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NTRK1 (neurotrophic receptor tyrosine kinase 1)

Identity

Alias (NCBI)MTC
TRK
TRK1
TRKA
Trk-A
p140-TrkA
HGNC (Hugo) NTRK1
HGNC Alias symbTRK
TRKA
MTC
HGNC Alias namehigh affinity nerve growth factor receptor
HGNC Previous nameneurotrophic tyrosine kinase, receptor, type 1
LocusID (NCBI) 4914
Atlas_Id 216
Location 1q23.1  [Link to chromosome band 1q23]
Location_base_pair Starts at 156860879 and ends at 156881850 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BCAN (1q23.1) / NTRK1 (1q23.1)CD74 (5q32) / NTRK1 (1q23.1)IRF2BP2 (1q42.3) / NTRK1 (1q23.1)
LMNA (1q22) / NTRK1 (1q23.1)MIR548F1 (1q31.1) / NTRK1 (1q23.1)MPRIP (17p11.2) / NTRK1 (1q23.1)
NFASC (1q32.1) / NTRK1 (1q23.1)NTRK1 (1q23.1) / CD5 (11q12.2)NTRK1 (1q23.1) / TFG (3q12.2)
NTRK1 (1q23.1) / TPM3 (1q21.3)NTRK1 (1q23.1) / TPR (1q31.1)RET (10q11.21) / NTRK1 (1q23.1)
RPL7A (9q34.2) / NTRK1 (1q23.1)SQSTM1 (5q35.3) / NTRK1 (1q23.1)SSBP2 (5q14.1) / NTRK1 (1q23.1)
TFG (3q12.2) / NTRK1 (1q23.1)TP53 (17p13.1) / NTRK1 (1q23.1)TPM3 (1q21.3) / NTRK1 (1q23.1)
TPR (1q31.1) / NTRK1 (1q23.1)TPR 1q31.1 / NTRK1 1q23.1IRF2BP2 1q42.3 / NTRK1 1q23.1
NFASC 1q32.1 / NTRK1 1q23.1SQSTM1 5q35.3 / NTRK1 1q23.1SSBP2 5q14.1 / NTRK1 1q23.1
TFG 3q12.2 / NTRK1 1q23.1TPM3 1q21.3 / NTRK1 1q23.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Breakpoints

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 4 ]
  Anaplastic large cell lymphoma (ALCL)
t(2;3)(p23;q21) TFG/ALK
t(2;5)(p23;q35) SQSTM1/ALK
t(5;9)(q35;q34) SQSTM1/NUP214


External links

Nomenclature
HGNC (Hugo)NTRK1   8031
LRG (Locus Reference Genomic)LRG_261
Cards
Entrez_Gene (NCBI)NTRK1    neurotrophic receptor tyrosine kinase 1
AliasesMTC; TRK; TRK1; TRKA; 
Trk-A; p140-TrkA
GeneCards (Weizmann)NTRK1
Ensembl hg19 (Hinxton)ENSG00000198400 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000198400 [Gene_View]  ENSG00000198400 [Sequence]  chr1:156860879-156881850 [Contig_View]  NTRK1 [Vega]
ICGC DataPortalENSG00000198400
TCGA cBioPortalNTRK1
AceView (NCBI)NTRK1
Genatlas (Paris)NTRK1
SOURCE (Princeton)NTRK1
Genetics Home Reference (NIH)NTRK1
Genomic and cartography
GoldenPath hg38 (UCSC)NTRK1  -     chr1:156860879-156881850 +  1q23.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NTRK1  -     1q23.1   [Description]    (hg19-Feb_2009)
GoldenPathNTRK1 - 1q23.1 [CytoView hg19]  NTRK1 - 1q23.1 [CytoView hg38]
ImmunoBaseENSG00000198400
Genome Data Viewer NCBINTRK1 [Mapview hg19]  
OMIM191315   256800   
Gene and transcription
Genbank (Entrez)AK126428 AK290759 AK312704 BC062580 BC136554
RefSeq transcript (Entrez)NM_001007792 NM_001012331 NM_002529
Consensus coding sequences : CCDS (NCBI)NTRK1
Gene ExpressionNTRK1 [ NCBI-GEO ]   NTRK1 [ EBI - ARRAY_EXPRESS ]   NTRK1 [ SEEK ]   NTRK1 [ MEM ]
Gene Expression Viewer (FireBrowse)NTRK1 [ Firebrowse - Broad ]
GenevisibleExpression of NTRK1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4914
GTEX Portal (Tissue expression)NTRK1
Human Protein AtlasENSG00000198400-NTRK1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)NTRK1
Human Protein Atlas [tissue]ENSG00000198400-NTRK1 [tissue]
HPRD01869
Protein Interaction databases
BioGRIDNTRK1
STRING (EMBL)NTRK1
ZODIACNTRK1
Ontologies - Pathways
Litterature
PubMed372 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXNTRK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:23:27 CEST 2021

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