NTNG2 (netrin G2)

2014-08-01  

Identity

HGNC
NTNG2
LOCATION
9q34.13
LOCUSID
84628
ALIAS
LHLL9381,Lmnt2,NEDBASH,NTNG1,bA479K20.1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 84628
MIM: 618689
HGNC: 14288
Ensembl: ENSG00000196358

Variants:

dbSNP: 84628
ClinVar: 84628
TCGA: ENSG00000196358
COSMIC: NTNG2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000196358ENST00000393229Q96CW9

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Cell adhesion molecules (CAMs)KEGGko04514
Axon guidanceKEGGhsa04360
Cell adhesion molecules (CAMs)KEGGhsa04514
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Post-translational modification: synthesis of GPI-anchored proteinsREACTOMER-HSA-163125

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
157053542005A family-based association study and gene expression analyses of netrin-G1 and -G2 genes in schizophrenia.30
175079102008Decreased mRNA expression of netrin-G1 and netrin-G2 in the temporal lobe in schizophrenia and bipolar disorder.22
229571042012Topography of Gng2- and NetrinG2-expression suggests an insular origin of the human claustrum.15
220414492011Crystal structure of the ligand binding domain of netrin G2.11
203821462010Abnormal expression of netrin-G2 in temporal lobe epilepsy neurons in humans and a rat model.7
200294092010Association of polymorphisms in the SLIT2 axonal guidance gene with anger in suicide attempters.2
316687032019Homozygous Missense Variants in NTNG2, Encoding a Presynaptic Netrin-G2 Adhesion Protein, Lead to a Distinct Neurodevelopmental Disorder.1

Citation

Dessen P

NTNG2 (netrin G2)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54514/ntng2