Atlas of Genetics and Cytogenetics in Oncology and Haematology


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NRXN2 (neurexin 2)

Identity

Alias (NCBI)-
HGNC (Hugo) NRXN2
HGNC Alias nameneurexin II
LocusID (NCBI) 9379
Atlas_Id 70978
Location 11q13.1  [Link to chromosome band 11q13]
Location_base_pair Starts at 64606174 and ends at 64643545 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ABL1 (9q34.12) / NRXN2 (11q13.1)DPY19L1 (7p14.3) / NRXN2 (11q13.1)INSR (19p13.2) / NRXN2 (11q13.1)
MACROD1 (11q13.1) / NRXN2 (11q13.1)NRXN2 (11q13.1) / ABL1 (9q34.12)NRXN2 (11q13.1) / GIT1 (17q11.2)
MACROD1 NRXN2DPY19L1 NRXN2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)NRXN2   8009
Cards
Entrez_Gene (NCBI)NRXN2    neurexin 2
Aliases
GeneCards (Weizmann)NRXN2
Ensembl hg19 (Hinxton)ENSG00000110076 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000110076 [Gene_View]  ENSG00000110076 [Sequence]  chr11:64606174-64643545 [Contig_View]  NRXN2 [Vega]
ICGC DataPortalENSG00000110076
TCGA cBioPortalNRXN2
AceView (NCBI)NRXN2
Genatlas (Paris)NRXN2
SOURCE (Princeton)NRXN2
Genetics Home Reference (NIH)NRXN2
Genomic and cartography
GoldenPath hg38 (UCSC)NRXN2  -     chr11:64606174-64643545 -  11q13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NRXN2  -     11q13.1   [Description]    (hg19-Feb_2009)
GoldenPathNRXN2 - 11q13.1 [CytoView hg19]  NRXN2 - 11q13.1 [CytoView hg38]
ImmunoBaseENSG00000110076
Genome Data Viewer NCBINRXN2 [Mapview hg19]  
OMIM600566   
Gene and transcription
Genbank (Entrez)AB023138 AB035266 AB177862 AK098211 BC150275
RefSeq transcript (Entrez)NM_001376262 NM_001376263 NM_001376265 NM_001376266 NM_001376267 NM_015080 NM_138732 NM_138734
Consensus coding sequences : CCDS (NCBI)NRXN2
Gene ExpressionNRXN2 [ NCBI-GEO ]   NRXN2 [ EBI - ARRAY_EXPRESS ]   NRXN2 [ SEEK ]   NRXN2 [ MEM ]
Gene Expression Viewer (FireBrowse)NRXN2 [ Firebrowse - Broad ]
GenevisibleExpression of NRXN2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9379
GTEX Portal (Tissue expression)NRXN2
Human Protein AtlasENSG00000110076-NRXN2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9P2S2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9P2S2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9P2S2
PhosPhoSitePlusQ9P2S2
Domaine pattern : Prosite (Expaxy)EGF_3 (PS50026)    LAM_G_DOMAIN (PS50025)   
Domains : Interpro (EBI)ConA-like_dom_sf    EGF-like_dom    Laminin_G    Neurexin-like   
Domain families : Pfam (Sanger)Laminin_G_2 (PF02210)   
Domain families : Pfam (NCBI)pfam02210   
Domain families : Smart (EMBL)4.1m (SM00294)  EGF (SM00181)  LamG (SM00282)  
Conserved Domain (NCBI)NRXN2
SuperfamilyQ9P2S2
AlphaFold pdb e-kbQ9P2S2   
Human Protein Atlas [tissue]ENSG00000110076-NRXN2 [tissue]
HPRD11859
Protein Interaction databases
DIP (DOE-UCLA)Q9P2S2
IntAct (EBI)Q9P2S2
BioGRIDNRXN2
STRING (EMBL)NRXN2
ZODIACNRXN2
Ontologies - Pathways
QuickGOQ9P2S2
Ontology : AmiGOtransmembrane signaling receptor activity  calcium channel regulator activity  plasma membrane  neuron cell-cell adhesion  signal transduction  chemical synaptic transmission  neurotransmitter secretion  synapse assembly  integral component of membrane  adult behavior  protein-containing complex  social behavior  vocal learning  metal ion binding  cell adhesion molecule binding  vocalization behavior  postsynaptic membrane assembly  neuroligin family protein binding  gephyrin clustering involved in postsynaptic density assembly  neuroligin clustering involved in postsynaptic membrane assembly  postsynaptic density protein 95 clustering  presynapse  
Ontology : EGO-EBItransmembrane signaling receptor activity  calcium channel regulator activity  plasma membrane  neuron cell-cell adhesion  signal transduction  chemical synaptic transmission  neurotransmitter secretion  synapse assembly  integral component of membrane  adult behavior  protein-containing complex  social behavior  vocal learning  metal ion binding  cell adhesion molecule binding  vocalization behavior  postsynaptic membrane assembly  neuroligin family protein binding  gephyrin clustering involved in postsynaptic density assembly  neuroligin clustering involved in postsynaptic membrane assembly  postsynaptic density protein 95 clustering  presynapse  
Pathways : KEGGCell adhesion molecules (CAMs)   
NDEx NetworkNRXN2
Atlas of Cancer Signalling NetworkNRXN2
Wikipedia pathwaysNRXN2
Orthology - Evolution
OrthoDB9379
GeneTree (enSembl)ENSG00000110076
Phylogenetic Trees/Animal Genes : TreeFamNRXN2
Homologs : HomoloGeneNRXN2
Homology/Alignments : Family Browser (UCSC)NRXN2
Gene fusions - Rearrangements
Fusion : QuiverNRXN2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNRXN2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NRXN2
dbVarNRXN2
ClinVarNRXN2
MonarchNRXN2
1000_GenomesNRXN2 
Exome Variant ServerNRXN2
GNOMAD BrowserENSG00000110076
Varsome BrowserNRXN2
ACMGNRXN2 variants
VarityQ9P2S2
Genomic Variants (DGV)NRXN2 [DGVbeta]
DECIPHERNRXN2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNRXN2 
Mutations
ICGC Data PortalNRXN2 
TCGA Data PortalNRXN2 
Broad Tumor PortalNRXN2
OASIS PortalNRXN2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNRXN2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNRXN2
Mutations and Diseases : HGMDNRXN2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaNRXN2
DgiDB (Drug Gene Interaction Database)NRXN2
DoCM (Curated mutations)NRXN2
CIViC (Clinical Interpretations of Variants in Cancer)NRXN2
Cancer3DNRXN2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600566   
Orphanet
DisGeNETNRXN2
MedgenNRXN2
Genetic Testing Registry NRXN2
NextProtQ9P2S2 [Medical]
GENETestsNRXN2
Target ValidationNRXN2
Huge Navigator NRXN2 [HugePedia]
ClinGenNRXN2
Clinical trials, drugs, therapy
MyCancerGenomeNRXN2
Protein Interactions : CTDNRXN2
Pharm GKB GenePA31787
PharosQ9P2S2
Clinical trialNRXN2
Miscellaneous
canSAR (ICR)NRXN2
HarmonizomeNRXN2
DataMed IndexNRXN2
Probes
Litterature
PubMed33 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXNRXN2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 16:13:10 CEST 2021

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