NSFL1C (NSFL1 cofactor)

2016-10-01  

Identity

HGNC
LOCATION
20p13
LOCUSID
ALIAS
P47,UBX1,UBXD10,UBXN2C,dJ776F14.1
FUSION GENES

Other Information

Locus ID:

NCBI: 55968
MIM: 606610
HGNC: 15912
Ensembl: ENSG00000088833

Variants:

dbSNP: 55968
ClinVar: 55968
TCGA: ENSG00000088833
COSMIC: NSFL1C

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000088833ENST00000216879Q9UNZ2
ENSG00000088833ENST00000353088Q9UNZ2
ENSG00000088833ENST00000381653F2Z2K0
ENSG00000088833ENST00000470376R4GMY2
ENSG00000088833ENST00000476071Q9UNZ2
ENSG00000088833ENST00000489203R4GNE6
ENSG00000088833ENST00000555568G3V4V8
ENSG00000088833ENST00000555944G3V4V8

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
191655272009Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia.56
229908572012p47 negatively regulates IKK activation by inducing the lysosomal degradation of polyubiquitinated NEMO.22
236498072013The UBXN-2/p37/p47 adaptors of CDC-48/p97 regulate mitosis by limiting the centrosomal recruitment of Aurora A.10
246126792014Brain-derived neurotrophic factor promotes angiogenic tube formation through generation of oxidative stress in human vascular endothelial cells.9
277857012017The opposite role of two UBA-UBX containing proteins, p47 and SAKS1 in the degradation of a single ERAD substrate, α-TCR.3

Citation

Dessen P

NSFL1C (NSFL1 cofactor)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56008/nsfl1c