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NRP2 (neuropilin 2)

Identity

Alias_symbol (synonym)VEGF165R2
Other aliasNP2
NPN2
PRO2714
HGNC (Hugo) NRP2
LocusID (NCBI) 8828
Atlas_Id 41583
Location 2q33.3  [Link to chromosome band 2q33]
Location_base_pair Starts at 205682500 and ends at 205798133 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
IER2 (19p13.2) / NRP2 (2q33.3)NRP2 (2q33.3) / PARD3B (2q33.3)NRP2 2q33.3 / PARD3B 2q33.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  NRP2/PARD3B (2q33)

External links

Nomenclature
HGNC (Hugo)NRP2   8005
Cards
Entrez_Gene (NCBI)NRP2  8828  neuropilin 2
AliasesNP2; NPN2; PRO2714; VEGF165R2
GeneCards (Weizmann)NRP2
Ensembl hg19 (Hinxton)ENSG00000118257 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000118257 [Gene_View]  ENSG00000118257 [Sequence]  chr2:205682500-205798133 [Contig_View]  NRP2 [Vega]
ICGC DataPortalENSG00000118257
TCGA cBioPortalNRP2
AceView (NCBI)NRP2
Genatlas (Paris)NRP2
WikiGenes8828
SOURCE (Princeton)NRP2
Genetics Home Reference (NIH)NRP2
Genomic and cartography
GoldenPath hg38 (UCSC)NRP2  -     chr2:205682500-205798133 +  2q33.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NRP2  -     2q33.3   [Description]    (hg19-Feb_2009)
EnsemblNRP2 - 2q33.3 [CytoView hg19]  NRP2 - 2q33.3 [CytoView hg38]
Mapping of homologs : NCBINRP2 [Mapview hg19]  NRP2 [Mapview hg38]
OMIM602070   
Gene and transcription
Genbank (Entrez)AF016098 AF022859 AF022860 AF119893 AF280544
RefSeq transcript (Entrez)NM_003872 NM_018534 NM_201264 NM_201266 NM_201267 NM_201279
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NRP2
Cluster EST : UnigeneHs.660596 [ NCBI ]
CGAP (NCI)Hs.660596
Alternative Splicing GalleryENSG00000118257
Gene ExpressionNRP2 [ NCBI-GEO ]   NRP2 [ EBI - ARRAY_EXPRESS ]   NRP2 [ SEEK ]   NRP2 [ MEM ]
Gene Expression Viewer (FireBrowse)NRP2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8828
GTEX Portal (Tissue expression)NRP2
Human Protein AtlasENSG00000118257-NRP2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO60462   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO60462  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO60462
Splice isoforms : SwissVarO60462
PhosPhoSitePlusO60462
Domaine pattern : Prosite (Expaxy)CUB (PS01180)    FA58C_1 (PS01285)    FA58C_2 (PS01286)    FA58C_3 (PS50022)    MAM_2 (PS50060)   
Domains : Interpro (EBI)ConA-like_dom_sf    CUB_dom    FA58C    Galactose-bd-like_sf    MAM_dom    Neuropilin    Neuropilin-2    Neuropilin_C    Sperma_CUB_dom_sf   
Domain families : Pfam (Sanger)CUB (PF00431)    DUF3481 (PF11980)    F5_F8_type_C (PF00754)    MAM (PF00629)   
Domain families : Pfam (NCBI)pfam00431    pfam11980    pfam00754    pfam00629   
Domain families : Smart (EMBL)CUB (SM00042)  FA58C (SM00231)  MAM (SM00137)  
Conserved Domain (NCBI)NRP2
DMDM Disease mutations8828
Blocks (Seattle)NRP2
PDB (SRS)2QQJ    2QQK    2QQL    2QQO    4QDQ    4QDR    4QDS    5DN2    5DQ0   
PDB (PDBSum)2QQJ    2QQK    2QQL    2QQO    4QDQ    4QDR    4QDS    5DN2    5DQ0   
PDB (IMB)2QQJ    2QQK    2QQL    2QQO    4QDQ    4QDR    4QDS    5DN2    5DQ0   
PDB (RSDB)2QQJ    2QQK    2QQL    2QQO    4QDQ    4QDR    4QDS    5DN2    5DQ0   
Structural Biology KnowledgeBase2QQJ    2QQK    2QQL    2QQO    4QDQ    4QDR    4QDS    5DN2    5DQ0   
SCOP (Structural Classification of Proteins)2QQJ    2QQK    2QQL    2QQO    4QDQ    4QDR    4QDS    5DN2    5DQ0   
CATH (Classification of proteins structures)2QQJ    2QQK    2QQL    2QQO    4QDQ    4QDR    4QDS    5DN2    5DQ0   
SuperfamilyO60462
Human Protein Atlas [tissue]ENSG00000118257-NRP2 [tissue]
Peptide AtlasO60462
HPRD03643
IPIIPI00029693   IPI00914842   IPI00218781   IPI00300891   IPI00300890   IPI01013755   IPI01011597   IPI00062784   IPI00032001   IPI00980885   IPI00398766   IPI00927187   
Protein Interaction databases
DIP (DOE-UCLA)O60462
IntAct (EBI)O60462
FunCoupENSG00000118257
BioGRIDNRP2
STRING (EMBL)NRP2
ZODIACNRP2
Ontologies - Pathways
QuickGOO60462
Ontology : AmiGOangiogenesis  positive regulation of endothelial cell proliferation  semaphorin receptor complex  outflow tract septum morphogenesis  vascular endothelial growth factor-activated receptor activity  protein binding  extracellular region  plasma membrane  cell adhesion  axon guidance  heparin binding  positive regulation of endothelial cell migration  membrane  integral component of membrane  semaphorin receptor activity  growth factor binding  cytokine binding  nerve development  signaling receptor activity  vascular endothelial growth factor signaling pathway  metal ion binding  vascular endothelial growth factor receptor signaling pathway  axon extension involved in axon guidance  sympathetic ganglion development  sympathetic neuron projection extension  sympathetic neuron projection guidance  semaphorin-plexin signaling pathway involved in neuron projection guidance  
Ontology : EGO-EBIangiogenesis  positive regulation of endothelial cell proliferation  semaphorin receptor complex  outflow tract septum morphogenesis  vascular endothelial growth factor-activated receptor activity  protein binding  extracellular region  plasma membrane  cell adhesion  axon guidance  heparin binding  positive regulation of endothelial cell migration  membrane  integral component of membrane  semaphorin receptor activity  growth factor binding  cytokine binding  nerve development  signaling receptor activity  vascular endothelial growth factor signaling pathway  metal ion binding  vascular endothelial growth factor receptor signaling pathway  axon extension involved in axon guidance  sympathetic ganglion development  sympathetic neuron projection extension  sympathetic neuron projection guidance  semaphorin-plexin signaling pathway involved in neuron projection guidance  
NDEx NetworkNRP2
Atlas of Cancer Signalling NetworkNRP2
Wikipedia pathwaysNRP2
Orthology - Evolution
OrthoDB8828
GeneTree (enSembl)ENSG00000118257
Phylogenetic Trees/Animal Genes : TreeFamNRP2
HOVERGENO60462
HOGENOMO60462
Homologs : HomoloGeneNRP2
Homology/Alignments : Family Browser (UCSC)NRP2
Gene fusions - Rearrangements
Fusion : MitelmanNRP2/PARD3B [2q33.3/2q33.3]  
Fusion PortalNRP2 2q33.3 PARD3B 2q33.3 BRCA HNSC
Fusion : QuiverNRP2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNRP2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NRP2
dbVarNRP2
ClinVarNRP2
1000_GenomesNRP2 
Exome Variant ServerNRP2
ExAC (Exome Aggregation Consortium)ENSG00000118257
GNOMAD BrowserENSG00000118257
Varsome BrowserNRP2
Genetic variants : HAPMAP8828
Genomic Variants (DGV)NRP2 [DGVbeta]
DECIPHERNRP2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNRP2 
Mutations
ICGC Data PortalNRP2 
TCGA Data PortalNRP2 
Broad Tumor PortalNRP2
OASIS PortalNRP2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNRP2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNRP2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NRP2
DgiDB (Drug Gene Interaction Database)NRP2
DoCM (Curated mutations)NRP2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NRP2 (select a term)
intoGenNRP2
Cancer3DNRP2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602070   
Orphanet
DisGeNETNRP2
MedgenNRP2
Genetic Testing Registry NRP2
NextProtO60462 [Medical]
TSGene8828
GENETestsNRP2
Target ValidationNRP2
Huge Navigator NRP2 [HugePedia]
snp3D : Map Gene to Disease8828
BioCentury BCIQNRP2
ClinGenNRP2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8828
Chemical/Pharm GKB GenePA31784
Clinical trialNRP2
Miscellaneous
canSAR (ICR)NRP2 (select the gene name)
Probes
Litterature
PubMed108 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNRP2
EVEXNRP2
GoPubMedNRP2
iHOPNRP2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Aug 27 11:41:31 CEST 2018
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