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NTRK1 (neurotrophic receptor tyrosine kinase 1)

Identity

Alias (NCBI)MTC
TRK
TRK1
TRKA
Trk-A
p140-TrkA
HGNC (Hugo) NTRK1
HGNC Alias symbTRK
TRKA
MTC
HGNC Alias namehigh affinity nerve growth factor receptor
HGNC Previous nameneurotrophic tyrosine kinase, receptor, type 1
LocusID (NCBI) 4914
Atlas_Id 216
Location 1q23.1  [Link to chromosome band 1q23]
Location_base_pair Starts at 156860879 and ends at 156881850 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BCAN (1q23.1) / NTRK1 (1q23.1)CD74 (5q32) / NTRK1 (1q23.1)IRF2BP2 (1q42.3) / NTRK1 (1q23.1)
LMNA (1q22) / NTRK1 (1q23.1)MIR548F1 (1q31.1) / NTRK1 (1q23.1)MPRIP (17p11.2) / NTRK1 (1q23.1)
NFASC (1q32.1) / NTRK1 (1q23.1)NTRK1 (1q23.1) / CD5 (11q12.2)NTRK1 (1q23.1) / TFG (3q12.2)
NTRK1 (1q23.1) / TPM3 (1q21.3)NTRK1 (1q23.1) / TPR (1q31.1)RET (10q11.21) / NTRK1 (1q23.1)
RPL7A (9q34.2) / NTRK1 (1q23.1)SQSTM1 (5q35.3) / NTRK1 (1q23.1)SSBP2 (5q14.1) / NTRK1 (1q23.1)
TFG (3q12.2) / NTRK1 (1q23.1)TP53 (17p13.1) / NTRK1 (1q23.1)TPM3 (1q21.3) / NTRK1 (1q23.1)
TPR (1q31.1) / NTRK1 (1q23.1)TPR NTRK1IRF2BP2 1q42.3 / NTRK1 1q23.1
NFASC 1q32.1 / NTRK1 1q23.1SQSTM1 5q35.3 / NTRK1 1q23.1SSBP2 5q14.1 / NTRK1 1q23.1
TFG 3q12.2 / NTRK1 1q23.1TPM3 1q21.3 / NTRK1 1q23.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Breakpoints

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 4 ]
  Anaplastic large cell lymphoma (ALCL)
t(2;3)(p23;q21) TFG/ALK
t(2;5)(p23;q35) SQSTM1/ALK
t(5;9)(q35;q34) SQSTM1/NUP214


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 20 ]
  Thyroid: Papillary Carcinoma with inv(7)(q21q34) AKAP9/BRAF
Thyroid: Papillary carcinoma/Adenocarcinoma
t(12;15)(p13;q25) ETV6/NTRK3 in solid tumors
Thyroid: Papillary carcinoma with inv(10)(p12.1q11.2) ACBD5/RET
del(1)(q22q23) LMNA/NTRK1
inv(1)(q21q23) TPM3/NTRK1
inv(1)(q23q31) TPR/NTRK1
inv(1)(q23q31) TPR/NTRK1
t(1;1)(q22;q23) LMNA/NTRK1
t(1;1)(q22;q23) LMNA/NTRK1
BCAN/NTRK1 (1q23)
t(1;1)(q23;q25) RABGAP1L/NTRK1
t(1;1)(q23;q32) NFASC/NTRK1
t(1;1)(q23;q42) IRF2BP2/NTRK1
t(1;3)(q23;q12) TFG/NTRK1
t(1;5)(q23;q14) SSBP2/NTRK1
t(1;5)(q23;q35) SQSTM1/NTRK1
t(1;5)(q23;q35) SQSTM1/NTRK1
t(1;7)(q23;p14) TRG/NTRK1
t(1;17)(q23;p13) TP53/NTRK1


External links

Nomenclature
HGNC (Hugo)NTRK1   8031
LRG (Locus Reference Genomic)LRG_261
Cards
Entrez_Gene (NCBI)NTRK1  4914  neurotrophic receptor tyrosine kinase 1
AliasesMTC; TRK; TRK1; TRKA; 
Trk-A; p140-TrkA
GeneCards (Weizmann)NTRK1
Ensembl hg19 (Hinxton)ENSG00000198400 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000198400 [Gene_View]  ENSG00000198400 [Sequence]  chr1:156860879-156881850 [Contig_View]  NTRK1 [Vega]
ICGC DataPortalENSG00000198400
TCGA cBioPortalNTRK1
AceView (NCBI)NTRK1
Genatlas (Paris)NTRK1
WikiGenes4914
SOURCE (Princeton)NTRK1
Genetics Home Reference (NIH)NTRK1
Genomic and cartography
GoldenPath hg38 (UCSC)NTRK1  -     chr1:156860879-156881850 +  1q23.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NTRK1  -     1q23.1   [Description]    (hg19-Feb_2009)
GoldenPathNTRK1 - 1q23.1 [CytoView hg19]  NTRK1 - 1q23.1 [CytoView hg38]
ImmunoBaseENSG00000198400
genome Data Viewer NCBINTRK1 [Mapview hg19]  
OMIM191315   256800   
Gene and transcription
Genbank (Entrez)AK126428 AK290759 AK312704 BC062580 BC136554
RefSeq transcript (Entrez)NM_001007792 NM_001012331 NM_002529
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NTRK1
Alternative Splicing GalleryENSG00000198400
Gene ExpressionNTRK1 [ NCBI-GEO ]   NTRK1 [ EBI - ARRAY_EXPRESS ]   NTRK1 [ SEEK ]   NTRK1 [ MEM ]
Gene Expression Viewer (FireBrowse)NTRK1 [ Firebrowse - Broad ]
GenevisibleExpression of NTRK1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4914
GTEX Portal (Tissue expression)NTRK1
Human Protein AtlasENSG00000198400-NTRK1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP04629   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP04629  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP04629
Splice isoforms : SwissVarP04629
PhosPhoSitePlusP04629
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)    RECEPTOR_TYR_KIN_II (PS00239)   
Domains : Interpro (EBI)Cys-rich_flank_reg_C    Ig-like_dom    Ig-like_dom_sf    Ig-like_fold    Kinase-like_dom_sf    Leu-rich_rpt    LRR_dom_sf    NTRK_C2    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser-Thr/Tyr_kinase_cat_dom    TrkA_TMD    Tyr_kinase_AS    Tyr_kinase_cat_dom    Tyr_kinase_neurotrophic_rcpt_1    Tyr_kinase_NGF_rcpt    Tyr_kinase_rcpt_2_CS   
Domain families : Pfam (Sanger)LRR_8 (PF13855)    Pkinase_Tyr (PF07714)    TPKR_C2 (PF16920)    TrkA_TMD (PF18613)   
Domain families : Pfam (NCBI)pfam13855    pfam07714    pfam16920    pfam18613   
Domain families : Smart (EMBL)LRRCT (SM00082)  TyrKc (SM00219)  
Conserved Domain (NCBI)NTRK1
DMDM Disease mutations4914
Blocks (Seattle)NTRK1
PDB (RSDB)1HE7    1SHC    1WWA    1WWW    2IFG    2N90    4AOJ    4CRP    4F0I    4GT5    4PMM    4PMP    4PMS    4PMT    4YNE    4YPS    5H3Q    5I8A    5JFS    5JFV    5JFW    5JFX    5KMI    5KMJ    5KMK    5KML    5KMM    5KMN    5KMO    5KVT    5WR7    6D1Y    6D1Z    6D20    6D22    6DKB    6DKG    6DKI    6DKW    6IQN    6J5L    6NPT    6NSP    6NSS    6PL1    6PL2    6PL3   
PDB Europe1HE7    1SHC    1WWA    1WWW    2IFG    2N90    4AOJ    4CRP    4F0I    4GT5    4PMM    4PMP    4PMS    4PMT    4YNE    4YPS    5H3Q    5I8A    5JFS    5JFV    5JFW    5JFX    5KMI    5KMJ    5KMK    5KML    5KMM    5KMN    5KMO    5KVT    5WR7    6D1Y    6D1Z    6D20    6D22    6DKB    6DKG    6DKI    6DKW    6IQN    6J5L    6NPT    6NSP    6NSS    6PL1    6PL2    6PL3   
PDB (PDBSum)1HE7    1SHC    1WWA    1WWW    2IFG    2N90    4AOJ    4CRP    4F0I    4GT5    4PMM    4PMP    4PMS    4PMT    4YNE    4YPS    5H3Q    5I8A    5JFS    5JFV    5JFW    5JFX    5KMI    5KMJ    5KMK    5KML    5KMM    5KMN    5KMO    5KVT    5WR7    6D1Y    6D1Z    6D20    6D22    6DKB    6DKG    6DKI    6DKW    6IQN    6J5L    6NPT    6NSP    6NSS    6PL1    6PL2    6PL3   
PDB (IMB)1HE7    1SHC    1WWA    1WWW    2IFG    2N90    4AOJ    4CRP    4F0I    4GT5    4PMM    4PMP    4PMS    4PMT    4YNE    4YPS    5H3Q    5I8A    5JFS    5JFV    5JFW    5JFX    5KMI    5KMJ    5KMK    5KML    5KMM    5KMN    5KMO    5KVT    5WR7    6D1Y    6D1Z    6D20    6D22    6DKB    6DKG    6DKI    6DKW    6IQN    6J5L    6NPT    6NSP    6NSS    6PL1    6PL2    6PL3   
Structural Biology KnowledgeBase1HE7    1SHC    1WWA    1WWW    2IFG    2N90    4AOJ    4CRP    4F0I    4GT5    4PMM    4PMP    4PMS    4PMT    4YNE    4YPS    5H3Q    5I8A    5JFS    5JFV    5JFW    5JFX    5KMI    5KMJ    5KMK    5KML    5KMM    5KMN    5KMO    5KVT    5WR7    6D1Y    6D1Z    6D20    6D22    6DKB    6DKG    6DKI    6DKW    6IQN    6J5L    6NPT    6NSP    6NSS    6PL1    6PL2    6PL3   
SCOP (Structural Classification of Proteins)1HE7    1SHC    1WWA    1WWW    2IFG    2N90    4AOJ    4CRP    4F0I    4GT5    4PMM    4PMP    4PMS    4PMT    4YNE    4YPS    5H3Q    5I8A    5JFS    5JFV    5JFW    5JFX    5KMI    5KMJ    5KMK    5KML    5KMM    5KMN    5KMO    5KVT    5WR7    6D1Y    6D1Z    6D20    6D22    6DKB    6DKG    6DKI    6DKW    6IQN    6J5L    6NPT    6NSP    6NSS    6PL1    6PL2    6PL3   
CATH (Classification of proteins structures)1HE7    1SHC    1WWA    1WWW    2IFG    2N90    4AOJ    4CRP    4F0I    4GT5    4PMM    4PMP    4PMS    4PMT    4YNE    4YPS    5H3Q    5I8A    5JFS    5JFV    5JFW    5JFX    5KMI    5KMJ    5KMK    5KML    5KMM    5KMN    5KMO    5KVT    5WR7    6D1Y    6D1Z    6D20    6D22    6DKB    6DKG    6DKI    6DKW    6IQN    6J5L    6NPT    6NSP    6NSS    6PL1    6PL2    6PL3   
SuperfamilyP04629
Human Protein Atlas [tissue]ENSG00000198400-NTRK1 [tissue]
Peptide AtlasP04629
HPRD01869
IPIIPI00025076   IPI00514519   IPI00383065   IPI00383961   IPI00747653   IPI00976109   IPI00982074   
Protein Interaction databases
DIP (DOE-UCLA)P04629
IntAct (EBI)P04629
FunCoupENSG00000198400
BioGRIDNTRK1
STRING (EMBL)NTRK1
ZODIACNTRK1
Ontologies - Pathways
QuickGOP04629
Ontology : AmiGOGolgi membrane  activation of MAPKK activity  positive regulation of protein phosphorylation  protein tyrosine kinase activity  protein tyrosine kinase activity  transmembrane receptor protein tyrosine kinase activity  transmembrane receptor protein tyrosine kinase activity  transmembrane receptor protein tyrosine kinase activity  GPI-linked ephrin receptor activity  neurotrophin receptor activity  neurotrophin p75 receptor binding  protein binding  ATP binding  early endosome  late endosome  plasma membrane  plasma membrane  integral component of plasma membrane  integral component of plasma membrane  protein phosphorylation  transmembrane receptor protein tyrosine kinase signaling pathway  multicellular organism development  nervous system development  axon guidance  aging  learning or memory  circadian rhythm  negative regulation of cell proliferation  response to radiation  cell surface  endosome membrane  nerve growth factor receptor activity  nerve growth factor receptor activity  programmed cell death involved in cell development  positive regulation of neuron projection development  positive regulation of phosphatidylinositol 3-kinase signaling  peptidyl-tyrosine phosphorylation  kinase binding  olfactory nerve development  B cell differentiation  axon  dendrite  response to nutrient levels  early endosome membrane  late endosome membrane  protein-containing complex  positive regulation of kinase activity  peptidyl-tyrosine autophosphorylation  nerve growth factor signaling pathway  nerve growth factor signaling pathway  mechanoreceptor differentiation  identical protein binding  protein homodimerization activity  neuronal cell body  negative regulation of apoptotic process  positive regulation of programmed cell death  neurotrophin binding  receptor complex  receptor complex  regulation of MAPK cascade  positive regulation of MAPK cascade  negative regulation of neuron apoptotic process  positive regulation of GTPase activity  positive regulation of Ras protein signal transduction  protein autophosphorylation  neurotrophin TRK receptor signaling pathway  neurotrophin TRK receptor signaling pathway  ephrin receptor signaling pathway  phosphatidylinositol-mediated signaling  nerve growth factor binding  sympathetic nervous system development  response to axon injury  detection of temperature stimulus involved in sensory perception of pain  detection of mechanical stimulus involved in sensory perception of pain  positive regulation of NF-kappaB transcription factor activity  response to hydrostatic pressure  response to electrical stimulus  regulation of protein kinase B signaling  positive regulation of synapse assembly  positive regulation of synaptic transmission, glutamatergic  recycling endosome membrane  Sertoli cell development  axonogenesis involved in innervation  behavioral response to formalin induced pain  positive regulation of ERK1 and ERK2 cascade  positive regulation of ERK1 and ERK2 cascade  cellular response to nicotine  cellular response to amyloid-beta  cellular response to nerve growth factor stimulus  cellular response to nerve growth factor stimulus  cellular response to nerve growth factor stimulus  
Ontology : EGO-EBIGolgi membrane  activation of MAPKK activity  positive regulation of protein phosphorylation  protein tyrosine kinase activity  protein tyrosine kinase activity  transmembrane receptor protein tyrosine kinase activity  transmembrane receptor protein tyrosine kinase activity  transmembrane receptor protein tyrosine kinase activity  GPI-linked ephrin receptor activity  neurotrophin receptor activity  neurotrophin p75 receptor binding  protein binding  ATP binding  early endosome  late endosome  plasma membrane  plasma membrane  integral component of plasma membrane  integral component of plasma membrane  protein phosphorylation  transmembrane receptor protein tyrosine kinase signaling pathway  multicellular organism development  nervous system development  axon guidance  aging  learning or memory  circadian rhythm  negative regulation of cell proliferation  response to radiation  cell surface  endosome membrane  nerve growth factor receptor activity  nerve growth factor receptor activity  programmed cell death involved in cell development  positive regulation of neuron projection development  positive regulation of phosphatidylinositol 3-kinase signaling  peptidyl-tyrosine phosphorylation  kinase binding  olfactory nerve development  B cell differentiation  axon  dendrite  response to nutrient levels  early endosome membrane  late endosome membrane  protein-containing complex  positive regulation of kinase activity  peptidyl-tyrosine autophosphorylation  nerve growth factor signaling pathway  nerve growth factor signaling pathway  mechanoreceptor differentiation  identical protein binding  protein homodimerization activity  neuronal cell body  negative regulation of apoptotic process  positive regulation of programmed cell death  neurotrophin binding  receptor complex  receptor complex  regulation of MAPK cascade  positive regulation of MAPK cascade  negative regulation of neuron apoptotic process  positive regulation of GTPase activity  positive regulation of Ras protein signal transduction  protein autophosphorylation  neurotrophin TRK receptor signaling pathway  neurotrophin TRK receptor signaling pathway  ephrin receptor signaling pathway  phosphatidylinositol-mediated signaling  nerve growth factor binding  sympathetic nervous system development  response to axon injury  detection of temperature stimulus involved in sensory perception of pain  detection of mechanical stimulus involved in sensory perception of pain  positive regulation of NF-kappaB transcription factor activity  response to hydrostatic pressure  response to electrical stimulus  regulation of protein kinase B signaling  positive regulation of synapse assembly  positive regulation of synaptic transmission, glutamatergic  recycling endosome membrane  Sertoli cell development  axonogenesis involved in innervation  behavioral response to formalin induced pain  positive regulation of ERK1 and ERK2 cascade  positive regulation of ERK1 and ERK2 cascade  cellular response to nicotine  cellular response to amyloid-beta  cellular response to nerve growth factor stimulus  cellular response to nerve growth factor stimulus  cellular response to nerve growth factor stimulus  
Pathways : KEGGMAPK signaling pathway    Endocytosis    Apoptosis    Neurotrophin signaling pathway    Pathways in cancer    Transcriptional misregulation in cancer    Thyroid cancer   
NDEx NetworkNTRK1
Atlas of Cancer Signalling NetworkNTRK1
Wikipedia pathwaysNTRK1
Orthology - Evolution
OrthoDB4914
GeneTree (enSembl)ENSG00000198400
Phylogenetic Trees/Animal Genes : TreeFamNTRK1
HOGENOMP04629
Homologs : HomoloGeneNTRK1
Homology/Alignments : Family Browser (UCSC)NTRK1
Gene fusions - Rearrangements
Fusion : MitelmanBCAN/NTRK1 [1q23.1/1q23.1]  
Fusion : MitelmanIRF2BP2/NTRK1 [1q42.3/1q23.1]  
Fusion : MitelmanNFASC/NTRK1 [1q32.1/1q23.1]  
Fusion : MitelmanSQSTM1/NTRK1 [5q35.3/1q23.1]  
Fusion : MitelmanSSBP2/NTRK1 [5q14.1/1q23.1]  
Fusion : MitelmanTFG/NTRK1 [3q12.2/1q23.1]  
Fusion : MitelmanTPM3/NTRK1 [1q21.3/1q23.1]  
Fusion : MitelmanTPR/NTRK1 [1q31.1/1q23.1]  
Fusion PortalIRF2BP2 1q42.3 NTRK1 1q23.1 THCA
Fusion PortalNFASC 1q32.1 NTRK1 1q23.1 GBM
Fusion PortalSQSTM1 5q35.3 NTRK1 1q23.1 THCA
Fusion PortalSSBP2 5q14.1 NTRK1 1q23.1 THCA
Fusion PortalTFG 3q12.2 NTRK1 1q23.1 THCA
Fusion PortalTPM3 1q21.3 NTRK1 1q23.1 THCA
Fusion : QuiverNTRK1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNTRK1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NTRK1
dbVarNTRK1
ClinVarNTRK1
MonarchNTRK1
1000_GenomesNTRK1 
Exome Variant ServerNTRK1
GNOMAD BrowserENSG00000198400
Varsome BrowserNTRK1
Genetic variants : HAPMAP4914
Genomic Variants (DGV)NTRK1 [DGVbeta]
DECIPHERNTRK1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNTRK1 
Mutations
ICGC Data PortalNTRK1 
TCGA Data PortalNTRK1 
Broad Tumor PortalNTRK1
OASIS PortalNTRK1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNTRK1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNTRK1
Mutations and Diseases : HGMDNTRK1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)Leiden Muscular Dystrophy pages
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Zhejiang University Center for Genetic and Genomic Medicine (ZJU-CGGM)
BioMutasearch NTRK1
DgiDB (Drug Gene Interaction Database)NTRK1
DoCM (Curated mutations)NTRK1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NTRK1 (select a term)
intoGenNTRK1
Cancer3DNTRK1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM191315    256800   
Orphanet935    905    10856    14205   
DisGeNETNTRK1
MedgenNTRK1
Genetic Testing Registry NTRK1
NextProtP04629 [Medical]
TSGene4914
GENETestsNTRK1
Target ValidationNTRK1
Huge Navigator NTRK1 [HugePedia]
snp3D : Map Gene to Disease4914
BioCentury BCIQNTRK1
ClinGenNTRK1
Clinical trials, drugs, therapy
Protein Interactions : CTD4914
Pharm GKB GenePA31817
Clinical trialNTRK1
Miscellaneous
canSAR (ICR)NTRK1 (select the gene name)
HarmonizomeNTRK1
DataMed IndexNTRK1
Probes
Litterature
PubMed361 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNTRK1
EVEXNTRK1
GoPubMedNTRK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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