NRP2 (neuropilin 2)

2004-02-01 Affiliation

Identity

HGNC

NRP2

LOCATION

2q33.3

LOCUSID

8828

ALIAS

NP2,NPN2,PRO2714,VEGF165R2

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 8828
MIM: 602070
HGNC: 8005
Ensembl: ENSG00000118257

Variants:

dbSNP: 8828
ClinVar: 8828
TCGA: ENSG00000118257
COSMIC: NRP2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000118257	ENST00000272849	O60462
ENSG00000118257	ENST00000357118	O60462
ENSG00000118257	ENST00000357785	O60462
ENSG00000118257	ENST00000360409	O60462
ENSG00000118257	ENST00000412873	O60462
ENSG00000118257	ENST00000417189	O60462
ENSG00000118257	ENST00000450507	C9JH98

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Signal Transduction	REACTOME	R-HSA-162582
Signaling by VEGF	REACTOME	R-HSA-194138
Neurophilin interactions with VEGF and VEGFR	REACTOME	R-HSA-194306
Developmental Biology	REACTOME	R-HSA-1266738
Axon guidance	REACTOME	R-HSA-422475
L1CAM interactions	REACTOME	R-HSA-373760
NrCAM interactions	REACTOME	R-HSA-447038

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA443937	Drug Toxicity	Disease	ClinicalAnnotation	associated	PK	PD	18451141
PA449212	daunorubicin	Chemical	ClinicalAnnotation	associated	PK	PD	18451141

References

Pubmed ID	Year	Title	Citations
16621967	2006	Neuropilin-2 interacts with VEGFR-2 and VEGFR-3 and promotes human endothelial cell survival and migration.	101
16816121	2006	Functional interaction of VEGF-C and VEGF-D with neuropilin receptors.	100
17699524	2007	Polysialylated neuropilin-2 is expressed on the surface of human dendritic cells and modulates dendritic cell-T lymphocyte interactions.	64
18182619	2008	Therapeutic targeting of neuropilin-2 on colorectal carcinoma cells implanted in the murine liver.	63
23436775	2013	GLI1 regulates a novel neuropilin-2/α6β1 integrin based autocrine pathway that contributes to breast cancer initiation.	63
18065694	2008	Neuropilin-1 and neuropilin-2 act as coreceptors, potentiating proangiogenic activity.	55
19580679	2009	Neuropilin-2 expression in breast cancer: correlation with lymph node metastasis, poor prognosis, and regulation of CXCR4 expression.	38
30057110	2018	An Unbiased Screen for Human Cytomegalovirus Identifies Neuropilin-2 as a Central Viral Receptor.	36
22777769	2012	VEGF/neuropilin-2 regulation of Bmi-1 and consequent repression of IGF-IR define a novel mechanism of aggressive prostate cancer.	34
19088020	2008	Neuropilin-2-mediated tumor growth and angiogenesis in pancreatic adenocarcinoma.	33

Citation

Dessen P

NRP2 (neuropilin 2)

Atlas Genet Cytogenet Oncol Haematol. 2004-02-01

Online version: http://atlasgeneticsoncology.org/gene/41583/nrp2