NSMCE2 (NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase)

2007-02-01  

Identity

HGNC
LOCATION
8q24.13
LOCUSID
ALIAS
C8orf36,MMS21,NSE2,ZMIZ7
FUSION GENES

Other Information

Locus ID:

NCBI: 286053
MIM: 617246
HGNC: 26513
Ensembl: ENSG00000156831

Variants:

dbSNP: 286053
ClinVar: 286053
TCGA: ENSG00000156831
COSMIC: NSMCE2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000156831ENST00000287437Q96MF7
ENSG00000156831ENST00000287437A0A024R9J6
ENSG00000156831ENST00000517315E5RFJ1
ENSG00000156831ENST00000517532E5RHW9
ENSG00000156831ENST00000518013E5RK09
ENSG00000156831ENST00000518146E5RG00
ENSG00000156831ENST00000519010A0A087WTZ8
ENSG00000156831ENST00000519712H0YB96
ENSG00000156831ENST00000520866A0A087WTZ8
ENSG00000156831ENST00000522563Q96MF7
ENSG00000156831ENST00000522563A0A024R9J6
ENSG00000156831ENST00000523741E5RIM1

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
SUMOylationREACTOMER-HSA-2990846
SUMO E3 ligases SUMOylate target proteinsREACTOMER-HSA-3108232
SUMOylation of DNA damage response and repair proteinsREACTOMER-HSA-3108214

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
160557142005Human MMS21/NSE2 is a SUMO ligase required for DNA repair.87
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
227515012012Scc1 sumoylation by Mms21 promotes sister chromatid recombination through counteracting Wapl.40
195498072009Prostate cancer risk associated loci in African Americans.37
204604802010Susceptibility loci associated with prostate cancer progression and mortality.30
215503422011The Nse2/Mms21 SUMO ligase of the Smc5/6 complex in the maintenance of genome stability.22
2524598420148q24 amplified segments involve novel fusion genes between NSMCE2 and long noncoding RNAs in acute myelogenous leukemia.15
195027852009SMC5 and MMS21 are required for chromosome cohesion and mitotic progression.13
181633892008Family-based SNP association study on 8q24 in bipolar disorder.12
277921892016Non-SMC Element 2 (NSMCE2) of the SMC5/6 Complex Helps to Resolve Topological Stress.11

Citation

Dessen P

NSMCE2 (NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43647/nsmce2