NT5C1A (5-nucleotidase, cytosolic IA)

2019-08-01  

Identity

HGNC
LOCATION
1p34.2
LOCUSID
ALIAS
CN-I,CN-IA,CN1,CN1A,CNI

Other Information

Locus ID:

NCBI: 84618
MIM: 610525
HGNC: 17819
Ensembl: ENSG00000116981

Variants:

dbSNP: 84618
ClinVar: 84618
TCGA: ENSG00000116981
COSMIC: NT5C1A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000116981ENST00000235628Q9BXI3

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Purine metabolismKEGGko00230
Pyrimidine metabolismKEGGko00240
Nicotinate and nicotinamide metabolismKEGGko00760
Purine metabolismKEGGhsa00230
Pyrimidine metabolismKEGGhsa00240
Nicotinate and nicotinamide metabolismKEGGhsa00760
Metabolic pathwaysKEGGhsa01100
MetabolismREACTOMER-HSA-1430728
Metabolism of nucleotidesREACTOMER-HSA-15869
Purine metabolismREACTOMER-HSA-73847
Purine catabolismREACTOMER-HSA-74259
Pyrimidine metabolismREACTOMER-HSA-73848
Pyrimidine catabolismREACTOMER-HSA-73621

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA128406956fluorouracilChemicalClinicalAnnotationassociated26906009
PA449027cladribineChemicalClinicalAnnotationassociated26906009
PA449748gemcitabineChemicalClinicalAnnotationassociated26906009

References

Pubmed IDYearTitleCitations
218734332011Suppression of 5'-nucleotidase enzymes promotes AMP-activated protein kinase (AMPK) phosphorylation and metabolism in human and mouse skeletal muscle.17
258920102016Cytosolic 5'-Nucleotidase 1A As a Target of Circulating Autoantibodies in Autoimmune Diseases.16
258576612016Seropositivity for NT5c1A antibody in sporadic inclusion body myositis predicts more severe motor, bulbar and respiratory involvement.12
158880282005Expression of human ecto-5'-nucleotidase in pig endothelium increases adenosine production and protects from NK cell-mediated lysis.4
307097692019Cytosolic 5'-nucleotidase 1A is overexpressed in pancreatic cancer and mediates gemcitabine resistance by reducing intracellular gemcitabine metabolites.3
193525422009Expression of cytosolic 5' nucleotidase does not correlate with expression of oxidative metabolism marker: myoglobine in human skeletal muscles.1
269060092016Pharmacogenetic characterization of naturally occurring germline NT5C1A variants to chemotherapeutic nucleoside analogs.1
170650912006Cell cycle dependent regulation of deoxycytidine kinase, deoxyguanosine kinase, and cytosolic 5'-nucleotidase I activity in MOLT-4 cells.0

Citation

Dessen P

NT5C1A (5-nucleotidase, cytosolic IA)

Atlas Genet Cytogenet Oncol Haematol. 2019-08-01

Online version: http://atlasgeneticsoncology.org/gene/58069/nt5c1a