Atlas of Genetics and Cytogenetics in Oncology and Haematology


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NTF3 (neurotrophin 3)

Identity

Alias_symbol (synonym)NGF2
Other aliasHDNF
NGF-2
NT-3
NT3
HGNC (Hugo) NTF3
LocusID (NCBI) 4908
Atlas_Id 50380
Location 12p13.31  [Link to chromosome band 12p13]
Location_base_pair Starts at 5432114 and ends at 5495299 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NTF3   8023
Cards
Entrez_Gene (NCBI)NTF3  4908  neurotrophin 3
AliasesHDNF; NGF-2; NGF2; NT-3; 
NT3
GeneCards (Weizmann)NTF3
Ensembl hg19 (Hinxton)ENSG00000185652 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000185652 [Gene_View]  chr12:5432114-5495299 [Contig_View]  NTF3 [Vega]
ICGC DataPortalENSG00000185652
TCGA cBioPortalNTF3
AceView (NCBI)NTF3
Genatlas (Paris)NTF3
WikiGenes4908
SOURCE (Princeton)NTF3
Genetics Home Reference (NIH)NTF3
Genomic and cartography
GoldenPath hg38 (UCSC)NTF3  -     chr12:5432114-5495299 +  12p13.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NTF3  -     12p13.31   [Description]    (hg19-Feb_2009)
EnsemblNTF3 - 12p13.31 [CytoView hg19]  NTF3 - 12p13.31 [CytoView hg38]
Mapping of homologs : NCBINTF3 [Mapview hg19]  NTF3 [Mapview hg38]
OMIM162660   
Gene and transcription
Genbank (Entrez)AK293895 AW190653 BC069773 BC107075 BU939830
RefSeq transcript (Entrez)NM_001102654 NM_002527
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NTF3
Cluster EST : UnigeneHs.99171 [ NCBI ]
CGAP (NCI)Hs.99171
Alternative Splicing GalleryENSG00000185652
Gene ExpressionNTF3 [ NCBI-GEO ]   NTF3 [ EBI - ARRAY_EXPRESS ]   NTF3 [ SEEK ]   NTF3 [ MEM ]
Gene Expression Viewer (FireBrowse)NTF3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4908
GTEX Portal (Tissue expression)NTF3
Protein : pattern, domain, 3D structure
UniProt/SwissProtP20783   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP20783  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP20783
Splice isoforms : SwissVarP20783
PhosPhoSitePlusP20783
Domaine pattern : Prosite (Expaxy)NGF_1 (PS00248)    NGF_2 (PS50270)   
Domains : Interpro (EBI)Cystine-knot_cytokine    Nerve_growth_factor-like    Nerve_growth_factor-rel    Nerve_growth_factor_CS    Neurotrophin-3   
Domain families : Pfam (Sanger)NGF (PF00243)   
Domain families : Pfam (NCBI)pfam00243   
Domain families : Smart (EMBL)NGF (SM00140)  
Domain structure : Prodom (Prabi Lyon)Nerve_growth_factor-rel (PD002052)   
Conserved Domain (NCBI)NTF3
DMDM Disease mutations4908
Blocks (Seattle)NTF3
PDB (SRS)1B8K    1BND    1NT3    3BUK   
PDB (PDBSum)1B8K    1BND    1NT3    3BUK   
PDB (IMB)1B8K    1BND    1NT3    3BUK   
PDB (RSDB)1B8K    1BND    1NT3    3BUK   
Structural Biology KnowledgeBase1B8K    1BND    1NT3    3BUK   
SCOP (Structural Classification of Proteins)1B8K    1BND    1NT3    3BUK   
CATH (Classification of proteins structures)1B8K    1BND    1NT3    3BUK   
SuperfamilyP20783
Human Protein AtlasENSG00000185652
Peptide AtlasP20783
HPRD01219
IPIIPI00025474   IPI00793439   
Protein Interaction databases
DIP (DOE-UCLA)P20783
IntAct (EBI)P20783
FunCoupENSG00000185652
BioGRIDNTF3
STRING (EMBL)NTF3
ZODIACNTF3
Ontologies - Pathways
QuickGOP20783
Ontology : AmiGOactivation of MAPK activity  positive regulation of receptor internalization  receptor binding  neurotrophin p75 receptor binding  protein binding  extracellular region  signal transduction  transmembrane receptor protein tyrosine kinase signaling pathway  cell-cell signaling  nervous system development  growth factor activity  positive regulation of cell proliferation  positive regulation of cell migration  cytoplasmic vesicle  activation of protein kinase B activity  positive regulation of peptidyl-serine phosphorylation  chemoattractant activity  regulation of apoptotic process  negative regulation of neuron apoptotic process  regulation of neuron differentiation  neuron projection morphogenesis  positive regulation of peptidyl-tyrosine phosphorylation  negative regulation of peptidyl-tyrosine phosphorylation  positive chemotaxis  induction of positive chemotaxis  activation of GTPase activity  positive regulation of actin cytoskeleton reorganization  
Ontology : EGO-EBIactivation of MAPK activity  positive regulation of receptor internalization  receptor binding  neurotrophin p75 receptor binding  protein binding  extracellular region  signal transduction  transmembrane receptor protein tyrosine kinase signaling pathway  cell-cell signaling  nervous system development  growth factor activity  positive regulation of cell proliferation  positive regulation of cell migration  cytoplasmic vesicle  activation of protein kinase B activity  positive regulation of peptidyl-serine phosphorylation  chemoattractant activity  regulation of apoptotic process  negative regulation of neuron apoptotic process  regulation of neuron differentiation  neuron projection morphogenesis  positive regulation of peptidyl-tyrosine phosphorylation  negative regulation of peptidyl-tyrosine phosphorylation  positive chemotaxis  induction of positive chemotaxis  activation of GTPase activity  positive regulation of actin cytoskeleton reorganization  
Pathways : KEGGMAPK signaling pathway    Neurotrophin signaling pathway   
NDEx NetworkNTF3
Atlas of Cancer Signalling NetworkNTF3
Wikipedia pathwaysNTF3
Orthology - Evolution
OrthoDB4908
GeneTree (enSembl)ENSG00000185652
Phylogenetic Trees/Animal Genes : TreeFamNTF3
HOVERGENP20783
HOGENOMP20783
Homologs : HomoloGeneNTF3
Homology/Alignments : Family Browser (UCSC)NTF3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNTF3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NTF3
dbVarNTF3
ClinVarNTF3
1000_GenomesNTF3 
Exome Variant ServerNTF3
ExAC (Exome Aggregation Consortium)NTF3 (select the gene name)
Genetic variants : HAPMAP4908
Genomic Variants (DGV)NTF3 [DGVbeta]
DECIPHERNTF3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNTF3 
Mutations
ICGC Data PortalNTF3 
TCGA Data PortalNTF3 
Broad Tumor PortalNTF3
OASIS PortalNTF3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNTF3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNTF3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NTF3
DgiDB (Drug Gene Interaction Database)NTF3
DoCM (Curated mutations)NTF3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NTF3 (select a term)
intoGenNTF3
Cancer3DNTF3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM162660   
Orphanet
MedgenNTF3
Genetic Testing Registry NTF3
NextProtP20783 [Medical]
TSGene4908
GENETestsNTF3
Target ValidationNTF3
Huge Navigator NTF3 [HugePedia]
snp3D : Map Gene to Disease4908
BioCentury BCIQNTF3
ClinGenNTF3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4908
Chemical/Pharm GKB GenePA31806
Clinical trialNTF3
Miscellaneous
canSAR (ICR)NTF3 (select the gene name)
Probes
Litterature
PubMed98 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNTF3
EVEXNTF3
GoPubMedNTF3
iHOPNTF3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:47:33 CEST 2017

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