Identity
HGNC
LOCATION
1q23.1
LOCUSID
ALIAS
MTC,TRK,TRK1,TRKA,Trk-A,p140-TrkA
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 4914
MIM: 191315
HGNC: 8031
Ensembl: ENSG00000198400
Variants:
dbSNP: 4914
ClinVar: 4914
TCGA: ENSG00000198400
COSMIC: NTRK1
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA154410481 | prasugrel | Chemical | ClinicalAnnotation | associated | PD | 23859572, 28820077 | |
| PA166182733 | larotrectinib sulfate | Chemical | LabelAnnotation | associated | |||
| PA166190161 | entrectinib | Chemical | LabelAnnotation | associated | |||
| PA34335 | RET | Gene | DataAnnotation | associated | |||
| PA445857 | Thyroid Neoplasms | Disease | Literature, MultilinkAnnotation | associated | 23788249 | ||
| PA446649 | Carcinoma, Medullary | Disease | DataAnnotation | associated | |||
| PA448497 | aspirin | Chemical | ClinicalAnnotation | associated | PD | 23859572, 28820077 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37988282 | 2024 | Pan-TRK immunohistochemistry in gynaecological mesenchymal tumours: diagnostic implications and pitfalls. | 0 |
| 38200609 | 2024 | TrkA promotes MDM2-mediated AGPS ubiquitination and degradation to trigger prostate cancer progression. | 0 |
| 38531265 | 2024 | A recurrent NTRK1 tyrosine kinase domain mutation pair is characteristic in a subset of dedifferentiated liposarcomas. | 0 |
| 38613194 | 2024 | Acquired NF2 mutation confers resistance to TRK inhibition in an ex vivo LMNA::NTRK1-rearranged soft-tissue sarcoma cell model. | 0 |
| 38791513 | 2024 | Molecular Characterization and Inhibition of a Novel Stress-Induced Mitochondrial Protecting Role for Misfolded TrkAIII in Human SH-SY5Y Neuroblastoma Cells. | 0 |
| 38967220 | 2024 | Neurotrophic tyrosine receptor kinase gene fusions in adult and pediatric patients with solid tumors: a clinicogenomic biobank and record linkage study of expression frequency and patient characteristics from Finland. | 0 |
| 37988282 | 2024 | Pan-TRK immunohistochemistry in gynaecological mesenchymal tumours: diagnostic implications and pitfalls. | 0 |
| 38200609 | 2024 | TrkA promotes MDM2-mediated AGPS ubiquitination and degradation to trigger prostate cancer progression. | 0 |
| 38531265 | 2024 | A recurrent NTRK1 tyrosine kinase domain mutation pair is characteristic in a subset of dedifferentiated liposarcomas. | 0 |
| 38613194 | 2024 | Acquired NF2 mutation confers resistance to TRK inhibition in an ex vivo LMNA::NTRK1-rearranged soft-tissue sarcoma cell model. | 0 |
| 38791513 | 2024 | Molecular Characterization and Inhibition of a Novel Stress-Induced Mitochondrial Protecting Role for Misfolded TrkAIII in Human SH-SY5Y Neuroblastoma Cells. | 0 |
| 38967220 | 2024 | Neurotrophic tyrosine receptor kinase gene fusions in adult and pediatric patients with solid tumors: a clinicogenomic biobank and record linkage study of expression frequency and patient characteristics from Finland. | 0 |
| 36537577 | 2023 | Human TrkAR649W mutation impairs nociception, sweating and cognitive abilities: a mouse model of HSAN IV. | 1 |
| 36726044 | 2023 | NTRK1 Spitz melanoma presenting clinically as an angioma. | 0 |
| 37070091 | 2023 | Transcriptomics reveals the effects of NTRK1 on endoplasmic reticulum stress response-associated genes in human neuronal cell lines. | 0 |
Citation
Dessen P
NTRK1 (neurotrophic receptor tyrosine kinase 1)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/216/ntrk1
