSG00000154146ENST00000412681A0A024R3M7

Expression (GTEx)

0
500
1000
1500
2000
2500
3000
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
195718082009Common variants conferring risk of schizophrenia.575
263666302015Neurogranin as a Cerebrospinal Fluid Biomarker for Synaptic Loss in Symptomatic Alzheimer Disease.64
210372402011Most genome-wide significant susceptibility loci for schizophrenia and bipolar disorder reported to date cross-traditional diagnostic boundaries.63
208757982010Neurogranin in cerebrospinal fluid as a marker of synaptic degeneration in Alzheimer's disease.60
263736052015Cerebrospinal fluid neurogranin: relation to cognition and neurodegeneration in Alzheimer's disease.60
268262042016Increased CSF neurogranin concentration is specific to Alzheimer disease.46
270189402016Diagnostic and Prognostic Utility of the Synaptic Marker Neurogranin in Alzheimer Disease.43
266982982015Neurogranin and YKL-40: independent markers of synaptic degeneration and neuroinflammation in Alzheimer's disease.35
247136972014Neurogranin alters the structure and calcium binding properties of calmodulin.23
297005972018Cerebrospinal fluid neurogranin concentration in neurodegeneration: relation to clinical phenotypes and neuropathology.21

Citation

Dessen P

NRGN (neurogranin)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/70969/nrgn