Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

NSUN2 (NOP2/Sun RNA methyltransferase 2)

Identity

Alias (NCBI)MISU
MRT5
SAKI
TRM4
HGNC (Hugo) NSUN2
HGNC Alias symbFLJ20303
TRM4
Misu
HGNC Alias nametRNA methyltransferase 4 homolog (S. cerevisiae)
 Myc-induced SUN-domain-containing protein
HGNC Previous nameMRT5
HGNC Previous nameNOL1/NOP2/Sun domain family, member 2
 NOP2/Sun domain family, member 2
 mental retardation, non-syndromic, autosomal recessive, 5
LocusID (NCBI) 54888
Atlas_Id 40599
Location 5p15.31  [Link to chromosome band 5p15]
Location_base_pair Starts at 6599239 and ends at 6633044 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
A2M (12p13.31) / NSUN2 (5p15.31)NSUN2 (5p15.31) / NSUN2 (5p15.31)NSUN2 (5p15.31) / SLC25A39 (17q21.31)
NSUN2 (5p15.31) / SOCS3 (17q25.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)NSUN2   25994
Cards
Entrez_Gene (NCBI)NSUN2    NOP2/Sun RNA methyltransferase 2
AliasesMISU; MRT5; SAKI; TRM4
GeneCards (Weizmann)NSUN2
Ensembl hg19 (Hinxton)ENSG00000037474 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000037474 [Gene_View]  ENSG00000037474 [Sequence]  chr5:6599239-6633044 [Contig_View]  NSUN2 [Vega]
ICGC DataPortalENSG00000037474
TCGA cBioPortalNSUN2
AceView (NCBI)NSUN2
Genatlas (Paris)NSUN2
SOURCE (Princeton)NSUN2
Genetics Home Reference (NIH)NSUN2
Genomic and cartography
GoldenPath hg38 (UCSC)NSUN2  -     chr5:6599239-6633044 -  5p15.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NSUN2  -     5p15.31   [Description]    (hg19-Feb_2009)
GoldenPathNSUN2 - 5p15.31 [CytoView hg19]  NSUN2 - 5p15.31 [CytoView hg38]
ImmunoBaseENSG00000037474
Genome Data Viewer NCBINSUN2 [Mapview hg19]  
OMIM610916   611091   
Gene and transcription
Genbank (Entrez)AB255451 AK000310 AK023994 AK055456 AK291144
RefSeq transcript (Entrez)NM_001193455 NM_017755
Consensus coding sequences : CCDS (NCBI)NSUN2
Gene ExpressionNSUN2 [ NCBI-GEO ]   NSUN2 [ EBI - ARRAY_EXPRESS ]   NSUN2 [ SEEK ]   NSUN2 [ MEM ]
Gene Expression Viewer (FireBrowse)NSUN2 [ Firebrowse - Broad ]
GenevisibleExpression of NSUN2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54888
GTEX Portal (Tissue expression)NSUN2
Human Protein AtlasENSG00000037474-NSUN2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ08J23   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ08J23  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ08J23
PhosPhoSitePlusQ08J23
Domaine pattern : Prosite (Expaxy)SAM_MT_RSMB_NOP (PS51686)   
Domains : Interpro (EBI)MeTrfase_RsmB/NOP2    RCMT    RCMT_NCL1    SAM-dependent_MTases   
Domain families : Pfam (Sanger)Methyltr_RsmB-F (PF01189)   
Domain families : Pfam (NCBI)pfam01189   
Conserved Domain (NCBI)NSUN2
SuperfamilyQ08J23
AlphaFold pdb e-kbQ08J23   
Human Protein Atlas [tissue]ENSG00000037474-NSUN2 [tissue]
HPRD08620
Protein Interaction databases
DIP (DOE-UCLA)Q08J23
IntAct (EBI)Q08J23
BioGRIDNSUN2
STRING (EMBL)NSUN2
ZODIACNSUN2
Ontologies - Pathways
QuickGOQ08J23
Ontology : AmiGOtRNA binding  RNA methylation  in utero embryonic development  RNA binding  nucleus  nucleoplasm  nucleolus  cytoplasm  cytoplasm  mitochondrion  spindle  tRNA modification  spermatid development  methyltransferase activity  regulation of mRNA export from nucleus  tRNA (cytosine-5-)-methyltransferase activity  tRNA (cytosine-5-)-methyltransferase activity  tRNA (cytosine-5-)-methyltransferase activity  tRNA methylation  tRNA methylation  meiotic cell cycle checkpoint signaling  chromatoid body  tRNA stabilization  hair follicle maturation  cell division  mRNA (cytidine-5-)-methyltransferase activity  extracellular exosome  mRNA methylation  regulation of stem cell differentiation  
Ontology : EGO-EBItRNA binding  RNA methylation  in utero embryonic development  RNA binding  nucleus  nucleoplasm  nucleolus  cytoplasm  cytoplasm  mitochondrion  spindle  tRNA modification  spermatid development  methyltransferase activity  regulation of mRNA export from nucleus  tRNA (cytosine-5-)-methyltransferase activity  tRNA (cytosine-5-)-methyltransferase activity  tRNA (cytosine-5-)-methyltransferase activity  tRNA methylation  tRNA methylation  meiotic cell cycle checkpoint signaling  chromatoid body  tRNA stabilization  hair follicle maturation  cell division  mRNA (cytidine-5-)-methyltransferase activity  extracellular exosome  mRNA methylation  regulation of stem cell differentiation  
NDEx NetworkNSUN2
Atlas of Cancer Signalling NetworkNSUN2
Wikipedia pathwaysNSUN2
Orthology - Evolution
OrthoDB54888
GeneTree (enSembl)ENSG00000037474
Phylogenetic Trees/Animal Genes : TreeFamNSUN2
Homologs : HomoloGeneNSUN2
Homology/Alignments : Family Browser (UCSC)NSUN2
Gene fusions - Rearrangements
Fusion Cancer (Beijing)A2M [12p13.31]  -  NSUN2 [5p15.31]  [FUSC002099]
Fusion : QuiverNSUN2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNSUN2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NSUN2
dbVarNSUN2
ClinVarNSUN2
MonarchNSUN2
1000_GenomesNSUN2 
Exome Variant ServerNSUN2
GNOMAD BrowserENSG00000037474
Varsome BrowserNSUN2
ACMGNSUN2 variants
VarityQ08J23
Genomic Variants (DGV)NSUN2 [DGVbeta]
DECIPHERNSUN2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNSUN2 
Mutations
ICGC Data PortalNSUN2 
TCGA Data PortalNSUN2 
Broad Tumor PortalNSUN2
OASIS PortalNSUN2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNSUN2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNSUN2
Mutations and Diseases : HGMDNSUN2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaNSUN2
DgiDB (Drug Gene Interaction Database)NSUN2
DoCM (Curated mutations)NSUN2
CIViC (Clinical Interpretations of Variants in Cancer)NSUN2
Cancer3DNSUN2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610916    611091   
Orphanet472    11804   
DisGeNETNSUN2
MedgenNSUN2
Genetic Testing Registry NSUN2
NextProtQ08J23 [Medical]
GENETestsNSUN2
Target ValidationNSUN2
Huge Navigator NSUN2 [HugePedia]
ClinGenNSUN2
Clinical trials, drugs, therapy
MyCancerGenomeNSUN2
Protein Interactions : CTDNSUN2
Pharm GKB GenePA134953940
PharosQ08J23
Clinical trialNSUN2
Miscellaneous
canSAR (ICR)NSUN2
HarmonizomeNSUN2
DataMed IndexNSUN2
Probes
Litterature
PubMed119 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXNSUN2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:23:23 CEST 2021

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.