Atlas of Genetics and Cytogenetics in Oncology and Haematology


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NRXN3 (neurexin 3)

Identity

Alias_namesC14orf60
chromosome 14 open reading frame 60
Alias_symbol (synonym)KIAA0743
Other alias
HGNC (Hugo) NRXN3
LocusID (NCBI) 9369
Atlas_Id 52734
Location 14q31.1  [Link to chromosome band 14q31]
Location_base_pair Starts at 79279339 and ends at 79868290 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CNIH1 (14q22.2) / NRXN3 (14q31.1)NRXN3 (14q31.1) / FMNL1 (17q21.31)NRXN3 (14q31.1) / KDM3B (5q31.2)
SND1 (7q32.1) / NRXN3 (14q31.1)SOS2 (14q21.3) / NRXN3 (14q31.1)TNFAIP8 (5q23.1) / NRXN3 (14q31.1)
SOS2 14q21.3 / NRXN3 14q31.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NRXN3   8010
Cards
Entrez_Gene (NCBI)NRXN3  9369  neurexin 3
AliasesC14orf60
GeneCards (Weizmann)NRXN3
Ensembl hg19 (Hinxton)ENSG00000021645 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000021645 [Gene_View]  chr14:79279339-79868290 [Contig_View]  NRXN3 [Vega]
ICGC DataPortalENSG00000021645
TCGA cBioPortalNRXN3
AceView (NCBI)NRXN3
Genatlas (Paris)NRXN3
WikiGenes9369
SOURCE (Princeton)NRXN3
Genetics Home Reference (NIH)NRXN3
Genomic and cartography
GoldenPath hg38 (UCSC)NRXN3  -     chr14:79279339-79868290 +  14q31.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NRXN3  -     14q31.1   [Description]    (hg19-Feb_2009)
EnsemblNRXN3 - 14q31.1 [CytoView hg19]  NRXN3 - 14q31.1 [CytoView hg38]
Mapping of homologs : NCBINRXN3 [Mapview hg19]  NRXN3 [Mapview hg38]
OMIM600567   
Gene and transcription
Genbank (Entrez)AB018286 AJ316284 AJ493127 AK056530 AK096247
RefSeq transcript (Entrez)NM_001105250 NM_001272020 NM_001330195 NM_004796 NM_138970
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NRXN3
Cluster EST : UnigeneHs.368307 [ NCBI ]
CGAP (NCI)Hs.368307
Alternative Splicing GalleryENSG00000021645
Gene ExpressionNRXN3 [ NCBI-GEO ]   NRXN3 [ EBI - ARRAY_EXPRESS ]   NRXN3 [ SEEK ]   NRXN3 [ MEM ]
Gene Expression Viewer (FireBrowse)NRXN3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9369
GTEX Portal (Tissue expression)NRXN3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y4C0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y4C0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y4C0
Splice isoforms : SwissVarQ9Y4C0
PhosPhoSitePlusQ9Y4C0
Domaine pattern : Prosite (Expaxy)ASX_HYDROXYL (PS00010)    EGF_3 (PS50026)    LAM_G_DOMAIN (PS50025)   
Domains : Interpro (EBI)ConA-like_dom    EGF-like_dom    EGF-type_Asp/Asn_hydroxyl_site    Laminin_G    Neurexin-like    NRXN3    Syndecan/Neurexin_dom   
Domain families : Pfam (Sanger)EGF (PF00008)    Laminin_G_2 (PF02210)    Syndecan (PF01034)   
Domain families : Pfam (NCBI)pfam00008    pfam02210    pfam01034   
Domain families : Smart (EMBL)4.1m (SM00294)  EGF (SM00181)  LamG (SM00282)  
Conserved Domain (NCBI)NRXN3
DMDM Disease mutations9369
Blocks (Seattle)NRXN3
SuperfamilyQ9Y4C0
Human Protein AtlasENSG00000021645
Peptide AtlasQ9Y4C0
HPRD08989
IPIIPI00034558   IPI00419705   IPI00853624   IPI00414249   IPI00854729   IPI01025492   IPI00216728   IPI00815776   IPI01026280   IPI00915413   IPI01025976   IPI01025370   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y4C0
IntAct (EBI)Q9Y4C0
FunCoupENSG00000021645
BioGRIDNRXN3
STRING (EMBL)NRXN3
ZODIACNRXN3
Ontologies - Pathways
QuickGOQ9Y4C0
Ontology : AmiGOreceptor activity  plasma membrane  integral component of plasma membrane  neuron cell-cell adhesion  neurotransmitter secretion  axon guidance  synapse assembly  learning  adult behavior  social behavior  metal ion binding  cell adhesion molecule binding  positive regulation of synapse assembly  vocalization behavior  positive regulation of synapse maturation  neuroligin family protein binding  presynapse  
Ontology : EGO-EBIreceptor activity  plasma membrane  integral component of plasma membrane  neuron cell-cell adhesion  neurotransmitter secretion  axon guidance  synapse assembly  learning  adult behavior  social behavior  metal ion binding  cell adhesion molecule binding  positive regulation of synapse assembly  vocalization behavior  positive regulation of synapse maturation  neuroligin family protein binding  presynapse  
Pathways : BIOCARTASynaptic Proteins at the Synaptic Junction [Genes]   
Pathways : KEGGCell adhesion molecules (CAMs)   
NDEx NetworkNRXN3
Atlas of Cancer Signalling NetworkNRXN3
Wikipedia pathwaysNRXN3
Orthology - Evolution
OrthoDB9369
GeneTree (enSembl)ENSG00000021645
Phylogenetic Trees/Animal Genes : TreeFamNRXN3
HOVERGENQ9Y4C0
HOGENOMQ9Y4C0
Homologs : HomoloGeneNRXN3
Homology/Alignments : Family Browser (UCSC)NRXN3
Gene fusions - Rearrangements
Fusion : MitelmanSOS2/NRXN3 [14q21.3/14q31.1]  [t(14;14)(q21;q24)]  
Fusion: TCGASOS2 14q21.3 NRXN3 14q31.1 SKCM
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNRXN3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NRXN3
dbVarNRXN3
ClinVarNRXN3
1000_GenomesNRXN3 
Exome Variant ServerNRXN3
ExAC (Exome Aggregation Consortium)NRXN3 (select the gene name)
Genetic variants : HAPMAP9369
Genomic Variants (DGV)NRXN3 [DGVbeta]
DECIPHERNRXN3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNRXN3 
Mutations
ICGC Data PortalNRXN3 
TCGA Data PortalNRXN3 
Broad Tumor PortalNRXN3
OASIS PortalNRXN3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNRXN3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNRXN3
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NRXN3
DgiDB (Drug Gene Interaction Database)NRXN3
DoCM (Curated mutations)NRXN3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NRXN3 (select a term)
intoGenNRXN3
Cancer3DNRXN3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600567   
Orphanet
MedgenNRXN3
Genetic Testing Registry NRXN3
NextProtQ9Y4C0 [Medical]
TSGene9369
GENETestsNRXN3
Target ValidationNRXN3
Huge Navigator NRXN3 [HugePedia]
snp3D : Map Gene to Disease9369
BioCentury BCIQNRXN3
ClinGenNRXN3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9369
Chemical/Pharm GKB GenePA31788
Clinical trialNRXN3
Miscellaneous
canSAR (ICR)NRXN3 (select the gene name)
Probes
Litterature
PubMed57 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNRXN3
EVEXNRXN3
GoPubMedNRXN3
iHOPNRXN3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:47:28 CEST 2017

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