Atlas of Genetics and Cytogenetics in Oncology and Haematology


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NRP1 (neuropilin 1)

Identity

Alias_symbol (synonym)NRP
VEGF165R
CD304
Other aliasBDCA4
NP1
HGNC (Hugo) NRP1
LocusID (NCBI) 8829
Atlas_Id 41582
Location 10p11.22  [Link to chromosome band 10p11]
Location_base_pair Starts at 33197619 and ends at 33334905 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
EGLN1 (1q42.2) / NRP1 (10p11.22)HIF1A (14q23.2) / NRP1 (10p11.22)NRP1 (10p11.22) / ANP32E (1q21.2)
NRP1 (10p11.22) / CUL2 (10p11.21)NRP1 (10p11.22) / ITGB1 (10p11.22)NRP1 (10p11.22) / PARD3 (10p11.22)
NRP1 (10p11.22) / VSTM4 (10q11.23)NRP1 (10p11.22) / WDR75 (2q32.2)UBR4 (1p36.13) / NRP1 (10p11.22)
WAC (10p12.1) / NRP1 (10p11.22)NRP1 10p11.22 / CUL2 10p11.21NRP1 10p11.22 / VSTM4 10q11.23

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NRP1   8004
Cards
Entrez_Gene (NCBI)NRP1  8829  neuropilin 1
AliasesBDCA4; CD304; NP1; NRP; 
VEGF165R
GeneCards (Weizmann)NRP1
Ensembl hg19 (Hinxton)ENSG00000099250 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000099250 [Gene_View]  chr10:33197619-33334905 [Contig_View]  NRP1 [Vega]
ICGC DataPortalENSG00000099250
TCGA cBioPortalNRP1
AceView (NCBI)NRP1
Genatlas (Paris)NRP1
WikiGenes8829
SOURCE (Princeton)NRP1
Genetics Home Reference (NIH)NRP1
Genomic and cartography
GoldenPath hg38 (UCSC)NRP1  -     chr10:33197619-33334905 -  10p11.22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NRP1  -     10p11.22   [Description]    (hg19-Feb_2009)
EnsemblNRP1 - 10p11.22 [CytoView hg19]  NRP1 - 10p11.22 [CytoView hg38]
Mapping of homologs : NCBINRP1 [Mapview hg19]  NRP1 [Mapview hg38]
OMIM602069   
Gene and transcription
Genbank (Entrez)AA973607 AB209641 AF016050 AF018956 AF086016
RefSeq transcript (Entrez)NM_001024628 NM_001024629 NM_001244972 NM_001244973 NM_001330068 NM_003873
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NRP1
Cluster EST : UnigeneHs.653996 [ NCBI ]
CGAP (NCI)Hs.653996
Alternative Splicing GalleryENSG00000099250
Gene ExpressionNRP1 [ NCBI-GEO ]   NRP1 [ EBI - ARRAY_EXPRESS ]   NRP1 [ SEEK ]   NRP1 [ MEM ]
Gene Expression Viewer (FireBrowse)NRP1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8829
GTEX Portal (Tissue expression)NRP1
Protein : pattern, domain, 3D structure
UniProt/SwissProtO14786   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO14786  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO14786
Splice isoforms : SwissVarO14786
PhosPhoSitePlusO14786
Domaine pattern : Prosite (Expaxy)CUB (PS01180)    FA58C_1 (PS01285)    FA58C_2 (PS01286)    FA58C_3 (PS50022)    MAM_1 (PS00740)    MAM_2 (PS50060)   
Domains : Interpro (EBI)ConA-like_dom    CUB_dom    FA58C    Galactose-bd-like    MAM_dom    Neuropilin    Neuropilin_C    NRP1   
Domain families : Pfam (Sanger)CUB (PF00431)    DUF3481 (PF11980)    F5_F8_type_C (PF00754)    MAM (PF00629)   
Domain families : Pfam (NCBI)pfam00431    pfam11980    pfam00754    pfam00629   
Domain families : Smart (EMBL)CUB (SM00042)  FA58C (SM00231)  MAM (SM00137)  
Conserved Domain (NCBI)NRP1
DMDM Disease mutations8829
Blocks (Seattle)NRP1
PDB (SRS)1KEX    2QQI    2QQM    2QQN    3I97    4DEQ    4RN5    5C7G    5L73   
PDB (PDBSum)1KEX    2QQI    2QQM    2QQN    3I97    4DEQ    4RN5    5C7G    5L73   
PDB (IMB)1KEX    2QQI    2QQM    2QQN    3I97    4DEQ    4RN5    5C7G    5L73   
PDB (RSDB)1KEX    2QQI    2QQM    2QQN    3I97    4DEQ    4RN5    5C7G    5L73   
Structural Biology KnowledgeBase1KEX    2QQI    2QQM    2QQN    3I97    4DEQ    4RN5    5C7G    5L73   
SCOP (Structural Classification of Proteins)1KEX    2QQI    2QQM    2QQN    3I97    4DEQ    4RN5    5C7G    5L73   
CATH (Classification of proteins structures)1KEX    2QQI    2QQM    2QQN    3I97    4DEQ    4RN5    5C7G    5L73   
SuperfamilyO14786
Human Protein AtlasENSG00000099250
Peptide AtlasO14786
HPRD03642
IPIIPI00299594   IPI00607733   IPI00165438   IPI00643859   IPI00646134   IPI00643127   IPI00939515   IPI00749187   IPI00639917   IPI01018659   IPI00873301   
Protein Interaction databases
DIP (DOE-UCLA)O14786
IntAct (EBI)O14786
FunCoupENSG00000099250
BioGRIDNRP1
STRING (EMBL)NRP1
ZODIACNRP1
Ontologies - Pathways
QuickGOO14786
Ontology : AmiGOangiogenesis  angiogenesis  branching involved in blood vessel morphogenesis  neuron migration  positive regulation of endothelial cell proliferation  sprouting angiogenesis  cell migration involved in sprouting angiogenesis  semaphorin receptor complex  vascular endothelial growth factor-activated receptor activity  vascular endothelial growth factor-activated receptor activity  protein binding  extracellular space  early endosome  cytosol  neurofilament  plasma membrane  plasma membrane  focal adhesion  signal transduction  cell-cell signaling  axon guidance  axonal fasciculation  heparin binding  response to wounding  animal organ morphogenesis  cell surface  positive regulation of endothelial cell migration  positive regulation of smooth muscle cell migration  coreceptor activity  integral component of membrane  dendrite development  semaphorin receptor activity  growth factor binding  growth factor binding  cytokine binding  facial nerve structural organization  trigeminal nerve structural organization  vestibulocochlear nerve structural organization  nerve development  branchiomotor neuron axon guidance  gonadotrophin-releasing hormone neuronal migration to the hypothalamus  axon  growth cone  retinal ganglion cell axon guidance  cytoplasmic vesicle  cellular response to hepatocyte growth factor stimulus  endothelial cell chemotaxis  cellular response to vascular endothelial growth factor stimulus  ventral trunk neural crest cell migration  vascular endothelial growth factor binding  VEGF-activated neuropilin signaling pathway  neuronal cell body  receptor complex  negative regulation of neuron apoptotic process  metal ion binding  platelet-derived growth factor receptor signaling pathway  vascular endothelial growth factor receptor signaling pathway  vascular endothelial growth factor receptor signaling pathway  hepatocyte growth factor receptor signaling pathway  positive regulation of axon extension involved in axon guidance  negative regulation of axon extension involved in axon guidance  artery morphogenesis  axon extension involved in axon guidance  positive regulation of peptidyl-tyrosine phosphorylation  positive chemotaxis  positive regulation of cytokine activity  axonogenesis involved in innervation  regulation of vesicle-mediated transport  dichotomous subdivision of terminal units involved in salivary gland branching  angiogenesis involved in coronary vascular morphogenesis  coronary artery morphogenesis  retina vasculature morphogenesis in camera-type eye  renal artery morphogenesis  sympathetic ganglion development  trigeminal ganglion development  positive regulation of ERK1 and ERK2 cascade  semaphorin-plexin signaling pathway  commissural neuron axon guidance  regulation of retinal ganglion cell axon guidance  endothelial tip cell fate specification  sensory neuron axon guidance  sorting endosome  motor neuron migration  sympathetic neuron projection extension  sympathetic neuron projection guidance  neural crest cell migration involved in autonomic nervous system development  toxin transport  semaphorin-plexin signaling pathway involved in neuron projection guidance  semaphorin-plexin signaling pathway involved in axon guidance  positive regulation of retinal ganglion cell axon guidance  VEGF-activated neuropilin signaling pathway involved in axon guidance  protein localization to early endosome  facioacoustic ganglion development  dorsal root ganglion morphogenesis  otic placode development  negative regulation of extrinsic apoptotic signaling pathway  
Ontology : EGO-EBIangiogenesis  angiogenesis  branching involved in blood vessel morphogenesis  neuron migration  positive regulation of endothelial cell proliferation  sprouting angiogenesis  cell migration involved in sprouting angiogenesis  semaphorin receptor complex  vascular endothelial growth factor-activated receptor activity  vascular endothelial growth factor-activated receptor activity  protein binding  extracellular space  early endosome  cytosol  neurofilament  plasma membrane  plasma membrane  focal adhesion  signal transduction  cell-cell signaling  axon guidance  axonal fasciculation  heparin binding  response to wounding  animal organ morphogenesis  cell surface  positive regulation of endothelial cell migration  positive regulation of smooth muscle cell migration  coreceptor activity  integral component of membrane  dendrite development  semaphorin receptor activity  growth factor binding  growth factor binding  cytokine binding  facial nerve structural organization  trigeminal nerve structural organization  vestibulocochlear nerve structural organization  nerve development  branchiomotor neuron axon guidance  gonadotrophin-releasing hormone neuronal migration to the hypothalamus  axon  growth cone  retinal ganglion cell axon guidance  cytoplasmic vesicle  cellular response to hepatocyte growth factor stimulus  endothelial cell chemotaxis  cellular response to vascular endothelial growth factor stimulus  ventral trunk neural crest cell migration  vascular endothelial growth factor binding  VEGF-activated neuropilin signaling pathway  neuronal cell body  receptor complex  negative regulation of neuron apoptotic process  metal ion binding  platelet-derived growth factor receptor signaling pathway  vascular endothelial growth factor receptor signaling pathway  vascular endothelial growth factor receptor signaling pathway  hepatocyte growth factor receptor signaling pathway  positive regulation of axon extension involved in axon guidance  negative regulation of axon extension involved in axon guidance  artery morphogenesis  axon extension involved in axon guidance  positive regulation of peptidyl-tyrosine phosphorylation  positive chemotaxis  positive regulation of cytokine activity  axonogenesis involved in innervation  regulation of vesicle-mediated transport  dichotomous subdivision of terminal units involved in salivary gland branching  angiogenesis involved in coronary vascular morphogenesis  coronary artery morphogenesis  retina vasculature morphogenesis in camera-type eye  renal artery morphogenesis  sympathetic ganglion development  trigeminal ganglion development  positive regulation of ERK1 and ERK2 cascade  semaphorin-plexin signaling pathway  commissural neuron axon guidance  regulation of retinal ganglion cell axon guidance  endothelial tip cell fate specification  sensory neuron axon guidance  sorting endosome  motor neuron migration  sympathetic neuron projection extension  sympathetic neuron projection guidance  neural crest cell migration involved in autonomic nervous system development  toxin transport  semaphorin-plexin signaling pathway involved in neuron projection guidance  semaphorin-plexin signaling pathway involved in axon guidance  positive regulation of retinal ganglion cell axon guidance  VEGF-activated neuropilin signaling pathway involved in axon guidance  protein localization to early endosome  facioacoustic ganglion development  dorsal root ganglion morphogenesis  otic placode development  negative regulation of extrinsic apoptotic signaling pathway  
Pathways : KEGGAxon guidance    HTLV-I infection   
NDEx NetworkNRP1
Atlas of Cancer Signalling NetworkNRP1
Wikipedia pathwaysNRP1
Orthology - Evolution
OrthoDB8829
GeneTree (enSembl)ENSG00000099250
Phylogenetic Trees/Animal Genes : TreeFamNRP1
HOVERGENO14786
HOGENOMO14786
Homologs : HomoloGeneNRP1
Homology/Alignments : Family Browser (UCSC)NRP1
Gene fusions - Rearrangements
Fusion : MitelmanNRP1/CUL2 [10p11.22/10p11.21]  
Fusion : MitelmanNRP1/VSTM4 [10p11.22/10q11.23]  [t(10;10)(p11;q11)]  
Fusion: TCGANRP1 10p11.22 CUL2 10p11.21 LGG
Fusion: TCGANRP1 10p11.22 VSTM4 10q11.23 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNRP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NRP1
dbVarNRP1
ClinVarNRP1
1000_GenomesNRP1 
Exome Variant ServerNRP1
ExAC (Exome Aggregation Consortium)NRP1 (select the gene name)
Genetic variants : HAPMAP8829
Genomic Variants (DGV)NRP1 [DGVbeta]
DECIPHERNRP1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNRP1 
Mutations
ICGC Data PortalNRP1 
TCGA Data PortalNRP1 
Broad Tumor PortalNRP1
OASIS PortalNRP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNRP1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNRP1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NRP1
DgiDB (Drug Gene Interaction Database)NRP1
DoCM (Curated mutations)NRP1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NRP1 (select a term)
intoGenNRP1
Cancer3DNRP1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602069   
Orphanet
MedgenNRP1
Genetic Testing Registry NRP1
NextProtO14786 [Medical]
TSGene8829
GENETestsNRP1
Target ValidationNRP1
Huge Navigator NRP1 [HugePedia]
snp3D : Map Gene to Disease8829
BioCentury BCIQNRP1
ClinGenNRP1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8829
Chemical/Pharm GKB GenePA31783
Clinical trialNRP1
Miscellaneous
canSAR (ICR)NRP1 (select the gene name)
Probes
Litterature
PubMed239 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNRP1
EVEXNRP1
GoPubMedNRP1
iHOPNRP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:47:27 CEST 2017

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