Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

NTRK1 (neurotrophic receptor tyrosine kinase 1)

Identity

Other namesMTC
TRK
TRK1
TRKA
Trk-A
p140-TrkA
HGNC (Hugo) NTRK1
LocusID (NCBI) 4914
Atlas_Id 216
Location 1q23.1  [Link to chromosome band 1q23]
Location_base_pair Starts at 156785542 and ends at 156851642 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
BCAN (1q23.1) / NTRK1 (1q23.1)CD74 (5q32) / NTRK1 (1q23.1)IRF2BP2 (1q42.3) / NTRK1 (1q23.1)
LMNA (1q22) / NTRK1 (1q23.1)MIR548F1 (1q31.1) / NTRK1 (1q23.1)MPRIP (17p11.2) / NTRK1 (1q23.1)
NFASC (1q32.1) / NTRK1 (1q23.1)NTRK1 (1q23.1) / CD5 (11q12.2)NTRK1 (1q23.1) / TFG (3q12.2)
NTRK1 (1q23.1) / TPM3 (1q21.3)NTRK1 (1q23.1) / TPR (1q31.1)RET (10q11.21) / NTRK1 (1q23.1)
RPL7A (9q34.2) / NTRK1 (1q23.1)SQSTM1 (5q35.3) / NTRK1 (1q23.1)SSBP2 (5q14.1) / NTRK1 (1q23.1)
TFG (3q12.2) / NTRK1 (1q23.1)TP53 (17p13.1) / NTRK1 (1q23.1)TPM3 (1q21.3) / NTRK1 (1q23.1)
TPR (1q31.1) / NTRK1 (1q23.1)TPM3 1q21.3 / NTRK1 1q23.1IRF2BP2 1q42.3 / NTRK1 1q23.1
NFASC 1q32.1 / NTRK1 1q23.1SQSTM1 5q35.3 / NTRK1 1q23.1SSBP2 5q14.1 / NTRK1 1q23.1
TFG 3q12.2 / NTRK1 1q23.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Breakpoints

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 3 ]
  Anaplastic large cell lymphoma (ALCL)
t(2;3)(p23;q21) TFG/ALK
t(2;5)(p23;q35) SQSTM1/ALK

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  Thyroid: Papillary Carcinoma with inv(7)(q21q34) AKAP9/BRAF
Thyroid: Papillary carcinoma/Adenocarcinoma
Thyroid: Papillary carcinoma with inv(10)(p12.1q11.2) ACBD5/RET

External links

Nomenclature
HGNC (Hugo)NTRK1   8031
Cards
Entrez_Gene (NCBI)NTRK1  4914  neurotrophic receptor tyrosine kinase 1
AliasesMTC; TRK; TRK1; TRKA; 
Trk-A; p140-TrkA
GeneCards (Weizmann)NTRK1
Ensembl hg19 (Hinxton)ENSG00000198400 [Gene_View]  chr1:156785542-156851642 [Contig_View]  NTRK1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000198400 [Gene_View]  chr1:156785542-156851642 [Contig_View]  NTRK1 [Vega]
ICGC DataPortalENSG00000198400
TCGA cBioPortalNTRK1
AceView (NCBI)NTRK1
Genatlas (Paris)NTRK1
WikiGenes4914
SOURCE (Princeton)NTRK1
Genomic and cartography
GoldenPath hg19 (UCSC)NTRK1  -     chr1:156785542-156851642 +  1q23.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)NTRK1  -     1q23.1   [Description]    (hg38-Dec_2013)
EnsemblNTRK1 - 1q23.1 [CytoView hg19]  NTRK1 - 1q23.1 [CytoView hg38]
Mapping of homologs : NCBINTRK1 [Mapview hg19]  NTRK1 [Mapview hg38]
OMIM155240   191315   256800   
Gene and transcription
Genbank (Entrez)AK126428 AK290759 AK312704 BC062580 BC136554
RefSeq transcript (Entrez)NM_001007792 NM_001012331 NM_002529
RefSeq genomic (Entrez)NC_000001 NC_018912 NG_007493 NT_004487 NW_004929293
Consensus coding sequences : CCDS (NCBI)NTRK1
Cluster EST : UnigeneHs.406293 [ NCBI ]
CGAP (NCI)Hs.406293
Alternative Splicing GalleryENSG00000198400
Gene ExpressionNTRK1 [ NCBI-GEO ]   NTRK1 [ EBI - ARRAY_EXPRESS ]   NTRK1 [ SEEK ]   NTRK1 [ MEM ]
Gene Expression Viewer (FireBrowse)NTRK1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4914
GTEX Portal (Tissue expression)NTRK1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP04629 (Uniprot)
NextProtP04629  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP04629
Splice isoforms : SwissVarP04629 (Swissvar)
Catalytic activity : Enzyme2.7.10.1 [ Enzyme-Expasy ]   2.7.10.12.7.10.1 [ IntEnz-EBI ]   2.7.10.1 [ BRENDA ]   2.7.10.1 [ KEGG ]   
PhosPhoSitePlusP04629
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)    RECEPTOR_TYR_KIN_II (PS00239)   
Domains : Interpro (EBI)Cys-rich_flank_reg_C    Ig-like_dom    Ig-like_fold    Ig_sub    Kinase-like_dom    L_dom-like    Leu-rich_rpt    NTRK_C2    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser-Thr/Tyr_kinase_cat_dom    Tyr_kinase_AS    Tyr_kinase_cat_dom    Tyr_kinase_neurotrophic_rcpt_1    Tyr_kinase_NGF_rcpt    Tyr_kinase_rcpt_2_CS   
Domain families : Pfam (Sanger)LRR_8 (PF13855)    Pkinase_Tyr (PF07714)    TPKR_C2 (PF16920)   
Domain families : Pfam (NCBI)pfam13855    pfam07714    pfam16920   
Domain families : Smart (EMBL)IG (SM00409)  LRRCT (SM00082)  TyrKc (SM00219)  
DMDM Disease mutations4914
Blocks (Seattle)NTRK1
PDB (SRS)1HE7    1SHC    1WWA    1WWW    2IFG    4AOJ    4CRP    4F0I    4GT5    4PMM    4PMP    4PMS    4PMT    4YNE    4YPS   
PDB (PDBSum)1HE7    1SHC    1WWA    1WWW    2IFG    4AOJ    4CRP    4F0I    4GT5    4PMM    4PMP    4PMS    4PMT    4YNE    4YPS   
PDB (IMB)1HE7    1SHC    1WWA    1WWW    2IFG    4AOJ    4CRP    4F0I    4GT5    4PMM    4PMP    4PMS    4PMT    4YNE    4YPS   
PDB (RSDB)1HE7    1SHC    1WWA    1WWW    2IFG    4AOJ    4CRP    4F0I    4GT5    4PMM    4PMP    4PMS    4PMT    4YNE    4YPS   
Structural Biology KnowledgeBase1HE7    1SHC    1WWA    1WWW    2IFG    4AOJ    4CRP    4F0I    4GT5    4PMM    4PMP    4PMS    4PMT    4YNE    4YPS   
SCOP (Structural Classification of Proteins)1HE7    1SHC    1WWA    1WWW    2IFG    4AOJ    4CRP    4F0I    4GT5    4PMM    4PMP    4PMS    4PMT    4YNE    4YPS   
CATH (Classification of proteins structures)1HE7    1SHC    1WWA    1WWW    2IFG    4AOJ    4CRP    4F0I    4GT5    4PMM    4PMP    4PMS    4PMT    4YNE    4YPS   
SuperfamilyP04629
Human Protein AtlasENSG00000198400
Peptide AtlasP04629
HPRD01869
IPIIPI00025076   IPI00514519   IPI00383065   IPI00383961   IPI00747653   IPI00976109   IPI00982074   
Protein Interaction databases
DIP (DOE-UCLA)P04629
IntAct (EBI)P04629
FunCoupENSG00000198400
BioGRIDNTRK1
STRING (EMBL)NTRK1
ZODIACNTRK1
Ontologies - Pathways
QuickGOP04629
Ontology : AmiGOactivation of MAPKK activity  positive regulation of protein phosphorylation  transmembrane receptor protein tyrosine kinase activity  GPI-linked ephrin receptor activity  neurotrophin p75 receptor binding  protein binding  ATP binding  endosome  early endosome  late endosome  plasma membrane  plasma membrane  integral component of plasma membrane  protein phosphorylation  microtubule-based movement  axon guidance  aging  learning or memory  circadian rhythm  negative regulation of cell proliferation  negative regulation of cell proliferation  response to radiation  cell surface  nerve growth factor receptor activity  developmental programmed cell death  positive regulation of neuron projection development  positive regulation of neuron projection development  response to activity  peptidyl-tyrosine phosphorylation  kinase binding  olfactory nerve development  B cell differentiation  axon  dendrite  cytoplasmic vesicle  response to nutrient levels  early endosome membrane  late endosome membrane  nerve growth factor signaling pathway  mechanoreceptor differentiation  response to drug  protein homodimerization activity  neuronal cell body  positive regulation of programmed cell death  neurotrophin binding  protein complex  receptor complex  negative regulation of neuron apoptotic process  positive regulation of GTPase activity  positive regulation of GTPase activity  response to ethanol  positive regulation of angiogenesis  positive regulation of Ras protein signal transduction  positive regulation of Ras protein signal transduction  protein autophosphorylation  neurotrophin TRK receptor signaling pathway  neurotrophin TRK receptor signaling pathway  ephrin receptor signaling pathway  phosphatidylinositol-mediated signaling  nerve growth factor binding  nerve growth factor binding  sympathetic nervous system development  response to axon injury  detection of temperature stimulus involved in sensory perception of pain  detection of mechanical stimulus involved in sensory perception of pain  positive regulation of NF-kappaB transcription factor activity  response to hydrostatic pressure  response to electrical stimulus  positive regulation of synapse assembly  positive regulation of synaptic transmission, glutamatergic  Sertoli cell development  axonogenesis involved in innervation  behavioral response to formalin induced pain  positive regulation of ERK1 and ERK2 cascade  positive regulation of ERK1 and ERK2 cascade  cellular response to nicotine  cellular response to nerve growth factor stimulus  
Ontology : EGO-EBIactivation of MAPKK activity  positive regulation of protein phosphorylation  transmembrane receptor protein tyrosine kinase activity  GPI-linked ephrin receptor activity  neurotrophin p75 receptor binding  protein binding  ATP binding  endosome  early endosome  late endosome  plasma membrane  plasma membrane  integral component of plasma membrane  protein phosphorylation  microtubule-based movement  axon guidance  aging  learning or memory  circadian rhythm  negative regulation of cell proliferation  negative regulation of cell proliferation  response to radiation  cell surface  nerve growth factor receptor activity  developmental programmed cell death  positive regulation of neuron projection development  positive regulation of neuron projection development  response to activity  peptidyl-tyrosine phosphorylation  kinase binding  olfactory nerve development  B cell differentiation  axon  dendrite  cytoplasmic vesicle  response to nutrient levels  early endosome membrane  late endosome membrane  nerve growth factor signaling pathway  mechanoreceptor differentiation  response to drug  protein homodimerization activity  neuronal cell body  positive regulation of programmed cell death  neurotrophin binding  protein complex  receptor complex  negative regulation of neuron apoptotic process  positive regulation of GTPase activity  positive regulation of GTPase activity  response to ethanol  positive regulation of angiogenesis  positive regulation of Ras protein signal transduction  positive regulation of Ras protein signal transduction  protein autophosphorylation  neurotrophin TRK receptor signaling pathway  neurotrophin TRK receptor signaling pathway  ephrin receptor signaling pathway  phosphatidylinositol-mediated signaling  nerve growth factor binding  nerve growth factor binding  sympathetic nervous system development  response to axon injury  detection of temperature stimulus involved in sensory perception of pain  detection of mechanical stimulus involved in sensory perception of pain  positive regulation of NF-kappaB transcription factor activity  response to hydrostatic pressure  response to electrical stimulus  positive regulation of synapse assembly  positive regulation of synaptic transmission, glutamatergic  Sertoli cell development  axonogenesis involved in innervation  behavioral response to formalin induced pain  positive regulation of ERK1 and ERK2 cascade  positive regulation of ERK1 and ERK2 cascade  cellular response to nicotine  cellular response to nerve growth factor stimulus  
Pathways : BIOCARTARole of Erk5 in Neuronal Survival [Genes]    Y branching of actin filaments [Genes]    Trka Receptor Signaling Pathway [Genes]   
Pathways : KEGGMAPK signaling pathway    Endocytosis    Apoptosis    Neurotrophin signaling pathway    Pathways in cancer    Transcriptional misregulation in cancer    Thyroid cancer   
NDEx NetworkNTRK1
Atlas of Cancer Signalling NetworkNTRK1
Wikipedia pathwaysNTRK1
Orthology - Evolution
OrthoDB4914
GeneTree (enSembl)ENSG00000198400
Phylogenetic Trees/Animal Genes : TreeFamNTRK1
Homologs : HomoloGeneNTRK1
Homology/Alignments : Family Browser (UCSC)NTRK1
Gene fusions - Rearrangements
Fusion: TCGAIRF2BP2 1q42.3 NTRK1 1q23.1 THCA
Fusion: TCGANFASC 1q32.1 NTRK1 1q23.1 GBM
Fusion: TCGASQSTM1 5q35.3 NTRK1 1q23.1 THCA
Fusion: TCGASSBP2 5q14.1 NTRK1 1q23.1 THCA
Fusion: TCGATFG 3q12.2 NTRK1 1q23.1 THCA
Fusion: TCGATPM3 1q21.3 NTRK1 1q23.1 THCA
Polymorphisms : SNP, variants
NCBI Variation ViewerNTRK1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NTRK1
dbVarNTRK1
ClinVarNTRK1
1000_GenomesNTRK1 
Exome Variant ServerNTRK1
ExAC (Exome Aggregation Consortium)NTRK1 (select the gene name)
Genetic variants : HAPMAP4914
Genomic Variants (DGV)NTRK1 [DGVbeta]
Mutations
ICGC Data PortalNTRK1 
TCGA Data PortalNTRK1 
Broad Tumor PortalNTRK1
OASIS PortalNTRK1 [ Somatic mutations - Copy number]
Cancer Gene: CensusNTRK1 
Somatic Mutations in Cancer : COSMICNTRK1 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)Leiden Muscular Dystrophy pages
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Zhejiang University Center for Genetic and Genomic Medicine (ZJU-CGGM)
BioMutasearch NTRK1
DgiDB (Drug Gene Interaction Database)NTRK1
DoCM (Curated mutations)NTRK1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NTRK1 (select a term)
intoGenNTRK1
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)1:156785542-156851642  ENSG00000198400
CONAN: Copy Number AnalysisNTRK1 
Mutations and Diseases : HGMDNTRK1
OMIM155240    191315    256800   
MedgenNTRK1
Genetic Testing Registry NTRK1
NextProtP04629 [Medical]
TSGene4914
GENETestsNTRK1
Huge Navigator NTRK1 [HugePedia]
snp3D : Map Gene to Disease4914
BioCentury BCIQNTRK1
ClinGenNTRK1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4914
Chemical/Pharm GKB GenePA31817
Clinical trialNTRK1
Miscellaneous
canSAR (ICR)NTRK1 (select the gene name)
Probes
Litterature
PubMed276 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNTRK1
EVEXNTRK1
GoPubMedNTRK1
iHOPNTRK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 19 19:05:23 CEST 2016

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.