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NRK (Nik related kinase)

Identity

Alias_symbol (synonym)DKFZp686A17109
Other aliasNESK
HGNC (Hugo) NRK
LocusID (NCBI) 203447
Atlas_Id 56162
Location Xq22.3  [Link to chromosome band Xq22]
Location_base_pair Starts at 105822543 and ends at 105958610 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
NRK (Xq22.3) / NRK (Xq22.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NRK   25391
Cards
Entrez_Gene (NCBI)NRK  203447  Nik related kinase
AliasesNESK
GeneCards (Weizmann)NRK
Ensembl hg19 (Hinxton)ENSG00000123572 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000123572 [Gene_View]  ENSG00000123572 [Sequence]  chrX:105822543-105958610 [Contig_View]  NRK [Vega]
ICGC DataPortalENSG00000123572
TCGA cBioPortalNRK
AceView (NCBI)NRK
Genatlas (Paris)NRK
WikiGenes203447
SOURCE (Princeton)NRK
Genetics Home Reference (NIH)NRK
Genomic and cartography
GoldenPath hg38 (UCSC)NRK  -     chrX:105822543-105958610 +  Xq22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NRK  -     Xq22.3   [Description]    (hg19-Feb_2009)
EnsemblNRK - Xq22.3 [CytoView hg19]  NRK - Xq22.3 [CytoView hg38]
Mapping of homologs : NCBINRK [Mapview hg19]  NRK [Mapview hg38]
OMIM300791   
Gene and transcription
Genbank (Entrez)AK131549 AK293500 AK300377 BC108702 BX538345
RefSeq transcript (Entrez)NM_198465
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NRK
Cluster EST : UnigeneHs.209527 [ NCBI ]
CGAP (NCI)Hs.209527
Alternative Splicing GalleryENSG00000123572
Gene ExpressionNRK [ NCBI-GEO ]   NRK [ EBI - ARRAY_EXPRESS ]   NRK [ SEEK ]   NRK [ MEM ]
Gene Expression Viewer (FireBrowse)NRK [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)203447
GTEX Portal (Tissue expression)NRK
Human Protein AtlasENSG00000123572-NRK [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7Z2Y5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7Z2Y5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7Z2Y5
Splice isoforms : SwissVarQ7Z2Y5
PhosPhoSitePlusQ7Z2Y5
Domaine pattern : Prosite (Expaxy)CNH (PS50219)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)CNH_dom    Kinase-like_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)CNH (PF00780)    Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00780    pfam00069   
Domain families : Smart (EMBL)CNH (SM00036)  S_TKc (SM00220)  
Conserved Domain (NCBI)NRK
DMDM Disease mutations203447
Blocks (Seattle)NRK
SuperfamilyQ7Z2Y5
Human Protein Atlas [tissue]ENSG00000123572-NRK [tissue]
Peptide AtlasQ7Z2Y5
HPRD14841
IPIIPI00375682   IPI00787350   IPI00922300   IPI00871409   
Protein Interaction databases
DIP (DOE-UCLA)Q7Z2Y5
IntAct (EBI)Q7Z2Y5
FunCoupENSG00000123572
BioGRIDNRK
STRING (EMBL)NRK
ZODIACNRK
Ontologies - Pathways
QuickGOQ7Z2Y5
Ontology : AmiGOMAPK cascade  protein serine/threonine kinase activity  ATP binding  cytoplasm  activation of JNKK activity  parturition  negative regulation of cell proliferation  signal transduction by protein phosphorylation  stress-activated protein kinase signaling cascade  actin cytoskeleton reorganization  activation of protein kinase activity  neuron projection morphogenesis  regulation of spongiotrophoblast cell proliferation  
Ontology : EGO-EBIMAPK cascade  protein serine/threonine kinase activity  ATP binding  cytoplasm  activation of JNKK activity  parturition  negative regulation of cell proliferation  signal transduction by protein phosphorylation  stress-activated protein kinase signaling cascade  actin cytoskeleton reorganization  activation of protein kinase activity  neuron projection morphogenesis  regulation of spongiotrophoblast cell proliferation  
NDEx NetworkNRK
Atlas of Cancer Signalling NetworkNRK
Wikipedia pathwaysNRK
Orthology - Evolution
OrthoDB203447
GeneTree (enSembl)ENSG00000123572
Phylogenetic Trees/Animal Genes : TreeFamNRK
HOVERGENQ7Z2Y5
HOGENOMQ7Z2Y5
Homologs : HomoloGeneNRK
Homology/Alignments : Family Browser (UCSC)NRK
Gene fusions - Rearrangements
Fusion : QuiverNRK
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNRK [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NRK
dbVarNRK
ClinVarNRK
1000_GenomesNRK 
Exome Variant ServerNRK
ExAC (Exome Aggregation Consortium)ENSG00000123572
GNOMAD BrowserENSG00000123572
Varsome BrowserNRK
Genetic variants : HAPMAP203447
Genomic Variants (DGV)NRK [DGVbeta]
DECIPHERNRK [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNRK 
Mutations
ICGC Data PortalNRK 
TCGA Data PortalNRK 
Broad Tumor PortalNRK
OASIS PortalNRK [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDNRK
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)X-chromosome gene database
BioMutasearch NRK
DgiDB (Drug Gene Interaction Database)NRK
DoCM (Curated mutations)NRK (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NRK (select a term)
intoGenNRK
Cancer3DNRK(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM300791   
Orphanet
DisGeNETNRK
MedgenNRK
Genetic Testing Registry NRK
NextProtQ7Z2Y5 [Medical]
TSGene203447
GENETestsNRK
Target ValidationNRK
Huge Navigator NRK [HugePedia]
snp3D : Map Gene to Disease203447
BioCentury BCIQNRK
ClinGenNRK
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD203447
Chemical/Pharm GKB GenePA134869113
Clinical trialNRK
Miscellaneous
canSAR (ICR)NRK (select the gene name)
Probes
Litterature
PubMed11 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNRK
EVEXNRK
GoPubMedNRK
iHOPNRK
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 6 11:27:01 CET 2018

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