Atlas of Genetics and Cytogenetics in Oncology and Haematology


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NUAK2 (NUAK family kinase 2)

Identity

Alias_namesNUAK family
Alias_symbol (synonym)SNARK
FLJ90349
Other alias
HGNC (Hugo) NUAK2
LocusID (NCBI) 81788
Atlas_Id 45666
Location 1q32.1  [Link to chromosome band 1q32]
Location_base_pair Starts at 205271191 and ends at 205290919 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
NUAK2 (1q32.1) / CYB5R1 (1q32.1)NUAK2 (1q32.1) / LEMD1 (1q32.1)NUAK2 1q32.1 / CYB5R1 1q32.1
NUAK2 1q32.1 / LEMD1 1q32.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NUAK2   29558
Cards
Entrez_Gene (NCBI)NUAK2  81788  NUAK family kinase 2
AliasesSNARK
GeneCards (Weizmann)NUAK2
Ensembl hg19 (Hinxton)ENSG00000163545 [Gene_View]  chr1:205271191-205290919 [Contig_View]  NUAK2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000163545 [Gene_View]  chr1:205271191-205290919 [Contig_View]  NUAK2 [Vega]
ICGC DataPortalENSG00000163545
TCGA cBioPortalNUAK2
AceView (NCBI)NUAK2
Genatlas (Paris)NUAK2
WikiGenes81788
SOURCE (Princeton)NUAK2
Genetics Home Reference (NIH)NUAK2
Genomic and cartography
GoldenPath hg19 (UCSC)NUAK2  -     chr1:205271191-205290919 -  1q32.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)NUAK2  -     1q32.1   [Description]    (hg38-Dec_2013)
EnsemblNUAK2 - 1q32.1 [CytoView hg19]  NUAK2 - 1q32.1 [CytoView hg38]
Mapping of homologs : NCBINUAK2 [Mapview hg19]  NUAK2 [Mapview hg38]
OMIM608131   
Gene and transcription
Genbank (Entrez)AK074830 AK303577 AK309520 AL136891 AM392904
RefSeq transcript (Entrez)NM_030952
RefSeq genomic (Entrez)NC_000001 NC_018912 NT_004487 NW_004929293
Consensus coding sequences : CCDS (NCBI)NUAK2
Cluster EST : UnigeneHs.497512 [ NCBI ]
CGAP (NCI)Hs.497512
Alternative Splicing GalleryENSG00000163545
Gene ExpressionNUAK2 [ NCBI-GEO ]   NUAK2 [ EBI - ARRAY_EXPRESS ]   NUAK2 [ SEEK ]   NUAK2 [ MEM ]
Gene Expression Viewer (FireBrowse)NUAK2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)81788
GTEX Portal (Tissue expression)NUAK2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H093   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H093  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H093
Splice isoforms : SwissVarQ9H093
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ9H093
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_dual-sp_kinase    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)NUAK2
DMDM Disease mutations81788
Blocks (Seattle)NUAK2
SuperfamilyQ9H093
Human Protein AtlasENSG00000163545
Peptide AtlasQ9H093
HPRD12172
IPIIPI00008883   
Protein Interaction databases
DIP (DOE-UCLA)Q9H093
IntAct (EBI)Q9H093
FunCoupENSG00000163545
BioGRIDNUAK2
STRING (EMBL)NUAK2
ZODIACNUAK2
Ontologies - Pathways
QuickGOQ9H093
Ontology : AmiGOmagnesium ion binding  protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  cytoplasm  protein phosphorylation  apoptotic process  actin cytoskeleton organization  intracellular signal transduction  cellular response to glucose starvation  negative regulation of apoptotic process  
Ontology : EGO-EBImagnesium ion binding  protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  cytoplasm  protein phosphorylation  apoptotic process  actin cytoskeleton organization  intracellular signal transduction  cellular response to glucose starvation  negative regulation of apoptotic process  
NDEx NetworkNUAK2
Atlas of Cancer Signalling NetworkNUAK2
Wikipedia pathwaysNUAK2
Orthology - Evolution
OrthoDB81788
GeneTree (enSembl)ENSG00000163545
Phylogenetic Trees/Animal Genes : TreeFamNUAK2
HOVERGENQ9H093
HOGENOMQ9H093
Homologs : HomoloGeneNUAK2
Homology/Alignments : Family Browser (UCSC)NUAK2
Gene fusions - Rearrangements
Fusion : MitelmanNUAK2/CYB5R1 [1q32.1/1q32.1]  
Fusion : MitelmanNUAK2/LEMD1 [1q32.1/1q32.1]  [t(1;1)(q32;q32)]  
Fusion: TCGANUAK2 1q32.1 CYB5R1 1q32.1 LGG
Fusion: TCGANUAK2 1q32.1 LEMD1 1q32.1 HNSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNUAK2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NUAK2
dbVarNUAK2
ClinVarNUAK2
1000_GenomesNUAK2 
Exome Variant ServerNUAK2
ExAC (Exome Aggregation Consortium)NUAK2 (select the gene name)
Genetic variants : HAPMAP81788
Genomic Variants (DGV)NUAK2 [DGVbeta]
DECIPHER (Syndromes)1:205271191-205290919  ENSG00000163545
CONAN: Copy Number AnalysisNUAK2 
Mutations
ICGC Data PortalNUAK2 
TCGA Data PortalNUAK2 
Broad Tumor PortalNUAK2
OASIS PortalNUAK2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNUAK2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNUAK2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NUAK2
DgiDB (Drug Gene Interaction Database)NUAK2
DoCM (Curated mutations)NUAK2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NUAK2 (select a term)
intoGenNUAK2
Cancer3DNUAK2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608131   
Orphanet
MedgenNUAK2
Genetic Testing Registry NUAK2
NextProtQ9H093 [Medical]
TSGene81788
GENETestsNUAK2
Huge Navigator NUAK2 [HugePedia]
snp3D : Map Gene to Disease81788
BioCentury BCIQNUAK2
ClinGenNUAK2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD81788
Chemical/Pharm GKB GenePA142671243
Clinical trialNUAK2
Miscellaneous
canSAR (ICR)NUAK2 (select the gene name)
Probes
Litterature
PubMed31 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNUAK2
EVEXNUAK2
GoPubMedNUAK2
iHOPNUAK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 30 15:12:50 CEST 2017

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