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NSMCE4A (NSE4 homolog A, SMC5-SMC6 complex component)

Identity

Alias_namesC10orf86
chromosome 10 open reading frame 86
non-SMC element 4 homolog A (S. cerevisiae)
NSE4 homolog, SMC5-SMC6 complex component A
Alias_symbol (synonym)FLJ20003
bA500G22.3
NSE4A
Other aliasNS4EA
HGNC (Hugo) NSMCE4A
LocusID (NCBI) 54780
Atlas_Id 52754
Location 10q26.13  [Link to chromosome band 10q26]
Location_base_pair Starts at 121957088 and ends at 121975228 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ZMIZ1 (10q22.3) / NSMCE4A (10q26.13)ZMIZ1 10q22.3 / NSMCE4A 10q26.13

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NSMCE4A   25935
Cards
Entrez_Gene (NCBI)NSMCE4A  54780  NSE4 homolog A, SMC5-SMC6 complex component
AliasesC10orf86; NS4EA; NSE4A
GeneCards (Weizmann)NSMCE4A
Ensembl hg19 (Hinxton)ENSG00000107672 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000107672 [Gene_View]  chr10:121957088-121975228 [Contig_View]  NSMCE4A [Vega]
ICGC DataPortalENSG00000107672
TCGA cBioPortalNSMCE4A
AceView (NCBI)NSMCE4A
Genatlas (Paris)NSMCE4A
WikiGenes54780
SOURCE (Princeton)NSMCE4A
Genetics Home Reference (NIH)NSMCE4A
Genomic and cartography
GoldenPath hg38 (UCSC)NSMCE4A  -     chr10:121957088-121975228 -  10q26.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NSMCE4A  -     10q26.13   [Description]    (hg19-Feb_2009)
EnsemblNSMCE4A - 10q26.13 [CytoView hg19]  NSMCE4A - 10q26.13 [CytoView hg38]
Mapping of homologs : NCBINSMCE4A [Mapview hg19]  NSMCE4A [Mapview hg38]
OMIM612987   
Gene and transcription
Genbank (Entrez)AF258584 AK000010 AK056579 AK222487 AK301658
RefSeq transcript (Entrez)NM_001167865 NM_017615
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NSMCE4A
Cluster EST : UnigeneHs.258798 [ NCBI ]
CGAP (NCI)Hs.258798
Alternative Splicing GalleryENSG00000107672
Gene ExpressionNSMCE4A [ NCBI-GEO ]   NSMCE4A [ EBI - ARRAY_EXPRESS ]   NSMCE4A [ SEEK ]   NSMCE4A [ MEM ]
Gene Expression Viewer (FireBrowse)NSMCE4A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54780
GTEX Portal (Tissue expression)NSMCE4A
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NXX6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NXX6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NXX6
Splice isoforms : SwissVarQ9NXX6
PhosPhoSitePlusQ9NXX6
Domains : Interpro (EBI)Nse4/EID    Nse4_C    Nse4_Nse3-bd   
Domain families : Pfam (Sanger)Nse4-Nse3_bdg (PF15412)    Nse4_C (PF08743)   
Domain families : Pfam (NCBI)pfam15412    pfam08743   
Conserved Domain (NCBI)NSMCE4A
DMDM Disease mutations54780
Blocks (Seattle)NSMCE4A
SuperfamilyQ9NXX6
Human Protein AtlasENSG00000107672
Peptide AtlasQ9NXX6
HPRD16585
IPIIPI00014367   IPI00029356   IPI00954487   
Protein Interaction databases
DIP (DOE-UCLA)Q9NXX6
IntAct (EBI)Q9NXX6
FunCoupENSG00000107672
BioGRIDNSMCE4A
STRING (EMBL)NSMCE4A
ZODIACNSMCE4A
Ontologies - Pathways
QuickGOQ9NXX6
Ontology : AmiGOchromosome, telomeric region  protein binding  nucleoplasm  nucleoplasm  DNA repair  DNA recombination  nuclear body  Smc5-Smc6 complex  positive regulation of response to DNA damage stimulus  
Ontology : EGO-EBIchromosome, telomeric region  protein binding  nucleoplasm  nucleoplasm  DNA repair  DNA recombination  nuclear body  Smc5-Smc6 complex  positive regulation of response to DNA damage stimulus  
NDEx NetworkNSMCE4A
Atlas of Cancer Signalling NetworkNSMCE4A
Wikipedia pathwaysNSMCE4A
Orthology - Evolution
OrthoDB54780
GeneTree (enSembl)ENSG00000107672
Phylogenetic Trees/Animal Genes : TreeFamNSMCE4A
HOVERGENQ9NXX6
HOGENOMQ9NXX6
Homologs : HomoloGeneNSMCE4A
Homology/Alignments : Family Browser (UCSC)NSMCE4A
Gene fusions - Rearrangements
Fusion : MitelmanZMIZ1/NSMCE4A [10q22.3/10q26.13]  [t(10;10)(q22;q26)]  
Fusion: TCGAZMIZ1 10q22.3 NSMCE4A 10q26.13 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNSMCE4A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NSMCE4A
dbVarNSMCE4A
ClinVarNSMCE4A
1000_GenomesNSMCE4A 
Exome Variant ServerNSMCE4A
ExAC (Exome Aggregation Consortium)NSMCE4A (select the gene name)
Genetic variants : HAPMAP54780
Genomic Variants (DGV)NSMCE4A [DGVbeta]
DECIPHERNSMCE4A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNSMCE4A 
Mutations
ICGC Data PortalNSMCE4A 
TCGA Data PortalNSMCE4A 
Broad Tumor PortalNSMCE4A
OASIS PortalNSMCE4A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNSMCE4A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNSMCE4A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NSMCE4A
DgiDB (Drug Gene Interaction Database)NSMCE4A
DoCM (Curated mutations)NSMCE4A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NSMCE4A (select a term)
intoGenNSMCE4A
Cancer3DNSMCE4A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612987   
Orphanet
MedgenNSMCE4A
Genetic Testing Registry NSMCE4A
NextProtQ9NXX6 [Medical]
TSGene54780
GENETestsNSMCE4A
Huge Navigator NSMCE4A [HugePedia]
snp3D : Map Gene to Disease54780
BioCentury BCIQNSMCE4A
ClinGenNSMCE4A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD54780
Chemical/Pharm GKB GenePA162398205
Clinical trialNSMCE4A
Miscellaneous
canSAR (ICR)NSMCE4A (select the gene name)
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNSMCE4A
EVEXNSMCE4A
GoPubMedNSMCE4A
iHOPNSMCE4A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:29:17 CEST 2017

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