NTF3 (neurotrophin 3)

2008-09-01  

Identity

HGNC
LOCATION
12p13.31
LOCUSID
ALIAS
HDNF,NGF-2,NGF2,NT-3,NT3

Other Information

Locus ID:

NCBI: 4908
MIM: 162660
HGNC: 8023
Ensembl: ENSG00000185652

Variants:

dbSNP: 4908
ClinVar: 4908
TCGA: ENSG00000185652
COSMIC: NTF3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000185652ENST00000331010P20783
ENSG00000185652ENST00000423158P20783

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
MAPK signaling pathwayKEGGhsa04010
Neurotrophin signaling pathwayKEGGko04722
Neurotrophin signaling pathwayKEGGhsa04722

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
195982352009Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome.92
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
183055712008Neurotrophins and their receptors stimulate melanoma cell proliferation and migration.45
235220422013Etv1 inactivation reveals proprioceptor subclasses that reflect the level of NT3 expression in muscle targets.43
185966922008Crystal structure of the neurotrophin-3 and p75NTR symmetrical complex.38
183136962008Altered expression of neurotrophic factors in patients with major depression.36
127109332003NT-3 gene delivery elicits growth of chronically injured corticospinal axons and modestly improves functional deficits after chronic scar resection.35
193579342009Increase in cerebellar neurotrophin-3 and oxidative stress markers in autism.35
190860532009Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.34
231855072012miR-200c targets a NF-κB up-regulated TrkB/NTF3 autocrine signaling loop to enhance anoikis sensitivity in triple negative breast cancer.33

Citation

Dessen P

NTF3 (neurotrophin 3)

Atlas Genet Cytogenet Oncol Haematol. 2008-09-01

Online version: http://atlasgeneticsoncology.org/gene/50380/ntf3