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NT5C3A (5'-nucleotidase, cytosolic IIIA)

Identity

Alias_namesNT5C3
5'-nucleotidase
Alias_symbol (synonym)UMPH1
PSN1
PN-I
UMPH
P5'N-1
cN-III
p36
POMP
hUMP1
Other aliasP5N-1
HGNC (Hugo) NT5C3A
LocusID (NCBI) 51251
Atlas_Id 50937
Location 7p14.3  [Link to chromosome band 7p14]
Location_base_pair Starts at 33014113 and ends at 33062797 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
MDM4 (1q32.1) / NT5C3A (7p14.3)NT5C3A (7p14.3) / MAP4 (3p21.31)PDGFA (7p22.3) / NT5C3A (7p14.3)
SLC37A1 (21q22.3) / NT5C3A (7p14.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NT5C3A   17820
Cards
Entrez_Gene (NCBI)NT5C3A  51251  5'-nucleotidase, cytosolic IIIA
AliasesNT5C3; P5'N-1; P5N-1; PN-I; 
POMP; PSN1; UMPH; UMPH1; cN-III; hUMP1; p36
GeneCards (Weizmann)NT5C3A
Ensembl hg19 (Hinxton)ENSG00000122643 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000122643 [Gene_View]  chr7:33014113-33062797 [Contig_View]  NT5C3A [Vega]
ICGC DataPortalENSG00000122643
TCGA cBioPortalNT5C3A
AceView (NCBI)NT5C3A
Genatlas (Paris)NT5C3A
WikiGenes51251
SOURCE (Princeton)NT5C3A
Genetics Home Reference (NIH)NT5C3A
Genomic and cartography
GoldenPath hg38 (UCSC)NT5C3A  -     chr7:33014113-33062797 -  7p14.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NT5C3A  -     7p14.3   [Description]    (hg19-Feb_2009)
EnsemblNT5C3A - 7p14.3 [CytoView hg19]  NT5C3A - 7p14.3 [CytoView hg38]
Mapping of homologs : NCBINT5C3A [Mapview hg19]  NT5C3A [Mapview hg38]
OMIM266120   606224   
Gene and transcription
Genbank (Entrez)AA482595 AF151067 AF312735 AK290118 AK314109
RefSeq transcript (Entrez)NM_001002009 NM_001002010 NM_001166118 NM_016489
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NT5C3A
Cluster EST : UnigeneHs.487933 [ NCBI ]
CGAP (NCI)Hs.487933
Alternative Splicing GalleryENSG00000122643
Gene ExpressionNT5C3A [ NCBI-GEO ]   NT5C3A [ EBI - ARRAY_EXPRESS ]   NT5C3A [ SEEK ]   NT5C3A [ MEM ]
Gene Expression Viewer (FireBrowse)NT5C3A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51251
GTEX Portal (Tissue expression)NT5C3A
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H0P0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H0P0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H0P0
Splice isoforms : SwissVarQ9H0P0
PhosPhoSitePlusQ9H0P0
Domains : Interpro (EBI)HAD-like_dom    Pyrimidine_nucleotidase_eu   
Domain families : Pfam (Sanger)UMPH-1 (PF05822)   
Domain families : Pfam (NCBI)pfam05822   
Conserved Domain (NCBI)NT5C3A
DMDM Disease mutations51251
Blocks (Seattle)NT5C3A
PDB (SRS)2CN1    2JGA    2VKQ   
PDB (PDBSum)2CN1    2JGA    2VKQ   
PDB (IMB)2CN1    2JGA    2VKQ   
PDB (RSDB)2CN1    2JGA    2VKQ   
Structural Biology KnowledgeBase2CN1    2JGA    2VKQ   
SCOP (Structural Classification of Proteins)2CN1    2JGA    2VKQ   
CATH (Classification of proteins structures)2CN1    2JGA    2VKQ   
SuperfamilyQ9H0P0
Human Protein AtlasENSG00000122643
Peptide AtlasQ9H0P0
HPRD05871
IPIIPI00619911   IPI00100192   IPI00647805   IPI00807412   IPI00916054   IPI00915809   IPI00915947   
Protein Interaction databases
DIP (DOE-UCLA)Q9H0P0
IntAct (EBI)Q9H0P0
FunCoupENSG00000122643
BioGRIDNT5C3A
STRING (EMBL)NT5C3A
ZODIACNT5C3A
Ontologies - Pathways
QuickGOQ9H0P0
Ontology : AmiGOnucleotide binding  magnesium ion binding  cytoplasm  mitochondrion  endoplasmic reticulum  cytosol  pyrimidine nucleoside metabolic process  5'-nucleotidase activity  5'-nucleotidase activity  5'-nucleotidase activity  2'-phosphotransferase activity  2'-phosphotransferase activity  nucleotide metabolic process  dephosphorylation  adenosine metabolic process  pyrimidine nucleoside catabolic process  
Ontology : EGO-EBInucleotide binding  magnesium ion binding  cytoplasm  mitochondrion  endoplasmic reticulum  cytosol  pyrimidine nucleoside metabolic process  5'-nucleotidase activity  5'-nucleotidase activity  5'-nucleotidase activity  2'-phosphotransferase activity  2'-phosphotransferase activity  nucleotide metabolic process  dephosphorylation  adenosine metabolic process  pyrimidine nucleoside catabolic process  
Pathways : KEGGPurine metabolism    Pyrimidine metabolism    Nicotinate and nicotinamide metabolism   
NDEx NetworkNT5C3A
Atlas of Cancer Signalling NetworkNT5C3A
Wikipedia pathwaysNT5C3A
Orthology - Evolution
OrthoDB51251
GeneTree (enSembl)ENSG00000122643
Phylogenetic Trees/Animal Genes : TreeFamNT5C3A
HOVERGENQ9H0P0
HOGENOMQ9H0P0
Homologs : HomoloGeneNT5C3A
Homology/Alignments : Family Browser (UCSC)NT5C3A
Gene fusions - Rearrangements
Fusion : MitelmanPDGFA/NT5C3A [7p22.3/7p14.3]  [t(7;7)(p14;p22)]  
Fusion : MitelmanSLC37A1/NT5C3A [21q22.3/7p14.3]  [t(7;21)(p14;q22)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNT5C3A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NT5C3A
dbVarNT5C3A
ClinVarNT5C3A
1000_GenomesNT5C3A 
Exome Variant ServerNT5C3A
ExAC (Exome Aggregation Consortium)NT5C3A (select the gene name)
Genetic variants : HAPMAP51251
Genomic Variants (DGV)NT5C3A [DGVbeta]
DECIPHERNT5C3A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNT5C3A 
Mutations
ICGC Data PortalNT5C3A 
TCGA Data PortalNT5C3A 
Broad Tumor PortalNT5C3A
OASIS PortalNT5C3A [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDNT5C3A
BioMutasearch NT5C3A
DgiDB (Drug Gene Interaction Database)NT5C3A
DoCM (Curated mutations)NT5C3A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NT5C3A (select a term)
intoGenNT5C3A
Cancer3DNT5C3A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM266120    606224   
Orphanet10371   
MedgenNT5C3A
Genetic Testing Registry NT5C3A
NextProtQ9H0P0 [Medical]
TSGene51251
GENETestsNT5C3A
Target ValidationNT5C3A
Huge Navigator NT5C3A [HugePedia]
snp3D : Map Gene to Disease51251
BioCentury BCIQNT5C3A
ClinGenNT5C3A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51251
Chemical/Pharm GKB GenePA31802
Clinical trialNT5C3A
Miscellaneous
canSAR (ICR)NT5C3A (select the gene name)
Probes
Litterature
PubMed35 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNT5C3A
EVEXNT5C3A
GoPubMedNT5C3A
iHOPNT5C3A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 14:02:03 CEST 2017

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