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NSUN4 (NOP2/Sun RNA methyltransferase family member 4)

Identity

Alias_namesNOL1/NOP2/Sun domain family, member 4
NOP2/Sun domain family, member 4
Alias_symbol (synonym)MGC22960
SHTAP
Other alias
HGNC (Hugo) NSUN4
LocusID (NCBI) 387338
Atlas_Id 54510
Location 1p33  [Link to chromosome band 1p33]
Location_base_pair Starts at 46341178 and ends at 46365152 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
EIF4G3 (1p36.12) / NSUN4 (1p33)NSUN4 (1p33) / BMPR1B (4q22.3)NSUN4 (1p33) / FAAH (1p33)
NSUN4 (1p33) / NCCRP1 (19q13.2)EIF4G3 1p36.12 / NSUN4 1p33NSUN4 1p33 / BMPR1B 4q22.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Squamous Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)NSUN4   31802
Cards
Entrez_Gene (NCBI)NSUN4  387338  NOP2/Sun RNA methyltransferase family member 4
AliasesSHTAP
GeneCards (Weizmann)NSUN4
Ensembl hg19 (Hinxton)ENSG00000117481 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000117481 [Gene_View]  chr1:46341178-46365152 [Contig_View]  NSUN4 [Vega]
ICGC DataPortalENSG00000117481
TCGA cBioPortalNSUN4
AceView (NCBI)NSUN4
Genatlas (Paris)NSUN4
WikiGenes387338
SOURCE (Princeton)NSUN4
Genetics Home Reference (NIH)NSUN4
Genomic and cartography
GoldenPath hg38 (UCSC)NSUN4  -     chr1:46341178-46365152 +  1p33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NSUN4  -     1p33   [Description]    (hg19-Feb_2009)
EnsemblNSUN4 - 1p33 [CytoView hg19]  NSUN4 - 1p33 [CytoView hg38]
Mapping of homologs : NCBINSUN4 [Mapview hg19]  NSUN4 [Mapview hg38]
OMIM615394   
Gene and transcription
Genbank (Entrez)AK021577 AK057420 AK097524 AK128066 AK291741
RefSeq transcript (Entrez)NM_001256127 NM_001256128 NM_199044
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NSUN4
Cluster EST : UnigeneHs.163424 [ NCBI ]
CGAP (NCI)Hs.163424
Alternative Splicing GalleryENSG00000117481
Gene ExpressionNSUN4 [ NCBI-GEO ]   NSUN4 [ EBI - ARRAY_EXPRESS ]   NSUN4 [ SEEK ]   NSUN4 [ MEM ]
Gene Expression Viewer (FireBrowse)NSUN4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)387338
GTEX Portal (Tissue expression)NSUN4
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96CB9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96CB9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96CB9
Splice isoforms : SwissVarQ96CB9
Catalytic activity : Enzyme2.1.1.- [ Enzyme-Expasy ]   2.1.1.-2.1.1.- [ IntEnz-EBI ]   2.1.1.- [ BRENDA ]   2.1.1.- [ KEGG ]   
PhosPhoSitePlusQ96CB9
Domaine pattern : Prosite (Expaxy)SAM_MT_RSMB_NOP (PS51686)   
Domains : Interpro (EBI)MeTrfase_RsmB/NOP2    RCMT    SAM-dependent_MTases   
Domain families : Pfam (Sanger)Methyltr_RsmB-F (PF01189)   
Domain families : Pfam (NCBI)pfam01189   
Conserved Domain (NCBI)NSUN4
DMDM Disease mutations387338
Blocks (Seattle)NSUN4
PDB (SRS)4FP9    4FZV   
PDB (PDBSum)4FP9    4FZV   
PDB (IMB)4FP9    4FZV   
PDB (RSDB)4FP9    4FZV   
Structural Biology KnowledgeBase4FP9    4FZV   
SCOP (Structural Classification of Proteins)4FP9    4FZV   
CATH (Classification of proteins structures)4FP9    4FZV   
SuperfamilyQ96CB9
Human Protein AtlasENSG00000117481
Peptide AtlasQ96CB9
HPRD14842
IPIIPI00303944   IPI00847475   IPI00847563   IPI01012870   IPI00443981   
Protein Interaction databases
DIP (DOE-UCLA)Q96CB9
IntAct (EBI)Q96CB9
FunCoupENSG00000117481
BioGRIDNSUN4
STRING (EMBL)NSUN4
ZODIACNSUN4
Ontologies - Pathways
QuickGOQ96CB9
Ontology : AmiGOprotein binding  mitochondrial matrix  mitochondrial large ribosomal subunit  methyltransferase activity  rRNA (cytosine-C5-)-methyltransferase activity  rRNA methylation  rRNA methylation  mature ribosome assembly  positive regulation of mitochondrial translation  small ribosomal subunit rRNA binding  
Ontology : EGO-EBIprotein binding  mitochondrial matrix  mitochondrial large ribosomal subunit  methyltransferase activity  rRNA (cytosine-C5-)-methyltransferase activity  rRNA methylation  rRNA methylation  mature ribosome assembly  positive regulation of mitochondrial translation  small ribosomal subunit rRNA binding  
NDEx NetworkNSUN4
Atlas of Cancer Signalling NetworkNSUN4
Wikipedia pathwaysNSUN4
Orthology - Evolution
OrthoDB387338
GeneTree (enSembl)ENSG00000117481
Phylogenetic Trees/Animal Genes : TreeFamNSUN4
HOVERGENQ96CB9
HOGENOMQ96CB9
Homologs : HomoloGeneNSUN4
Homology/Alignments : Family Browser (UCSC)NSUN4
Gene fusions - Rearrangements
Fusion : MitelmanEIF4G3/NSUN4 [1p36.12/1p33]  [t(1;1)(p33;p36)]  
Fusion : MitelmanNSUN4/BMPR1B [1p33/4q22.3]  [t(1;4)(p33;q22)]  
Fusion: TCGAEIF4G3 1p36.12 NSUN4 1p33 LUAD
Fusion: TCGANSUN4 1p33 BMPR1B 4q22.3 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNSUN4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NSUN4
dbVarNSUN4
ClinVarNSUN4
1000_GenomesNSUN4 
Exome Variant ServerNSUN4
ExAC (Exome Aggregation Consortium)NSUN4 (select the gene name)
Genetic variants : HAPMAP387338
Genomic Variants (DGV)NSUN4 [DGVbeta]
DECIPHERNSUN4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNSUN4 
Mutations
ICGC Data PortalNSUN4 
TCGA Data PortalNSUN4 
Broad Tumor PortalNSUN4
OASIS PortalNSUN4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNSUN4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNSUN4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NSUN4
DgiDB (Drug Gene Interaction Database)NSUN4
DoCM (Curated mutations)NSUN4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NSUN4 (select a term)
intoGenNSUN4
Cancer3DNSUN4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM615394   
Orphanet
MedgenNSUN4
Genetic Testing Registry NSUN4
NextProtQ96CB9 [Medical]
TSGene387338
GENETestsNSUN4
Target ValidationNSUN4
Huge Navigator NSUN4 [HugePedia]
snp3D : Map Gene to Disease387338
BioCentury BCIQNSUN4
ClinGenNSUN4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD387338
Chemical/Pharm GKB GenePA134953046
Clinical trialNSUN4
Miscellaneous
canSAR (ICR)NSUN4 (select the gene name)
Probes
Litterature
PubMed18 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNSUN4
EVEXNSUN4
GoPubMedNSUN4
iHOPNSUN4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 25 19:22:48 CEST 2017

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