Atlas of Genetics and Cytogenetics in Oncology and Haematology


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NRXN2 (neurexin 2)

Identity

Other alias-
HGNC (Hugo) NRXN2
LocusID (NCBI) 9379
Atlas_Id 70978
Location 11q13.1  [Link to chromosome band 11q13]
Location_base_pair Starts at 64606174 and ends at 64723188 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ABL1 (9q34.12) / NRXN2 (11q13.1)DPY19L1 (7p14.3) / NRXN2 (11q13.1)INSR (19p13.2) / NRXN2 (11q13.1)
MACROD1 (11q13.1) / NRXN2 (11q13.1)NRXN2 (11q13.1) / ABL1 (9q34.12)NRXN2 (11q13.1) / GIT1 (17q11.2)
MACROD1 NRXN2DPY19L1 NRXN2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NRXN2   8009
Cards
Entrez_Gene (NCBI)NRXN2  9379  neurexin 2
Aliases
GeneCards (Weizmann)NRXN2
Ensembl hg19 (Hinxton)ENSG00000110076 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000110076 [Gene_View]  chr11:64606174-64723188 [Contig_View]  NRXN2 [Vega]
ICGC DataPortalENSG00000110076
TCGA cBioPortalNRXN2
AceView (NCBI)NRXN2
Genatlas (Paris)NRXN2
WikiGenes9379
SOURCE (Princeton)NRXN2
Genetics Home Reference (NIH)NRXN2
Genomic and cartography
GoldenPath hg38 (UCSC)NRXN2  -     chr11:64606174-64723188 -  11q13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NRXN2  -     11q13.1   [Description]    (hg19-Feb_2009)
EnsemblNRXN2 - 11q13.1 [CytoView hg19]  NRXN2 - 11q13.1 [CytoView hg38]
Mapping of homologs : NCBINRXN2 [Mapview hg19]  NRXN2 [Mapview hg38]
OMIM600566   
Gene and transcription
Genbank (Entrez)AB023138 AB035266 AB177862 AK098211 BC150275
RefSeq transcript (Entrez)NM_015080 NM_138732 NM_138734
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NRXN2
Cluster EST : UnigeneHs.372938 [ NCBI ]
CGAP (NCI)Hs.372938
Alternative Splicing GalleryENSG00000110076
Gene ExpressionNRXN2 [ NCBI-GEO ]   NRXN2 [ EBI - ARRAY_EXPRESS ]   NRXN2 [ SEEK ]   NRXN2 [ MEM ]
Gene Expression Viewer (FireBrowse)NRXN2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9379
GTEX Portal (Tissue expression)NRXN2
Human Protein AtlasENSG00000110076-NRXN2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9P2S2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9P2S2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9P2S2
Splice isoforms : SwissVarQ9P2S2
PhosPhoSitePlusQ9P2S2
Domaine pattern : Prosite (Expaxy)EGF_3 (PS50026)    LAM_G_DOMAIN (PS50025)   
Domains : Interpro (EBI)ConA-like_dom    EGF-like_dom    Laminin_G    Neurexin-like    NRXN2    Syndecan/Neurexin_dom   
Domain families : Pfam (Sanger)Laminin_G_2 (PF02210)    Syndecan (PF01034)   
Domain families : Pfam (NCBI)pfam02210    pfam01034   
Domain families : Smart (EMBL)4.1m (SM00294)  EGF (SM00181)  LamG (SM00282)  
Conserved Domain (NCBI)NRXN2
DMDM Disease mutations9379
Blocks (Seattle)NRXN2
SuperfamilyQ9P2S2
Human Protein Atlas [tissue]ENSG00000110076-NRXN2 [tissue]
Peptide AtlasQ9P2S2
HPRD11859
IPIIPI00428732   IPI00007921   IPI00185612   IPI00873833   IPI00657653   IPI00879594   IPI00879745   IPI00879309   IPI00916106   
Protein Interaction databases
DIP (DOE-UCLA)Q9P2S2
IntAct (EBI)Q9P2S2
FunCoupENSG00000110076
BioGRIDNRXN2
STRING (EMBL)NRXN2
ZODIACNRXN2
Ontologies - Pathways
QuickGOQ9P2S2
Ontology : AmiGOtransmembrane signaling receptor activity  calcium channel regulator activity  plasma membrane  neuron cell-cell adhesion  signal transduction  chemical synaptic transmission  neurotransmitter secretion  synapse assembly  integral component of membrane  adult behavior  social behavior  vocal learning  protein complex  metal ion binding  cell adhesion molecule binding  regulation of molecular function  vocalization behavior  postsynaptic membrane assembly  neuroligin family protein binding  gephyrin clustering involved in postsynaptic density assembly  neuroligin clustering involved in postsynaptic membrane assembly  postsynaptic density protein 95 clustering  presynapse  
Ontology : EGO-EBItransmembrane signaling receptor activity  calcium channel regulator activity  plasma membrane  neuron cell-cell adhesion  signal transduction  chemical synaptic transmission  neurotransmitter secretion  synapse assembly  integral component of membrane  adult behavior  social behavior  vocal learning  protein complex  metal ion binding  cell adhesion molecule binding  regulation of molecular function  vocalization behavior  postsynaptic membrane assembly  neuroligin family protein binding  gephyrin clustering involved in postsynaptic density assembly  neuroligin clustering involved in postsynaptic membrane assembly  postsynaptic density protein 95 clustering  presynapse  
Pathways : KEGGCell adhesion molecules (CAMs)   
NDEx NetworkNRXN2
Atlas of Cancer Signalling NetworkNRXN2
Wikipedia pathwaysNRXN2
Orthology - Evolution
OrthoDB9379
GeneTree (enSembl)ENSG00000110076
Phylogenetic Trees/Animal Genes : TreeFamNRXN2
HOVERGENQ9P2S2
HOGENOMQ9P2S2
Homologs : HomoloGeneNRXN2
Homology/Alignments : Family Browser (UCSC)NRXN2
Gene fusions - Rearrangements
Fusion: TCGAMACROD1 NRXN2
Fusion: TCGADPY19L1 NRXN2
Fusion: Tumor Portal NRXN2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNRXN2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NRXN2
dbVarNRXN2
ClinVarNRXN2
1000_GenomesNRXN2 
Exome Variant ServerNRXN2
ExAC (Exome Aggregation Consortium)ENSG00000110076
GNOMAD BrowserENSG00000110076
Genetic variants : HAPMAP9379
Genomic Variants (DGV)NRXN2 [DGVbeta]
DECIPHERNRXN2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNRXN2 
Mutations
ICGC Data PortalNRXN2 
TCGA Data PortalNRXN2 
Broad Tumor PortalNRXN2
OASIS PortalNRXN2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNRXN2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNRXN2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NRXN2
DgiDB (Drug Gene Interaction Database)NRXN2
DoCM (Curated mutations)NRXN2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NRXN2 (select a term)
intoGenNRXN2
Cancer3DNRXN2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600566   
Orphanet
MedgenNRXN2
Genetic Testing Registry NRXN2
NextProtQ9P2S2 [Medical]
TSGene9379
GENETestsNRXN2
Target ValidationNRXN2
Huge Navigator NRXN2 [HugePedia]
snp3D : Map Gene to Disease9379
BioCentury BCIQNRXN2
ClinGenNRXN2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9379
Chemical/Pharm GKB GenePA31787
Clinical trialNRXN2
Miscellaneous
canSAR (ICR)NRXN2 (select the gene name)
Probes
Litterature
PubMed28 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNRXN2
EVEXNRXN2
GoPubMedNRXN2
iHOPNRXN2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Nov 9 12:19:26 CET 2017

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