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NTRK1 (neurotrophic tyrosine kinase, receptor, type 1)

Identity

Other namesMTC
TRK
TRK1
TRKA
Trk-A
p140-TrkA
HGNC (Hugo) NTRK1
LocusID (NCBI) 4914
Location 1q23.1
Location_base_pair Starts at 156785542 and ends at 156851642 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Breakpoints

 

Other Leukemias implicated (Data extracted from papers in the Atlas)

Leukemias 11q23ChildAMLID1615 11q23ID1030

Other Solid tumors implicated (Data extracted from papers in the Atlas)

Solid Tumors AmeloblastomID5945

External links

Nomenclature
HGNC (Hugo)NTRK1   8031
Cards
Entrez_Gene (NCBI)NTRK1  4914  neurotrophic tyrosine kinase, receptor, type 1
GeneCards (Weizmann)NTRK1
Ensembl (Hinxton)ENSG00000198400 [Gene_View]  chr1:156785542-156851642 [Contig_View]  NTRK1 [Vega]
ICGC DataPortalENSG00000198400
AceView (NCBI)NTRK1
Genatlas (Paris)NTRK1
WikiGenes4914
SOURCE (Princeton)NM_001007792 NM_001012331 NM_002529
Genomic and cartography
GoldenPath (UCSC)NTRK1  -  1q23.1   chr1:156785542-156851642 +  1q23.1   [Description]    (hg19-Feb_2009)
EnsemblNTRK1 - 1q23.1 [CytoView]
Mapping of homologs : NCBINTRK1 [Mapview]
OMIM155240   191315   256800   
Gene and transcription
Genbank (Entrez)AK126428 AK290759 AK312704 BC062580 BC136554
RefSeq transcript (Entrez)NM_001007792 NM_001012331 NM_002529
RefSeq genomic (Entrez)AC_000133 NC_000001 NC_018912 NG_007493 NT_004487 NW_001838531 NW_004929293
Consensus coding sequences : CCDS (NCBI)NTRK1
Cluster EST : UnigeneHs.406293 [ NCBI ]
CGAP (NCI)Hs.406293
Alternative Splicing : Fast-db (Paris)GSHG0001057
Alternative Splicing GalleryENSG00000198400
Gene ExpressionNTRK1 [ NCBI-GEO ]     NTRK1 [ SEEK ]   NTRK1 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP04629 (Uniprot)
NextProtP04629  [Medical]
With graphics : InterProP04629
Splice isoforms : SwissVarP04629 (Swissvar)
Catalytic activity : Enzyme2.7.10.1 [ Enzyme-Expasy ]   2.7.10.12.7.10.1 [ IntEnz-EBI ]   2.7.10.1 [ BRENDA ]   2.7.10.1 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)    RECEPTOR_TYR_KIN_II (PS00239)   
Domains : Interpro (EBI)Cys-rich_flank_reg_C    Ig-like_dom    Ig-like_fold    Ig_sub    Kinase-like_dom    Leu-rich_rpt    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser-Thr/Tyr_kinase_cat_dom    Tyr_kinase_AS    Tyr_kinase_cat_dom    Tyr_kinase_neurotrophic_rcpt_1    Tyr_kinase_NGF_rcpt    Tyr_kinase_rcpt_2_CS   
Related proteins : CluSTrP04629
Domain families : Pfam (Sanger)LRR_8 (PF13855)    Pkinase_Tyr (PF07714)   
Domain families : Pfam (NCBI)pfam13855    pfam07714   
Domain families : Smart (EMBL)IG (SM00409)  LRRCT (SM00082)  TyrKc (SM00219)  
DMDM Disease mutations4914
Blocks (Seattle)P04629
PDB (SRS)1HE7    1SHC    1WWA    1WWW    2IFG    4AOJ    4F0I    4GT5   
PDB (PDBSum)1HE7    1SHC    1WWA    1WWW    2IFG    4AOJ    4F0I    4GT5   
PDB (IMB)1HE7    1SHC    1WWA    1WWW    2IFG    4AOJ    4F0I    4GT5   
PDB (RSDB)1HE7    1SHC    1WWA    1WWW    2IFG    4AOJ    4F0I    4GT5   
Human Protein AtlasENSG00000198400
Peptide AtlasP04629
HPRD01869
IPIIPI00025076   IPI00514519   IPI00383065   IPI00383961   IPI00747653   IPI00976109   IPI00982074   
Protein Interaction databases
DIP (DOE-UCLA)P04629
IntAct (EBI)P04629
FunCoupENSG00000198400
BioGRIDNTRK1
InParanoidP04629
Interologous Interaction database P04629
IntegromeDBNTRK1
STRING (EMBL)NTRK1
Ontologies - Pathways
Ontology : AmiGOactivation of MAPKK activity  transmembrane receptor protein tyrosine kinase activity  neurotrophin p75 receptor binding  protein binding  ATP binding  endosome  early endosome  late endosome  plasma membrane  plasma membrane  integral component of plasma membrane  protein phosphorylation  transmembrane receptor protein tyrosine kinase signaling pathway  activation of adenylate cyclase activity  activation of phospholipase C activity  small GTPase mediated signal transduction  Ras protein signal transduction  axon guidance  aging  learning or memory  negative regulation of cell proliferation  negative regulation of cell proliferation  response to radiation  cell surface  nerve growth factor receptor activity  developmental programmed cell death  positive regulation of neuron projection development  positive regulation of neuron projection development  response to activity  peptidyl-tyrosine phosphorylation  peptidyl-tyrosine phosphorylation  olfactory nerve development  B cell differentiation  axon  dendrite  cytoplasmic vesicle  response to nutrient levels  early endosome membrane  late endosome membrane  positive regulation of Ras GTPase activity  positive regulation of Ras GTPase activity  nerve growth factor signaling pathway  mechanoreceptor differentiation  response to drug  protein homodimerization activity  neuronal cell body  positive regulation of programmed cell death  neurotrophin binding  protein complex  receptor complex  negative regulation of neuron apoptotic process  response to ethanol  positive regulation of angiogenesis  positive regulation of Ras protein signal transduction  positive regulation of Ras protein signal transduction  protein autophosphorylation  ephrin receptor binding  neurotrophin TRK receptor signaling pathway  neurotrophin TRK receptor signaling pathway  phosphatidylinositol-mediated signaling  nerve growth factor binding  nerve growth factor binding  sympathetic nervous system development  response to axon injury  detection of temperature stimulus involved in sensory perception of pain  detection of mechanical stimulus involved in sensory perception of pain  positive regulation of NF-kappaB transcription factor activity  response to hydrostatic pressure  response to electrical stimulus  positive regulation of synaptic transmission, glutamatergic  Sertoli cell development  axonogenesis involved in innervation  positive regulation of ERK1 and ERK2 cascade  positive regulation of ERK1 and ERK2 cascade  cellular response to nicotine  cellular response to nerve growth factor stimulus  
Ontology : EGO-EBIactivation of MAPKK activity  transmembrane receptor protein tyrosine kinase activity  neurotrophin p75 receptor binding  protein binding  ATP binding  endosome  early endosome  late endosome  plasma membrane  plasma membrane  integral component of plasma membrane  protein phosphorylation  transmembrane receptor protein tyrosine kinase signaling pathway  activation of adenylate cyclase activity  activation of phospholipase C activity  small GTPase mediated signal transduction  Ras protein signal transduction  axon guidance  aging  learning or memory  negative regulation of cell proliferation  negative regulation of cell proliferation  response to radiation  cell surface  nerve growth factor receptor activity  developmental programmed cell death  positive regulation of neuron projection development  positive regulation of neuron projection development  response to activity  peptidyl-tyrosine phosphorylation  peptidyl-tyrosine phosphorylation  olfactory nerve development  B cell differentiation  axon  dendrite  cytoplasmic vesicle  response to nutrient levels  early endosome membrane  late endosome membrane  positive regulation of Ras GTPase activity  positive regulation of Ras GTPase activity  nerve growth factor signaling pathway  mechanoreceptor differentiation  response to drug  protein homodimerization activity  neuronal cell body  positive regulation of programmed cell death  neurotrophin binding  protein complex  receptor complex  negative regulation of neuron apoptotic process  response to ethanol  positive regulation of angiogenesis  positive regulation of Ras protein signal transduction  positive regulation of Ras protein signal transduction  protein autophosphorylation  ephrin receptor binding  neurotrophin TRK receptor signaling pathway  neurotrophin TRK receptor signaling pathway  phosphatidylinositol-mediated signaling  nerve growth factor binding  nerve growth factor binding  sympathetic nervous system development  response to axon injury  detection of temperature stimulus involved in sensory perception of pain  detection of mechanical stimulus involved in sensory perception of pain  positive regulation of NF-kappaB transcription factor activity  response to hydrostatic pressure  response to electrical stimulus  positive regulation of synaptic transmission, glutamatergic  Sertoli cell development  axonogenesis involved in innervation  positive regulation of ERK1 and ERK2 cascade  positive regulation of ERK1 and ERK2 cascade  cellular response to nicotine  cellular response to nerve growth factor stimulus  
Pathways : BIOCARTARole of Erk5 in Neuronal Survival [Genes]    Y branching of actin filaments [Genes]    Trka Receptor Signaling Pathway [Genes]   
Pathways : KEGGMAPK signaling pathway    Endocytosis    Apoptosis    Neurotrophin signaling pathway    Pathways in cancer    Transcriptional misregulation in cancer    Thyroid cancer   
Protein Interaction DatabaseNTRK1
Wikipedia pathwaysNTRK1
Gene fusion - rearrangments
Rearrangement : COSMICNTRK1 [1q23.1]  -  TFG [3q12.2]
Rearrangement : COSMICNTRK1 [1q23.1]  -  TPM3 [1q21.3]
Rearrangement : COSMICTFG [3q12.2]  -  NTRK1 [1q23.1]
Rearrangement : COSMICTPM3 [1q21.3]  -  NTRK1 [1q23.1]
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)NTRK1
SNP (GeneSNP Utah)NTRK1
SNP : HGBaseNTRK1
Genetic variants : HAPMAPNTRK1
1000_GenomesNTRK1 
ICGC programENSG00000198400 
Cancer Gene: CensusNTRK1 
CONAN: Copy Number AnalysisNTRK1 
Somatic Mutations in Cancer : COSMICNTRK1 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)Leiden Muscular Dystrophy pages
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Zhejiang University Center for Genetic and Genomic Medicine (ZJU-CGGM)
Mutations and Diseases : HGMDNTRK1
OMIM155240    191315    256800   
MedgenNTRK1
GENETestsNTRK1
Disease Genetic AssociationNTRK1
Huge Navigator NTRK1 [HugePedia]  NTRK1 [HugeCancerGEM]
Genomic VariantsNTRK1  NTRK1 [DGVbeta]
Exome VariantNTRK1
dbVarNTRK1
ClinVarNTRK1
snp3D : Map Gene to Disease4914
General knowledge
Homologs : HomoloGeneNTRK1
Homology/Alignments : Family Browser (UCSC)NTRK1
Phylogenetic Trees/Animal Genes : TreeFamNTRK1
Chemical/Protein Interactions : CTD4914
Chemical/Pharm GKB GenePA31817
Clinical trialNTRK1
Cancer Resource (Charite)ENSG00000198400
Other databases
Probes
Litterature
PubMed255 Pubmed reference(s) in Entrez
CoreMineNTRK1
iHOPNTRK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 13 13:05:32 CEST 2014

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