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NTN4 (netrin 4)

Identity

Other aliasPRO3091
HGNC (Hugo) NTN4
LocusID (NCBI) 59277
Atlas_Id 47709
Location 12q22  [Link to chromosome band 12q22]
Location_base_pair Starts at 95657807 and ends at 95790815 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
DNAJC22 (12q13.12) / NTN4 (12q22)NTN4 (12q22) / CCDC38 (12q23.1)NTN4 (12q22) / KTN1 (14q22.3)
NTN4 (12q22) / SPG7 (16q24.3)TIAM2 (6q25.3) / NTN4 (12q22)TRIM24 (7q33) / NTN4 (12q22)
DNAJC22 12q13.12 / NTN4 12q22NTN4 12q22 / CCDC38 12q23.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NTN4   13658
Cards
Entrez_Gene (NCBI)NTN4  59277  netrin 4
AliasesPRO3091
GeneCards (Weizmann)NTN4
Ensembl hg19 (Hinxton)ENSG00000074527 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000074527 [Gene_View]  chr12:95657807-95790815 [Contig_View]  NTN4 [Vega]
ICGC DataPortalENSG00000074527
TCGA cBioPortalNTN4
AceView (NCBI)NTN4
Genatlas (Paris)NTN4
WikiGenes59277
SOURCE (Princeton)NTN4
Genetics Home Reference (NIH)NTN4
Genomic and cartography
GoldenPath hg38 (UCSC)NTN4  -     chr12:95657807-95790815 -  12q22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NTN4  -     12q22   [Description]    (hg19-Feb_2009)
EnsemblNTN4 - 12q22 [CytoView hg19]  NTN4 - 12q22 [CytoView hg38]
Mapping of homologs : NCBINTN4 [Mapview hg19]  NTN4 [Mapview hg38]
OMIM610401   
Gene and transcription
Genbank (Entrez)AF119916 AF278532 AF297711 AK024691 AK026833
RefSeq transcript (Entrez)NM_001329700 NM_001329701 NM_001329702 NM_021229
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NTN4
Cluster EST : UnigeneHs.201034 [ NCBI ]
CGAP (NCI)Hs.201034
Alternative Splicing GalleryENSG00000074527
Gene ExpressionNTN4 [ NCBI-GEO ]   NTN4 [ EBI - ARRAY_EXPRESS ]   NTN4 [ SEEK ]   NTN4 [ MEM ]
Gene Expression Viewer (FireBrowse)NTN4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)59277
GTEX Portal (Tissue expression)NTN4
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9HB63   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9HB63  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9HB63
Splice isoforms : SwissVarQ9HB63
PhosPhoSitePlusQ9HB63
Domaine pattern : Prosite (Expaxy)EGF_1 (PS00022)    EGF_LAM_1 (PS01248)    EGF_LAM_2 (PS50027)    LAMININ_NTER (PS51117)    NTR (PS50189)   
Domains : Interpro (EBI)Laminin_EGF    Laminin_N    Netrin_domain    Netrin_module_non-TIMP    TIMP-like_OB-fold   
Domain families : Pfam (Sanger)Laminin_EGF (PF00053)    Laminin_N (PF00055)    NTR (PF01759)   
Domain families : Pfam (NCBI)pfam00053    pfam00055    pfam01759   
Domain families : Smart (EMBL)C345C (SM00643)  EGF_Lam (SM00180)  LamNT (SM00136)  
Conserved Domain (NCBI)NTN4
DMDM Disease mutations59277
Blocks (Seattle)NTN4
SuperfamilyQ9HB63
Human Protein AtlasENSG00000074527
Peptide AtlasQ9HB63
HPRD10121
IPIIPI00328091   IPI00472613   IPI00385236   IPI01022535   
Protein Interaction databases
DIP (DOE-UCLA)Q9HB63
IntAct (EBI)Q9HB63
FunCoupENSG00000074527
BioGRIDNTN4
STRING (EMBL)NTN4
ZODIACNTN4
Ontologies - Pathways
QuickGOQ9HB63
Ontology : AmiGOprotein binding  basement membrane  plasma membrane  axon guidance  neuron remodeling  laminin-1 binding  regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signaling  
Ontology : EGO-EBIprotein binding  basement membrane  plasma membrane  axon guidance  neuron remodeling  laminin-1 binding  regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signaling  
Pathways : KEGGAxon guidance   
NDEx NetworkNTN4
Atlas of Cancer Signalling NetworkNTN4
Wikipedia pathwaysNTN4
Orthology - Evolution
OrthoDB59277
GeneTree (enSembl)ENSG00000074527
Phylogenetic Trees/Animal Genes : TreeFamNTN4
HOVERGENQ9HB63
HOGENOMQ9HB63
Homologs : HomoloGeneNTN4
Homology/Alignments : Family Browser (UCSC)NTN4
Gene fusions - Rearrangements
Fusion : MitelmanDNAJC22/NTN4 [12q13.12/12q22]  [t(12;12)(q13;q22)]  
Fusion : MitelmanNTN4/CCDC38 [12q22/12q23.1]  [t(12;12)(q22;q23)]  
Fusion: TCGADNAJC22 12q13.12 NTN4 12q22 BRCA
Fusion: TCGANTN4 12q22 CCDC38 12q23.1 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNTN4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NTN4
dbVarNTN4
ClinVarNTN4
1000_GenomesNTN4 
Exome Variant ServerNTN4
ExAC (Exome Aggregation Consortium)NTN4 (select the gene name)
Genetic variants : HAPMAP59277
Genomic Variants (DGV)NTN4 [DGVbeta]
DECIPHERNTN4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNTN4 
Mutations
ICGC Data PortalNTN4 
TCGA Data PortalNTN4 
Broad Tumor PortalNTN4
OASIS PortalNTN4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNTN4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNTN4
intOGen PortalNTN4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NTN4
DgiDB (Drug Gene Interaction Database)NTN4
DoCM (Curated mutations)NTN4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NTN4 (select a term)
intoGenNTN4
Cancer3DNTN4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610401   
Orphanet
MedgenNTN4
Genetic Testing Registry NTN4
NextProtQ9HB63 [Medical]
TSGene59277
GENETestsNTN4
Target ValidationNTN4
Huge Navigator NTN4 [HugePedia]
snp3D : Map Gene to Disease59277
BioCentury BCIQNTN4
ClinGenNTN4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD59277
Chemical/Pharm GKB GenePA31815
Clinical trialNTN4
Miscellaneous
canSAR (ICR)NTN4 (select the gene name)
Probes
Litterature
PubMed36 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNTN4
EVEXNTN4
GoPubMedNTN4
iHOPNTN4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:47:34 CEST 2017

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