NTS (neurotensin)

2007-02-01  

Identity

HGNC
LOCATION
12q21.31
LOCUSID
ALIAS
NMN-125,NN,NT,NT/N,NTS1

Other Information

Locus ID:

NCBI: 4922
MIM: 162650
HGNC: 8038
Ensembl: ENSG00000133636

Variants:

dbSNP: 4922
ClinVar: 4922
TCGA: ENSG00000133636
COSMIC: NTS

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000133636ENST00000256010P30990
ENSG00000133636ENST00000256010Q6FH20
ENSG00000133636ENST00000551529G3V1X6

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA449841haloperidolChemicalMultilinkAnnotationassociated27023437

References

Pubmed IDYearTitleCitations
219941222012CD133(+) liver tumor-initiating cells promote tumor angiogenesis, growth, and self-renewal through neurotensin/interleukin-8/CXCL1 signaling.80
230640142012A major lineage of enteroendocrine cells coexpress CCK, secretin, GIP, GLP-1, PYY, and neurotensin but not somatostatin.77
119121332002Neurotensin induces protein kinase C-dependent protein kinase D activation and DNA synthesis in human pancreatic carcinoma cell line PANC-1.48
218069462011Neurotensin signaling activates microRNAs-21 and -155 and Akt, promotes tumor growth in mice, and is increased in human colon tumors.48
271936872016An obligatory role for neurotensin in high-fat-diet-induced obesity.43
175701312008PKD, PKD2, and p38 MAPK mediate Hsp27 serine-82 phosphorylation induced by neurotensin in pancreatic cancer PANC-1 cells.39
190860532009Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.34
204680642010Association study of 182 candidate genes in anorexia nervosa.30
212332152011Neurotensin triggers dopamine D2 receptor desensitization through a protein kinase C and beta-arrestin1-dependent mechanism.29
207318142010Neurotensin is increased in serum of young children with autistic disorder.26

Citation

Dessen P

NTS (neurotensin)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46378/nts